Clinical trials: Trauma Nervous System
Post Concussion Syndrome, Head Injury
Evaluation of Two Treatments for Chronic Post Concussion Syndrome
This study is designed to investigate factors that are associated with prolonged recovery from mild head injury. The investigators are particularly interested in defining the impact of anxiety related variables, such as health…
- Trial name
- NCT00871884
- Testing
- Psychoeducation, Relaxation Training, Interoceptive Exposure
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Shoulder Pain, Shoulder Injuries
Finnish Imaging of Shoulder Trauma
The FIMAGE-Trauma study is an extension of the FIMAGE study and aims to answer the question if rotator cuff tears found on shoulder imaging after a shoulder injury are caused by the index trauma or are rather incidental findings.
- Conditions
- Shoulder Pain, Shoulder Injuries, Rotator Cuff Tears, Glenoid Labrum Tear
- Trial name
- FIMAGE-T (NCT05800184)
- Where
- 4 sites in Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Chronic Tendinopathy
Percutaneous Needle Tenotomy (PNT) Versus Platelet Rich Plasma (PRP) With PNT in the Treatment of Chronic Tendinosis
Tendinopathy is a clinical syndrome of chronic pain and tendon degeneration that impairs a person's ability to perform daily activities and recreation.
- Trial name
- NCT01833598
- Testing
- PNT + PRP, PNT alone
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Traumatic Brain Injury, Multiple Sclerosis
Measuring Cerebral Blood Flow Using Pseudo-continuous Arterial Spin Labeling Perfusion Magnetic Resonance Imaging
This study will test a new MRI sequence that measures cerebral blood flow (CBF). Because this technique for measuring CBF is new, there is little information on what the normal values for different regions of the brain should be.
- Conditions
- Traumatic Brain Injury, Multiple Sclerosis, Alzheimer's Disease, Tumor
- Trial name
- NCT02767609
- Testing
- Magnetic Resonance Imaging
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Traumatic Brain Injury
Integrated Eye Tracking and Neural Monitoring for TBI: Optimization
Traumatic brain injury (TBI) is one of the most frequent injuries affecting service members. Unfortunately, current neurocognitive assessment tools are unable to reliably detect mild TBI more than a few days post- injury.
- Trial name
- NCT03451058
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Back Pain, Occupational Diseases
Redesigning Patient Handling Tasks to Prevent Nursing Back Injuries
This study is one of several initiated by the investigators to reduce musculoskeletal injuries in patient care providers. Nurses have one of the highest incidences of work related back injuries of any profession.
- Trial name
- NCT00012844
- Testing
- Redesigning patient handling tasks using equip: Arjo Bianca Overhead Lift, Hill-Rom Resident Transfer Device, TranSit Chair, Total Care Bed, Redesigned patient handling tasks using work practice controls: setting bed height at correct level; applying anti-embolism stockings from foot of bed
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Wheelchair Users
Impact of Pushrim Activated Power Assist Wheelchairs on Mobility Among People With Tetraplegia
The purpose of this three phase study is to evaluate a Pushrim Activated Power Assist Wheelchair (PAPAW). Phase I will examine whether the steady-state, metabolic energy efficiency for propelling a manual wheelchair with and…
- Trial name
- NCT00281463
- Testing
- Pushrim Activated Power Assist
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- VA Pittsburgh Healthcare System
Traumatic Brain Injury
Imaging of Traumatic Brain Injury
This project aims to study the prognostic ability of various MRI imaging markers in the evaluation of TBI patients. Cognitive, social, and occupational recovery will be measured at each time point, and compared to MRI findings.
- Trial name
- Imaging of TBI (NCT01196299)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Traumatic Brain Injury, Suicidality
Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
Those with traumatic brain injury (TBI) are at increased risk for suicidal behavior, and suicidality is associated with executive dysfunction.
- Trial name
- NCT01043432
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury
Developing Process-Specific Verbal Memory Interventions for Veterans With Tramatic Brain Injury (TBI)
Blast-related and blunt traumatic brain injury is a key priority area of Rehabilitation Research \& Development (RR\&D) and represents a critically important public health problem facing the Veteran population.
- Trial name
- DPSVM (NCT02310633)
- Testing
- Memory Strategy Training, Errorless Learning, Retrieval Practice
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Shoulder Pain, Rotator Cuff Tear
Efficacy of Interscalene Brachial Plexus Block With Liposomal Bupivacaine for Arthroscopic Shoulder Surgery
The purpose of this study is to compare the quality and duration of pain relief after shoulder surgery provided by a single injection of liposomal bupivacaine versus standard bupivacaine when administered as an interscalene…
- Trial name
- NCT01977352
- Testing
- Liposomal bupivacaine, Bupivacaine 0.25%
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Severe Traumatic Brain Injury
The Systemic Nature of Severe Traumatic Brain Injury
Severe traumatic brain injury (sTBI) is a devastating condition with no targeted therapies available to prevent secondary injury.
- Trial name
- MANTRA (NCT07679126)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Corewell Health West
Job Stress, Workplace Stress
Breath Regulation and Yogic Exercise An Online Therapy for Calm and Happiness During the COVID-19 Pandemic
This study will examine the feasibility of conducting an online Randomized Controlled Trial (RCT) in frontline hospital and long term care healthcare staff in managing COVID-19 patients in London, ON.
- Conditions
- Job Stress, Workplace Stress, Compassion Fatigue, Psychological Trauma
- Trial name
- BREATH (NCT04368676)
- Testing
- Sudarshan Kriya Yoga (SKY), Health Enhancement Program
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mild Traumatic Brain Injury
Functional MRI Study of Attention in Normal Controls and Traumatic Brain Injured Patients
The purpose of this study will be to assess the attentional ability of patients with mild to moderate traumatic brain injury (TBI) using the functional Magnetic Resonance Imaging (fMRI) technique.
- Trial name
- NCT00580918
- Testing
- functional magnetic resonance imaging fMRI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Post Traumatic Stress Disorder, Insomnia Disorder
RESILIENT : A Self-Managed Online Platform for Victims of Sexual Assault
There are 636,000 self-reported cases of sexual assault annually in Canada, and nine out of ten persons who have experienced sexual assault are women.
- Conditions
- Post Traumatic Stress Disorder, Insomnia Disorder, Major Depressive Disorder
- Trial name
- NCT05811897
- Testing
- Self-Managed Online Treatment, Therapist-Assisted Online Treatment
- Where
- Canada
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Laval University
Traumatic Brain Injury
Translational Research Examining Acupuncture Treatment in Traumatic Brain Injury
The purpose of this study is to examine the effects of acupuncture on cerebral blood flow (CBF) and blood biomarkers during the acute 10-day window following traumatic brain injury, to determine if those changes correlate with…
- Trial name
- TREAT-TBI (NCT02623218)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- AOMA Graduate School of Integrative Medicine
All Cause Mortality, Cardiovascular Diseases
Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality
The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years).
- Conditions
- All Cause Mortality, Cardiovascular Diseases, Invasive Cancer, Liver Cirrhosis
- Trial name
- UNATI (NCT06338215)
- Testing
- Moderate Alcohol Drinking Pattern, Abstention
- Where
- Spain
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Subacromial Impingement Syndrome, Central Nervous System Sensitization
Muscle Function, Central Nervous System Sensitization, and Pain Profiling in Patients With Subacromial Pain (SAP-CNSS).
In this case-control study, the investigators compare shoulder muscle function, pain, and central nervous system sensitization in patients with Subacromial Pain (SAP) to that in healthy controls.
- Trial name
- NCT03326466
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital