Clinical trials: Trauma Exposure
Post Traumatic Stress Disorder, Problem Drinking
Tools for Health and Resilience Implemented After Violence Exposure (Project THRIVE)
Sexual assault victimization is a common and particularly harmful form of trauma that is associated with increased risk for high-risk drinking and other conditions of public health concern, such as PTSD.
- Trial name
- NCT03703258
- Testing
- App-based intervention
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Washington
PTSD
Ketamine-enhanced Prolonged Exposure Therapy in PTSD
The purpose of this study is to test the safety and efficacy of repeated doses of ketamine as compared to placebo to reduce symptoms of Posttraumatic Stress Disorder (PTSD) among Veteran receiving Prolonged Exposure Therapy.
- Trial name
- NCT04560660
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder
Ketamine and Prolonged Exposure in PTSD
This study aims at investigating the effectiveness of the drug, Ketamine, in combination with Prolonged Exposure (PE) therapy for people suffering from PTSD.
- Trial name
- NCT03960658
- Testing
- ketamine-enhanced prolonged exposure
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Osteoradionecrosis
Management of Mandibular ORN: PENTO as Medical Treatment
Mandibular osteoradionecrosis, despite its low incidence, remains being the most problematic and irreversible complication after head and neck radiotherapy with no medical treatment to limit or reduce symptoms.
- Trial name
- PENTO (NCT02368457)
- Testing
- Pentoxifylline and Tocopherol
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Hospital Vall d'Hebron
PTSD, Cardiac Arrest
Acceptance and Mindfulness Based Exposure Therapy for Survivors of Cardiac Arrest
The primary goal of this uncontrolled pilot trial is to examine feasibility, acceptability, safety, and preliminary efficacy of a new behavioral treatment for survivors of sudden cardiac arrest with clinically elevated symptoms…
- Trial name
- AMBET (NCT04596891)
- Testing
- Psychotherapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Post Traumatic Stress Disorder
Transcranial Direct Current Stimulation (tDCS) in Human Subjects With PTSD Receiving an Exposure-based, Behavioral Therapy
The primary objective of this study is to evaluate the safety, feasibility, and psychological and physiological treatment benefits of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, when…
- Trial name
- NCT05419999
- Testing
- Soterix 1x1 tDCS mini CT, Written Exposure Therapy (WET)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder
PROlonGed ExpoSure Sertraline
The current research study aims to compare the effectiveness of two proven treatments for posttraumatic stress disorder (PTSD): Prolonged Exposure (PE), sertraline, and their combination.
- Trial name
- PROGrESS (NCT01524133)
- Testing
- Sertraline, Prolonged Exposure Therapy
- Where
- 4 sites in United States
- Volunteers
- 223 people
- Sponsor
- VA Ann Arbor Healthcare System
Post-Traumatic Stress Disorder
Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) With/Without Yohimbine
The proposed study has three distinct but related research objectives. The first goal is to measure physiological correlates of successful treatment with Prolonged Exposure (PE) therapy for posttraumatic stress disorder (PTSD) in…
- Trial name
- NCT01031979
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- VA Office of Research and Development
PTSD and Alcohol Use Disorder
Topiramate and Prolonged Exposure
Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) frequently co-occur, and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Trial name
- TOP (NCT03176953)
- Testing
- topiramate, prolonged exposure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-traumatic
Analyzing Female Trauma Exposed Responses to a Medication
This purpose of this study is to look at the safety of the experimental drug GSK561679 as well as its effects on PTSD symptoms, thinking and memory, startle reaction, stress hormones, and mental health symptoms in comparison to…
- Trial name
- AFTER (NCT01814332)
- Testing
- GSK561679
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- VA Office of Research and Development
Other Specified Personal Exposures and History Presenting Hazards to Health, Knowledge, Attitudes, Practice
Safe Play Areas for Ross County Kids Project
Specific Aim 1 - In collaboration with partners in Ross County, renovate and develop playgrounds in Chillicothe. Specific Aim 2 - In collaboration with partners in Ross County, promote safe play and play areas for children on…
- Conditions
- Other Specified Personal Exposures and History Presenting Hazards to Health, Knowledge, Attitudes, Practice, Fall Involving Playground Equipment, Occurrence on Farm
- Trial name
- SPARK (NCT01291225)
- Testing
- Playground renovation and development, Educational campaign
- Where
- United States
- Volunteers
- 311 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Allergic Conjunctivitis
Safety and Efficacy Study of AL-53817 and AL-78843 Ophthalmic Solutions for Allergic Conjunctivitis
The purpose of this study is to evaluate two investigational ophthalmic solutions for reduction in ocular redness in subjects with allergic conjunctivitis.
