Clinical trials: Trauma
Anterior Cruciate Ligament Tear
Moderated Blood Flow Restriction After Anterior Cruciate Ligament Reconstruction
The aim of this study is to determine if there is a difference in post operative rehabilitation after anterior cruciate ligament (ACL) reconstruction surgery while using moderated blood flow therapy vs. standard physical therapy.
- Trial name
- Delfi (NCT02911909)
- Testing
- Delfi, Standard rehabilitation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Missouri-Columbia
Spinal Cord Injuries, Cardiometabolic Diseases
High Intensity Interval Exercise SCI
This study will determine if the implementation of a home-based telehealth high intensity interval exercise-training (HIIT)program can significantly improve cardiometabolic health and physical function in a cohort of individuals…
- Trial name
- NCT04940598
- Testing
- high intensity interval exercise, No-exercise control group
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Alabama at Birmingham
Hypoxic-Ischemic Encephalopathy, Brain Injury
Prospective Research in Infants With Mild Encephalopathy
A multicenter observational pilot study will be conducted to determine the natural history of infants with early diagnosis (≤ 6 hrs of age) of mild neonatal encephalopathy (NE) who are not qualified for therapeutic hypothermia.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Brain Injury, Neonatal Seizure
- Trial name
- PRIME (NCT01747863)
- Testing
- Neurologic examination
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 63 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Post-Traumatic Stress Disorders, Opiate Use Disorder
Optimal Treatment of Veterans With PTSD and Comorbid OUD
The objective of this study is to test a standard psychotherapy for PTSD in Veterans who also suffer from Opiate Use Disorder (OUD).
- Trial name
- NCT03605342
- Testing
- Buprenorphine, Cognitive Processing Therapy (CPT), Individual Drug Counseling (IDC)
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Acute Lung Injury (ALI) Associated With COVID-19, Lung Inflammation Associated With COVID-19
TD-0903 for ALI Associated With COVID-19
This Phase 2 study will evaluate the efficacy, safety, pharmacodynamics and pharmacokinetics of inhaled TD-0903 compared with a matching placebo in combination with standard of care (SOC) in hospitalized patients with confirmed…
- Trial name
- NCT04402866
- Testing
- TD-0903
- Where
- 24 sites in United States, Brazil and 5 more
- Volunteers
- 235 people
- Sponsor
- Theravance Biopharma
Trauma, Hiv
Developing a Trauma-focused Intervention for Older Adults Living With HIV
Investigators are adapting the LIFT and REFLECT interventions for older adults living with HIV who have been exposed to childhood sexual abuse.
- Conditions
- Trauma, Hiv, Aging
- Trial name
- NCT05287230
- Testing
- CoSHA (Coping with childhood Sexual Abuse, HIV, and Aging), Control
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of South Carolina
Spinal Cord Injury Cervical, Upper Extremity Dysfunction
Transcutaneous Electrical Spinal Stimulation to Restore Upper Extremity Functions in Spinal Cord Injury
Stimulation of the spinal cord may induce the growth and reorganization of neural pathways leading to the re-animation of paralyzed limbs.
- Trial name
- ADDRESS (NCT03184792)
- Testing
- Transcutaneous spinal stimulation, Physical therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Washington
Surgical Procedure, Unspecified
A Trial to Evaluate Negative Pressure Incision Management System for Groin Wounds in Vascular Surgery Patients
The purpose of this research study is to investigate if a new negative pressure incision (surgical cut) management system, could reduce the occurrence of groin wound infections after vascular surgery.
- Trial name
- NCT02399111
- Testing
- Prevena Incision Management System
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Northwell Health
Traumatic Brain Injury
CENTER-TBI: Collaborative European NeuroTrauma Effectiveness Research in TBI
The research aims of the CENTER-TBI study are to: 1. better characterize Traumatic Brain Injury (TBI) as a disease and describe it in a European context, and 2. identify the most effective clinical interventions for managing TBI.
- Trial name
- CENTER-TBI (NCT02210221)
- Where
- 65 sites in Austria, Belgium and 17 more
- Volunteers
- 4,559 people
- Sponsor
- University Hospital, Antwerp
ISCHEMIC CARDIOMYOPATHY
Clinical Trial of Manganese-Enhanced MRI (MEMRI) to Assess Peri-Infarct Injury
The purpose of this study is to evaluate the safety and tolerance of a new intravenous diagnostic agent, SeeMore or EVP 1001-1, in patients with Cardiovascular Disease (MEMRI scan).
- Trial name
- NCT02933034
- Testing
- Manganese-enhanced MRI contrast reagent, Gadolinium-enhanced MRI contrast reagent
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Stanford University
Diabetic Foot Ulcers, Diabetic Foot Wounds
Wound Edge Changes Following Treatment With Santyl
The goal of this study is to evaluate changes in the healing tissue of diabetic foot wounds following 14 days of treatment with Santyl or its vehicle base.
- Trial name
- NCT01197898
- Testing
- Collagenase Santyl Ointment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Healthpoint
Diabetes Mellitus, Type 2
Post-authorisation Safety Study in Patients With Type 2 Diabetes to Assess the Risk of Liver Injury, Kidney Injury, Urinary Tract and Genital Infections, and Diabetic Ketoacidosis in Patients Treated With Empagliflozin, Compared to DPP-4 Inhibitors
Empagliflozin (Jardiance), a highly potent and selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), was approved in Europe in May 2014 for the treatment of type 2 diabetes mellitus (T2DM) to improve glycaemic…
- Trial name
- NCT02864914
- Testing
- Empagliflozin, DPP-4 inhibitors
- Where
- United Kingdom
- Volunteers
- 333,580 people
- Sponsor
- Boehringer Ingelheim
Hematoma, Subdural, Chronic
Role of Dexamethasone in the Conservative Treatment of Chronic Subdural Hematoma
Current opinion regarding the use of steroids in the treatment of chronic subdural hematomas are mostly based on observational studies.
- Trial name
- NCT02362321
- Testing
- Dexamethasone
- Volunteers
- 20 people
- Sponsor
- CHU de Quebec-Universite Laval
Carpal Tunnel Syndrome
Comparison of Two Techniques for the Treatment of Carpal Tunnel Syndrome
The main objective of this study is to compare the complete section of the transverse carpal ligament with another median nerve release technique and to determine if the incidence of post-surgical pillar pain is lower for either…
- Trial name
- STCCOT (NCT05468814)
- Testing
- Z-plasty, Conventional
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Edema Arm, Fracture; Wrist
Taping to Control Edema in Patients With Forearm Plaster for Wrist Fracture.
Wrist fractures are a very common event affecting patients of all ages and are estimated to account for approximately 10% -25% of all fractures. 70-90% of fractures are treated with closed reduction and forearm cast.
- Trial name
- NCT04683887
- Testing
- Tape application
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Azienda Unita Sanitaria Locale di Piacenza
Post-traumatic Stress Disorder
Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance
The purpose of this study is to compare the effectiveness of two cognitive behavioral group psychotherapy interventions in controlling the subjective sleep disturbance in veterans with Post-traumatic Stress Disorder.
- Trial name
- NCT00108628
- Testing
- Imagery Rehearsal, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome
mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms
Purpose of this study is to investigate the mechanisms of action of hyperbaric oxygen therapy for persistent post-concussive symptoms after mild tramatic brain injury
- Trial name
- BIMA (NCT01611194)
- Testing
- Hyperbaric oxygen (HBO2) at 1.5 atms
- Where
- 5 sites in United States
- Volunteers
- 71 people
- Sponsor
- U.S. Army Medical Research and Development Command
Seroma
Fibrin Glue in Inguinal Lymphadenectomy
Seroma is one of the most common encountered morbidities after inguinal lymph node dissection (ILND). It can cause not only much nuisance to both patients and doctors but also its presence can lead to many complications.
- Trial name
- NCT04666051
- Testing
- Application of fibrin glue sealant
- Volunteers
- 32 people
- Sponsor
- Menoufia University
Non Small Cell Lung Cancer
Feasibility Study of Enhanced MRI for Early Stage Non Small Cell Lung Cancer (NSCLC)
This is a pilot study. A pilot study is done with a small number of participants to see if a technique works before using it in a larger research study.
- Trial name
- NCT01799135
- Testing
- DCE-MRI scan, Stereotactic Body Radiation Therapy, 4D-CT scan
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Dana-Farber Cancer Institute
Obstructive Sleep Apnea (OSA), Post-Traumatic Stress Disorder (PTSD)
Comparison Study Using APAP With and Without SensAwake in Patients With OSA and PTSD
The purpose of this research is to examine the application of AutoCPAP with and without SensAwake in subjects with OSA and Post-Traumatic Stress Disorder (PTSD), and evaluate whether patients achieve better sleep quality and…
- Trial name
- NCT02549508
- Testing
- AutoCPAP with SensAwake On, AutoCPAP with SensAwake Off
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Fisher and Paykel Healthcare
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