Clinical trials: Transplantation Lung
Cytomegalovirus Infections, Transplant-Related Disorder
Open Label Trial of Oral Letermovir for CMV Prophylaxis in Thoracic Transplant Recipients
Open label study to determine tolerability and efficacy of letermovir for CMV prophylaxis in heart and lung transplant recipients. The study hypotheses are: 1.
- Trial name
- NCT06066957
- Testing
- Letermovir 480 MG [Prevymis]
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Lung Transplant Rejection
Transbronchial Biopsies With Cryoprobe in Patients With Lung Transplantation.
The survival of lung transplant patients (PD) is limited mainly by Infections, graft dysfunction in the immediate postoperative period and chronic dysfunction. Up to 36% have an episode of acute rejection after transplantation.
- Trial name
- NCT03090581
- Testing
- Biopsies CP, Biopsies FC
- Where
- Spain
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Graft vs Host Disease
Pentostatin for High Risk and Refractory Chronic Graft Versus Host Disease in Children
This is a multicenter trial through the Pediatric Blood and Marrow Transplant Consortium. The Primary hypothesis of this study is that because of its effect as a potent immunosuppressive agent targeting lymphocytes, pentostatin…
- Trial name
- NCT00144430
- Testing
- Pentostatin
- Where
- 25 sites in United States
- Volunteers
- 60 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Chronic GVHD
SHR0302 and Steroid As First Line Therapy for Chronic GVHD
The purpose of this study is to evaluate the efficacy of SHR0302 in combination with Prednisone as first line therapy in patients with moderate to severe chronic graft-versus-host disease (GVHD).
- Trial name
- NCT04146207
- Testing
- SHR0302, Prednisone
- Where
- 2 sites in China
- Volunteers
- 28 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML)
CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant
The purpose of this study is to learn more about the effects of (classification determinant) CD34+ stem cell selection on graft versus host disease (GVHD) in children, adolescents, and young adults.
- Conditions
- Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML), Myelodysplastic Syndrome (MDS), Juvenile Myelomonocytic Leukemia (JMML)
- Trial name
- NCT02061800
- Testing
- CliniMACS CD34+ Reagent System, Thiotepa, Cyclophosphamide
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Diane George
Lung Transplant; Complications, Primary Graft Dysfunction
Identifying Optimal PEEP After Lung Transplantation
Lung Transplantation (LuTX) is the curative treatment for selected patients with end-stage lung disease. Primary Graft Dysfunction (PGD), a specific form of respiratory failure occurring within the first 72 hours after graft…
- Trial name
- PEEP-LuTX (NCT05691205)
- Testing
- PEEP
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Policlinico Hospital
Lung Transplant Rejection
Next Generation Sequencing to Detect Acute Rejection in Lung Transplant Patients.
Lung transplantation is a consolidated treatment in selected patients with end-stage respiratory diseases; however, acute rejection remains an important cause of lung allograft loss and a risk factor for chronic allograft…
- Trial name
- NGS-ACRL (NCT05260372)
- Testing
- Quantification of donor-derived cell-free DNA
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Rejection Lung Transplant
MICRA - Pilot Study
Acute cell rejection is a common complication of lung transplantation. The pathological diagnosis is based on the performance of transbronchial biopsies which are associated with a significant risk of potentially severe…
- Trial name
- MICRA (NCT04536883)
- Testing
- microscopy confocal
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Lung Transplantation
Prospective Intervention Study to Improve HRQoL and Exercise Tolerance After Lung Transplantation (Ergo-LTx)
A prospective, interventional rehabilitation program was initiated to improve exercise capacity and psychosocial functioning in patients after lung transplantation (LTx) and to evaluate long-term effects on health-related quality…
- Trial name
- Ergo-LTx (NCT00753155)
- Testing
- exercise training; psychosocial support
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
COPD, Interstitial Pneumonia
Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results.
- Conditions
- COPD, Interstitial Pneumonia, Bronchiectasis, Respiratory Failure
- Trial name
- NCT06922916
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhejiang University
Myelofibrosis, Postlung Transplant (Bronchiolitis Obliterans)
A Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Itacitinib
This is a mutli-center open-label study to provide continued supply of itacitinib to participants from the following Incyte-sponsored studies of itacitinib: INCB39110-209, INCB39110-213, INCB39110-214, INCB39110-230, and…
- Conditions
- Myelofibrosis, Postlung Transplant (Bronchiolitis Obliterans), Chronic Graft Versus Host Disease
- Trial name
- NCT04640025
- Testing
- itacitinib
- Where
- 21 sites in United States, Austria and 7 more
- Volunteers
- 18 people
- Sponsor
- Incyte Corporation
Disorder Related to Lung Transplantation, CLAD, Bronchiolitis Obliterans
European Trial of Pirfenidone in BOS, A European Multi-center Study
A European multi-centre, randomised, double-blind placebo-controlled trial of Pirfenidone in bronchiolitis-obliterans-syndrome grade 1-3 in lung transplant recipients. Randomized double blinded, placebo controlled study.
- Trial name
- EPOS (NCT02262299)
- Testing
- Pirfenidone
- Where
- 9 sites in Belgium, Denmark and 5 more
- Volunteers
- 90 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Primary Lung Graft Dysfunction
Comparison by Transoesophageal Assessement of Systolic Right Ventricle Function Measures in Perioperative Care of Pulmonary Transplant.
The aim of the study is to describe the early adaptation of the right ventricle assessed by echocardiography to change of pulmonary circulation secondary to pulmonary transplantation.
- Trial name
- ETO VD PERIOP (NCT02887560)
- Testing
- transoesophageal echocardiography
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Strasbourg, France
Cancer Metastatic to the Liver, Hepatocellular Carcinoma
A Study to Assess PV-10 Chemoablation of Cancer of the Liver
This open-label study will evaluate the safety, tolerability, pharmacokinetics and effect on tumor growth following a single intralesional injection of PV-10 in subjects with either (a) hepatocellular carcinoma (HCC) that is not…
- Conditions
- Cancer Metastatic to the Liver, Hepatocellular Carcinoma, Metastatic Melanoma, Metastatic Ocular Melanoma
- Trial name
- NCT00986661
- Testing
- PV-10 (10% rose bengal disodium)
- Where
- 5 sites in United States
- Volunteers
- 78 people
- Sponsor
- Provectus Biopharmaceuticals, Inc.
Lung Transplant, Post Lung Transplantation
CLAD Phenotype Specific Risk Factors and Mechanisms
While many patients experience benefits from transplant, complications such as infections and lung rejection may affect long term survival and quality of life.
- Trial name
- NCT02631720
- Testing
- Blood Draw, Bronchoscopy
- Where
- 5 sites in United States, Canada
- Volunteers
- 884 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Vaccine Hesitancy
Investigation on the Hesitancy of COVID-19 Vaccination Among Liver Transplant Recipients in China
On WeChat platform, through a point-to-point connection, and carry on the questionnaire survey to collect information of liver transplant recipients followed-up by the department of Liver Surgery, Renji Hospital Shanghai Jiao…
- Trial name
- NCT05532592
- Testing
- Perceptions and attitudes towards COVID-19 and COVID-19 vaccine
- Where
- China
- Volunteers
- 449 people
- Sponsor
- RenJi Hospital
Lung Transplant; Complications, Chronic Kidney Diseases
Immunosuppressive Regimen on Changes in Renal Function and Transplant Rejection Rate in Patients With Lung Transplant
This retrospective single-center analyzes the impact of switch of immunosuppressive regimen on renal function and transplant rejection rate in patients with lung transplant.
- Trial name
- NCT03657004
- Where
- Germany
- Volunteers
- 145 people
- Sponsor
- University of Giessen
Alpha-1 Antitrypsin Deficiency
Alpha-1 Antitrypsin Deficiency Adult Liver Study
The investigators hypothesize that there is liver injury (inflammation, fibrosis, cirrhosis) in adults with Alpha-1 Antitrypsin Deficiency (AATD), which is asymptomatic, under-recognized, and undiagnosed.
- Trial name
- NCT02014415
- Testing
- Liver Biopsy (Biopsy Group Only)
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- St. Louis University
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Subcutaneous Treprostinil as a Bridge to Lung Transplantation in Severe Pulmonary Hypertension: A Single-Arm Retrospective Study
This single-arm, retrospective study aims to evaluate the safety and efficacy of subcutaneous treprostinil as a bridge therapy for lung transplantation in patients with severe pulmonary hypertension (PH).
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Chronic Lung Disease-Associated Pulmonary Hypertension, Lung Transplantation
- Trial name
- NCT06605326
- Testing
- Subcutaneous Treprostinil
- Volunteers
- 46 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Post-Lung Transplantation Bronchiectasis
Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes After Lung Transplant
The purpose of this research is to study the effect of training the inspiratory muscles (i.e. the muscle that allow you to breath-in) on exercise capacity, quality of life, and short-term clinical outcomes in patients post lung…
- Trial name
- NCT04783155
- Testing
- POWERBreathe Plus®, Cardiopulmonary rehabilitation post lung transplant
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic