Clinical trials: Transplantation Lung
Interstitial Lung Disease, COPD
Pulmonary Hypertension SOLAR
The main goal of this study is to develop a noninvasive signature for pulmonary vascular remodeling in Group 3 PH patients, using hyperpolarized 129Xe magnetic resonance imaging (129Xe MRI).
- Conditions
- Interstitial Lung Disease, COPD, Pulmonary Arterial Hypertension
- Trial name
- PH SOLAR (NCT04778046)
- Testing
- Hyperpolarized 129Xe
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Bastiaan Driehuys
Lung Transplantation, Acute Kidney Injury
Short- and Long-Term Renal Outcomes Following Lung Transplantation
Evaluation of acute kidney injury, renal recovery and development of chronic kidney disease in patients undergoing lung transplantation
- Trial name
- NCT03046277
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Giessen
Bronchiolitis Obliterans, Bone Marrow Transplantation
Effectiveness of Azithromycin Therapy in Improvement of Symptoms and Lung Function in Patients With Bronchiolitis Obliterans After Bone Marrow Transplantation
Bronchiolitis obliterans syndrome (BOS), an obstructive airway disease as a result of chronic rejection, is one of the major causes of morbidity and mortality in long-term survivors of allogeneic bone marrow transplantation…
- Trial name
- NCT00563251
- Testing
- Azithromycin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hospital Authority, Hong Kong
Pulmonary Disease, Chronic Obstructive, Emphysema
Evaluating the Effects of Surgical and Non-Surgical Treatment Options in People With Emphysema
Emphysema is a lung disease that involves damage to the air sacs in the lungs and can lead to breathing difficulties. Treatment options for people with emphysema include pulmonary rehabilitation, lung volume reduction surgery…
- Trial name
- NCT00675454
- Where
- United States
- Volunteers
- 802 people
- Sponsor
- Washington University School of Medicine
Lung Transplant Infection, Lower Respiratory Tract Infection
Preliminary Study of Dornase Alfa to Treat Chest Infections Post Lung Transplant.
Patients who have undergone lung transplantation are at an increased risk of developing chest infections due to long-term medication suppressing the immune response.
- Trial name
- NCT01952470
- Testing
- Dornase Alfa, Isotonic Saline.
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- The Alfred
Chronic Graft-Versus Host Disease
Treatment of Chronic GVHD of Liver or Lungs by ECP
Chronic graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation and the leading cause of death more than 2 years after transplantation.During the past 30 years survival of…
- Trial name
- NCT00271869
- Testing
- Extracorporeal photoimmunotherapy
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
CKD, Dialysis
Long Term Cardio-Vascular Risk Assessment in CKD and Kidney Transplanted Patients Following SARS-COV-2
The occurrence of novel coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), has offered an unmatched global challenge for the healthcare research community.
- Conditions
- CKD, Dialysis, Kidney Transplant, COVID-19
- Trial name
- CARDIO SCARS (NCT05125913)
- Testing
- FMD, Arterial stiffness, Assessment of IMT
- Where
- Romania
- Volunteers
- 250 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Idiopathic Pulmonary Arterial Hypertension
Safety and Efficacy Study of Transplantation of EPCs to Treat Idiopathic Pulmonary Arterial Hypertension
Experimental data suggest that transplantation of endothelial progenitor cells (EPCs) attenuates monocrotaline-induced pulmonary hypertension in rats and dogs.
- Trial name
- NCT00257413
- Testing
- Transplantation of autologous endothelial progenitor cells
- Where
- China
- Sponsor
- Zhejiang University
Immune and Microbial Reconstitution, Systemic Viral Infection
Monitoring of Immune and Microbial Reconstitution in (HCT) and Novel Immunotherapies
This protocol serves as a mechanism to collect, store, and distribute bodily fluid and tissue samples obtained from Hematopoietic Cell Transplant (HCT) or novel immunotherapy patients and their donors at the Masonic Cancer Center…
- Conditions
- Immune and Microbial Reconstitution, Systemic Viral Infection, Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease
- Trial name
- NCT03557749
- Testing
- Blood Sample, Stool Sample, Urine Sample
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Lung Transplant Rejection
PREdiction of Chronic LUng Allograft Dysfunction
Chronic lung allograft dysfunction (CLAD) is the leading cause of long-term mortality after lung transplantation. Several risk factors for CLAD have been identified, but the exact pathophysiology and triggering molecular factors…
- Trial name
- PRELUD (NCT03967340)
- Where
- 10 sites in France
- Volunteers
- 240 people
- Sponsor
- Nantes University Hospital
Respiratory Tract Disease, Kidney Transplantation
Evaluation of the Respiratory Function in Renal Transplanted Children
Objectives: While a respiratory abnormality was found in 50% of pediatric renal transplant recipients in a study conducted in Belgium and the Netherlands in 2008, the respiratory status of transplanted children in France remains…
- Conditions
- Respiratory Tract Disease, Kidney Transplantation, Pediatric
- Trial name
- SPIROKID (NCT03571542)
- Testing
- pulmonary function
- Where
- 5 sites in France
- Volunteers
- 385 people
- Sponsor
- Nantes University Hospital
Interstitial Fibrosis/Tubular Atrophy of Transplanted Kidneys
Magnetic Resonance Elastography of Transplanted Kidney (GREFFE_ELASTO IRM)
: GREFFE_ELASTO IRM will evaluate Magnetic Resonance Elastography (MRE) in renal transplant patients with suspected interstitial fibrosis/tubular atrophy lesions requiring biopsy graft sampling under ultrasound control.
- Trial name
- NCT03918161
- Testing
- MRE exam
- Where
- France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Bordeaux
Transplant-Related Disorder, Frail Elderly Syndrome
Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients
The objective of this study is to assess the feasibility and effectiveness of dedicated ambulator-assisted physical activity in lung transplant inpatients.
- Conditions
- Transplant-Related Disorder, Frail Elderly Syndrome, Sarcopenia, Lung Graft Dysfunction
- Trial name
- iFRAIL (NCT03636412)
- Testing
- Ambulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The Cleveland Clinic
Lung Transplant
The Effect of Nutrition and BMI on on Lung Capacity, Functional Capacity and Mortality in End-Stage Lung Patients
The aim of this study was to investigate the effect of nutritional risk index, BMI and body fat, muscle ratio on functional capacity, lung capacity, exercise capacity index, all-cause mortality, post-transplant intensive care…
- Trial name
- NCT06283680
- Testing
- Lung transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 213 people
- Sponsor
- Aylin Seylam Küşümler
COPD
Adipose Derived Stem Cells Transplantation for Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is the name for a collection of lung diseases including chronic bronchitis, emphysema and chronic obstructive airways disease.
- Trial name
- NCT02645305
- Testing
- Adipose derived stem cells
- Where
- 3 sites in Vietnam
- Volunteers
- 20 people
- Sponsor
- University of Science Ho Chi Minh City
Heart Transplant Failure, Anesthesia
Impact of Atelectasis on RVEDP Following Orthotropic Heart Transplantation
Following orthoptopic heart transplantation (OHT), children undergo surveillance cardiac catheterizations to assess for signs of rejection including muscle biopsy as well as pressure measurements to guide post transplant…
- Trial name
- NCT06140810
- Testing
- Lung Recruitment
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor College of Medicine
SARS-CoV Infection, Corona Virus Infection
Corona Virus Infection Among Liver Transplant Recipients
A new strain of coronavirus that caused severe respiratory disease in infected individuals was initially identified in China's Wuhan City in December 2019.
- Conditions
- SARS-CoV Infection, Corona Virus Infection, Liver Transplant Recipient, COVID-19
- Trial name
- NCT04565782
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Hematologic Neoplasms
Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies
Background: People with blood cancers often receive blood or bone marrow transplants. But even with these treatments, the risk of relapse is high.
- Trial name
- NCT05327023
- Testing
- donor lymphocyte infusion, Cyclophosphamide, Busulfan
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Lung Transplant; Complications
Primary Graft Dysfunction Score in Lung Transplantation
The validity of several functional parameters, which could be included in a new PGD scoring system, will be tested in a prospective pilot study of 80 consecutive bilateral lung transplant recipients in high volume lung transplant…
- Trial name
- NCT03276403
- Testing
- PiCCO Catheter
- Where
- 2 sites in Austria, Canada
- Volunteers
- 80 people
- Sponsor
- Assoc.-Prof. Dr. Konrad Hoetzenecker, PhD
Lung Transplant
Factors Predicting Success in Lung Transplant Recipients Who Have Undergone Intensive Post-operative Rehabilitation
This is a retrospective review of the COLTT program outcomes and factors that predict recovery of functional status after lung transplantation.
- Trial name
- NCT03299504
- Testing
- Exercise
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Indiana University Health Methodist Hospital