Clinical trials: Transplantation Lung
Cystic Fibrosis
Needs in Education for Pulmonary or Cardiopulmonary Transplanted Cystic Fibrosis Patients
Main objective : This project aims to assess the educational needs of patients who received a lung transplantation or a simultaneous heart-lung transplantation for mucoviscidosis.
- Trial name
- NCT01285895
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Pulmonary Disease
Planned Semi-Elective Lung Transplantation Using 10C Cold Static Preservation
This is a prospective, single-arm study to demonstrate the proof-of-concept of semi-elective lung transplantation. We plan to evaluate 15 patients that receive lung(s) delayed for transplantation under our study criteria.
- Trial name
- NCT04568694
- Testing
- Delayed Lung Transplantation, Conventional Lung Transplantation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- NYU Langone Health
Blood And Marrow Transplantation, Adult Respiratory Distress Syndrome
Mesenchymal Stem Cells (MSCs) for Treatment of Acute Respiratory Distress Syndrome (ARD) in Patients With Malignancies
The goal of this clinical research study is to learn about the safety of giving mesenchymal stem cells (MSCs) to patients who have ARDS.
- Trial name
- NCT02804945
- Testing
- Mesenchymal Stem Cells (MSCs)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Bronchoalveolar Lavage Fluid, Lung Infection
Diagnosis of Lung Complication After Allo-HSCT by Multiple Parameter System Through BAL
The aim of this study was to evaluate the diagnostic yield for lung complication after allo-HSCT by multiple parameter system through BAL.
- Trial name
- SHSYXY-BAL (NCT04051372)
- Testing
- Bronchoscopic Alveolar Lavage
- Volunteers
- 250 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Lung Transplant Rejection
Cryoprobe Biopsy and Chronic Rejection in Lung Transplant Recipients
The goal of this clinical trial is to evaluate which biopsy collection method helps to better diagnose rejection and relevant pathologic findings in lung transplant recipients.
- Trial name
- NCT06824402
- Testing
- Forceps Biopsy, Cryoprobe Biopsy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Transplantation Infection, Cytomegalovirus Infections
Clinical Trial of Efficacy and Safety of the Combination of Reduced Duration Prophylaxis Followed by Immuno-guided Prophylaxis in Lung Transplant Recipients.
To assess the efficacy of reduced duration prophylaxis followed by immuno-guided prophylaxis to prevent cytomegalovirus disease.
- Trial name
- CYTOCOR (NCT03699254)
- Testing
- Valganciclovir, Ganciclovir
- Where
- 7 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Invasive Aspergillosis, Invasive Pulmonary Aspergillosis
VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults
The purpose of the trial is to evaluate the safety and efficacy of a new antifungal with a novel mechanism of action in immunocompromised adults with invasive aspergillosis.
- Trial name
- NCT03327727
- Testing
- Investigational Agent: VL-2397, Standard treatment: Voriconazole, Isavuconazole, or Liposomal amphotericin B
- Where
- 28 sites in United States, Belgium and 4 more
- Volunteers
- 4 people
- Sponsor
- Vical
Lung Transplant; Complications, Disability Evaluation
Assessment of Lung Transplant Recipients Within The Scope of International Classification of Functioning, Disability and Health
This study was aimed to evaluate the patients undergoing lung transplantation under the International Classification of Functionality, Disability and Health (ICF) and to examine the relationships between the age at which lung…
- Trial name
- NCT05376605
- Testing
- assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Ankara City Hospital Bilkent
Lung Transplantation
Transplanting Lungs From Uncontrolled Donation After Circulatory Death
The study team developed an uncontrolled donation after circulatory death (uDCD) protocol that preserves lungs for just over 3 hours after death using positive end expiratory pressure (PEEP) and supplemental oxygen.
- Trial name
- NCT06327945
- Testing
- Lung uDCD Protocol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NYU Langone Health
Immunologic Deficiency Syndromes, Chediak-Higashi Syndrome
Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies
OBJECTIVES: I. Provide curative immunoreconstituting allogeneic bone marrow transplantation for patients with primary immunodeficiencies. II.
- Conditions
- Immunologic Deficiency Syndromes, Chediak-Higashi Syndrome, Common Variable Immunodeficiency, Graft Versus Host Disease
- Trial name
- NCT00006054
- Testing
- anti-thymocyte globulin, busulfan, cyclophosphamide
- Where
- United States
- Sponsor
- Fairview University Medical Center
Lung Transplantation
Planned Semi-Elective Lung Tx Study
In the current practice of lung transplantation, transplants are performed on a 24/7 schedule with a significant amount of procedures occurring overnight in order to minimize organ ischemic time.
- Trial name
- NCT04616365
- Testing
- Semi-Elective Lung Transplantation
- Where
- 3 sites in Austria, Canada and 1 more
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Chronic Rejection, Lung Transplantation
Predictive Factors for Chronic Rejection in Lung Transplant Recipients: COLT Study
Obliterative Bronchiolitis (OB) is the major cause of long-term lung allograft loss for patients with end stage pulmonary diseases like cystic fibrosis.
- Trial name
- COLT (NCT00980967)
- Testing
- Study of predictive factors
- Where
- 11 sites in France
- Volunteers
- 700 people
- Sponsor
- Nantes University Hospital
Lung Transplant Infection, Hepatitis C
Lung Transplant HCV, Pilot Study
In this study HCV negative recipients will be transplanted with HCV positive lungs. Investigators will attempt to decrease infectivity rates by performing Normothermic Ex vivo Lung Perfusion (EVLP), which is an approved method of…
- Trial name
- NCT03112044
- Testing
- Sofosbuvir-velpatasvir (400 mg/100 mg), Ex Vivo Lung Perfusion (EVLP)
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University Health Network, Toronto
COVID-19, Organ Transplant
Immune Registry for Organ Transplantation From COVID Positive Donors.
The purpose of this study is to collect data generated by standard clinical practice to determine the short term and long term clinical outcomes of recipients of solid organ transplantation from COVID-19 infected donors and…
- Trial name
- NCT05595837
- Testing
- Standard organ transplant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Lung Transplantation, Antibody Mediated Rejection
Quantitative Parameters of HLA-DQ Antibodies in Lung Transplantation
The aim is to compare the quantitative parameters of de novo anti-HLA DQ Donor Specific Antibodies (DSA), determined at the time of their discovery by surface plasmon resonance (SPR), between recipients that developed a Chronic…
- Conditions
- Lung Transplantation, Antibody Mediated Rejection, Chronic Lung Allograft Dysfunction
- Trial name
- AFFIHLA-P (NCT03474536)
- Where
- 5 sites in France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Bordeaux
Pulmonary Hypertension
Predictors of Pulmonary Hypertension in Patients With Advanced Lung Diseases
First, the aim of the study was to evaluate the usefulness of echocardiographic parameters for detecting pulmonary hypertension (PH) in patients with advanced lung disease referred for lung transplantation.
- Trial name
- NCT02777957
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Silesian Centre for Heart Diseases
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Xenon MRI Pulm Hypertension
The overall objective outlined in this study is to determine how pulmonary vascular remodeling in PAH at a cellular and pathological level is associated with changes in gas exchange physiology and hemodynamics (monitored with…
- Trial name
- Jupiter PH (NCT04991454)
- Testing
- 129Xe Hyperpolarized
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bastiaan Driehuys
Lung Cancer
Microbiota Transplant in Advanced Lung Cancer Treated With Immunotherapy
The gut microbiota can modulate the effectiveness of cancer therapies, especially immunotherapy. Manipulating the microbial populations in patients with advanced lung cancer through fecal microbiota transplantation from healthy…
- Trial name
- NCT04924374
- Testing
- Microbiota Transplant plus anti PD1 therapy, anti PD1 therapy
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-1)
The objective of this trial is to assess the efficacy and safety of aerosolized liposomal cyclosporine A (L-CsA) as add-on therapy to standard of care (SoC) as compared to SoC alone in single lung transplant recipients with…
- Conditions
- Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant, Lung Transplant Rejection, Lung Transplant; Complications
- Trial name
- BOSTON-1 (NCT03657342)
- Testing
- Liposomal Cyclosporine A, standard of care
- Where
- 39 sites in United States, Belgium and 5 more
- Volunteers
- 62 people
- Sponsor
- Zambon SpA
Respiratory Disease
Study of Variations of Pleural and Esophageal Pressures Under Mechanical Ventilation After Lung Transplantation
The primary objective of the study is to determine the correlation between mean pleural pressure and oesophageal pressure in the immediate aftermath of bi-pulmonary transplantation.
- Trial name
- NCT03179644
- Testing
- Measurement of oesophageal pressure and pleural pressure
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique Hopitaux De Marseille