Clinical trials: Transplantation Lung
Lung Transplantation
Anaesthesiologic Considerations for Intraoperative ECMO Anticoagulation During Lung Transplantation
Extracorporeal membrane oxygenation (ECMO) is a frequently used extracorporeal support measure during the intraoperative period in lung transplantation.
- Trial name
- NCT06054997
- Where
- Czechia
- Volunteers
- 141 people
- Sponsor
- University Hospital, Motol
Brain Death, Organ Donors
Naloxone for Optimizing Hypoxemia Of Lung Donors
Brain-dead patients who provide authorization for organ donation will be randomized to naloxone or placebo if baseline arterial blood gas (ABG) after initiation of OPO (Organ Procurement Organization) management reveals…
- Conditions
- Brain Death, Organ Donors, Lung Transplantation
- Trial name
- NO-HOLDS (NCT02581111)
- Testing
- Naloxone, Normal saline
- Where
- 4 sites in United States
- Volunteers
- 199 people
- Sponsor
- Washington University School of Medicine
COPD, Asthma
Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen
An open label study in 40-60 subjects with diagnosed lung airway disease and in 10-20 normal controls. Each subject will receive PFP as a contrast agent to visualize the airway and alveolar spaces in their lungs using magnetic…
- Conditions
- COPD, Asthma, Cystic Fibrosis, Emphysema
- Trial name
- NCT01710449
- Testing
- perfluorinated gas/oxygen mixture
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Hal C Charles
Lung Transplantation, Pulmoner Rehabilitation
Evaluation of Hydroxymethylbutyrate Supplementation in Lung Transplant Candidates Receiving Pulmonary Rehabilitation
Lung transplantation (LTx) is an accepted treatment option for patients with end-stage lung disease who do not respond to non-transplant treatments.
- Conditions
- Lung Transplantation, Pulmoner Rehabilitation, Lun Transplant Candidates
- Trial name
- NCT07660991
- Testing
- HMB
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Okan University
Sickle Cell Disease, Chronic Kidney Diseases
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions
The purpose of this study is to test the efficacy of a peer support coaching intervention to improve activated chronic illness self-management versus an attention control group in 225 adolescents and young adults with childhood…
- Conditions
- Sickle Cell Disease, Chronic Kidney Diseases, Systemic Lupus Erythematosus, Childhood Cancer
- Trial name
- PiCASO (NCT03938324)
- Testing
- PiCASO Intervention Group
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Duke University
Breast Cancer, Kidney Cancer
Peripheral Stem Cell Transplantation in Treating Patients With Melanoma or Small Cell Lung, Breast, Testicular, or Kidney Cancer That is Metastatic or That Cannot Be Treated With Surgery
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Breast Cancer, Kidney Cancer, Lung Cancer, Melanoma (Skin)
- Trial name
- NCT00006126
- Testing
- busulfan, cyclophosphamide, etoposide
- Sponsor
- Northwestern University
Lung Transplantation
Activity Coaching in Patients Post Lung Transplantation
Lung transplantation is an ultimate, effective treatment option for selected patients with end stage lung disease, improving quality of life and extending survival.
- Trial name
- NCT04122768
- Testing
- Multi-component physical activity tele coaching intervention, Light coaching intervention
- Where
- Belgium
- Volunteers
- 108 people
- Sponsor
- KU Leuven
Lung Transplantation
Immunosuppressive Therapy With Certican (Everolimus) After Lung Transplantation
The purpose of this study is to determine whether Everolimus is effective in the treatment and prevention of chronic graft dysfunction and chronic graft rejection after lung transplantation.
- Trial name
- NCT00402532
- Testing
- Everolimus, Mycophenolatmofetil
- Where
- Germany
- Volunteers
- 190 people
- Sponsor
- Hannover Medical School
Lung Diseases
Transplanting Hepatitis C Lungs Into Negative Lung Recipients
This study is being conducted to determine safety and effectiveness of transplanting lungs from Hepatitis C-positive donors into Hepatitis C-negative patients on the lung transplant waitlist, who will then be treated with…
- Trial name
- SHELTER (NCT03724149)
- Testing
- Zepatier, Epclusa
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Carcinomas, Amyloidosis
B-Receptor Signaling in Cardiomyopathy
We hope to determine the importance of different genes (including B receptors) in anthracycline-induced cardiomyopathy. This has important benefits to patients exposed to anthracyclines, as this could help determine whether…
- Conditions
- Carcinomas, Amyloidosis, Anal Cancer, Anemia
- Trial name
- NCT01135849
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Daniel Bernstein
Lung Transplantation
Telecommunication Via Cell Phones During Post-Operative Treatment After Lung Transplantation
In an investigation should be evaluated in contrast to a control group with standard post-treatment therapy (using home spirometry) after lung transplantation if transfer of home spirometry recordings to the transplant center via…
- Trial name
- TeleTx (NCT00536926)
- Testing
- Home spirometry with data transfer via cell phone, Home spirometer with BT-cellphone, Home spirometer w/o BT
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Hannover Medical School
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
The purpose of this research study is to learn about the safety of transplanting lungs obtained from non-heart-beating donors (NHBDs) that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01615484
- Testing
- Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™, STEEN Solution™
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2)
The objective of this trial was to assess the efficacy and safety of aerosolized liposomal cyclosporine A (L-CsA) as add-on therapy to standard of care (SoC) as compared to SoC alone in double lung transplant (DLT) recipients…
- Conditions
- Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant, Lung Transplant Rejection, Lung Transplant; Complications
- Trial name
- BOSTON-2 (NCT03656926)
- Testing
- Liposomal Cyclosporine A, Standard of Care
- Where
- 40 sites in United States, Austria and 7 more
- Volunteers
- 169 people
- Sponsor
- Zambon SpA
Brain Death, Lung Transplantation
Organ Donation Survey Among Health Care Professionals in Argentina
The aim of this study is to gather information about knowledge, professional experience and attitude toward organ donation among health care professionals involved in the care of potential donors about the procurement process and…
- Conditions
- Brain Death, Lung Transplantation, Respiration, Artificial, Tissue and Organ Procurement
- Trial name
- NCT03458052
- Where
- Argentina
- Volunteers
- 200 people
- Sponsor
- Hospital Italiano de Buenos Aires
Lung Transplantation
Neural Respiratory Drive Combined With Pro-Brain Natriuretic Peptide (Pro-BNP) as Predictor of Deterioration After Lung Transplantation
Lung transplantation has become a promising therapeutic option for various end-stage lung diseases. However, many factors such as infection, graft rejection, airway complications would cause deterioration and shorten the survival…
- Trial name
- NCT07525440
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Bronchiolitis Obliterans
Targeted Therapy of Bronchiolitis Obliterans Syndrome
This phase II trial studies how well giving fluticasone propionate, azithromycin, and montelukast sodium (FAM) together works in treating patients with bronchiolitis obliterans who previously underwent stem cell transplant.
- Trial name
- FAM for BOS (NCT01307462)
- Testing
- fluticasone propionate, montelukast sodium, azithromycin
- Where
- 11 sites in United States
- Volunteers
- 36 people
- Sponsor
- Stephanie Lee
Lung Transplant Failure and Rejection, Primary Graft Dysfunction
CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation
Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD).
- Trial name
- NCT04558333
- Testing
- blood and exhaled breath specimens
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- University Hospital, Antwerp
Lung Preservation
International Randomized Study of the TransMedics Organ Care System (OCS Lung) for Lung Preservation and Transplantation
A prospective, international, multi-center, randomized controlled trial comparing preservation of donor lungs using OCS-Lung perfusion device (Treatment Group) to cold flush and storage (Control Group).
- Trial name
- INSPIRE (NCT01630434)
- Testing
- OCS Lung, Cold flush and storage
- Where
- 21 sites in United States, Australia and 7 more
- Volunteers
- 320 people
- Sponsor
- TransMedics
Non Small Cell Lung Cancer
Fecal Microbiota Transplant(FMT) Combination With Tislelizumab in Advanced or Metastatic NSCLC
This study aims to investigate the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment for non-small cell lung cancer (NSCLC) patients whose disease has progressed after immune checkpoint inhibitor (ICI)…
- Trial name
- FMT-LUNG (NCT07432984)
- Testing
- Tislelizumab, Fecal Microbiota Transplant(FMT)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Se-Hoon Lee
Lung Transplant; Complications
Preventing Rehospitalization in Lung Transplant Recipients Utilizing mHealth
Lung transplantation has several important aims: 1) extend survival; 2) relieve disability, and 3) improve health-related quality of life (HRQL) for adults suffering from end-stage lung disease.
- Trial name
- PERSPIRE (NCT03792698)
- Testing
- Aidcube digital app-based platform
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania