Clinical trials: Transplants
Antibody-mediated Rejection
A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Kidney Transplants Who Have Antibody-Mediated Rejection (AMR)
In this study, researchers will learn more about the use of felzartamab in kidney transplant patients who have antibody-mediated rejection, also known as AMR. Kidney transplants can save lives for people with kidney failure.
- Trial name
- TRANSCEND (NCT06685757)
- Testing
- Felzartamab
- Where
- 56 sites in United States, Argentina and 10 more
- Volunteers
- 132 people
- Sponsor
- Biogen
Renal Transplantation
Efficacy and Safety of FTY720 in de Novo Adult Renal Transplant Recipients
This study will evaluate the safety and efficacy of FTY720 combined with cyclosporine and corticosteroids in patients receiving a kidney organ transplant
- Trial name
- NCT00239785
- Testing
- FTY720
- Volunteers
- 684 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Transplant; Complications
Solid Organ Transplant SHINGRIX
This study will assess the immune responses to the recombinant, AS01-adjuvanted varicella zoster virus subunit (HZ/su) vaccine or SHINGRIX in immunosuppressed patients, particularly those who have received a renal transplant, and…
- Trial name
- NCT03993717
- Testing
- SHINGRIX
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Emory University
Ischemic Stroke, Ischaemic Cerebral Infarction
Study of Purified Umbilical Cord Blood CD34+ Stem Cell on Chronic Ischemic Stroke
The purpose of the study is to determine the safety and possible effectiveness of brain transplants of CD34+ stem cells obtained from umbilical cord blood (UCB) to treat stroke.
- Conditions
- Ischemic Stroke, Ischaemic Cerebral Infarction, Infarction, Middle Cerebral Artery, Ischemia
- Trial name
- NCT01438593
- Testing
- Intercerebral implantation of allogenic CD34+ stem cell
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- China Medical University Hospital
Cytomegalovirus Infections
Prophylactic Use of Maribavir for the Prevention of Cytomegalovirus (CMV) Disease in Stem Cell Transplant Recipients
The purpose of this research study is to investigate whether or not maribavir is safe and effective for preventing CMV disease when taken by mouth for up to 12 weeks in patients who have had a stem cell transplant.
- Trial name
- NCT00411645
- Testing
- maribavir
- Where
- 97 sites in United States, Belgium and 7 more
- Volunteers
- 681 people
- Sponsor
- Shire
Revision of Meniscal Transplant
Revision Meniscal Transplants; Lateral and Medial
During the period 1989-1999, a number of patients underwent a meniscal transplantation. A few transplants were not successful. These patients form the population of this study.
- Trial name
- NCT01189357
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University Hospital, Ghent
Non-melanomatous Skin Cancer
Acitretin in Preventing Skin Cancers in Patients With Previously Treated Skin Cancers Who Have Undergone Organ Transplantation
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of acitretin may be an effective way to prevent the recurrence or further development of skin…
- Trial name
- NCT00003611
- Testing
- acitretin
- Where
- 11 sites in United States
- Volunteers
- 129 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Hiv
HOPE in Action Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients
The primary objective of this study is to determine if an HIV-infected donor liver (HIVD+) transplant is safe with regards to major transplant-related and HIV-related complications
- Trial name
- NCT03734393
- Testing
- HIVD+/R+
- Where
- 26 sites in United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Deficiency of Anterior Cruciate Ligament, Displacement of Bone Allograft
MRI Study of Ballooning and Ligamentisation Short Transplants ACL Hamstring According to Technical DT4
MRI study of ballooning and ligamentisation short transplants of anterior cruciate ligament (ACL) according to DT4 technique in 60 patients with more than one year of follow up.
