Clinical trials: Transplantation Lung
Lung Transplant Failure
Respiratory Physiotherapy as a Tool to Increase the Number of Solid Organ Donors
The main objective of the project is to determine the variation of PaO2 / FiO2 (PaFi) after the use of mechanical insufflation-exsufflation (MI-E) or mechanical cough assistant in the donor in brain death (DBD) and in the…
- Trial name
- NCT06202859
- Testing
- MIE
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Vall d'Hebron Institute Research
Graft-versus-Host Disease
Lenalidomide (Revlimid®) as Second Line Therapy in Patients With Chronic Graft-Vs-Host Disease (GVHD)
The goal of this clinical research study is to learn if Revlimid® (lenalidomide), along with standard-of-care steroid treatment you are already receiving, can help to control Chronic Graft-Versus-Host Disease (cGVHD).
- Trial name
- NCT00675441
- Testing
- Lenalidomide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- M.D. Anderson Cancer Center
Kidney Transplantation
The Long-term Effect of Marine Omega-3 Fatty Acid Supplementation in Renal Transplantation
This is a long-term intervention study on the effects of marine n-3 PUFAs in renal transplantation. Our hypothesis is that patients treated with marine n-3 PUFA supplementation will have less decline in kidney transplant function…
- Trial name
- EMiRA (NCT03018041)
- Testing
- Omacor
- Where
- 6 sites in Norway
- Volunteers
- 174 people
- Sponsor
- Joe Chan
Lung Transplant
Immuno-humoral Rejection Markers in Pulmonary Transplant
Open multicentric prospective study performed on pulmonary transplanted patients to detect the values of different diagnostic markers for immuno- humoral reaction and their roles in the humoral rejection for those patients.
- Trial name
- RHUM-TP (NCT01791166)
- Testing
- Blood test for detecting the circulatory anti-HLA antibodies by ELISA and LUMINEX tests
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Hopital Foch
Stem Cell Transplant Complications
Role of Stem Cell Therapy in Interstitial Pulmonary Fibrosis
Currently, the application status of MSCs as treatment modalities in IPF is still in its infancy and remains exploratory. Although a number of safety and efficacy clinical trials of MSCs as therapeutic options in immune-mediated…
- Trial name
- NCT03187431
- Testing
- autologous bone marrow mesenchymal stem cells
- Volunteers
- 12 people
- Sponsor
- Assiut University
Covid19, Liver Transplant
Liver Transplantation and Coronavirus Disease 2019 (COVID-19)
The COVID-19 pandemic together with the strategies that are applied to control it are generating high morbidity and mortality worldwide.
- Trial name
- NCT04695756
- Testing
- COVID-19 pandemic
- Where
- Argentina
- Volunteers
- 1,000 people
- Sponsor
- Hospital Italiano de Buenos Aires
Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans
Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD
This study is for people who have had a lung transplant and developed a condition called chronic lung allograft dysfunction (CLAD), which is a type of chronic rejection.
- Conditions
- Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans, Extracorporeal Photopheresis
- Trial name
- NCT07434869
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Brian Keller
Bone Density, Overweight
Nutritional Problems After Lung and Heart Transplantation
Part 1) Bone health after transplantation - possible influence of vitamin K Part 2) Fat metabolism and endocrine parameters - possible predictors for developement of overweight after transplantation
- Trial name
- NCT00826254
- Testing
- Vitamin K
- Where
- Norway
- Volunteers
- 94 people
- Sponsor
- Oslo University Hospital
Graft Vs Host Disease, Acute-graft-versus-host Disease
Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial
This study is about determining if an aerobic and resistance exercise intervention is feasible in patients diagnosed with acute or chronic GVHD (Graft-Versus-Host Disease) after having an allogeneic stem cell transplant.
- Conditions
- Graft Vs Host Disease, Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease
- Trial name
- RESTART (NCT05236062)
- Testing
- Exercise, Attention control
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Dana-Farber Cancer Institute
Acute Lung Injury
Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment
Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this complication.
- Trial name
- NCT00852605
- Testing
- Intermittent Non-Invasive Ventilation
- Volunteers
- 86 people
- Sponsor
- Technische Universität Dresden
Transplant Recipient, Infections, Coronavirus
Multicentric Study of Coronavirus Disease 2019 (COVID-2019) in Solid Organ Transplant Recipients
The overall purpose of this project is to better understand the incidence, risk factors, etiology, clinical manifestations and outcome of tCOVID19 in solid organ transplant recipients.
