Clinical trials: Transplantation, Liver
Liver Transplantation
The Effect of Norepinephrine on Cardiac Output in Patients Undergoing Liver Transplant .
Early administration of NE in liver transplant recipient might enhance cardiac output through an increase in cardiac preload .
- Trial name
- NCT04376281
- Testing
- Noradrenaline
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Cairo University
Living Donor Liver Transplantation
DCreg in Living Donor Liver Transplantation
Phase I/II, single center, prospective, open-label, non-controlled, non-randomized, interventional, cohort study in which low risk living donor liver transplant (LDLT) recipients will receive a single infusion of donor-derived…
- Trial name
- NCT03164265
- Testing
- Regulatory Donor-Derived Dendritic Cell infusion
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Angus W. Thomson PhD DSc
Liver Transplantation, Anxiety
Endogenous Melatonin Levels on Anxiety in Living Liver Donors
Interesting in living liver donor transplantation have greatly increased because of inadequacy of cadaveric organs and the inability to supply the growing need for cadaveric transplantation.
- Conditions
- Liver Transplantation, Anxiety, Melatonin
- Trial name
- NCT04230707
- Testing
- Endogenous Melatonin Levels
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Transplantation, Living Donor
Rectus-Intercostal Fascial Plane Block for Liver Transplantation Donors
Postoperative pain control plays a crucial role in enhancing recovery and improving early mobilization in living liver donors. The rectus-intercostal fascial plane (RIFP) block is a novel ultrasound-guided regional anesthesia…
- Conditions
- Liver Transplantation, Living Donor, Postoperative Pain
- Trial name
- NCT07233096
- Testing
- Rectus Intercostal Plane Block, Control (No Block)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istinye University
End Stage Liver Disease, Sarcopenia
Exercise Intervention in Liver Transplant Patients
The purpose of this study is to learn more about the effects of exercise on functional status and outcomes on patients with end-stage liver disease on the liver transplant waiting list and who have undergone liver transplantation.
- Conditions
- End Stage Liver Disease, Sarcopenia, Liver Cirrhoses
- Trial name
- NCT02367092
- Testing
- Exercise Program
- Where
- 3 sites in United States
- Volunteers
- 83 people
- Sponsor
- University of California, San Francisco
Liver Transplant; Complications, Pain, Postoperative
Effects of Comedy Therapy on Pain and Comfort Levels in Liver Transplant Recipients
This study was conducted to investigate the effects of watching excerpts from classical Turkish comedy films on pain and comfort levels in liver transplant recipients during the postoperative period.
- Conditions
- Liver Transplant; Complications, Pain, Postoperative, Care Acceptor, Health
- Trial name
- NCT06816628
- Testing
- comedy therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bitlis Eren University
Acute Kidney Injury, Chronic Kidney Diseases
Neohepatic Albumin-Bilirubin Scores on Renal Outcomes in Living-donor Liver Transplantation Recipients
This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.
- Conditions
- Acute Kidney Injury, Chronic Kidney Diseases, Graft Failure
- Trial name
- NCT06340607
- Where
- South Korea
- Volunteers
- 3,422 people
- Sponsor
- Asan Medical Center
Liver Transplant Surgery
Fibrinogen in Liver Transplant
The study is a prospective, multi-centered, unblinded, randomized controlled pilot study. The primary objective is to compare functional hemostatic capacity of two approved products Intercept Fibrinogen Complex (IFC) to Standard…
- Trial name
- NCT07265843
- Testing
- Intercept Fibrinogen Complex (IFC), Cryoprecipitate Antihemophilic Factor (AHF)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Trauma Hemostatis and Oxygenation Research (THOR) Network
Liver Diseases, Liver Cirrhosis
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial.
- Conditions
- Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
- Trial name
- CHANCE (NCT04613921)
- Testing
- Observational Protocol
- Where
- 106 sites in United States, Argentina and 25 more
- Volunteers
- 3,000 people
- Sponsor
- European Foundation for Study of Chronic Liver Failure
Liver Transplantation
S100β and Neuron Specific Enolase Levels in Liver Transplantation
Several neurological problems which include both central nervous system and peripheral nervous system can occur as a result of acute liver failure or severe chronic liver failure.
- Trial name
- NCT03453047
- Testing
- S100β and Neuron specific enolase (NSE)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bora Dinc
Liver Diseases, Kidney Diseases
Hypothermic Oxygenated Perfusion Versus Static Cold Storage for Marginal Graft
One of the major challenge in the field of organ transplantation is the shortage of donor organs. Many patients waiting for organ transplantation die during the waiting time and many patients wait for organ transplantation many…
- Trial name
- PIO (NCT03031067)
- Testing
- Machine perfusion
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Matteo Ravaioli
Liver Transplant
OCS Liver PROTECT Continued Access Protocol
Continued Access Protocol to evaluate the effectiveness of the OCS Liver System to preserve and assess donor livers.
- Trial name
- NCT04186221
- Testing
- OCS Liver System
- Where
- 17 sites in United States
- Volunteers
- 74 people
- Sponsor
- TransMedics
Liver Transplant Failure
Early Allograft Failure Simplified Estimation (EASE) in Liver Transplantation
A variety of clinical scores have been developed with the intent to predict early allograft failure after liver transplantation.
- Trial name
- EASE (NCT03858088)
- Testing
- Liver transplantation
- Where
- Italy
- Volunteers
- 2,350 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
End Stage Liver Disease
Study of Peripheral Tissue Oxygenation in End-stage Liver Disease Patients During Liver Transplantation
End - stage liver disease can cause many problems to the patients including fatigue, weakness,jaundice, confusion, abdominal pain and distension. Another important problem is the cardiovascular system (heart and blood vessels).
- Trial name
- NCT01794637
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Zhejiang University
Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease
The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and…
- Trial name
- NCT06359496
- Testing
- No intervention factor
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Liver Diseases
APHP Plateform of Normothermic Perfusion for Rehabilitation of Hepatic Grafts
This study aimed to evaluate fatty liver grafts, considered as unsuitable for upfront liver transplantation, by using normothermic perfusion. Grafts have to be allocated to one of 3 liver transplantation centres of Paris.
- Trial name
- PENOFOR (NCT04154696)
- Testing
- Liver transplantation of a graft after assessment by normothermic perfusion
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatitis C
Grazoprevir/Elbasvir for Treatment of Hepatitis C Virus Genotype 4 Post Kidney Transplant
This is a prospective, interventional, case-control study at King Faisal Specialist Hospital \& Research Centre in post-renal transplant patients who are receiving Grazoprevir/Elbasvir combination.
- Trial name
- NCT03359746
- Testing
- Grazoprevir/Elbasvir
- Volunteers
- 40 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Liver Transplantation
Study of the Effect of Everolimus Immunosuppressive Combination Therapies on Renal Function When Used as a Maintenance Treatment for Liver Transplant Patients.
A 24-month multi-center, open-label, randomized, controlled study to evaluate the evolution of renal function in maintenance liver transplant recipients receiving everolimus plus reduced TAC or everolimus plus mycophenolate…
- Trial name
- Prometheus (NCT03596970)
- Testing
- TAC withdrawal, Everolimus with reduced TAC
- Sponsor
- Novartis Pharmaceuticals
Hepatitis C Infection
Study of Hepatitis C Virus (HCV) Entry Inhibitor in Liver Transplant Recipients With HCV Infection
This study will test the safety and tolerability of HCV Entry Inhibitor ITX 5061 in Liver Transplant Recipients with Hepatitis C infection.
- Trial name
- NCT01560468
- Testing
- ITX 5061
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Schiano, Thomas D., MD
Liver Transplant; Complications, Cirrhosis
Technology Enabled Strategies to Promote Treatment Adherence in Liver Transplant
Liver transplantation is increasingly performed for older adults with multiple comorbidities. Medication adherence is key to maintaining proper function of the transplanted liver and optimize health; however, adhering to…
- Conditions
- Liver Transplant; Complications, Cirrhosis, End Stage Liver DIsease, Medication Adherence
- Trial name
- TEST (NCT05260268)
- Testing
- TEST Intervention
- Where
- 3 sites in United States
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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