- Trial name
- MRI-DT4 (NCT02626975)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Lille
Heart and Lung Transplants
The Experience, Perceptions and Unexpressed Needs of Heart and Lung Transplant Patients Admitted to Intensive Care
Qualitative descriptive phenomenological study aimed to investigate the experience, perceptions and unexpressed needs of patients undergoing heart and lung transplantation admitted to intensive care unit through semi-structured…
- Trial name
- ReF2201 (NCT06773052)
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Chronic Kidney Disease, Stage 4, Chronic Kidney Disease, Stage 5
BZLF1 Peptide Vaccine (OSU-2131) With QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants
This phase 1B trial tests the safety, side effects and best dose of rh-Hsc70- BZLF1 peptide complex (OSU-2131) with Stimulon (Trademark) QS-21 and evaluates how well it works in preventing Epstein-Barr virus (EBV) infection and…
- Conditions
- Chronic Kidney Disease, Stage 4, Chronic Kidney Disease, Stage 5, EBV-Related Lymphoproliferative Disorder, EBV-Related Malignant Neoplasm
- Trial name
- NCT06741072
- Testing
- Biospecimen Collection, Dulbecco''s Phosphate-Buffered Saline, Peptide Vaccine
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Respiratory Tract Viral Infections, Human Metapneumovirus (hMPV) Infection
Study of ALVR106 in Patients With Respiratory Viral Infections After Hematopoietic Cell and Solid Organ Transplant
A study to evaluate ALVR106; an allogeneic, off-the-shelf multi-virus specific T cell therapy that targets four community acquired respiratory viruses: respiratory syncytial virus (RSV), influenza, human metapneumovirus (hMPV)…
- Conditions
- Respiratory Tract Viral Infections, Human Metapneumovirus (hMPV) Infection, Parainfluenza (PIV) Infection, Respiratory Syncytial Viral (RSV) Infection
- Trial name
- NCT04933968
- Testing
- ALVR106
- Where
- 21 sites in United States
- Volunteers
- 17 people
- Sponsor
- AlloVir
Influenza
Assess the Risk of Solid Organ Transplant Rejection Following Vaccination With Pandemrix™ in UK
This study aims to assess the risk of solid organ transplant (SOT) rejection following vaccination with Pandemrix™ and/ or seasonal influenza vaccination.
- Trial name
- NCT01715792
- Testing
- Data collection
- Where
- United Kingdom
- Volunteers
- 587 people
- Sponsor
- GlaxoSmithKline
Antibody Mediated Rejection
Cyclophosphamide Therapy for Refractory Antibody-Mediated Rejection (AMR) in Kidney Transplants
The study hypothesis is that short-term low dose cyclophosphamide therapy will be effective in resolving inflammation in patients with late phase antibody-mediated rejection refractory to current standard of care treatment.
- Trial name
- NCT01630538
- Testing
- Cyclophosphamide
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Manitoba
Lung Diseases
Transplanting Hepatitis C Lungs Into Negative Lung Recipients
This study is being conducted to determine safety and effectiveness of transplanting lungs from Hepatitis C-positive donors into Hepatitis C-negative patients on the lung transplant waitlist, who will then be treated with…
- Trial name
- SHELTER (NCT03724149)
- Testing
- Zepatier, Epclusa
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Cutaneous Squamous Cell Carcinoma, Advanced Cancer
Cemiplimab in AlloSCT/SOT Recipients With CSCC
In this research study, Cemiplimab is being evaluated as a treatment for advanced cutaneous squamous cell carcinoma in participants who have previously received an allogeneic hematopoietic stem cell transplant or kidney…
- Trial name
- CONTRAC (NCT04339062)
- Testing
- Cemiplimab, Everolimus, Sirolimus
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dana-Farber Cancer Institute
Zoster; Herpes
Zoster Vaccine to Enhance Protection Against Zoster in Solid-organ Transplantation
Shingles is caused by the same virus that causes chickenpox. After someone has chickenpox, the virus stays in the body and can become active again later in life. This is called shingles.
- Trial name
- ZEST (NCT07443709)
- Testing
- Booster dose of the recombinant zoster vaccine (RZV, Shingrix®)
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- Oriol Manuel
Solid Organ Transplant Recipients
TIXAGEVIMAB/CILGAVIMAB Protection of Covid-19 in Transplanted Patients
Covid-19 has a very bad prognosis in solid organ transplant recipients with a 60 days-mortality exceeding 20%. For this reason, transplant patients were prioritized to receive Covid-19 vaccination since December 2020 in France.
- Trial name
- TIXCI-TRANS (NCT05234398)
- Testing
- Blood and saliva samplings
- Where
- 2 sites in France
- Sponsor
- Hospices Civils de Lyon
Transplant Recipients
COVID-19 Research in Organ Transplant Recipients
COVID-19 is a global major public health emergency that disproportionately affects patients with risk factors such as advanced age, heart and lung disease, diabetes, hypertension, as well as compromised immunity.
- Trial name
- CORONA (NCT04407221)
- Where
- Sweden
- Volunteers
- 1,100 people
- Sponsor
- Vastra Gotaland Region
Fanconi Syndrome
Observational Follow-up Study of Haplo-identical Transplants in Fanconi Disease
This observational protocol will allow for an independent, prospective evaluation of the improvement in survival of patients with Fanconi disease in hematological deadlock due to the absence of an HLA-identical donor and having…
- Trial name
- HAPLO-FANCONI (NCT05903365)
- Testing
- Blood sampling
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris