Clinical trials: Trauma, Spinal Cord
Spinal Cord Injury, Quadriplegia
Electrical Activation of The Diaphragm for Ventilatory Assist
OBJECTIVES: The objectives of this study are to test the Diaphragm Pacing Stimulation (DPS) System for treating chronic ventilatory insufficiency in persons with respiratory muscle paralysis.
- Trial name
- NCT00010374
- Testing
- NeuRx DPS
- Where
- 5 sites in United States, Canada
- Volunteers
- 54 people
- Sponsor
- Synapse Biomedical
Spina Bifida Aperta, Acquired Traumatic Spinal Cord Injury
Self-esteem and Neuro-urological Follow-up in Patients With Spina Bifida or Spinal Cord Injury
With improved life expectancy over the last fifty years, spina bifida has become a disease of the adult. One of the major stakes for these patients is the preservation of a regular follow-up of uro-nephrologicals risk factors and…
- Trial name
- ESTIME (NCT01606618)
- Where
- 16 sites in France
- Volunteers
- 111 people
- Sponsor
- Rennes University Hospital
Spinal Cord Injuries
Combined Magnetic Stimulation and Ultrasound for Detrusor Overactivity in SCI
This clinical trial aims to investigate whether the combination of high-frequency sacral nerve root magnetic stimulation and bladder-directed ultrasound therapy can effectively improve detrusor overactivity (involuntary bladder…
- Trial name
- NCT07704268
- Testing
- Transcranial Magnetic Stimulation (TMS) Device /Ultrasound therapy device
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Shengjing Hospital
Cerebral Palsy, Spinal Muscular Atrophy
Pediatric Powered Wheelchair Standing Devices: An Exploratory Study
For children who use a power wheelchair, a powered wheelchair standing device (PWSD) may be considered for daily use. A PWSD allows a child to electronically move between sitting and standing and can be driven in either position.
- Conditions
- Cerebral Palsy, Spinal Muscular Atrophy, Spinal Cord Injuries, Spina Bifida
- Trial name
- NCT05117827
- Testing
- Power Wheelchair Standing Device
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Pressure Ulcer
Oxandrolone to Heal Pressure Ulcers
This study is designed to determine whether the use of oxandrolone, an anabolic steroid, can heal pressure ulcers in persons with spinal cord injury (SCI).
- Trial name
- NCT00101361
- Testing
- Oxandrolone
- Where
- 16 sites in United States, Puerto Rico
- Volunteers
- 212 people
- Sponsor
- US Department of Veterans Affairs
Spasticity, Muscle, Spinal Cord Injuries
Long-term Efficacy of Spasticity-correcting Surgery and Botulinum Toxin Injections for Upper Limb Spasticity Treatment
Spasticity - a variety of motor over-activity and part of the upper motor neuron syndrome - is a common cause of impaired motor function after brain injuries of different etiologies.
- Conditions
- Spasticity, Muscle, Spinal Cord Injuries, Traumatic Brain Injury, Stroke
- Trial name
- NCT03910101
- Testing
- Hand surgery and intensive rehabilitation
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Vastra Gotaland Region
Spinal Cord Injuries, Chronic Spinal Cord Injury
NVG-291 in Spinal Cord Injury Subjects
A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2a Study of NVG-291 in Spinal Cord Injury Subjects
- Conditions
- Spinal Cord Injuries, Chronic Spinal Cord Injury, Subacute Spinal Cord Injury
- Trial name
- NCT05965700
- Testing
- NVG-291
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NervGen Pharma
Spinal Cord Injuries
Brivaracetam to Reduce Neuropathic Pain in Chronic Spinal Cord Injury
Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to all pharmacological intervention.
- Trial name
- NCT04379011
- Testing
- Brivaracetam
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Spinal Cord Injuries
Ketogenic Diet to Improve Neuro-recovery
The purpose of this project is to determine if 5 weeks of ketogenic (KD, high-fat) diet vs. standard diet (SD) significantly improves motor and sensory function, glycemic function, and functional independence in patients with…
- Trial name
- NCT03509571
- Testing
- Ketogenic Diet, Standard Diet
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Ohio State University
Spinal Cord Injuries
Motor Learning Approach for Manual Wheelchair Users
The overall purpose of this project is to pilot test a manual wheelchair (MWC) training program based on motor learning theory to improve wheelchair propulsion for manual wheelchair users (MWUs) with spinal cord injury (SCI).
- Trial name
- NCT03781609
- Testing
- Roller system group (RG), Overground group (OG)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injuries
Comparison of an Exoskeleten With an End-effector for Assisted Gait Training in Spinal Cord Injury
Aim is to compare exoskeleton assisted gait training with end-effector assisted gait training in Spinal Cord Rehabilitation
- Trial name
- NCT03544398
- Testing
- robot assisted gait training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Erenköy Physical Therapy and Rehabilitation Hospital
Spinal Cord Injuries
Spinal Stimulation in Chronic Spinal Cord Injury
Electrical spinal stimulation combined with activity-based rehabilitation (ABR) can improve motor and autonomic function in individuals suffering from varying degrees of paralysis.
- Trial name
- NCT04132596
- Testing
- Transcutaneous spinal cord stimulation, Activity Based Therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- The Neurokinex Charitable Trust
Acute Spinal Cord Injury
Study to Evaluate the Safety and Pharmacokinetics of ALMB-0166 in Patients With Acute Spinal Cord Injury
The purpose of this study is to assess the safety, tolerability and pharmacokinetics of ALMB-0166 in patients with acute spinal cord injury.
- Trial name
- NCT05524103
- Testing
- ALMB-0166
- Where
- 2 sites in China
- Volunteers
- 24 people
- Sponsor
- AlaMab Therapeutics (Shanghai) Inc.
SCI - Spinal Cord Injury, Cardiovascular Risk Factor
Cardiovascular Risk Markers in Spinal Cord Injured Subjects of the Wheelchair Dancer Study
The present study will analyze if exercise is able to elicit the well-known anti-atherogenic effects in patients with SCI. This will be evaluated by measuring vascular parameters such as endothelial and inflammatory blood…
- Trial name
- NCT03352505
- Where
- 2 sites in Austria
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Adolescent Idiopathic Scoliosis (AIS)
Personalized Prevention and Treatment Strategies for Adolescent Idiopathic Scoliosis Via a Comprehensive Health Management Platform
Spinal cord injury (SCI), leads to functional deficits and complications like neurogenic bladder and deep vein thrombosis, imposing a global annual financial burden.
- Trial name
- NCT06314594
- Testing
- Conventional treatment, intervention treatment
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hangzhou Medical College
Spinal Cord Injuries
Umbilical Cord Blood Mononuclear Cell Transplant to Treat Chronic Spinal Cord Injury
The purpose of this study is to investigate the feasibility, safety, efficacy and optimal dose of umbilical cord blood mononuclear cell transplant in the treatment of chronic spinal cord injuries.
- Trial name
- NCT01354483
- Testing
- Umbilical Cord Blood Mononuclear Cell, Methylprednisolone, Lithium Carbonate Tablet
- Where
- China
- Volunteers
- 20 people
- Sponsor
- China Spinal Cord Injury Network
Cervical Spinal Cord Injury
Feasibility and Safety of a Combined Augmented Reality and Functional Electrical Stimulation System
Cervical spinal cord injury (cSCI) can result in substantial loss of upper-limb function, with associated socio-economic impact on affected individuals and the healthcare system.
- Trial name
- NCT07299734
- Testing
- AR + FES
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Multiple Sclerosis, Spinal Cord Injury
Motivational Interviewing to Increase Physical Activity to Treat Depression in People Aging With MS or SCI
This study compares two approaches to helping people who are aging with MS or SCI and are experiencing depressed mood to become more physically active. The study is carried out entirely by telephone.
- Trial name
- inMotion (NCT00947232)
- Testing
- Motivational interviewing, Education
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Washington
Spinal Cord Injury
Mobility and Therapeutic Benefits Resulting From Exoskeleton Use in a Clinical Setting (SC140121 Study 1 and 2)
The proposed study is intended to inform the hypotheses that (1) regular dosing of exoskeleton walking will provide health benefits to non-ambulatory and poorly-ambulatory individuals with SCI, including decreased pain and…
- Trial name
- NCT03082898
- Testing
- Indego Exoskeleton
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Vanderbilt University
Cervical Spinal Cord Injury
Improving Upper Extremity Function and Trunk Stability After Cervical Spinal Cord Injury (SCI)
Ninety-nine individuals meeting the study's inclusion/exclusion criteria will be enrolled in this study. The objective of this study is to evaluate three different therapeutic approaches to synergistically retrain functional…
- Trial name
- NCT05191121
- Testing
- FTP Alone, FTP+Con-FES, FTP+WPHF-FES
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Craig Hospital