Clinical trials: Transplantation Lung
Chronic Rejection in Lung Transplant, Cytokine Production in Bos Post Lung Transplant
Early Indicators of Chronic Rejection in Lung Transplant
The purpose of this research is to discover the different patterns of cytokine production in patients who may develop Bronchiolitis Obliterans Syndrome-0p (BOS-0p) which means ongoing rejection.
- Trial name
- BOS (NCT00449332)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Chicago
Complication of Transplanted Lung
Assessment of Cough Reflex in Lung Transplant Recipients
The purpose of this study is to evaluate the presence of cough reflex in the transplanted lung of patients who have had either a single or double lung transplant or heart-lung transplant at University of Texas Medical Branch.
- Trial name
- NCT00584077
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans
Etanercept for Non-Infectious Lung Injury Following Bone Marrow Transplantation
The purpose of this study is to determine the effects of etanercept, and define the toxicity, when administered to patients with acute non-infectious lung injury (idiopathic pneumonia syndrome, IPS) and with subacute pulmonary…
- Conditions
- Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans, Pneumonia
- Trial name
- NCT00029328
- Testing
- etanercept
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- FDA Office of Orphan Products Development
Lung Transplant; Complications
4DX Functional Lung Imaging in the Diagnosis of Chronic Lung Allograft Dysfunction After Lung Transplantation
This is a pilot study to determine the utility of Novel Functional Lung Imaging and Ventilation (4DxV) Analysis software in measurement of lung ventilation abnormalities and diagnosis of chronic lung allograft dysfunction (CLAD)…
- Trial name
- NCT04892719
- Testing
- Fluoroscopic chest imaging with 4Dx technology software analysis
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Lung Transplant Failure and Rejection, Lung Transplant Infection
Liquid biopsiEs fOr luNg AllogRaft Damage classificatiOn - LEONARDO
LTx has the shortest survival of all solid organ transplants. The complex and time-demanding diagnostics of allograft dysfunction are a significant reason for this.
- Trial name
- LEONARDO (NCT06679257)
- Testing
- cell-free dNA
- Where
- Sweden
- Volunteers
- 146 people
- Sponsor
- Jesper Magnusson
Bronchiolitis Obliterans
Long-term Safety Follow-up Study in the Prevention of Bronchiolitis Obliterans Syndrome (BOS)
The purpose of this study is to evaluate long-term safety of L-CsA in prevention of bronchiolitis obliterans syndrome (BOS) following lung transplantation (LTx) in patients previously enrolled in phase II/III L-CsA clinical trial…
- Trial name
- NCT01439958
- Testing
- Inhalation
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- Pari Pharma GmbH
Idiopathic Pulmonary Fibrosis, Emphysema or COPD
Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure
The purpose of this study is to determine whether a lung transplantation prior to bone marrow transplantation (BMT) would allow for restoration of pulmonary function prior to BMT, allowing to proceed to BMT, to restore…
- Trial name
- NCT03500731
- Testing
- CD3/CD19 negative hematopoietic stem cells, Rituximab, Alemtuzumab
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Paul Szabolcs
Pneumocystis Jirovecii Pneumonia, Kidney Transplantation
Low- vs Standard-Dose TMP-SMX for Prevention of Pneumocystis Pneumonia After Kidney Transplantation
This study is a prospective randomized controlled trial designed to evaluate the efficacy and safety of low-dose versus standard-dose trimethoprim-sulfamethoxazole (TMP-SMX) for the prevention of Pneumocystis jirovecii pneumonia…
- Trial name
- TMP-SMX PJP (NCT07619027)
- Testing
- Trimethoprim-Sulfamethoxazole (TMP-SMX)
- Volunteers
- 1,084 people
- Sponsor
- Anhui Provincial Hospital
End-stage Lung Disease
BREATHE Study: Spontaneous Breathing-Preserved Anesthesia and Surgical Strategy for Hospital Recovery in Lung Transplantation
The goal of this study is to learn whether a spontaneous-breathing ("tubeless") anesthesia and surgery strategy can improve early recovery and remain safe for adults who receive a lung transplant.
- Trial name
- BREATHE-LTx (NCT07384546)
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 110 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Graft-versus-host Disease
Daily IL-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease
Chronic GVHD is a medical condition that may occur after a bone marrow, stem cell or cord blood transplant. The donor's immune system may recognize the your body (the host) as foreign and attempt to 'reject' it.