- Trial name
- COVIDSOT (NCT04319172)
- Where
- Spain
- Volunteers
- 488 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Obliterative Bronchiolitis
Bronchodilator Responsiveness in Obliterative Bronchiolitis
This study has been designed to provide a substantial evidence of acute bronchodilator responsiveness to two sequentially inhaled drugs, a beta2-agonist (i.e., albuterol) and an anticholinergic (i.e., tiotropium bromide), in a…
- Trial name
- BD-OB (NCT01112241)
- Testing
- albuterol plus tiotropium
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Pulmonary Infiltrate New
FOB in HSCT and Leukemia Patients With Acute Respiratory Symptoms and Pulmonary Infiltrates
Pulmonary infiltrates frequently complicate the care of hematopoietic stem cell transplant (HSCT) and leukemia patients. Bronchoalveolar lavage (BAL) is frequently used to evaluate new pulmonary infiltrates in this population…
- Trial name
- NCT01328873
- Testing
- Microbiological analysis
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Northside Hospital, Inc.
Solid Organ Transplantation, Chronic Kidney Disease
Immune Response to Influenza Vaccination
The purpose of this study is to evaluate the immune response to a routine influenza vaccination. Influenza vaccination is given as part of routine standard of care in these individuals and is not part of the study protocol.
- Trial name
- NCT00551837
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Lung Diseases
Study to Evaluate the Value of the Follow-up of CALCIneurin Activity to MOdulate Calcineurin Inhibitors-induced Immunosuppression in Lung Transplantation
The study is an interventional, multicentre, prospective, randomized, controlled, single-blind, comparative trial of two processes for adjusting the inhibitor of calcineurin (CNI) dosage in lung transplant recipients.
- Trial name
- CalciMo-TP (NCT02897895)
- Testing
- levels of CNI in whole blood, Calcineurin activity (CN-a) in peripheral blood mononuclear cells (PBMCs)
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Lung Diseases
Increasing Lung Transplant Availability Using Normothermic Ex Vivo Lung Perfusion (EVLP) at a Dedicated EVLP Facility
The objective of this study is to evaluate the safety and effectiveness of the Centralized Lung Evaluation System (CLES) in enabling evaluation of potential donor lungs not otherwise used for transplant into subjects with end…
- Trial name
- NCT03641677
- Testing
- Centralized Lung Evaluation System, Lung Transplant
- Where
- 13 sites in United States
- Volunteers
- 174 people
- Sponsor
- Lung Bioengineering Inc.
Chronic Obstructive Pulmonary Disease, Pulmonary Fibrosis
Using Health-related Quality of Life (HRQL) in Routine Clinical Care
The objective of this study is to assess the effects of using HRQL measures in the clinical care of pre- and post-lung transplant patients.
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Fibrosis, Pulmonary Hypertension, Cystic Fibrosis
- Trial name
- NCT00457301
- Testing
- HUI score card
- Where
- Canada
- Volunteers
- 213 people
- Sponsor
- University of Alberta
Kidney Diseases, Chronic Kidney Diseases
NAVIGATE Kidney: A Multi-level Intervention to Reduce Kidney Health Disparities
The overarching goal of this project is to refine and adapt previous work on the NAVIGATE-Kidney project for individuals with CKD.
- Trial name
- NAV-Kidney (NCT06810622)
- Testing
- Community health worker intervention, Standard Care (in control arm)
- Where
- 2 sites in United States
- Volunteers
- 448 people
- Sponsor
- University of Colorado, Denver
Obstructive Airway Disease
Prospective Evaluation of the Efficacy of Budesonide/Formoterol in Bronchiolitis Obliterans in AHSCT
The usual treatment for obstructive airway disease (OAD) after allogeneic hematopoietic stem cell transplantation (AHSCT) , which is related to graft versus host disease (GVHD), consists of intensification of systemic…
- Trial name
- Alloforb (NCT00624754)
- Testing
- Formoterol/Budesonide, lactose
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Malignant Hematological Diseases
Efficacy of Azithromycin to Prevent Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation
The occurrence of bronchiolitis obliterans syndrome (SBO) after allogeneic hematopoietic stem cell transplantation (HSCT) is considered to be a chronic pulmonary graft versus host disease (GVHD) that is associated with…
- Trial name
- ALLOZITHRO (NCT01959100)
- Testing
- Azithromycin
- Where
- France
- Volunteers
- 480 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris