Clinical trials: Transplantation Lung
Pulmonary Hypertension, Kidney Transplantation
Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation
The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.
- Conditions
- Pulmonary Hypertension, Kidney Transplantation, Haemodialysis
- Trial name
- NCT04842591
- Testing
- exercise echocardiography
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Graz
Hematologic Neoplasms
Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies
Background: People with blood cancers often receive blood or bone marrow transplants. But even with these treatments, the risk of relapse is high.
- Trial name
- NCT05327023
- Testing
- donor lymphocyte infusion, Cyclophosphamide, Busulfan
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2)
The objective of this trial was to assess the efficacy and safety of aerosolized liposomal cyclosporine A (L-CsA) as add-on therapy to standard of care (SoC) as compared to SoC alone in double lung transplant (DLT) recipients…
- Conditions
- Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant, Lung Transplant Rejection, Lung Transplant; Complications
- Trial name
- BOSTON-2 (NCT03656926)
- Testing
- Liposomal Cyclosporine A, Standard of Care
- Where
- 40 sites in United States, Austria and 7 more
- Volunteers
- 169 people
- Sponsor
- Zambon SpA
Complication of Transplanted Lung
Assessment of Cough Reflex in Lung Transplant Recipients
The purpose of this study is to evaluate the presence of cough reflex in the transplanted lung of patients who have had either a single or double lung transplant or heart-lung transplant at University of Texas Medical Branch.
- Trial name
- NCT00584077
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Heart Transplant Failure, Anesthesia
Impact of Atelectasis on RVEDP Following Orthotropic Heart Transplantation
Following orthoptopic heart transplantation (OHT), children undergo surveillance cardiac catheterizations to assess for signs of rejection including muscle biopsy as well as pressure measurements to guide post transplant…
- Trial name
- NCT06140810
- Testing
- Lung Recruitment
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor College of Medicine
Antibody-mediated Rejection, Allosensitization
Isatuximab in Lung Transplant Recipients
The purpose of this study is to determine the safety and feasibility of adding isatuximab to standard of care therapies in patients who will receive a lung transplant, but have significant antibodies against the donor…
- Trial name
- NCT05862766
- Testing
- Isatuximab, bone marrow biopsy
- Where
- United States
- Sponsor
- NYU Langone Health
Bronchiolitis Obliterans, Sleep Disordered Breathing Central
Sleep Disorders in Bronchiolitis Obliterans Syndrome 2&3
This study is to determine whether sleep disorders contribute to impaired quality of life and mobility in patients with Bronchiolitis Obliterans syndrome and whether non invasive positive airways pressure ventilation can improve…
- Trial name
- NCT02109237
- Testing
- Assessment of sleep disorders and treatment if required
- Where
- Australia
- Sponsor
- The Prince Charles Hospital
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Pulmonary Complications
Pulmonary Complications of Allografts
This is a prognostic study of the late lung complications arising at the patient's having received an allograft of hematopoetic stem cells.
- Trial name
- ALLOPULM (NCT01219972)
- Where
- France
- Volunteers
- 245 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatitis B Virus (HBV), Lung Transplant Recipient
Combined Light, ExVivo, and Antivirals for Recipients of Lungs From HBV Donors
The aim of the study is to show that transplantation of lungs from Hepatitis B-infected donors is safe when using EVLP with UV light inactivation plus antivirals
- Trial name
- CLEAR-HBV (NCT07189377)
- Testing
- Entecavir, HBIG, EVLP UV Light Treatment
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Cytomegalovirus Infections
Comparison of Oral Valganciclovir and Placebo for the Prevention of Cytomegalovirus (CMV) After Lung Transplantation
The study evaluated the efficacy and safety of a prolonged, continuous course of Valganciclovir (Valgan) in the prevention of CMV by comparing 3 months of Vaglanciclovir, the standard of care upon initiation of the study, to 12…
- Trial name
- Valgan (NCT00227370)
- Testing
- valganciclovir
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Duke University
Patients Following Lung Transplantation (Single and Double)
Effects of a Whole Body Vibration Training in Patients After Lung Transplantation
Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients following lung transplantation.
- Trial name
- NCT01480960
- Testing
- Pulmonary rehabilitation + whole body vibration training
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Lung Transplant Infection, Lung Transplant Rejection
Extracorporeal Photopheresis (ECP) After Lung Transplantation
The purpose of this study is to investigate the use of ECP for lung-transplanted patients to reduce the occurrence of acute and chronic rejection and CMV-infection.
- Trial name
- NCT05721079
- Testing
- ECP (Extracorporeal Photopheresis System)
- Where
- Austria
- Volunteers
- 62 people
- Sponsor
- Medical University of Vienna
Lung Transplantation
Electrostimulation Program for Lung Transplant Recipients in the ICU
This study aims to evaluate rectus femoris muscle mass in lung transplant recipients and the effect of a training program during ICU admission based on the use of electrical muscle stimulation (EMS)
- Trial name
- NCT05410522
- Testing
- EMS Program
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Universidad Complutense de Madrid
Bronchoalveolar Lavage Fluid, Lung Infection
Diagnosis of Lung Complication After Allo-HSCT by Multiple Parameter System Through BAL
The aim of this study was to evaluate the diagnostic yield for lung complication after allo-HSCT by multiple parameter system through BAL.
- Trial name
- SHSYXY-BAL (NCT04051372)
- Testing
- Bronchoscopic Alveolar Lavage
- Volunteers
- 250 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Lung Transplantation, End Stage Lung Disease
Respiratory, Limb Muscle Properties, and Physical Performance in Adult Lung Transplant Recipients
The goal of this observational study is to evaluate respiratory and limb muscle properties in adults awaiting lung transplantation and determine how these measures relate to physical performance, symptoms, and recovery after…
- Trial name
- NCT07747337
- Testing
- Respiratory and Limb Muscle Assessment
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Florida
COPD
Autologous Transplantation of Bronchial Basal Cells for Treatment of COPD
Chronic Obstructive Pulmonary Disease (COPD) is a disease characterized by long-term poor airflow, resulting in chronic pulmonary heart disease, chronic respiratory failure or even death.
- Trial name
- NCT03655795
- Testing
- Bronchial basal cells
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Lung Transplant
Tocilizumab in Lung Transplantation
This is a trial in which 100 primary lung transplant recipients will be randomized (1:1) to receive either Tocilizumab (six doses over 20 weeks) plus standard triple maintenance immunosuppression or placebo (sterile normal…
- Trial name
- ALL IN LUNG (NCT06033196)
- Testing
- Tocilizumab
- Where
- 21 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Heart Transplantation, COVID-19 Virus Infection
Covid-19 Vaccine Response in Heart Transplant Recipients
Clinical studies indicate a decrease in vaccine efficacy in certain immunocompromised populations (kidney transplant recipients, patients undergoing chemotherapy).
- Conditions
- Heart Transplantation, COVID-19 Virus Infection, COVID-19 Vaccine
- Trial name
- COVHEART (NCT05268679)
- Testing
- Biospecimen Collection, Questionnaire, Electronic Health Record Review
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury(ALI)
A Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantation
Sepsis is a systemic inflammatory response syndrome triggered by infection, and it is a common critical illness in clinical practice, often leading to multiple organ dysfunction.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury(ALI), Sepsis Related Acute Lung Injury/Acute Respiratory Distress Syndrome
- Trial name
- NCT07342205
- Testing
- Human-derived active intestinal bacterial liquid group
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine