Clinical trials: Transplants
Graft Rejection, Kidney Failure
Study Comparing Two Sirolimus Regimens vs. Tacrolimus and Mycophenolate Mofetil Regimen in Kidney Transplant Recipients
To demonstrate the superiority of SRL + TAC elimination + corticosteroids (Group I) and SRL + MMF + corticosteroids (Group II) to TAC + MMF + corticosteroids (Group III) with respect to renal allograft function at month 12…
- Conditions
- Graft Rejection, Kidney Failure, Kidney Transplant
- Trial name
- NCT00266123
- Testing
- Sirolimus
- Volunteers
- 420 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Liver Transplant, Fungal Infection
An Assessment of Voriconazole Pharmacokinetics and Pharmacogenetics in Liver Transplant Recipients - Pilot Study
A fixed-dosing regimen of voriconazole is routinely used as prophylaxis against aspergillosis in liver transplant patients admitted to the transplant intensive care unit at UPMC.
- Trial name
- NCT00371605
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Renal Transplant Recipients
Sexual Function in Male Renal Transplant Patients
Sexual dysfunction is common in male patients with chronic renal failure on dialysis and after renal trasnplantation. Multiple factors play a role in this important clinical problem.
- Trial name
- NCT00271830
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Montefiore Medical Center
Kidney Transplant
Metabolic and Renal Effects of Rosiglitazone in Kidney Transplant
Abnormalities in glucidic and lipidic metabolism are common features in renal transplant patients on chronic immunossupression with steroids and calcineurin inhibitors.
- Trial name
- NCT00309309
- Testing
- Rosiglitazone
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Kidney Transplant
EXTEND Protocol for Transplanted Patient to Evaluate Kidney Function
The long-term use of calcineurin inhibitors in the maintenance phase after kidney transplantation is associated with typical adverse effects, such as potential contribution to progressive impairment of renal function…
- Trial name
- NCT00302497
- Testing
- basiliximab
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Transplant
Pneumonia Vaccine in Liver Transplant Recipients: a Booster Strategy Using a Conjugate Vaccine
The trial will compare a group of patients whose immune system is primed with the pneumococcal conjugate vaccine and then given a boost with polysaccharide vaccine (prime-boost strategy) vs.
- Trial name
- NCT00152802
- Testing
- The polysaccharide vaccine Pneumovax (Merck-Frosst), The conjugate vaccine used will be Prevnar (Wyeth vaccines)
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- University Health Network, Toronto
Kidney Transplant
Low Dose Sirolimus or CsA-Based Maintenance Immunosuppression After Induction With Campath-1 in Kidney Transplantation
During the past 15 years, however, the superior immunosuppressive efficacy of CsA and the well-known toxicity of long-term steroid therapy have prompted trials of steroid withdrawal from renal allograft recipients at various…
- Trial name
- NCT00309270
- Testing
- Campath-1H
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Renal Transplant Recipients
Web Based Renal Transplant Patient Medication Education
Information technology will be brought directly to renal transplant recipients to help them learn about the large number of medications they are required to take on a life long basis, in order to prevent errors and improve safety.
- Trial name
- NCT00327483
- Testing
- Internet based education software
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Renal Transplant Recipients, Posttransplant Diabetes Mellitus
Efficacy and Safety of Nateglinide Treatment in Renal Transplant Recipients
The objective of the present study is to evaluate both the efficacy and safet of nateglinide in renal transplanta recipients with posttransplant diabetes mellitus or impaired glucose tolerance.
- Conditions
- Renal Transplant Recipients, Posttransplant Diabetes Mellitus, Posttransplant Impaired Glucose Tolerance
- Trial name
- NCT00319189
- Testing
- Nateglinide
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- University of Oslo School of Pharmacy
Renal Transplant Recipients
Calcineurin Inhibitor-Free Immunosuppression in Renal Transplant Recipients at Low Immunogenic Risk
To compare renal function (51Cr-EDTA clearance) 12 months posttransplant, in primary renal allograft recipients (from cadaveric donor) at low immunogenic risk, 0 DR mis-match, receiving immunosuppressive therapy with A) Zenapax®…
- Trial name
- NCT00138970
- Testing
- Zenapax®, CellCept® and prednisolone, Sandimmun Neoral®, CellCept® and prednisolone
- Volunteers
- 70 people
- Sponsor
- University of Oslo School of Pharmacy