Clinical trials: Trauma
PTSD, Alcohol Use Disorder
Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems
The investigators propose to conduct a clinical trial to evaluate sertraline treatment efficacy in a large sample of military veterans with a dual diagnosis of PTSD and Alcohol Use Disorder who are receiving Cognitive and…
- Trial name
- DDx (NCT02504931)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Trauma Injury, Bone Infection
ICG 24h Prior to Operative Treatment of Orthopaedic Infection
The focus of this study is to (1) Explore variability in distribution of 24h ICG in bone and soft tissue infection (2) Evaluate the change in 24h ICG distribution from pre to post debridement (3) Preliminarily determine whether…
- Trial name
- NCT04927637
- Testing
- imaging 24 hours following intravenous administration of ICG
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Trauma, Opioid Use
Relieving Acute Pain (RAP) Study: A Pilot Study
The United States (US) faces a crisis of pain management. According to the 2012 National Health Interview Survey, almost 50 million adults in the US reported having significant chronic or severe pain (Nahin 2015).
- Conditions
- Trauma, Opioid Use, Spine Fusion
- Trial name
- NCT03426137
- Testing
- Oxycodone, Ketorolac
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Maryland, Baltimore
Mechanical Ventilation, Single-lung Ventilation
Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time
The results of this study will help to define the capability and reliability of PulmoVista 500 to detect changes in both global and regional ventilation.
- Conditions
- Mechanical Ventilation, Single-lung Ventilation, ARDS, ALI - Acute Lung Injury
- Trial name
- NCT03076983
- Testing
- Lung Monitoring with EIT device (PulmoVista 500)
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Drägerwerk AG & Co. KGaA
Face-lift, Facial Rhytidectomy
Efficacy and Safety of FS VH S/D 4 S-apr for Flap Adherence in Rhytidectomy
The purpose of the study is to compare the safety and efficacy of FS VH S/D 4 s-apr versus standard of care in adhering tissue and improving wound healing in subjects undergoing facelift.
- Trial name
- NCT00999141
- Testing
- FS VH S/D 4 s-apr
- Where
- 6 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
ACL Tear
Effects of Blood Flow Restriction Rehabilitation After Anterior Cruciate Ligament Reconstruction
The study is a prospective randomized control trial consisting of subjects requiring ACL reconstruction with BTB autograft. Subjects were randomly divided into two groups following their inclusion in the study.
- Trial name
- NCT04484961
- Testing
- Blood flow restriction (BFR)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Neonatal Brachial Plexus Palsy
NMES Efficacy on Patients With NBPP
Neonatal Brachial Plexus Palsy (NBPP), characterized by weakness and sensory loss in the affected arm, results from damage in the prenatal period to the nerves extending from the spine to the arm.
- Trial name
- NCT01999465
- Testing
- Standard NMES device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Hip Dysplasia, Femoroacetabular Impingement
Hip Scope Fascia-iliaca (FI) Block Study
Patients undergoing a hip scope procedure will be recruited for this study. They will be randomized to either receive a nerve block or no nerve block (pain medicine only).
- Conditions
- Hip Dysplasia, Femoroacetabular Impingement, Acetabular Labrum Tear
- Trial name
- NCT02365961
- Testing
- ropivicaine, clonidine, Epinephrine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- The Hawkins Foundation
Subacromial Impingement, Subacromial Impingement Syndrome
Subacromial Methylprednisolone Versus Ketorolac for Shoulder Impingement
The investigators aim to compare subacromial ketorolac (non-steroidal anti-inflammatory drug) versus methylprednisolone (steroid) for the treatment of shoulder impingement syndrome.
- Trial name
- NCT03913702
- Testing
- Ketorolac Tromethamine, Methylprednisolone Acetate
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Ankle (Ligaments); Instability (Old Injury)
Balance Training vs. Balance Training w/ STARS
Chronic Ankle Instability (CAI) is a health condition that results in repeated ankle sprains and other residual impairments. CAI has been linked to many different causative factors including sensory and motor deficits that affect…
- Trial name
- NCT01790581
- Testing
- Balance Training, STARS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Charlotte
Wound Heal
Utility of Restrata With Split Thickness Skin Graft to Reconstruct the Forearm Donor Site
Understand association between use of Restrata (Acera Surgical Inc., St. Louis, MO) in forearm flap reconstruction with donor site healing and function
- Trial name
- NCT04829331
- Testing
- Restrata
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Acera Surgical, Inc.
Prematurity, Bronchopulmonary Dysplasia
Inhaled Nitric Oxide and Neuroprotection in Premature Infants
The purpose of this study is to determine whether inhaled nitric oxide improves the neurological outcome for premature infants.
- Conditions
- Prematurity, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Periventricular Leukomalacia
- Trial name
- NOVA2 (NCT00515281)
- Testing
- inhaled nitric oxide, oxygen
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- University of Chicago
Cognitive Disorders, Delirium
The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction
Ketamine is a commonly used anesthetic medication which is used for induction of anesthesia as well as as an analgesic. It has been shown to have anti-inflammatory properties which may decrease post-operative complications…
- Conditions
- Cognitive Disorders, Delirium, Acute Kidney Injury
- Trial name
- NCT02554253
- Testing
- Ketamine, Propofol
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Mayo Clinic
Arthroplasty, Knee Replacement, Wound Healing
Zip® Surgical Skin Closure Device vs. Staples for Skin Closure in Subjects Having Undergone Bilateral Knee Arthroplasty
Study designed to compare the Zip Surgical Skin Closure device vs. conventional staples for wound closure following bi lateral knee replacement surgery.
- Trial name
- NCT02460172
- Testing
- Zip Surgical Skin Closure, Steel Staples
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- ZipLine Medical Inc.
Delirium
Use of Transdermal Clonidine in Trauma Patients
This study will attempt to learn how to better treat trauma patients with delirium who are on a breathing machine. Delirium, also known as acute, temporary brain dysfunction, is a common reason why ventilated patients can not be…
- Trial name
- NCT01139996
- Testing
- Clonidine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Memorial Health University Medical Center
Substance Use Disorder, Post-traumatic Stress Disorder
Mindful Self Compassion for Combat Deployed Veterans With Moral Injury and Co-occurring PTSD-SUD
Veterans with co-occurring Posttraumatic Stress Disorder and Substance Use Disorder (PTSD-SUD) experience more severe symptomatology and poorer response to existing treatments than Veterans with either disorder alone.
- Conditions
- Substance Use Disorder, Post-traumatic Stress Disorder, Moral Injury
- Trial name
- NCT03681288
- Testing
- Mindful Self-Compassion
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- VA Office of Research and Development
Seroma, Wound Dehiscence
Prevention of Seroma Formation and Wound Complications Using NPWT Devices
The specific aim of this study is to improve post-operative wound care in the morbidly-obese body-contouring patient population following massive weight loss undergoing either panniculectomy or formal abdominoplasty, those…
- Conditions
- Seroma, Wound Dehiscence, Wound Infection
- Trial name
- NCT02147288
- Testing
- Renasys*GO Negative Pressure Wound Therapy System
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Yale University
Respiratory Syncytial Virus (RSV)
A Study to Assess the Safety and Effectiveness of Palivizumab Administered to Children at High Risk of Severe Respiratory Syncytial Virus (RSV) Infection in the Russian Federation and the Republic of Belarus
This is a Phase 3b, prospective, multicenter, open-label, non-controlled study to assess the safety and effectiveness of immunoprophylaxis with the intramuscular (IM) administration of the liquid formulation of palivizumab for…
- Trial name
- Synagis Russia (NCT02968173)
- Testing
- Palivizumab
- Volunteers
- 50 people
- Sponsor
- AbbVie
Acute Kidney Injury, Cardiac Disease
The Prevention of Erythropoietin on Cardiac Surgery-associated Acute Kidney Injury
To testify the prevention of Erythropoietin on cardiac surgery associated-acute kidney injury, and trying to provide evidence for protecting the renal function and improving the prognosis for patients after cardiac surgery.
- Conditions
- Acute Kidney Injury, Cardiac Disease, Surgery
- Trial name
- NCT03007537
- Testing
- Erythropoietin, 0.9% sodium chloride, cardiac surgery
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
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