Clinical trials: Transplantation Lung
Lung Transplant; Complications, Lung Transplant; Infection or Inflammation
Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes
This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers.
- Conditions
- Lung Transplant; Complications, Lung Transplant; Infection or Inflammation, Lung Transplant Rejection, Lung Transplant Failure
- Trial name
- PROMISE (NCT06399302)
- Where
- 19 sites in United States, Canada
- Volunteers
- 2,600 people
- Sponsor
- Duke University
Lung Transplantation
Film Array Pneumonia Plus Panel® Multiplex PCR for Early Adaptation of Antibiotic Prophylaxis During Lung Transplantation
Postoperative pneumonia significantly worsens the prognosis for patients undergoing lung transplantation (LT). It is therefore recommended to use antibiotic prophylaxis after LT, although the specific types of antibiotics or the…
- Trial name
- FilmArray-TP (NCT07792018)
- Testing
- Early adapation of antibiotic prophylaxis according to FAPP results.
- Volunteers
- 98 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Advanced Lung Disease
Treating Frailty in Lung Transplant Candidates (PREHAB)
In this pilot project, 35 lung transplant candidates will be recruited to participate in a three month individualized home-based program focused on exercise and nutrition optimization.
- Trial name
- PREHAB (NCT03457545)
- Testing
- Home-based pulmonary rehabilitation, Aidcube
- Volunteers
- 26 people
- Sponsor
- University of California, San Francisco
Chronic Obstructive Pulmonary Disease (COPD)
REGEND001 Autologous Basal Layer Stem Cell Transplantation for Chronic Obstructive Pulmonary Disease (COPD): A Translational Application Study
This clinical trial aims to evaluate the safety and efficacy of REGEND001, an autologous bronchial basal cell therapy, for the treatment of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT06946953
- Testing
- P63+ lung progenitors
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Lung Transplant; Pain
Evaluating the Impact of Cryo-analgesia on Recovery After Double Lung Transplantation
The goal of this pilot trial is to learn whether the use of cryo nerve block and its effect on sensation in the chest alters recovery after bilateral lung transplantation, and to which extent these parameters are influenced.
- Trial name
- CRyoLTRiX (NCT06959056)
- Testing
- cryo nerve block at T3-T8 intercostal nerves bilaterally
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Gasthuisberg
Acute Lung Injury
Thoracic Fluid Content and Acute Lung Injury
To study the association of the thoracic fluid content and acute lung injury during liver transplantation.
- Trial name
- NCT01922557
- Testing
- NICOM
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- National Taiwan University Hospital
COVID-19
Homologous vs Heterologous Third Vaccination in Kidney Transplant Recipients Kidney Transplant Recipients
Randomized-controlled trial comparing homologous (mRNA vaccine) vs. heterologous (vector vaccine) for third SARS-CoV-2 vaccine dose in kidney transplant recipients not responding to initial prime-boost vaccination with an mRNA…
- Trial name
- BOOST_TX (NCT05324319)
- Testing
- Ad26COVS1, ChAdOx1 SARS2 Vaccine, BNT162B2
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Pulmonary Diseases, Oxygen Therapy
Effects of High-Flow Nasal Cannula on Exercise Outcomes in Lung Transplant Candidates: A Pilot Study
The study evaluated patients on the national lung transplant waiting list. It was pioneering in assessing high-complexity patients with severe pulmonary diseases subjected to a cardiopulmonary rehabilitation protocol using a…
- Conditions
- Pulmonary Diseases, Oxygen Therapy, High-flow Nasal Cannula, Exercise Tolerance
- Trial name
- NCT06620081
- Testing
- Performance Tests, Functional Tests
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Israelita Albert Einstein
Lung Transplant; Complications
Validation of the Respiratory Function of Pulmonary Transplants to Anticipate Unplanned Hospitalizations
Acute cellular and/or humoral rejection and early graft infections after pulmonary transplant (<2.5 years) are common and can lead to chronic dysfunction of the transplanted organ or Chronic Lung Allograft Dysfunction, CLAD.
- Trial name
- TRANSADOM (NCT03368365)
- Testing
- Ventilotel ®
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Grenoble
Airway Complications Post Lung Transplant
Biodegradable Airway Stent Post Lung Transplant
Introduction and rationale Benign airway stenosis or malacia is a frequent complication of lung transplantation occurring in 4-24% of patients, most often occurring two to nine months post-transplant.
- Trial name
- NCT05334199
- Testing
- Biodegradable stent
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Influenza
Influenza Vaccine in Lung Transplant Patients - Antibody
This is a sub-study of a 5-year study designed to investigate how antibody and T cell responses following influenza vaccine compare among lung transplant patients, patients waiting for lung transplantation, and healthy…
- Trial name
- NCT04533139
- Testing
- Influenza vaccine
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of Wisconsin, Madison
Stem Cell Transplant Complications, Respiratory Disease
Efficacy of Fluticasone Propionate Associated With Salmeterol Using Inhalation Chamber Versus Placebo to Improve the Respiratory Function in Children Over Six Years of Age Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation With a Decline of FEV1 ≥10% From Pre Transplantation
Bronchiolitis Obliterative Syndrome (BOS) is the primary noninfectious pulmonary complication after hematopoietic stem cell transplantation (HSCT) and usually carries a poor prognosis.
- Conditions
- Stem Cell Transplant Complications, Respiratory Disease, Bronchiolitis Obliterans
- Trial name
- RESPPEDOBS (NCT04655508)
- Testing
- Seretide
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Disease
Comparing Methods for Tracking Health Information at Home After Lung Transplant
The purpose of this randomized controlled trial is to test the efficacy of a novel intervention, Pocket PATH (Personal Assistant for Tracking Health) for promoting self-care agency, self-care behaviors, and transplant-related…
- Trial name
- NCT00818025
- Testing
- Pocket PATH (Personal Assistant for Tracking Health)
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- University of Pittsburgh
Chronic Graft-versus-host Disease
MSC for Treatment of cGVHD After Allo-HSCT
The purpose of this study is to evaluate the efficacy of mesenchymal stem cells in patients with chronic graft-versus-host disease.
- Trial name
- NCT04692376
- Testing
- Mesenchymal stem cells, Glucocorticoids, cyclosporine
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Ischemic Motor Stroke, Chronic
Intracerebral Transplantation of Neural Stem Cells for the Treatment of Ischemic Stroke
The study is to determine the safety of human neural stem cell transplantation for the treatment of paralysis and related symptoms due to chronic motor stroke and to determine the maximum tolerated dose.
- Trial name
- NCT03296618
- Testing
- NSI-566
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Suzhou Neuralstem Biopharmaceuticals
Lung Transplant, Post Lung Transplantation
CLAD Phenotype Specific Risk Factors and Mechanisms
While many patients experience benefits from transplant, complications such as infections and lung rejection may affect long term survival and quality of life.
- Trial name
- NCT02631720
- Testing
- Blood Draw, Bronchoscopy
- Where
- 5 sites in United States, Canada
- Volunteers
- 884 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans
Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD
This study is for people who have had a lung transplant and developed a condition called chronic lung allograft dysfunction (CLAD), which is a type of chronic rejection.
- Conditions
- Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans, Extracorporeal Photopheresis
- Trial name
- NCT07434869
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Brian Keller
Lung Transplantation, Bronchiolitis Obliterans
Surveillance Study of Viral Infections Following Lung Transplantation
The present study was conducted to study the impact community acquired respiratory virus (CARV) infections in an outpatient setting on graft function of lung transplant recipients.
- Conditions
- Lung Transplantation, Bronchiolitis Obliterans, Epstein-Barr Virus Infections, Paramyxoviridae Infections
- Trial name
- NCT00701922
- Where
- Germany
- Volunteers
- 388 people
- Sponsor
- Hannover Medical School
Lung Transplant, Dysphagia
TEE and Dysphagia in Lung Transplantation
The primary outcome of this study is dysphagia (difficulty swallowing) on postoperative speech and swallow evaluation following lung transplantation.
- Trial name
- NCT06089434
- Testing
- Transesophageal Echocardiography (TEE) with limited number of TEE clips, Transesophageal Echocardiography (TEE) with number of TEE clips per attending anesthesiologist
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of California, Los Angeles
Cognitive Dysfunctions
Neurological Complications - Pulmonary Transplant
A monocentric prospective open study to evaluate the frequency and nature of cognitive complications in the 3rd month post pulmonary transplant.
- Trial name
- NCT01818193
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hopital Foch