Clinical trials: Trauma/Injury Problem, open to volunteers
Post Traumatic Stress Disorder (PTSD), Depression
Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
The VA wants to understand what type of integrative and whole health approaches are helpful for Veterans. The study is comparing two primary care based mental health treatments, a mindfulness class that teaches mindfulness…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Depression, Anxiety
- Trial name
- NCT06162741
- Testing
- Primary Care Brief Mindfulness Training (PCBMT), Moving Forward (MF)
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Orthopedic Disorder, Trauma Injury
X-BS Ortho Bone Graft Study
Randomised investigation of the osteoconductive performance and safety of CE-marked FDBS bone graft (GraftR3®), with contextual reference to CE-marked IBS (MBCP® Putty), in the filling of orthopaedic bone defects.
- Conditions
- Orthopedic Disorder, Trauma Injury, Extremity Injury
- Trial name
- NCT06326827
- Testing
- FDBS (GraftR3®), IBS (MBCP® Putty)
- Volunteers
- 200 people
- Sponsor
- Advanced Medical Solutions Ltd.
Trauma Injury
Bioimpedance for Ortho Trauma
Patients with high-energy extremity trauma will undergo imaging with an EIT device in the Emergency Department, Operating Room, Orthopaedic Clinic, and In-patient hospital rooms.
- Trial name
- NCT06858488
- Testing
- Extremity Surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chest Trauma
Thorax vs. Trauma Injury Severity Scores as Outcome Predictors in Chest Trauma
The goal of this observational study is to compare the predictive utility of the Thorax Trauma Severity Score (TTSS) and the Trauma and Injury Severity Score (TRISS) in determining outcomes among patients presenting with chest…
- Trial name
- TTSS/TRISS/ER (NCT06707441)
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- Al-Nahrain University
Depression and Quality of Life, Sexual Violence
Empowerment Self Defense Program for Adult Native Women Survivors of Sexual Violence
The purpose of this study is to culturally adapt and evaluate an empowerment self-defense (ESD) program (i.e., IMpower) for AI/AN women who have experienced SV in their lifetime and currently experiencing moderate to severe…
- Conditions
- Depression and Quality of Life, Sexual Violence, PTSD, Suicidal Ideation
- Trial name
- ESD (NCT07712796)
- Testing
- Empowerment self-defense training
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Michigan
Trauma Injury, Trauma
OCT in Open Fracture and Infected Fracture
This is a pilot prospective, observational study of patients with open or infected fracture evaluating the feasibility and acceptability of OCT, a light-based imaging modality that requires no drug or contrast agent.
- Conditions
- Trauma Injury, Trauma, Open Fracture, Fracture Infection
- Trial name
- NCT05785182
- Testing
- Open Fracture, Infected Fracture
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Trauma Injury
How Many Patients Suffering Major Trauma Would be Eligible for a Pre-hospital Transfusion
The aim of the study is to measure the number of patients being cared for by a medical team for major trauma who could benefit from a transfusion labile blood products and thus provide a scientific argument in favour of supplying…
- Trial name
- TRAP (NCT06494293)
- Testing
- Data Collection
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Hôpital NOVO
Trauma Injury
Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury
Traumatic injury is a leading cause of morbidity and mortality in young adults, and remains a substantial economic and health care burden.
- Trial name
- NCT02577731
- Testing
- Bone marrow collection, Blood collection, Clinical data collection
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Florida
Post Traumatic Stress Disorder, Complex Posttraumatic Stress Disorder
Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress
In the last four years alone, residents of Puerto Rico have experienced a slew of natural disasters including Hurricane Maria in 2017, earthquakes in 2019 and 2020, the continued COVID-19 pandemic from 2020-2022, and most…
- Conditions
- Post Traumatic Stress Disorder, Complex Posttraumatic Stress Disorder, Stress, Burn Out
- Trial name
- NCT05701111
- Testing
- Start with the Heart Students, Start with the Heart Teachers, Cue Centered Therapy Counselors
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 80,800 people, healthy volunteers welcome
- Sponsor
- Stanford University
Executive Function Deficits (EFD), Developmental Coordination Disorder
Let's CO-OPerate! Together we Are Stronger
The goal of this replicated single case experimental study using a randomized multiple baseline design across participants and goals is to enable children/adolescents (aged 8-16 years) with developmental coordination disorders…
- Conditions
- Executive Function Deficits (EFD), Developmental Coordination Disorder, Acquired Brain Injury (Including Stroke), Brain Injury, Fetus and Neonate
- Trial name
- NCT07085403
- Testing
- Cognitive Orientation to daily Occupational Performance (CO-OP) is a cognitive problem-solving approach
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hopitaux de Saint-Maurice
Rib Fractures, Rib Fracture Multiple
UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture
Traumatic rib fractures (i.e., broken ribs caused by a physical injury) are common and very painful. They also often lead to serious complications, more time spent in hospital, and can even lead to death.
- Conditions
- Rib Fractures, Rib Fracture Multiple, Rib; Fracture, With Flail Chest, Pain
- Trial name
- UNPIN (NCT05865327)
- Testing
- Cryoneurolysis
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Geriatrics, Trauma Injury
Patient Experience of Older Adults Living Alone With Injuries
This study aims to explore the patient experiences of living alone older adults with injuries, and to examine the effects of a "Geriatric Trauma Care Program" in older adults with limb injuries who live alone.
- Conditions
- Geriatrics, Trauma Injury, Living Alone
- Trial name
- NCT07610161
- Testing
- Geriatric Trauma Care Program
- Where
- 2 sites in Taiwan
- Volunteers
- 110 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Trauma Injury, Thromboembolism
Antithrombin to Improve Thromboprophylaxis and Reduce the Incidence of Trauma-Related Venous Thromboembolism
The purpose of this study is to determine if additional interventions will assist with decreasing the risk and/or severity of thromboembolism (clotting complications) in patients who have experienced a major traumatic event.
- Conditions
- Trauma Injury, Thromboembolism, Venous Thromboembolism
- Trial name
- TRAIT (NCT05794165)
- Testing
- Thrombate infusion
- Where
- 5 sites in United States
- Volunteers
- 314 people
- Sponsor
- Bryan Cotton
Alcohol Use Disorder (AUD), PTSD
Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building
This is a two-part study to develop and test a brief, virtual therapy program for lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people who have experienced trauma and use alcohol.
- Trial name
- RISE (NCT07217795)
- Testing
- CBT + expressive writing, Wait-List Control
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Rhode Island
Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms
Personalizing Treatment Delivery
Anxiety and anxiety-related disorders frequently co-occur with alcohol use problems resulting in an enormous humanitarian and economic cost to society.
- Conditions
- Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms, Alcohol; Use, Problem; Alcohol Use Disorder
- Trial name
- NCT05821634
- Testing
- Personalized intervention condition: Cognitive behavioral therapy skills, Therapeutic control condition: Cognitive behavioral therapy skills, Tracking control condition: Supportive counseling
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Rutgers, The State University of New Jersey
Problem Behavior, Aggression
Manualized Assessment and Treatment Model of Challenging Behavior
Despite decades of mounting single-case-design evidence for the efficacy of applied behavior analysis (ABA) and other approaches for the assessment and treatment of challenging behavior, an evidence-based comprehensive approach…
- Conditions
- Problem Behavior, Aggression, Self-Injury
- Trial name
- NCT05928247
- Testing
- Functional Communication Training (FCT), Non-Contingent Reinforcement (NCR), Competing Items and Response Blocking
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Fractures, Bone, Trauma Injury
Study of ICG Fluorescence Imaging in Open Fracture and Infection Patients
The purpose of this study is to determine whether an indocyanine green (ICG) fluorescence imaging system (cBPI) can be used to provide surgeons with information about bone health or bone blood flow.
- Trial name
- cBPI (NCT06793644)
- Testing
- Immunofluorescence Imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Trauma Injury, Coagulopathy
Predictive Accuracy of PLR and PNR in Detecting ETIC
Observational study to know what is the predictive accuracy of platelet-neutrophil ratio (PNR) and platelet-lymphocyte ratio (PLR) done in patients presenting to ED( emergency department)within 6 hours of trauma; in detecting…
- Trial name
- ETIC (NCT07046858)
- Where
- India
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Jubilee Mission Medical College and Research Institute
Autism Spectrum Disorder, Challenging Behaviour
Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism
The goal of this clinical trial is to learn if propranolol can help reduce challenging behaviors associated with Autism Spectrum Disorder, including aggression, self-injury, and severe disruptive behaviors.
- Conditions
- Autism Spectrum Disorder, Challenging Behaviour, Aggression, Severe Disruptive Behaviour Disorders
- Trial name
- NCT07091279
- Testing
- Propranolol
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Jeremy Veenstra-vanderweele
Mental Health Issue
Implementation Supports to Reduce Burnout in Therapists Delivering Child Trauma EBPs
The majority of children exposed to early adversity and trauma do not have access to sustainably delivered evidence-based mental health programs (EBPs), despite the growing prevalence of large-scale multiple-EBP implementation…
- Trial name
- SUPPORTS (NCT04712461)
- Testing
- SUPPORTS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- San Diego State University