Clinical trials: Transplants
Immunosuppression, Kidney Transplantation
The Differential Effects of 3 Different Immunosuppressive
The study is a laboratory investigation comparing the regulatory effects of different immunosuppressive therapies in an in vitro human MLR assay of selecting specific immunosuppressive therapy to promote a regulatory profile and…
- Trial name
- NCT00729248
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Northwestern University
HBV, Kidney Transplantation
Viral Immunity in Solid Organ Transplant Recipients: Monitoring Of The Response To Hepatitis B Booster Vaccination
Solid Organ Transplantation (SOT) is made possible by the use of a lifelong immunosuppressive treatment. This treatment limits the response of the immune system, enabling long-term survival of the transplanted organ, but also…
- Conditions
- HBV, Kidney Transplantation, Liver Transplantation
- Trial name
- VITAMIN (NCT06307808)
- Testing
- Tacrolimus, Belatacept
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Grenoble
Lymphoma, Leukemia
Phase I Study of Sequential Cord Blood Transplants
The purpose of this study is to determine the safety of sequential cord blood transplantation (2 cord blood units) for patients who have diseases that are capable of being cured by allogeneic stem cell transplant but do not have…
- Conditions
- Lymphoma, Leukemia, Multiple Myeloma, Myelodysplastic Syndrome
- Trial name
- NCT00299767
- Testing
- sequential cord blood transplantation
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
SARS-CoV-2
Solid Organ Transplant Recipients With SARS-CoV-2 French Registry
Patients with comorbid condition are known to be at high risk of severe forms of Covid-19. It is highly probable that immunocompromised patients like solid organ transplant (SOT) recipients are also at risk of severe forms of…
- Trial name
- TX-COVID (NCT04360707)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Immunity, Cellular
Clinical Evaluation of Quantiferon-Monitor to Predict Outcomes in Solid Organ Transplant Recipients
The study will prospectively determine the clinical utility of non-pathogen specific cellular immunity assessment using the Quantiferon-Monitor to quantify the degree of immunosuppression.
- Trial name
- QTF-Monitor (NCT02560857)
- Testing
- Quantiferon-Monitor assay
- Where
- Canada
- Volunteers
- 151 people
- Sponsor
- Deepali Kumar
Microsporidiosis Intestinal
Interest of Nitazoxanide Treatment of Enterocytozoon Bieneusi Intestinal Microsporidiosis
Microsporidia are pathogenic fungi mainly responsible for profuse watery diarrhea, requiring management in immunocompromised patients.
- Trial name
- NITAZO-SPORE (NCT05417815)
- Where
- 24 sites in France, Guadeloupe
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hematologic Diseases, Hematologic Malignancy
CD34+ Enriched Transplants From HLA-Compatible Patients With Hematologic Malignancies
This is a Phase II trial testing disease-specific myeloablative conditioning regimens for preparatory cytoreduction of patients receiving allogeneic HLA-compatible related or unrelated transplants of GCSF-mobilized peripheral…
- Conditions
- Hematologic Diseases, Hematologic Malignancy, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- 2019-KOE-001 (NCT04282174)
- Testing
- CliniMACS, Bone Marrow Transplant, Hyperfractionated Total Body Irradiation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baptist Health South Florida
Cancer
Immune Reconstitution in Stem Cell Transplant Recipients
This specimen collection lab protocol will allow the investigators to prospectively study immune reconstitution in patients being treated for hematologic disorders and immune factors affecting graft versus host disease in…
- Trial name
- NCT02129543
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Miami
Hyperkalaemia Requiring Postoperative Dialysis, Metabolic Acidosis
Perioperative Fluid Management in Patients Receiving Cadaveric Renal Transplants
In this study we want to show that the choice of a balanced type fluid solution for the perioperative fluid management of patients receiving cadaveric renal transplantation results in less occurrence of intra- and postoperative…
- Trial name
- NCT01075750
- Where
- Austria
- Volunteers
- 150 people
- Sponsor
- Medical University of Vienna
Acute Leukemias, Chronic Leukemias
Busulfan and Cyclophosphamide Instead of Total Boby Irradiation (TBI) and Cyclophosphamide for Hematological Malignancies Hematocrit (HCT)
Long-term follow-up studies have demonstrated significant late toxicities of total body irradiation (TBI), which are most marked in children radiated at a young age.
- Conditions
- Acute Leukemias, Chronic Leukemias, Myelodysplastic Syndrome, Juvenile Myelomonocytic Leukemia
- Trial name
- NCT01339988
- Testing
- Busulfan/Cyclophosphamide
- Volunteers
- 10 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Ewing's Sarcoma/Soft Tissue Sarcoma, Neuroblastoma
A Combined Study in Pediatric Cancer Patients for Dose Ranging and Efficacy/Safety of Plerixafor Plus Standard Regimens for Mobilization Versus Standard Regimens Alone
This is a multi-site study with plerixafor in pediatric cancer patients. The study will be conducted in 2 stages: Stage 1 is a dose-escalation study.
- Conditions
- Ewing's Sarcoma/Soft Tissue Sarcoma, Neuroblastoma, Brain Tumors
- Trial name
- NCT01288573
- Testing
- plerixafor
- Where
- 27 sites in Belgium, Czechia and 10 more
- Volunteers
- 46 people
- Sponsor
- Genzyme, a Sanofi Company
Ischemic Stroke, Ischaemic Cerebral Infarction
Study of Purified Umbilical Cord Blood CD34+ Stem Cell on Chronic Ischemic Stroke
The purpose of the study is to determine the safety and possible effectiveness of brain transplants of CD34+ stem cells obtained from umbilical cord blood (UCB) to treat stroke.
- Conditions
- Ischemic Stroke, Ischaemic Cerebral Infarction, Infarction, Middle Cerebral Artery, Ischemia
- Trial name
- NCT01438593
- Testing
- Intercerebral implantation of allogenic CD34+ stem cell
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- China Medical University Hospital
Solid Organ Transplant Rejection, Organ Rejection Transplants
Expanded Access for Use of ExoFlo in Abdominal Solid Organ Transplant Patients
This Expanded Access Protocol will provide access to the IMP ExoFlo for patients who have severe or life-threatening abdominal solid organ transplant rejection or who are evaluated and determined to be at high risk of progression…
- Conditions
- Solid Organ Transplant Rejection, Organ Rejection Transplants, Organ Rejection
- Trial name
- NCT05215288
- Testing
- ExoFlo
- Where
- 2 sites in United States
- Sponsor
- Direct Biologics, LLC
Actinic Keratosis
Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients
This phase IIA study evaluates the effects of calcipotriene plus 5- fluorouracil immunotherapy for skin cancer prevention in organ transplant recipients.
- Trial name
- NCT05699603
- Testing
- Biopsy, Calcipotriene, Fluorouracil
- Where
- 4 sites in United States
- Volunteers
- 56 people
- Sponsor
- University of Arizona
Post-Transplant Infections, Post-Transplant Renal Insufficiency
Study of the Complications Associated With Certain Stem Cell Transplants
Background: The National Institutes of Health (NIH) performs up to 100 allogenic stem cell transplants (allo-HSCT) each year. Many studies already look at different problems that can follow a transplant.
- Conditions
- Post-Transplant Infections, Post-Transplant Renal Insufficiency, Post-Transplant Pulmonary Complications
- Trial name
- NCT01919099
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Myeloma
UARK 2008-02 A Trial for High-risk Myeloma Evaluating Accelerating and Sustaining Complete Remission
There have been four previous Total Therapy (TT1 through IIIB) studies for multiple myeloma at the MIRT from 1989 to present. Results have shown that participants treated on these studies had better outcomes (meaning they have…
- Trial name
- NCT00869232
- Testing
- Velcade, Melphalan, Thalidomide
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Arkansas
Hand Transplant, Hand Replant
Cortical Organization in Allogeneic Transplants or Heterotopic Hand Replants
The investigators hope to gain insights into the functional organization of the human cerebral cortex in response to upper limb amputation and surgical interventions including hand replantation and hand transplantation.
- Trial name
- NCT01618682
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Christine M. Kleinert Institute for Hand and Microsurgery
Transplant-Related Disorder, Hepatitis B Virus Infection
Optimal Timing of Hepatitis B Vaccination After Transplants
The investigators aim to perform a randomized clinical trial to determine the optimal timing of hepatitis B vaccination after hematopoietic cell transplantation (HCT) through evaluating the immunity effect of two different…
- Conditions
- Transplant-Related Disorder, Hepatitis B Virus Infection, Vaccine Reaction
- Trial name
- NCT06888479
- Testing
- hepatitis B vaccine
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Kidney Transplant Recipients
Measuring and Improving Medication Adherence in Kidney Transplant Patients
Nonadherence to medication is a major obstacle to successful treatment of renal transplant patients. This study has two primary aims.
- Trial name
- NCT02639949
- Testing
- Cognitive-behavioral adherence promotion program, Standard Care
- Volunteers
- 45 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pediatric Solid Organ Transplant Patients
Standard Dose Versus High-Dose Inactivated Flu Vaccine in Pediatric Solid Organ Transplant Patients
This is a phase I trial in which the both the safety and immunogenicity of the standard dose flu vaccine will be compared with high dose flu vaccine in children that have undergone solid organ transplantation (SOT).
- Trial name
- NCT01525004
- Testing
- High-Dose trivalent inactivated influenza vaccine, Standard dose trivalent inactivated influenza vaccine
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Vanderbilt University