Clinical trials: Transplants
Organ Transplantation
Antibody Production Following H1N1 Influenza Vaccination in Organ Transplant Patients
Organ transplant patients and staff members at the Transplant Institute have received pandemic H1N1 influenza vaccine (Pandemrix) and specific antibody production was measured by haemagglutination inhibition according to the…
- Trial name
- NCT01254955
- Testing
- H1N1 vaccine Pandemrix
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Graft vs Host Disease, Hematologic Neoplasm
Cell Selection for Bone Marrow Transplants to Prevent Graft-Versus-Host-Disease
Blood contains different kinds of cells, white blood cells, red blood cells, and platelets. In order to treat certain diseases, specific cell types can be removed from blood and transplanted into patients.
- Trial name
- NCT00001872
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hematologic Diseases, Hematologic Malignancy
CD34+ Enriched Transplants From HLA-Compatible Patients With Hematologic Malignancies
This is a Phase II trial testing disease-specific myeloablative conditioning regimens for preparatory cytoreduction of patients receiving allogeneic HLA-compatible related or unrelated transplants of GCSF-mobilized peripheral…
- Conditions
- Hematologic Diseases, Hematologic Malignancy, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- 2019-KOE-001 (NCT04282174)
- Testing
- CliniMACS, Bone Marrow Transplant, Hyperfractionated Total Body Irradiation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baptist Health South Florida
Cancer
Immune Reconstitution in Stem Cell Transplant Recipients
This specimen collection lab protocol will allow the investigators to prospectively study immune reconstitution in patients being treated for hematologic disorders and immune factors affecting graft versus host disease in…
- Trial name
- NCT02129543
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Miami
Graft-versus-leukemia, Graft vs Host Disease
Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell Transplants
This study will provide follow-up evaluation and care of patients who have undergone allogeneic (donor) stem cell transplantation at the NIH Clinical Center.
- Conditions
- Graft-versus-leukemia, Graft vs Host Disease, Graft Rejection
- Trial name
- NCT00106925
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Contraception, Contraception Behavior
Contraception for Solid Organ Transplant Patients: Utilizing Social Media
The purpose of this study is to use an electronic survey to explore Solid Organ Transplant patients' contraceptive knowledge and counseling.
- Conditions
- Contraception, Contraception Behavior, Contraceptive Usage, Reproductive Health
- Trial name
- NCT03979950
- Testing
- Survey
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Bone Marrow Transplant
Perspectives on Bone Marrow Donors Who Donate for Their Parent
The purpose of this pilot study is to explore the role of family function on decision-making for bone marrow donors who donated for their parent, and to assess the unique supportive care needs of these participants.
- Trial name
- NCT03758911
- Testing
- Semi-structured Interview
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cell-mediated Immune Response
Performance Comparison of QuantiFERON Monitor in Solid Organ Transplant Recipients
To compare the performance of the QuantiFERON Monitor assay against existing methodology.
- Trial name
- NCT02416414
- Testing
- QuantiFERON Monitor Assay, Existing methodology
- Where
- 4 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- QIAGEN Gaithersburg, Inc
Anorexia Nervosa, Microbiome Dysbiosis
Feasibility Study of Using Fecal Microbiota Transplants in Anorexia Nervosa
The investigators hypothesize that prolonged undernutrition in anorexia nervosa alters the microbiome to a different steady-state (dysbiotic) composition that sustains the disease, even after returning to normal diet.
- Trial name
- ReBoot (NCT05834010)
- Testing
- Fecal Microbiome Transplant
- Where
- 3 sites in Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Kidney Transplant
The Study of Long-term Deterioration of Kidney Transplants.
This study is being done to create a kidney transplant database with information from many transplant centers for the purpose of studying ways to help improve transplant outcomes and the care of transplant recipients.
- Trial name
- NCT00217126
- Where
- United States
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Transplants
Creating a Patient-centered Report Card for Solid Organ Transplant Candidates
Choosing a transplant center that will accept a particular candidate can be difficult and challenging for patients with end-stage organ failure.
- Trial name
- NCT03610555
- Testing
- Intervention 1 - SRTR (age question 1st), Intervention 2 - SRTR (BMI question 1st), Intervention 3 - TCST (age question 1st)
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Ajay Israni, MD
Wound Healing Complication
Effect of Topically-Applied Hyaluronic-Acid on Palatal Epithelial Wound Closure
Aim of the study is to assess the therapeutic effects of topical hyaluronic-acid use on secondary wound healing of the free gingival graft donor site.
- Trial name
- NCT02534415
- Testing
- Periodontal dressing material, 0.2% Hyaluronic acid gel, 0.8% Hyaluronic acid gel
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Marmara University
Organ Transplantation
Antibody Levels Against 2009 Influenza A H1N1 One Year After Vaccination With Pandemrix and 2010 Fluarix Booster in Organ Transplant Recipients.
Organ transplant patients who participated in a retrospective study and received 2009 Pandemrix vaccine during autumn 2009 are included in this study.
- Trial name
- NCT01256931
- Where
- Sweden
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Organ Transplantation, Transplantation Immunology
Immune Monitoring and Assay Development in Organ Transplant Recipients
The purpose of this study to develop a well-characterized library of blood, biopsy tissue, and urine samples from transplant patients. Subjects without transplants will also be enrolled for comparison.
- Trial name
- IMP (NCT01283295)
- Where
- 2 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Emory University
Varicella, Transplants
Response and Clearance of Viral DNA Following Administration of Live Attenuated Varicella Vaccine.
Varicella zoster virus (VZV) can lead to significant morbidity and mortality in transplant recipients. Current recommendations suggest a 4 week waiting period between vaccination and transplantation and consideration of booster…
- Trial name
- NCT02692066
- Testing
- varicella vaccine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Organ Transplants
RCT Comparing Tailored Versus Targeted Organ Donation Video Education
The primary purpose of this 3-phase mixed methods design study is to investigate how presenting content at varying levels of audience specificity (generic, targeted, and tailored) influences organ donor registration behavior…
- Trial name
- NCT02676102
- Testing
- Control Group, Targeted Intervention, Tailored Intervention
- Where
- United States
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
A Clinical Trial Evaluating Fecal Microbiota Transplantation (FMT) in Adolescents With ADHD
The primary goals of this phase 2 clinical trial are to determine the feasibility, safety, and tolerability of oral Fecal Microbiota Transplantation (FMT) in adolescents (aged 13-17) with Attention-Deficit/Hyperactivity Disorder…
- Conditions
- ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD - Combined Type
- Trial name
- FMT-ADHD-2026 (NCT07756255)
- Testing
- Fecal Microbiota Transplant (FMT), Nitazoxanide 500mg BID, Vancomycin 250mg BID
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Quality of Life
Transplantoux Health Evaluation Study
The primary aim is to evaluate the short- and long-term effect of the 'Transplantoux' exercise training intervention in solid organ transplant recipients with matched control sample of transplant recipients in view of selected…
- Trial name
- THES (NCT02533245)
- Testing
- Home-based indiviualized exercise training program, Supervised group training sessions, Climb of the Mont Ventoux
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Transplants and Implants, Hearing Loss
Evaluation of Performance and Usability of N6 in the Paediatric Population
The purpose of this study is to evaluate the performance and usability of the N6 system in children with the N5 system.
- Trial name
- NCT01800929
- Testing
- N6
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cochlear, Asia Pacific
Organ Transplantation
Survey on the Evaluation of Medication Information Leaflets for Organ Transplant Patients
The aim of this study is to collect feedback from organ transplant patients or their caregivers/relatives on the medication information leaflets we've developed, using a questionnaire, and to adjust the content to better meet the…
- Trial name
- NCT06652919
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universität Münster