Clinical trials: Transplantation Lung
Lung-transplant Recipients
Nintedanib in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome Grade 0p-1-2
Lung transplantation (TxP) is now a validated treatment of end-stage pulmonary diseases, but long-term graft and patient survival are still hampered by the development of chronic allograft dysfunction (CLAD) affecting > 50% of…
- Trial name
- INFINITx BOS (NCT03283007)
- Testing
- Nintedanib
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hematopoietic Stem Cell Transplantation
Effects of Pulmonary Rehabilitation in Hematopoietic Stem Cell Transplantation Recipients
Stem cell transplantation is a process in which stem cells are harvested from either a patient's or donor's bone morrow or peripheral blood for intravenous infusion.
- Trial name
- NCT03625063
- Testing
- Exercise training group, Control training group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Kidney Transplantation, Kidney Failure
Effect of 3g Versus 2 g MMF in Combination With Tacrolimus on Progression of Renal Allograft Interstitial Fibrosis
Development of chronic changes (scarring) in transplanted kidney tissue is a major cause of long-term kidney function deterioration and ultimately graft loss. It results from both immunologic and non-immunologic mechanisms.
- Trial name
- NCT01860183
- Testing
- Mycophenolate mofetil
- Where
- Croatia
- Volunteers
- 76 people
- Sponsor
- Clinical Hospital Merkur
Sinusoidal Obstruction Syndrome, Veno-occlusive Disease
Defibrotide Dose-escalation for SOS Post-HSCT
This research study is being done to determine the safety and tolerability of increasing doses of defibrotide within a single patient with sinusoidal obstructive syndrome (SOS)/veno-occlusive disease (VOD) after hematopoietic…
- Trial name
- NCT05987124
- Testing
- Defibrotide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York Medical College
Physical Activity After Organ Transplantation
High-intensity Training Safely Improves Exercise Capacity in Heart, Lung, Kidney, and Liver Transplant Recipients: a Comparative Study
The investigators will investigate whether high-intensity exercise training can safely improve physical performance in long-term stable heart, kidney, lung, and liver transplant recipients.
- Trial name
- NCT03329586
- Testing
- High-intensity training
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lung Transplant
Contribution of Learning and Practice of Different Complementary Therapies in Pulmonary Transplant Patients
The aim of the study is to evaluate, 3 months after lung transplantation, integration and appropriation by the patient of complementary techniques (" Toolbox " included relaxation, autohypnosis, relaxation therapy, TENS (if pain)…
- Trial name
- TOOLBOX (NCT03167528)
- Testing
- Relaxation, Hypnosis, Holistic gymnastics
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hopital Foch
Post Intensive Care Syndrome (PICS), PTSD - Post Traumatic Stress Disorder
ICU-VR Prior to ICU Admission
Rationale: A substantial proportion of the Intensive Care Unit (ICU) survivors develop psychological impairments due to their ICU admission.
- Trial name
- NCT06642636
- Testing
- Intensive Care Unit-specific Virtual Reality
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Denzel Drop
COVID-19
Covid Vaccination in Liver Transplantation
The goal of this retrospective study is to evaluate the proportion of seroconversion after 2 doses mRNA anti-SARS-CoV2 vaccination in a cohort of high risk liver transplanted patients.
- Trial name
- VACCHEPA (NCT05079165)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
COVID-19 Respiratory Infection
Evolution of Respiratory Function in Lung Transplant Patients With Moderate to Severe Covid-19 Infection
The SARS-Cov-2 infection pandemic has caused a large number of acute respiratory failures and deaths across the world. Certain factors have been identified as associated with a higher risk of developing a severe form and dying.
- Trial name
- Cov- EvoLuT (NCT06490744)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Strasbourg, France
Melanoma Stage IV, Unresectable Melanoma
A Phase Ib Trial to Evaluate the Safety and Efficacy of FMT and Nivolumab in Subjects With Metastatic or Inoperable Melanoma, MSI-H, dMMR or NSCLC
A Phase Ib trial to evaluate the safety and efficacy of Fecal Microbial Transplantation (FMT) in combination with Nivolumab in subjects with metastatic or inoperable melanoma, microsatellite instability-high (MSI-H) or…
- Conditions
- Melanoma Stage IV, Unresectable Melanoma, NSCLC Stage IV
- Trial name
- NCT04521075
- Testing
- Fecal Microbial Transplantation by capsules
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Ella Therapeutics Ltd
Equally of Delivery Systems of Local Anesthesia in Bronchoscopy
Topical Anesthesia / Bronchoscopy
The primary aim of this study is to compare a simplified single-use product (LMA® MAD Nasal™ Intranasal Mucosal Atomization Device, Teleflex medical, Kernen Germany) for topical nasopharyngeal anesthesia in comparison to a…
- Trial name
- TNA (NCT02237651)
- Testing
- topical anesthesia multi-use device, topical anesthesia Intranasal Mucosal Atomization
- Where
- Germany
- Volunteers
- 252 people
- Sponsor
- Hannover Medical School
Long-term Effects Secondary to Cancer Therapy in Children, Pulmonary Complications
Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation
RATIONALE: Assessing the long-term effects of bone marrow transplant on lung function in patients may improve the ability to plan treatment.
- Trial name
- NCT00009711
- Testing
- management of therapy complications
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Fred Hutchinson Cancer Center
Respiratory Syncytial Virus Infections
A Study Evaluating Persistence of the Immune Response of the Adjuvanted Respiratory Syncytial Virus (RSV) Vaccine and the Safety and Immune Response Following Revaccination in Adults 18 Years of Age and Above Who Received Lung or Kidney Transplant
This study evaluates persistence of the immune response of the adjuvanted RSV vaccine and the safety and immunogenicity following revaccination in adults 18 years of age and above who received lung or kidney transplant.
- Trial name
- NCT07092865
- Testing
- Adjuvanted RSVPreF3 vaccine
- Where
- 38 sites in United States, Australia and 6 more
- Volunteers
- 168 people
- Sponsor
- GlaxoSmithKline
Lung Transplantation
Patient Education Study to Determine Knowledge Acquisition in Patients Preparing to Undergo Lung Transplantation
The Lung Transplant Team at Tampa General Hospital has identified a need to improve both the quality and quantity of the education that is provided to patients listed for lung transplantation.
- Trial name
- NCT02177916
- Testing
- Education
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tampa General Hospital
Fecal Microbiota Transplantation, COVID-19 Infection
A Controlled Study on Regulation of Systemic Inflammation by Fecal Bacteria Transplantation in Patients With COVID-19.
A total of 30 hospitalized patients with COVID-19 over 60 years old were enrolled in this study and were divided into the experimental group (n=15) and the control group (n=15) at a ratio of 1:1.
- Trial name
- NCT05873348
- Testing
- Fecal microbiota transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai 10th People's Hospital
Kidney Transplant Infection
Study of Pulmonary Infections (Pneumonia) in Kidney Transplant Recipients Admitted to Hospital
The investigators aimed to identify prognosis factors associated with in-hospital complications and assess the epidemiology, management, and outcomes of community-acquired pneumonia in a kidney transplant recipients' cohort.
- Trial name
- NCT05142748
- Where
- France
- Volunteers
- 132 people
- Sponsor
- CHU de Reims
Hematopoietic Stem Cell Transplant (HSCT), Bronchiolitis Obliterans (BO)
Ruxolitinib for Early Lung Dysfunction After Hematopoietic Stem Cell Transplant
Hematopoietic stem cell transplant (HSCT) is an effective but toxic therapy, and lung injury affects as many as 25% of children receiving HSCT.
- Trial name
- HSCT (NCT04908735)
- Testing
- Ruxolitinib
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Fungal Infection
A Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients (MK-5592-105)
This single site study will examine plasma and alveolar compartment (AC) levels of posaconazole in cystic fibrosis (CF) and non-cystic fibrosis (non-CF) lung transplant recipients receiving routine post-operative anti-fungal…
- Trial name
- PAPAL (NCT01667107)
- Testing
- Posaconazole, Calogen®
- Volunteers
- 26 people
- Sponsor
- Merck Sharp & Dohme LLC
Stress, Psychological, Caregiver Burden
Wellness Coaching for Caregivers of Thoracic Transplant Candidates
Researchers are studying the effects of a health coaching intervention on the stress and burden of caregivers of patients awaiting heart or lung transplant.
- Trial name
- NCT04245228
- Testing
- Wellness Coach
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Histiocytosis, Langerhans-cell
Reduced Intensity Hematopoietic Cell Transplantation for Patients With Resistant Langerhans Cell Histiocytosis
RATIONALE: Giving a monoclonal antibody, such as alemtuzumab, and chemotherapy drugs, such as fludarabine and melphalan, before a donor stem cell transplant helps stop the patient's immune system from rejecting the donor's stem…
- Trial name
- NCT00618540
- Testing
- alemtuzumab, fludarabine phosphate, melphalan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Masonic Cancer Center, University of Minnesota