Clinical trials: Trauma/Injury Problem, open to volunteers
Trauma Injury, Trauma, Multiple
Effectiveness of a Self-management Program After Traumatic Injury
Traumatic injuries, defined as a physical injury with sudden onset, are a leading cause to disability and impaired health. Persons who sustain a traumatic injury often report problems in daily life activities and reduced quality…
- Conditions
- Trauma Injury, Trauma, Multiple, Polytrauma
- Trial name
- SEMPO (NCT06305819)
- Testing
- self-management support program, Control group
- Where
- Norway
- Volunteers
- 220 people
- Sponsor
- Oslo University Hospital
Psychiatric Problem, Child Neglect
Implementing Dyadic Developmental Psychotherapy (DDP) - Evaluation Research
The objective of this study is to evaluate the implementation and use of Dyadic Developmental Psychotherapy (DDP) in three centra, with particular focus on its potential effects on the quality of the observable caregiver-child…
- Conditions
- Psychiatric Problem, Child Neglect, Maltreatment, Child Behavior Problem
- Trial name
- NCT04763720
- Testing
- Dyadic Developmental Psychotherapy
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Sykehuset Telemark
Mental Health Issue
Implementation Supports to Reduce Burnout in Therapists Delivering Child Trauma EBPs
The majority of children exposed to early adversity and trauma do not have access to sustainably delivered evidence-based mental health programs (EBPs), despite the growing prevalence of large-scale multiple-EBP implementation…
- Trial name
- SUPPORTS (NCT04712461)
- Testing
- SUPPORTS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Urologic Diseases, Male Urogenital Diseases
Bioengineered Penile Tissue Constructs for Irreversibly Damaged Penile Corpora
The primary objective of this clinical trial is to evaluate the safety of autologous engineered corpora cavernosa + albuginea constructs for treatment of complex penile deformities.
- Conditions
- Urologic Diseases, Male Urogenital Diseases, Penile Diseases, Corpus Callosum Malformation
- Trial name
- NCT03463239
- Testing
- Autologous tissue engineered corpora
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Trauma Injury of Hand Multiple, Neurologic Disorder
Arm Use With Soft-robotic Glove
This study, aimed at investigating the impact of using a supportive soft-robotic glove on actual arm and hand use in daily life, is designed as a single-case experimental design study.
- Trial name
- NCT06033027
- Testing
- Carbonhand
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Roessingh Research and Development
Trauma Injury, Depression
Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
Animal assisted therapy (AAT) with dogs has been shown to be beneficial for a wide range of patients with both acute and chronic illnesses, including spinal cord injuries, heart failure, myocardial infarctions, strokes, cancer…
- Conditions
- Trauma Injury, Depression, Anxiety, Anger
- Trial name
- NCT06812247
- Testing
- Therapy dog visits, Dog handler visits
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Boston Medical Center
Trauma Injury, Sepsis
Pathological Myeloid Activation After Sepsis and Trauma
The goal of this observational study is to better understand what happens to circulating blood after a patient experiences severe trauma injury.
- Conditions
- Trauma Injury, Sepsis, Immunosuppression, Chronic Critical Illness
- Trial name
- NCT05616130
- Testing
- Data Collection, Bone marrow collection and blood collection, Serial interviews to complete surveys and questionnaires
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of Florida
Autism Spectrum Disorder, Challenging Behaviour
Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism
The goal of this clinical trial is to learn if propranolol can help reduce challenging behaviors associated with Autism Spectrum Disorder, including aggression, self-injury, and severe disruptive behaviors.
- Conditions
- Autism Spectrum Disorder, Challenging Behaviour, Aggression, Severe Disruptive Behaviour Disorders
- Trial name
- NCT07091279
- Testing
- Propranolol
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Jeremy Veenstra-vanderweele
PTSD, Alcohol; Use, Problem
Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma
The U.S. Deaf community - a group of more than one million Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure…
- Trial name
- NCT06278922
- Testing
- Seeking Safety + Signs of Safety toolkit, Treatment as usual
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Massachusetts, Worcester
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital
Calcaneus Fracture, Displaced Intra-Articular Fracture of Calcaneus (Diagnosis)
Permissive Weight Bearing in Displaced Intra-articular Calcaneal Fractures
The goal of the proposed study is to define the optimal rehabilitation for trauma patients with Displaced Intra-articular Calcaneal Fractures, either Permissive Weight Bearing (PWB) or Restricted Weight Bearing (RWB) regarding…
- Conditions
- Calcaneus Fracture, Displaced Intra-Articular Fracture of Calcaneus (Diagnosis), Trauma Injury
- Trial name
- PIONEER (NCT05721378)
- Testing
- Permissive Weight Bearing group, Restricted Weight Bearing group
- Where
- 11 sites in Netherlands
- Volunteers
- 115 people
- Sponsor
- Maastricht University Medical Center
Rib Fractures, Rib Fracture Multiple
UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture
Traumatic rib fractures (i.e., broken ribs caused by a physical injury) are common and very painful. They also often lead to serious complications, more time spent in hospital, and can even lead to death.
- Conditions
- Rib Fractures, Rib Fracture Multiple, Rib; Fracture, With Flail Chest, Pain
- Trial name
- UNPIN (NCT05865327)
- Testing
- Cryoneurolysis
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Trauma Injury
Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury
Traumatic injury is a leading cause of morbidity and mortality in young adults, and remains a substantial economic and health care burden.
- Trial name
- NCT02577731
- Testing
- Bone marrow collection, Blood collection, Clinical data collection
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Florida
Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms
Personalizing Treatment Delivery
Anxiety and anxiety-related disorders frequently co-occur with alcohol use problems resulting in an enormous humanitarian and economic cost to society.
- Conditions
- Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms, Alcohol; Use, Problem; Alcohol Use Disorder
- Trial name
- NCT05821634
- Testing
- Personalized intervention condition: Cognitive behavioral therapy skills, Therapeutic control condition: Cognitive behavioral therapy skills, Tracking control condition: Supportive counseling
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Rutgers, The State University of New Jersey
Trauma Injury
Reducing Low-value Care for Trauma Admissions
In Canada, injury leads to more potential years of life lost and to greater costs than heart and stroke diseases combined. Furthermore, more than 50% of patients hospitalised following injury do not receive optimal care, 20% of…
- Trial name
- NCT05744154
- Testing
- Audit & feedback with educational outreach and facilitation, Simple audit & feedback (usual practice)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Laval University
Trauma Injury, Modified Trauma Scoring Systems
FOUR Score-Modified Trauma Scores for Mortality Prediction
The goal of this multicenter prospective observational cohort study is to develop and validate FOUR Score-modified trauma scoring systems for mortality prediction in adult trauma patients.
- Conditions
- Trauma Injury, Modified Trauma Scoring Systems, FOUR Score
- Trial name
- FOUR-TRAUMA (NCT07819279)
- Where
- Iraq
- Volunteers
- 2,000 people
- Sponsor
- Al-Nahrain University
Chest Trauma
Thorax vs. Trauma Injury Severity Scores as Outcome Predictors in Chest Trauma
The goal of this observational study is to compare the predictive utility of the Thorax Trauma Severity Score (TTSS) and the Trauma and Injury Severity Score (TRISS) in determining outcomes among patients presenting with chest…
- Trial name
- TTSS/TRISS/ER (NCT06707441)
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- Al-Nahrain University
Kidney Function Issue, Acute Kidney Injury
N-Acetylcysteine Roles in Preserving Renal Function Measured by Urinary KIM-1 (Kidney Injury Molecule-1) and Serum Creatinine on Cancer Patients With Cisplatin Based Chemotherapy: A Randomized Placebo-Controlled Trial
The goal of this clinical trial is to learn if N-Acetylcysteine drug works to protect kidney function in adults patient with cancer.
- Conditions
- Kidney Function Issue, Acute Kidney Injury, Cancer (Solid Tumors), Kidney Function Tests
- Trial name
- NCT07156786
- Testing
- N-acetylcysteine (NAC)
- Volunteers
- 72 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Trauma Injury, Trauma
OCT in Open Fracture and Infected Fracture
This is a pilot prospective, observational study of patients with open or infected fracture evaluating the feasibility and acceptability of OCT, a light-based imaging modality that requires no drug or contrast agent.
- Conditions
- Trauma Injury, Trauma, Open Fracture, Fracture Infection
- Trial name
- NCT05785182
- Testing
- Open Fracture, Infected Fracture
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Depression, Anxiety, Trauma
Psychoeducation, Relaxation, PrOblem Solving, Activation, Cognitive Coping Therapy for Adolescents and Youth in HIV Care
The proposed PROACT study will test the effectiveness of a mental health intervention (psychotherapy) for multiple common mental health conditions (depressive, anxiety and trauma symptoms) among adolescents and youth with HIV in…
- Conditions
- Depression, Anxiety, Trauma, HIV-1-infection
- Trial name
- PROACT (NCT06247527)
- Testing
- Psychoeducation, Relaxation, PrOblem solving, Activation, Cognitive coping Therapy, Standard of care
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- University of Nairobi