- Trial name
- NCT02079649
- Testing
- AL-53817 Ophthalmic Solution, 0.1%, AL-78843 Ophthalmic Solution, 0.03%, Dexamethasone Ophthalmic Suspension, 0.1%
- Volunteers
- 224 people
- Sponsor
- Alcon Research
HIV, Trauma Exposure
Improving the Health of South African Women With Traumatic Stress in HIV Care (C0147)
In this study, the investigators propose to develop Improving AIDS Care after Trauma (ImpACT), an intervention based on theories of stress and coping and evidence-based treatment for traumatic stress.
- Trial name
- ImpACT (NCT02223390)
- Testing
- Improving AIDS Care after Trauma (ImpACT)
- Where
- South Africa
- Volunteers
- 64 people
- Sponsor
- Duke University
Tetraplegia, Hypothermia
Effect of Heat Exposure on Cognition in Persons With Tetraplegia
The ability to maintain normal body temperature (Tcore) is impaired in persons with tetraplegia: subnormal Tcore and vulnerability to hypothermia (<95 F) have been documented in this population after exposure to even mild…
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT02488824
- Testing
- Warm Temperature
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD
Dexamethasone Plus Virtual Reality Exposure Therapy for PTSD
Evidence from preliminary studies suggests that people with PTSD have heightened fear responses and that cortisol suppression reduces this heightened fear.
- Trial name
- Dex (NCT01965366)
- Testing
- Virtual reality exposure therapy, 0.5 mg DEX
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Emory University
Stress Disorders, Post-Traumatic Stress Disorder
Comparing Virtual Reality Exposure Therapy to Prolonged Exposure
This study is evaluating the efficacy of virtual reality exposure therapy (VRET) by comparing it to prolonged exposure therapy (PE) and a waitlist(WL) group for the treatment of post traumatic stress disorder (PTSD) in active…
- Trial name
- VRPE Extension (NCT01459705)
- Testing
- Prolonged Exposure Therapy (PE), Virtual Reality Exposure Therapy (VRET), Waitlist
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- National Center for Telehealth and Technology
Inflammation, Sleep Deprivation
Circadian Rhythm Disruption Effects on Smoke Inhalation
Particulate matter exposure during smoke inhalation provokes inflammatory immune responses in people exposed to burning biomass including fire fighters and civilians.
- Conditions
- Inflammation, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Shift Work Type, Smoke Inhalation
- Trial name
- NCT04955431
- Testing
- Sleep Restriction, Normal Sleep
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Montana
Posttraumatic Stress Disorder
Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure Therapy
The purpose of this study is to combine a single infusion of Ketamine with 7-days of trauma focus psychotherapy to relieve post traumatic stress disorder (PTSD) symptoms more effectively.
- Trial name
- PTSD (NCT02727998)
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Sunburn, Erythema, Sun Protection
UV Exposure Assessed With Wearable Sensor and Sun Protection
The goal is to prevent ultraviolet light (UV) overexposure by providing consumers with relevant, easy-to-access, specifically actionable information.
- Trial name
- NCT03344796
- Testing
- Goal attainment
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Posttraumatic Stress Disorders, Chronic Insomnia
Integrated CBT-I and PE on Sleep and PTSD Outcomes (Impact Study)
This study aims to examine whether integrating insomnia and PTSD treatment will enhance sleep, PTSD, and quality of life outcomes.
- Trial name
- NCT02774642
- Testing
- CBTI-PE, Hygiene-PE
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- VA Office of Research and Development