Clinical trials: Transplantation Lung
Sleep Wake Disorders, Lung Transplantation
Low-Frequency rTMS for In-Hospital Sleep Disturbance After Lung Transplantation
This randomized, double-blind, sham-controlled trial will evaluate whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve in-hospital sleep quality in adult lung transplant recipients during early…
- Trial name
- TMS-SLEEP-LTx (NCT07796425)
- Testing
- Active Low-Frequency Repetitive Transcranial Magnetic Stimulation
- Volunteers
- 152 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Bronchiolitis Obliterans Syndrome
Novel Pulmonary Function Measures for Diagnosis of Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem-Cell Transplantation in Children
In this study, we will study 129Xe-MRI and LCI as tools for diagnosis of BOS in pediatric patients who have received Hematopoietic Stem Cell Transplantation (HSCT) and have been identified as eligible for this study.
- Trial name
- NCT04391335
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- The Hospital for Sick Children
COPD, Emphysema
Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplant
The study will evaluate the efficacy and safety of basiliximab Vs placebo as induction therapy combined with standard triple immunosuppression therapy, in the prevention of acute rejection episodes and prevention of Bronchiolitis…
- Conditions
- COPD, Emphysema, Alpha-1 Antitrypsan Deficiency
- Trial name
- NCT00188825
- Testing
- basiliximab
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University Health Network, Toronto
Pulmonary Hypertension Due to Left Heart Disease, Pulmonary Hypertension (PH)
Evaluation of the BMPR2-Activin Signaling Pathway in Group II Pulmonary Hypertension.
Previous data from our group showed reduced BMPR2 isoform A in pulmonary hypertension associated with left heart disease (PH-LHD) of valvular origin.
- Conditions
- Pulmonary Hypertension Due to Left Heart Disease, Pulmonary Hypertension (PH), Heart Failure
- Trial name
- BREATHE-PH (NCT07537517)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Metabolic Syndrome
Feasibility of a Home Exercise Program to Manage Post-transplant Metabolic Syndrome
Post-transplant metabolic syndrome (PTMS) affects about 50% liver transplant (OLT) and 25% lung transplant (LTx) recipients at 12-18 months post-transplant.
- Trial name
- NCT04965142
- Testing
- Exercise Training
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University Health Network, Toronto
Lung Transplant Failure and Rejection
Clinical Trials in Organ Transplantation Extension Study
The purpose of the study is to continue to follow subjects who were enrolled in the CTOT-20 CLAD Phenotypes study. Subjects will provide clinical data and complete quality of life questionnaires that will be used to determine the…
- Trial name
- CTOT-ES (NCT04126746)
- Where
- 5 sites in United States, Canada
- Volunteers
- 501 people
- Sponsor
- Duke University
Lung Transplant Infection, Pneumonia, Bacterial
Antimicrobial Therapeutic Drug Monitoring During Lung Transplant Perioperative Phase
Background: Post-LUTX pneumonia represents a leading cause of death along the first month after LUTX. Donor-derived transmission of pathogenic species occurs up to 25% of recipients receiving a graft with a positive BAL culture…
- Conditions
- Lung Transplant Infection, Pneumonia, Bacterial, Antibiotic Resistant Strain
- Trial name
- NCT06583642
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Policlinico Hospital
Hematopoietic Stem Cell Transplantation
Physical Inactivity in Candidates of HSCT
Decreased number of steps and poorer quality of life are prevalently observed among candidates of hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT03915210
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Gazi University
Lung Diseases, Lung Neoplasms
Observational Bronchoscopy Video Data Collection Study With Adult Patients
The primary aim is to develop a software algorithm that has the capacity to detect the normal 18 anatomical structures of the lung by using the position of the scope during the bronchoscopy procedure and using existing…
- Conditions
- Lung Diseases, Lung Neoplasms, Lung Cancer, Lung Transplantation
- Trial name
- NCT06465797
- Testing
- Bronchoscopy
- Where
- Denmark
- Volunteers
- 115 people
- Sponsor
- Ambu A/S
Immunodeficiency, Immunosuppression
ImmunoCARE: Rapid, Accurate COVID Testing to Reduce Hospitalization of Immunocompromised Individuals
The investigators will examine whether a combination of at-home nucleic acid amplification tests, on-demand telemedicine, and delivery of prescriptions such as Paxlovid quickly after testing positive for COVID-19, can reduce…
- Conditions
- Immunodeficiency, Immunosuppression, HIV Infections, Graft Versus Host Disease
- Trial name
- NCT05655546
- Testing
- Access to Cue Health COVID-19 Remote testing and treatment for COVID-19
- Where
- United States
- Volunteers
- 2,117 people
- Sponsor
- Scripps Translational Science Institute
Asthma, COPD
The Natural History of Small Airways Physiology in Diseased and Healthy States
Spirometry is a useful clinical tool for the assessment and monitoring of lung disease, however, it does not provide information on peripheral airways resistance.
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- NCT00677560
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Non Small Cell Lung Cancer, Respiratory Tract Neoplasm
Study for Evaluating the Safety and Feasibility of Fecal Microbiota Transplant in Stage II-III NSCLC Patients Using ICI Responders as Donors (MIGRANT)
This is a randomized, phase II, multi-centre clinical trial. Sample size: 68 patients (Experimental Arm (Durvalumab + chemotherapy + FMT capsules): 34 patients, Control Arm (Durvalumab + chemotherapy): 34 patients) Population…
- Trial name
- MIGRANT (NCT07247786)
- Testing
- Biological: Fecal Microbiota Transplantation, Durvalumab, Paclitaxel
- Where
- 20 sites in Spain
- Volunteers
- 68 people
- Sponsor
- Fundación GECP
Lung Transplant Infection
Evaluation of Tolsura When Used as Prophylaxis After Lung Transplantation
This is a single-center, observational study of Tolsura PK sampling in lung transplant recipients
- Trial name
- Tolsura (NCT04652050)
- Testing
- Tolsura
- Where
- United States
- Sponsor
- Hong Nguyen
Transplantation Infection, Pulmonary Transplantation
Assessment of Information Provided on Infectious Risk in Solid Organ Transplantation
Solid organ transplantation (lung, kidney, liver, and heart) is a major therapeutic option for many end-stage chronic diseases. In France, several hundred patients undergo transplantation each year, supported by advances in…
- Trial name
- ENVIR-TRANS (NCT07788417)
- Where
- 8 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Stem Cell Transplant Complications, Pulmonary Complication
Change in Management Following Bronchoscopy in Hematopoietic Stem Cell Transplant Patients With Pulmonary Infiltrates
Hematopoietic stem cell transplant (HSCT) is a modality that is increasingly utilized to treat various haematological disorders with a varying degree of success.
- Trial name
- NCT04998903
- Testing
- Fiberoptic Bronchoscopy
- Where
- Saudi Arabia
- Volunteers
- 51 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Chronic Graft-Versus-Host Disease, Acute Graft-Versus-Host Disease
Donor Regulatory T Cells Infusion in Patients With Chronic Graft-versus-host Disease (GVHD)
The immune system has offensive and defensive capacities. In bone marrow transplantation, offensive cells in the donor grafts may attack host's organs, leading to a complication known as Graft versus Host Disease (GVDH).
- Conditions
- Chronic Graft-Versus-Host Disease, Acute Graft-Versus-Host Disease, Steroid Refractory Graft-Versus-Host Disease
- Trial name
- NCT01903473
- Testing
- Rapamycin, T regulatory cells
- Where
- 2 sites in Belgium
- Volunteers
- 19 people
- Sponsor
- University of Liege
CMV, Lung Transplant Recipient
Combination Letermovir and Standard of Care Antiviral for Enhanced Antiviral Response in Cytomegalovirus Infection in Lung Transplant Recipients
The primary objective of the CLEAR-CMV trial is to evaluate the efficacy of letermovir therapy plus standard of care (SOC) antiviral compared to SOC plus placebo in achieving clearance of CMV viremia by week 3 in lung transplant…
- Trial name
- CLEAR-CMV (NCT07235683)
- Testing
- Letermovir, Valganciclovir/Ganciclovir
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Allogeneic Hematopoietic Cell Transplant Recipients
Prospective Phase II Study for Assessment of Regulatory Immune Cell Populations After Allogeneic HSCT
Allogeneic hematopoietic cell transplantation offers high cure rates for patients with hematological and oncological diseases. Graft-versus-host disease (attack of donor's white blood cells on patient's tissues) is a serious…
- Trial name
- NCT00587574
- Where
- 2 sites in Austria, Czechia
- Volunteers
- 150 people
- Sponsor
- Medical University of Vienna
Lung Cancer
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003860
- Testing
- filgrastim, carboplatin, etoposide
- Where
- 22 sites in France
- Volunteers
- 36 people
- Sponsor
- UNICANCER
Chronic Graft-versus-host Disease
Tear Cytokine Analysis as a Prediction or Diagnostic Marker in Ocular GvHD
Investigate the profiles of tear cytokines in patients who underwent stem cell transplantation (SCT) and attempted to determine the applicability of tear cytokines in the diagnosis of chronic graft-versus-host disease (GVHD).
- Trial name
- NCT02411474
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Yonsei University