Clinical trials: Transplantation Lung
Lung Transplant Failure
Impact of the Ex-vivo Pulmonary Perfusion System on the Microbiome of Lung Grafts and Their Inflammatory Reaction.
It is known that the interactions of the graft and recipient microbiome are capable of modulating immune responses, inducing resilience or exacerbation of various inflammatory or fibrotic processes, therefore variations in the…
- Trial name
- ExBioma (NCT06250517)
- Testing
- EVLP, Cold preservation
- Where
- Spain
- Volunteers
- 7 people
- Sponsor
- Vall d'Hebron Institute Research
Kidney Diseases, Kidney Transplant; Complications
Immunological Safety and Effectiveness of the First Booster Dose of mRNA Vaccines Against COVID-19 in Kidney Transplant Recipients.
Prospective observational trial to assess immunological safety (anti-HLA antibodies, donor-derived cell-free DNA) and immunological effectiveness (anti-SARS-CoV-2 IgG) of the first booster dose of SARS-CoV-2 mRNA vaccines in…
- Conditions
- Kidney Diseases, Kidney Transplant; Complications, COVID-19, Vaccine Adverse Reaction
- Trial name
- NCT05483725
- Testing
- Booster dose of mRNA vaccine
- Where
- Czechia
- Volunteers
- 108 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Lung Transplant Rejection
Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation
Objective: To evaluate the potential impact of molecular phenotyping of transbronchial biopsies in lung transplant recipients with allograft dysfunction, and the potential for developing a safer endobronchial mucosal biopsy…
- Trial name
- INTERLUNG (NCT02812290)
- Testing
- Lung transplant biopsy bites.
- Where
- 11 sites in United States, Australia and 4 more
- Volunteers
- 700 people
- Sponsor
- University of Alberta
Infection
Voriconazole as Prophylactic Therapy in Lung Transplant Recipients
The purpose of this study is to compare the safety and efficacy of Voriconazole with Itraconazole following lung transplantation.
- Trial name
- VORI (NCT00455364)
- Testing
- Voriconazole
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Hematologic Malignancy, GvHD
Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)
The purpose of this Phase 1, first in human open-label study is to assess the safety and tolerability of TRX-103 in patients with hematological malignancies undergoing HLA-mismatched related or unrelated hematopoietic stem cell…
- Conditions
- Hematologic Malignancy, GvHD, GVHD,Acute, GVHD, Chronic
- Trial name
- NCT06462365
- Testing
- TRX103
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Tr1X, Inc.
Leukemia, Myelogenous
Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia Failing TKIs Therapy
Patients newly diagnosed with chronic phase chronic myeloid leukemia undergo treatment with TK inhibitors (TKI). A possible cause of TK failure is represented by the insufficient recovery of normal Ph- hematopoiesis during TKI…
- Conditions
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Trial name
- NCT02638467
- Testing
- Bosutinib, Bone Marrow Transplant, Bone Marrow cells
- Where
- 2 sites in Italy
- Volunteers
- 2 people
- Sponsor
- University of Milano Bicocca
Bronchiolitis Obliterans
Study of Pulmonary MRI for the Diagnosis of Bronchiolitis Obliterans Syndrome After Allogeneic Stem Cell Transplantation
Bronchiolitis Obliterans Syndrome (BOS) is a major complication of Hematopoietic Stem cell Transplantation (HSCT) occurring in the context of chronic GVHD and associated with a poor prognosis.
- Trial name
- IRM-A (NCT04080232)
- Testing
- lung MRI
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Bordeaux
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Bronchiolitis Obliterans
Itacitinib for the Treatment of Bronchiolitis Obliterans Syndrome After Donor Hematopoietic Cell Transplant
This phase I trial studies how well itacitinib works for the treatment of bronchiolitis obliterans syndrome after donor hematopoietic cell transplant.
- Trial name
- NCT04239989
- Testing
- Itacitinib, Itacitinib Adipate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Transplantation, Psychosomatic Medicine
Psychosocial Evaluation Prior to Lung Transplantation
In a prospective longitudinal cohort study we aim at investigating the extent to which pre-transplant psychosocial levels of functioning predict the medical and psychosocial outcomes of lung transplantation.
- Trial name
- EVALUT (NCT02799810)
- Volunteers
- 200 people
- Sponsor
- Hannover Medical School
Lung Transplantation
Patient Reported Outcomes in Living Donor Lung Transplantation
The purpose of the present study is to investigate how the health of donors in living donor lung transplantation will change after transplant operations.
- Trial name
- NCT00905697
- Testing
- Living donor lung transplantation
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Kyoto University, Graduate School of Medicine
COPD
Respiratory Muscles in End-stage Lung Disease: Pathophysiological Processes & Clinical Consequences
Rationale: In patients with chronic lung diseases, the role of respiratory muscle dysfunction has been underestimated. Also, current treatment options, like chronic NIV and lung transplantation (LTx), might also have deleterious…
- Trial name
- Re-MAP (NCT06935825)
- Where
- 4 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Osteopenia, Complications of Heart-lung Transplant
Comparison of Pamidronate With Zoledronic Acid for Transplant Related Bone Loss Prevention
The purpose of this trial is to see whether zoledronic acid is better than pamidronate to treat low bone density in heart and lung transplant patients.
- Conditions
- Osteopenia, Complications of Heart-lung Transplant, Other Complications of Lung Transplant
- Trial name
- NCT00164008
- Testing
- zoledronic acid vs pamidronate
- Volunteers
- 56 people
- Sponsor
- Bayside Health
Covid19
Efficacy, Safety, and Immunogenicity of Vaccine Reimmunization With a Third Homologous Versus Heterologous Dose Against COVID-19 in Patients Undergoing Solid Organ Transplantation.
Patients undergoing solid organ transplantation randomly selected from those who have received two doses of Spikevax (Moderna) vaccine, provided that a minimum of 8 weeks have elapsed from the second dose to the time of the start…
- Trial name
- REIN-TX (NCT05048940)
- Testing
- Janssen vaccine, Spikevax (Moderna) vaccine
- Where
- Spain
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Reflux, Gastroesophageal Reflux Disease (GERD)
RESULT (REflux Surgery in Lung Transplantation) Preliminary Study Protocol
The purpose of the prospective study is to collect information surrounding lung transplant in order to develop a randomized study to determine if prevention of gastroesophageal reflux disease (GERD) related aspiration (stomach…
- Trial name
- RESULT (NCT01406210)
- Where
- 4 sites in United States, Canada
- Volunteers
- 647 people
- Sponsor
- Duke University
Lung Transplantation
Ex-Vivo Lung Reconditioning
Only about 15% of the potential candidates for lung donation are considered suitable for transplantation. Thus, a strategy that could improve the quality and precision of assessment of nonacceptable donor lungs could have a major…
- Trial name
- ExVivo (NCT02906436)
- Testing
- Xvivo Chamber
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Hopital Foch
Immunosuppression, COVID-19
Additional Recombinant COVID-19 Humoral and Cell-Mediated Immunogenicity in Immunosuppressed Populations
To determine whether providing a recombinant booster COVID-19 vaccine improves sustained humoral and cell-mediated immunogenicity against SARS-CoV-2 in immunosuppressed patients with Inflammatory Bowel Disease (IBD) and/or solid…
- Trial name
- NCT06027229
- Testing
- NVX-CoV2372
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Wisconsin, Madison
Graft Rejection, Kidney Transplantation
TRAnscriptional Profile of Peripheral Blood Cells in Patient With Chronic Kidney and Lung Rejection: Correlation With Response to Extracorporeal Photo-aphereSiS
With this project, the research team aims to identify the molecular pathways associated with the response to extracorporeal photonchemioapheresis (ECP) in kidney or lung transplant patients suffering from chronic rejection, by…
- Conditions
- Graft Rejection, Kidney Transplantation, Lung Transplantation, Antibody-Mediated Rejection
- Trial name
- TRACKLESS (NCT07316829)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Acute Lung Injury
CALIPSO: Calfactant for Acute Lung Injury in Pediatric Stem Cell Transplant and Oncology Patients
Acute lung injury (ALI) is a common, life-threatening complication among pediatric leukemia and lymphoma and hematopoietic stem cell transplant (HSCT) recipients.
- Trial name
- CALIPSO (NCT00999713)
- Testing
- Calfactant
- Where
- 16 sites in United States, Canada
- Volunteers
- 43 people
- Sponsor
- Milton S. Hershey Medical Center
Hepatopulmonary Syndrome, Liver Cirrhosis
Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study
Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 < 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations.
- Trial name
- HPS (NCT03092401)
- Volunteers
- 142 people
- Sponsor
- Hospices Civils de Lyon