- Trial name
- NCT01366092
- Testing
- Interleukin-2
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Dana-Farber Cancer Institute
Acute Lung Injury
Risk Factors of Postoperative Acute Lung Injury Following Liver Transplantation
Postoperative acute lung injury (ALI) during the first 72 hours after liver transplantation is not uncommon. Injury may occur because liver transplantation is often associated with prolonged operative time, large volumes of fluid…
- Trial name
- NCT02412800
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Lung, Lung Transplant
Comparative Study Between Sternal Closure With Sternalock® Blue Versus Steel Wire Submitted To Bilateral Anterior Transsternal Thoracotomy (Clamshell) For Bilateral Lung Transplant
This will be a prospective, randomized clinical trial, comparing the sternal alignment between the fixation with rigid plate X steel wires.
- Trial name
- LungTx-Lock (NCT05055739)
- Testing
- Rigid plate X steel wires
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Lung Transplantation, Bronchiolitis Obliterans
Dry Powder Inhalation of Cyclosporine A in Lung Transplant Patients With Bronchiolitis Obliterans Syndrome
The purpose of this study is to investigate whether dry powder inhalation of Cyclosporine A is beneficial in lung transplant patients with Bronchiolitis Obliterans Syndrome.
- Trial name
- NCT00378677
- Testing
- Cyclosporine A dry powder inhalation (Drug)
- Where
- Netherlands
- Volunteers
- 7 people
- Sponsor
- University Medical Center Groningen
Chronic Allograft Dysfunction
Study of STX-100 in Renal Transplant Patients With Interstitial Fibrosis and Tubular Atrophy (IF/TA)
This Phase 2 study is a multi-center, randomized, double-blind, placebo-controlled, single followed by multiple dose, dose escalation study designed to evaluate the safety, tolerability, pharmacokinetics, immunogenicity, and…
- Trial name
- NCT00878761
- Testing
- STX-100
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Stromedix, Inc.
Lung Transplant
Tocilizumab in Lung Transplantation
This is a trial in which 100 primary lung transplant recipients will be randomized (1:1) to receive either Tocilizumab (six doses over 20 weeks) plus standard triple maintenance immunosuppression or placebo (sterile normal…
- Trial name
- ALL IN LUNG (NCT06033196)
- Testing
- Tocilizumab
- Where
- 21 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Copd, End Stage Lung Disease
Health Coaching Telemedicine Program for Lung Transplant Candidates With End-stage Lung Disease.
Lung transplantation has become standard of care for selected patients with end stage pulmonary disease. While on the lung transplantation waiting list, patient health, emotional wellbeing and quality of life can deteriorate.
- Trial name
- HCTP (NCT06428513)
- Testing
- HCTP
- Where
- Israel
- Volunteers
- 56 people
- Sponsor
- Sheba Medical Center
Allograft Rejection, Lung Transplantation
Vitamin D in Bronchiolitis Obliterans Syndrome
Vitamin D deficiency occurs in around 50% of our transplant population. Preventive treatment with Vitamin D (D-cure) can reduce the prevalence of Bronchiolitis Obliterans Syndrome after lung transplantation
- Conditions
- Allograft Rejection, Lung Transplantation, Bronchiolitis Obliterans
- Trial name
- VIT001 (NCT01212406)
- Testing
- Vitamin D
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Transplant; Complications, COVID19
COVID-19 in Liver Transplant Recipients
Prospective observational study aimed at analyzing the incidence, clinical characteristics and outcomes of COVID-19 in LT in Spain.
- Conditions
- Liver Transplant; Complications, COVID19, Respiratory Failure
- Trial name
- COVID19-SETH (NCT04361591)
- Testing
- Observational only
- Where
- Spain
- Volunteers
- 121 people
- Sponsor
- Hospital Clinic of Barcelona
Lung Transplantation
Efficacy Regarding Renal Function of Everolimus in Combination With Specific Standard Immunosuppressive Regimen Lung Transplant Recipients
This trial evaluated the efficacy of an everolimus-based quadruple low immunosuppressive regimen versus a standard immunosuppressive regimen concerning kidney function in lung transplant recipients.
- Trial name
- 4EVERLUNG (NCT01404325)
- Testing
- standard therapy, Everolimus
- Where
- 9 sites in Germany
- Volunteers
- 130 people
- Sponsor
- Novartis Pharmaceuticals
Stem Cell Transplantation, Fatigue
Severe Fatigue in Stem Cell Transplantation
Fatigue is a common symptom during allogeneic-hematopoietic stem cell transplantation (allo-HSCT). However, effects of severe fatigue on pulmonary functions, blood cells, dyspnea, muscle strength, exercise capacity, depression…
- Trial name
- NCT03448471
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Gazi University