Clinical trials: Transplantation Lung
Bronchiolitis Obliterans Syndrome
Forced Oscillation Versus Spirometry in Diagnosing Post Pulmonary Transplant Bronchiolitis Obliterans Syndrome
A study to evaluate the role of forced oscillation in precocious diagnosis of bronchiolitis obliterans syndrome in patients with pulmonary transplant (time difference in detecting distal airways functional impairment by forced…
- Trial name
- OSCILLOPOUMON (NCT01807975)
- Testing
- Forced oscillation
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Hopital Foch
Hematological Diseases
Study on Systemic and Airway Biomarkers in Haemopoietic Stem Cell Transplantation
Haemopoietic stem cell transplantation (HSCT) has become a major life-saving treatment for many haematological conditions, mostly malignancies.
- Trial name
- NCT00956358
- Where
- Hong Kong
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Lung Transplant Rejection, Antibody-mediated Rejection
Lung Transplant Plasmapheresis/Belatacept/Carfilzomib for Antibody Mediated Rejection and Desensitization
Antibody mediated rejection (AMR) post transplant contributes to poor long term outcomes after lung transplantation. Additionally, high antibodies detected pre transplant in candidates limit donor availability for lung…
- Trial name
- NCT03805178
- Testing
- Belatacept, Carfilzomib
- Sponsor
- Duke University
Histiocytosis, Langerhans-cell
Reduced Intensity Hematopoietic Cell Transplantation for Patients With Resistant Langerhans Cell Histiocytosis
RATIONALE: Giving a monoclonal antibody, such as alemtuzumab, and chemotherapy drugs, such as fludarabine and melphalan, before a donor stem cell transplant helps stop the patient's immune system from rejecting the donor's stem…
- Trial name
- NCT00618540
- Testing
- alemtuzumab, fludarabine phosphate, melphalan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
COVID-19
Clinical Research of Human Mesenchymal Stem Cells in the Treatment of COVID-19 Pneumonia
The COVID-19 pneumonia has grown to be a global public health emergency since patients were first detected in Wuhan, China, in December 2019, which spread quickly to worldwide and presented a serious threat to public health.
- Trial name
- NCT04339660
- Testing
- UC-MSCs
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Puren Hospital Affiliated to Wuhan University of Science and Technology
Vaccination, Respiratory Syncytial Virus (RSV)
Immunogenicity and Safety of Respiratory Syncytial Virus Vaccine in Lung Transplant Recipients
The purpose of this study is to compare the immunogenicity and safety of respiratory syncytial virus (RSV) vaccination between lung transplant recipients and immunocompetent adults and to provide evidence to guide RSV vaccination…
- Conditions
- Vaccination, Respiratory Syncytial Virus (RSV), Lung Transplant Recipient
- Trial name
- NCT07895394
- Testing
- RSVPreF3 vaccination
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Chronic Graft-Versus Host Disease
Treatment of Chronic GVHD of Liver or Lungs by ECP
Chronic graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation and the leading cause of death more than 2 years after transplantation.During the past 30 years survival of…
- Trial name
- NCT00271869
- Testing
- Extracorporeal photoimmunotherapy
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Lung Transplant Rejection
A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction
This double-blind, randomized, placebo-controlled, multinational, multicenter, parallel-group, Phase 3, 2-arm, study will investigate the efficacy and safety of belumosudil compared with placebo, both administered on top of…
- Trial name
- ROCKaspire (NCT06082037)
- Testing
- Belumosudil, Azithromycin
- Where
- 85 sites in United States, Australia and 18 more
- Volunteers
- 180 people
- Sponsor
- Sanofi
Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease
Study of Ruxolitinib for Acute and Chronic Graft Versus Host Disease
While hematopoietic stem cell transplant (HSCT) is an effective therapy, graft versus host disease (GVHD) is the most significant complication after HSCT.
- Conditions
- Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease, Solid Organ Transplant
- Trial name
- NCT05121142
- Testing
- Ruxolitinib
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bronchiolitis Obliterans, Bone Marrow Transplantation
Effectiveness of Azithromycin Therapy in Improvement of Symptoms and Lung Function in Patients With Bronchiolitis Obliterans After Bone Marrow Transplantation
Bronchiolitis obliterans syndrome (BOS), an obstructive airway disease as a result of chronic rejection, is one of the major causes of morbidity and mortality in long-term survivors of allogeneic bone marrow transplantation…
- Trial name
- NCT00563251
- Testing
- Azithromycin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hospital Authority, Hong Kong
Anxiety, Stress
Therapeutic Virtual Reality: Helps Reduce Anxiety and Pain During Bronchial Fibroscopies in Lung Transplant Patients.
Marie Lannelongue Hospital is a hospital specialized in lung transplantation. Lung transplant patients require regular check-ups by bronchial fibroscopy. This examination is known to be anxious, stressful and sometimes painful.
- Conditions
- Anxiety, Stress, Pain, Bronchial Fibroscopy
- Trial name
- REVDOU (NCT04731792)
- Testing
- Virtual Reality
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Lung Transplant Failure
Intraoperative Echocardiographic Evaluation of Pulmonary Vein Velocities and Outcomes in Lung Transplantation
This study will evaluate if an association exists between levels of blood flow through the pulmonary veins and the incidence of graft dysfunction post operatively.
- Trial name
- NCT03052153
- Testing
- No investigational intervention performed for this study
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Advanced Lung Disease, Lung Transplant
Progressive Rehabilitation Therapy in Patients With Advanced Lung Disease
The International Society of Heart and Lung Transplantation Registry data shows that there is a growing population of critically ill patients with advanced lung disease undergoing lung transplantation.
- Conditions
- Advanced Lung Disease, Lung Transplant, Extracorporeal Membrane Oxygenation
- Trial name
- NCT03562728
- Testing
- MRP and NMES(neuromuscular electric stimulation), Standard of Care
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Maryland, Baltimore
Bronchiectasis
Follow-up Study of Autologous Transplantation of P63+ Lung Progenitor Cells for Treatment of Bronchiectasis
This is the follow-up study of autologous transplantation of P63+ lung progenitor cells (LPCs) for treatment of bronchiectasis (NCT03655808).
- Trial name
- NCT06164093
- Testing
- RNA sequencing is performed on the remaining LPCs, Immunofluorescence staining is performed in the surgically resected lung tissue sections
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Ruijin Hospital
Disorder Related to Lung Transplantation
Copenhagen Acute Renal Complications After Transplantations Study Group
Lung transplanted patients experience marked decrease in renal function post transplant mainly due to cyclosporine induced renal changes.
- Trial name
- CARCATS (NCT02744872)
- Testing
- Felodipine
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Fungal Infection
A Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients (MK-5592-105)
This single site study will examine plasma and alveolar compartment (AC) levels of posaconazole in cystic fibrosis (CF) and non-cystic fibrosis (non-CF) lung transplant recipients receiving routine post-operative anti-fungal…
- Trial name
- PAPAL (NCT01667107)
- Testing
- Posaconazole, Calogen®
- Volunteers
- 26 people
- Sponsor
- Merck Sharp & Dohme LLC
COVID - 19, Renal Transplant
Safety and Effectiveness of a Remdesivir Treatment to Prevent Severe COVID-19 in Kidney Transplant Patients
Since the start of the COVID-19 pandemic, the approach to solid organ transplantation has evolved. Transplants using organs (excluding lungs) from COVID-19-positive donors have shown short-term safety, but there is limited data…
- Conditions
- COVID - 19, Renal Transplant, SARS CoV 2 Infection
- Trial name
- COVIDKIDNEY (NCT07197164)
- Testing
- Remdesivir (RDV)
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Exercise, Lung Transplantation
Lung Transplant G0 (LTGO): Improving Self-Management of Exercise After Lung Transplantation
Estimated costs, from thirty days prior to lung transplant up through six months post surgery, exceed 1 million dollars per patient and routine medical costs average approximately fifty thousand dollars per year thereafter.
- Trial name
- LTGO (NCT03728257)
- Testing
- LTGO-Home Based Exercise, Enhanced Usual Care
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Pittsburgh
Lung Transplant
CIS001 Extension Study of Cyclosporine Inhalation Solution
This trial is a longterm follow up of a phase III study of inhaled cyclosporine for the prevention of chronic rejection in lung transplant recipients.
- Trial name
- CIS002 (NCT00938236)
- Testing
- Cyclosporine Inhalation Solution (CIS)
- Where
- 16 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- APT Pharmaceuticals, Inc.