Clinical trials: Transplantation Lung
Disorder Related to Lung Transplantation, CLAD, Bronchiolitis Obliterans
European Trial of Pirfenidone in BOS, A European Multi-center Study
A European multi-centre, randomised, double-blind placebo-controlled trial of Pirfenidone in bronchiolitis-obliterans-syndrome grade 1-3 in lung transplant recipients. Randomized double blinded, placebo controlled study.
- Trial name
- EPOS (NCT02262299)
- Testing
- Pirfenidone
- Where
- 9 sites in Belgium, Denmark and 5 more
- Volunteers
- 90 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lung Transplantation
Pharmacokinetics of Imipenem During Ex Vivo Lung Perfusion (EVLP)
Ex vivo lung perfusion (EVLP) is an established strategy to evaluate and optimize high-risk donor lungs that would otherwise be rejected for transplantation mainly due to the presence of edema or infection.
- Trial name
- NCT02670239
- Testing
- normothermic ex vivo lung perfusion
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Lung Transplantation
Immunosuppressive Therapy With Certican (Everolimus) After Lung Transplantation
The purpose of this study is to determine whether Everolimus is effective in the treatment and prevention of chronic graft dysfunction and chronic graft rejection after lung transplantation.
- Trial name
- NCT00402532
- Testing
- Everolimus, Mycophenolatmofetil
- Where
- Germany
- Volunteers
- 190 people
- Sponsor
- Hannover Medical School
Transplant-Related Lung Cancer
Non-ablative Oligofractionated Radiation Therapy Before Surgical Transplantation As Radiovaccination
This is a prospective phase I study to determine the safety and feasibility of non-ablative oligofractionated radiation therapy (NORT) before lung transplantation for patients with underlying pulmonary malignancy.
- Trial name
- NORThSTAR (NCT04782752)
- Testing
- Radiation: Varying Doses of RT
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Marc de Perrot
Chronic Lung Disease, Lung Transplant Rejection
Safety of Endobronchial Mesenchymal Stromal Cells in the Treatment of Chronic Lung Allograft Dysfunction
Lung transplantation is the only therapeutic alternative for more and more patients with respiratory diseases in their most advanced stages.
- Trial name
- ENDOSCLAD (NCT06514378)
- Testing
- Mesenchymal stem cells
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Instituto De Investigación Sanitaria Puerta De Hierro-Segovia De Arana
Lung Transplant Infection, Lung Transplant; Complications
AlloSure Lung Assessment and Metagenomics Outcomes Study
ALAMO is a prospective, multi-center, perspective, registry of patients receiving LungCare™ (AlloSure®-Lung, AlloMap Lung, and HistoMap) for surveillance post-transplant.
- Conditions
- Lung Transplant Infection, Lung Transplant; Complications, Lung Transplant Failure and Rejection
- Trial name
- ALAMO (NCT05050955)
- Where
- 22 sites in United States, Canada
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- CareDx
Lung Transplantation
Telecommunication Via Cell Phones During Post-Operative Treatment After Lung Transplantation
In an investigation should be evaluated in contrast to a control group with standard post-treatment therapy (using home spirometry) after lung transplantation if transfer of home spirometry recordings to the transplant center via…
- Trial name
- TeleTx (NCT00536926)
- Testing
- Home spirometry with data transfer via cell phone, Home spirometer with BT-cellphone, Home spirometer w/o BT
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Hannover Medical School
End Stage Chronic Obstructive Airways Disease
VASCULUX-examination of the Pulmonary VASCUlar Barrier in Patients During LUng Transplantation
Lung transplantation is a well established method for surgical therapy for patients with end stage pulmonary disease. The investigators seek to determine to which extent the pulmonary vascular barrier gets harmed during lung…
- Trial name
- VASCULUX (NCT02225249)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Lung Transplant Rejection, Antibody-mediated Rejection
Belatacept Pilot Study in Lung Transplantation Immunosuppression in Lung Transplantation
This is a pilot randomized controlled trial examining the feasibility of conducting a large scale randomized controlled trial of belatacept-based immunosuppression in lung transplantation.
- Trial name
- NCT03388008
- Testing
- Belatacept, Tacrolimus, ATG
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Washington University School of Medicine
Lymphocytic Bronchi(Oli)Tis Post-lung Transplantation
Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation
This study investigates the role of azithromycin treatment for lymphocytic bronchitis/bronchiolitis after lung transplantation.
- Trial name
- AZI002 (NCT01109160)
- Testing
- Azithromycin Dihydrate
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- KU Leuven
Lung Transplantation
Lung Transplant Candidates: Effects of Aerobic vs. HIIT Training on ICF Assessments
Lung transplantation is a crucial surgical intervention aimed at increasing survival rates in patients with end-stage lung diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, idiopathic pulmonary…
- Trial name
- NCT07065318
- Testing
- LV-HIIT (Low-Volume High-Intensity Interval Training), MICT (Moderate-Intensity Continuous Training), Ergometer cycle
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara City Hospital Bilkent
Cystic Fibrosis, Lungtransplantation
Upper and Lower Airway Colonization in Cystic Fibrosis Patients After Lung Transplantation
A hot topic in lung transplantation is the treatment of persisting sinus disease/colonization in CF patients to prevent descending graft colonization and chronic allograft dysfunction.
- Conditions
- Cystic Fibrosis, Lungtransplantation, Paranasal Sinus Diseases
- Trial name
- NCT02591524
- Testing
- Bronchoalveolar and Nasal Lavage
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Hannover Medical School
Graft Vs Host Disease, Acute-graft-versus-host Disease
Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial
This study is about determining if an aerobic and resistance exercise intervention is feasible in patients diagnosed with acute or chronic GVHD (Graft-Versus-Host Disease) after having an allogeneic stem cell transplant.
- Conditions
- Graft Vs Host Disease, Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease
- Trial name
- RESTART (NCT05236062)
- Testing
- Exercise, Attention control
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Dana-Farber Cancer Institute
Pulmonary Disease
Early Lung Rehabilitation Care for Patients After Double Lung Transplantation
Develop appropriate individual programs for patients to implement lung rehabilitation safely and effectively.
- Trial name
- NCT04922879
- Testing
- Individualized lung rehabilitation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
End-stage Lung Disease
BREATHE Study: Spontaneous Breathing-Preserved Anesthesia and Surgical Strategy for Hospital Recovery in Lung Transplantation
The goal of this study is to learn whether a spontaneous-breathing ("tubeless") anesthesia and surgery strategy can improve early recovery and remain safe for adults who receive a lung transplant.
- Trial name
- BREATHE-LTx (NCT07384546)
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 110 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Graft-versus-host Disease (GVHD)
A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3)
The purpose of this study is to assess the efficacy of ruxolitinib against best available therapy in participants with steroid-refractory chronic graft-versus-host disease (SR cGvHD).
- Trial name
- NCT03112603
- Testing
- Ruxolitinib, Extracorporeal photopheresis (ECP), Low-dose methotrexate (MTX)
- Where
- 191 sites in United States, Australia and 29 more
- Volunteers
- 330 people
- Sponsor
- Incyte Corporation
Allogeneic Stem Cell Transplantation, SARS-CoV2 Infection
Impact of COVID-19 Pandemic on Allogeneic Stem Cell Transplantation Organization : a French Experience
the SARS-CoV2 pandemic has led to a major reorganization of the French Hematology and stem cell transplant departments since march 2020.
- Conditions
- Allogeneic Stem Cell Transplantation, SARS-CoV2 Infection, COVID-19
- Trial name
- covidallo (NCT05088941)
- Where
- France
- Volunteers
- 89 people
- Sponsor
- Central Hospital, Nancy, France
Lung Transplant Infection, Pneumonia, Bacterial
Antimicrobial Therapeutic Drug Monitoring During Lung Transplant Perioperative Phase
Background: Post-LUTX pneumonia represents a leading cause of death along the first month after LUTX. Donor-derived transmission of pathogenic species occurs up to 25% of recipients receiving a graft with a positive BAL culture…
- Conditions
- Lung Transplant Infection, Pneumonia, Bacterial, Antibiotic Resistant Strain
- Trial name
- NCT06583642
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Policlinico Hospital
Stem Cell Transplantation
Physical Impairments in Allogeneic-HSCT
Pulmonary functions, exercise capacity and muscle strength deteriorate in survived hematopoietic stem cell transplantation (HSCT) recipients due to toxic effects of chemotherapy, radiotherapy, conditioning regimens and/or…
- Trial name
- NCT03448627
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Gazi University
Acute Lung Injury
Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment
Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this complication.
- Trial name
- NCT00852605
- Testing
- Intermittent Non-Invasive Ventilation
- Volunteers
- 86 people
- Sponsor
- Technische Universität Dresden