Clinical trials: Transplantation Lung
Graft-versus-Host Disease
Lenalidomide (Revlimid®) as Second Line Therapy in Patients With Chronic Graft-Vs-Host Disease (GVHD)
The goal of this clinical research study is to learn if Revlimid® (lenalidomide), along with standard-of-care steroid treatment you are already receiving, can help to control Chronic Graft-Versus-Host Disease (cGVHD).
- Trial name
- NCT00675441
- Testing
- Lenalidomide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- M.D. Anderson Cancer Center
Atrial Fibrillation, Lung Transplant; Complications
Intraoperative Amiodarone to Prevent Atrial Fibrillation in Lung Transplant Patients
This study will prospectively evaluate the use of an amiodarone releasing hydrogel applied to the pulmonary veins and atria at the time of lung transplantation.
- Trial name
- NCT03221764
- Testing
- Amiodarone with CoSeal, CO2 driver
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Lung Transplant
Contribution of Learning and Practice of Different Complementary Therapies in Pulmonary Transplant Patients
The aim of the study is to evaluate, 3 months after lung transplantation, integration and appropriation by the patient of complementary techniques (" Toolbox " included relaxation, autohypnosis, relaxation therapy, TENS (if pain)…
- Trial name
- TOOLBOX (NCT03167528)
- Testing
- Relaxation, Hypnosis, Holistic gymnastics
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hopital Foch
Hepatitis C
A Study of the Use of Hepatitis C Positive Donors for Hepatitis C Negative Lung Transplant Recipients With Post-transplant Treatment With Mavyret
Patients who are Hepatitis C Negative (HCV negative) and are on the waiting list for a lung transplant at NYULH who consent to participate in this study will receive a lung transplant from a deceased donor that is HCV positive.
- Trial name
- NCT03523871
- Testing
- Mavyret
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Self-management, Lung Transplant
Health Coaching to Improve Self-Management in Thoracic Transplant Candidates
Ability to adhere to complex medical regimens is critical to achieving successful transplant outcomes, as non-adherent patients suffer graft failure and death following transplantation.
- Conditions
- Self-management, Lung Transplant, Heart Transplant
- Trial name
- NCT03150095
- Testing
- Health coaching
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Lung Transplant Rejection
Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation
Objective: To evaluate the potential impact of molecular phenotyping of transbronchial biopsies in lung transplant recipients with allograft dysfunction, and the potential for developing a safer endobronchial mucosal biopsy…
- Trial name
- INTERLUNG (NCT02812290)
- Testing
- Lung transplant biopsy bites.
- Where
- 11 sites in United States, Australia and 4 more
- Volunteers
- 700 people
- Sponsor
- University of Alberta
Non Small Cell Lung Cancer, Respiratory Tract Neoplasm
Study for Evaluating the Safety and Feasibility of Fecal Microbiota Transplant in Stage II-III NSCLC Patients Using ICI Responders as Donors (MIGRANT)
This is a randomized, phase II, multi-centre clinical trial. Sample size: 68 patients (Experimental Arm (Durvalumab + chemotherapy + FMT capsules): 34 patients, Control Arm (Durvalumab + chemotherapy): 34 patients) Population…
- Trial name
- MIGRANT (NCT07247786)
- Testing
- Biological: Fecal Microbiota Transplantation, Durvalumab, Paclitaxel
- Where
- 20 sites in Spain
- Volunteers
- 68 people
- Sponsor
- Fundación GECP
Lung Transplantation
Biodegradable Stents in Lung Transplantation
A prospective observational trial involving 10 patients is planned. Intervention "SX-ELLA Stent Degradable DV Bronchial (DV Stent)" will be implanted in the target lesion in general anesthesia under fluoroscopy or by direct…
- Trial name
- NCT00929942
- Testing
- SX-ELLA Stent Degradable DV Bronchial (DV Stent)
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Hannover Medical School
Bronchiolitis Obliterable Syndrome
Longitudinal Pulmonary Chronic Graft-versus-host-disease (GvHD) Assessment in Hematopoietic Stem Cell Transplantation (HSCT) Patients
Prospective observational study on the clinical characteristics of pulmonary graft-versus-host disease in patients after hematopoietic stem cell transplantation.
- Trial name
- NCT07297303
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
SARS-CoV Infection, Corona Virus Infection
Corona Virus Infection Among Liver Transplant Recipients
A new strain of coronavirus that caused severe respiratory disease in infected individuals was initially identified in China's Wuhan City in December 2019.
- Conditions
- SARS-CoV Infection, Corona Virus Infection, Liver Transplant Recipient, COVID-19
- Trial name
- NCT04565782
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Lung Transplant Rejection
PREdiction of Chronic LUng Allograft Dysfunction
Chronic lung allograft dysfunction (CLAD) is the leading cause of long-term mortality after lung transplantation. Several risk factors for CLAD have been identified, but the exact pathophysiology and triggering molecular factors…
- Trial name
- PRELUD (NCT03967340)
- Where
- 10 sites in France
- Volunteers
- 240 people
- Sponsor
- Nantes University Hospital
Lung Cancer
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003860
- Testing
- filgrastim, carboplatin, etoposide
- Where
- 22 sites in France
- Volunteers
- 36 people
- Sponsor
- UNICANCER
Organ Transplantation
A Facilitated Access Program to Provide Everolimus (RAD) Maintenance for Patients Completing Therapy in RAD Trials in Solid Organ Transplantation
Facilitated access to everolimus until it is commercially available and reimbursable by appropriate parties
- Trial name
- NCT00149981
- Testing
- everolimus (RAD)
- Where
- 153 sites in United States, Australia and 17 more
- Sponsor
- Novartis Pharmaceuticals
Lung Transplant Recipient, Donor Specific Antibodies
DSA Intragraft in Lung Transplantation: Diagnostic and Prognostic Value in Antibody Mediated Rejection
The diagnosis of AMR in lung transplant recipients is difficult and often comes too late, because of lack of standardized definition.
- Conditions
- Lung Transplant Recipient, Donor Specific Antibodies, Antibody Mediated Rejection
- Trial name
- NCT03702257
- Testing
- bronchoscopy.
- Where
- 5 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Transplant Recipient
Upper Limb Exercise Capacity: Lung Transplant vs. Healthy Controls
Lung transplantation is a surgical intervention for end-stage lung diseases (e.g., COPD, cystic fibrosis, idiopathic pulmonary fibrosis).
- Trial name
- NCT07065981
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Chronic Respiratory Disease
Autologous Bronchial Basal Cells Transplantation for Treatment of CRD Including COPD, BE and PF
Chronic respiratory diseases including chronic obstructive pulmonary disease (COPD), bronchiectasis (BE) or pulmonary fibrosis (PF) are usually not curable with damaged pulmonary structure and function.
- Trial name
- NCT03153800
- Testing
- bronchial basal cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Regend Therapeutics
Lung Diseases
Multi-Omics-Based Prediction of Allograft Dysfunction After Lung Transplantation
By establishing a prospective, multicenter lung transplantation clinical cohort, this study aims to systematically evaluate the utility of cfDNA fragmentomics, peripheral blood single-cell sequencing, and proteomics in monitoring…
- Trial name
- NCT07243964
- Testing
- longitudinal changes in multi-omics profiling of peripheral blood
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Chang Chen
SARS-CoV-2
Solid Organ Transplant Recipients With SARS-CoV-2 French Registry
Patients with comorbid condition are known to be at high risk of severe forms of Covid-19. It is highly probable that immunocompromised patients like solid organ transplant (SOT) recipients are also at risk of severe forms of…
- Trial name
- TX-COVID (NCT04360707)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Lung Transplant Failure
Respiratory Physiotherapy as a Tool to Increase the Number of Solid Organ Donors
The main objective of the project is to determine the variation of PaO2 / FiO2 (PaFi) after the use of mechanical insufflation-exsufflation (MI-E) or mechanical cough assistant in the donor in brain death (DBD) and in the…
- Trial name
- NCT06202859
- Testing
- MIE
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Vall d'Hebron Institute Research
Advanced Lung Disease, COPD
Effects of Inpatient Pulmonary Rehabilitation on Frailty in Patients After Lung-Transplantation
Frailty is closely linked to the success of lung transplantations (LTx) (1,2). Studies have shown that frailty causes a diminished physical performance in candidates for LTx and an increased 30 day rate of re-hospitalization…
- Conditions
- Advanced Lung Disease, COPD, Interstitial Lung Disease
- Trial name
- NCT04184180
- Where
- Germany
- Volunteers
- 33 people
- Sponsor
- Klaus Kenn