Clinical trials: Trauma Nervous System
PTSD, Alzheimer Disease
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)
The goal of this First-In-Human (FIH) trial is to learn about safety and PharmacoKinetics (PK) in healthy adult volunteers. The main questions it aims to answer are: What is the safety of single ascending doses of the…
- Conditions
- PTSD, Alzheimer Disease, Brain Diseases, Neuro-Degenerative Disease
- Trial name
- NCT05921929
- Testing
- Fluoroethylnormemantine (FENM)
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- ReST Therapeutics
Sun Protection, Skin Burn
Pediatricians and Family Physicians Knowledge and Awareness on Sun Protection
Sunlight has very important effects on the body. In addition to its positive effects such as regulation of circadian rhythm, synthesis of vitamin D and regulation of mood, it also has negative effects on the skin such as sunburn…
- Conditions
- Sun Protection, Skin Burn, Sunburn
- Trial name
- NCT06720402
- Testing
- Sun protection knowledge
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Marmara University
TBI (Traumatic Brain Injury)
Stimulating After Recovery From Traumatic Brain Injury
This is a preliminary, prospective interventional study to investigate the feasibility of using transcutaneous alternating current stimulation (TACS) after a traumatic brain injury (TBI) to improve cognitive function and…
- Trial name
- SMART (NCT05327829)
- Testing
- External non-invasive stimulation, COGED
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hyperthermia, Chronic Primary Pain
Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain
This study, in a quasi-experimental matched two-group pre-post design, investigates the effect of serial water-filtered whole-body hyperthermia on circadian core body temperature, the somatosensory system (nociception) and the…
- Conditions
- Hyperthermia, Chronic Primary Pain, Widespread Pain, Muscular Disease
- Trial name
- HYPPRI-1 (NCT07101978)
- Testing
- serial whole body hyperthermia
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
Shoulder Pain, Shoulder Injuries
SPR PNS for Chronic Shoulder Pain
The purpose of this research is to gather post-market data regarding the effectiveness of the SPRINT Peripheral Nerve Stimulation (PNS) System for the treatment of chronic shoulder pain due to chronic degenerative changes of your…
- Conditions
- Shoulder Pain, Shoulder Injuries, Shoulder Arthritis
- Trial name
- NCT05649917
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- International Spine, Pain and Performance Center
Lingual Nerve Injuries
Removal of Impacted Molars With Lingual Split Technique
This research assesses removal of mandibular third molars by the lingual split technique with using Walter's lingual retractor for retracting lingual flap, and evaluates the lingual nerve injury that may result after applying…
- Trial name
- NCT05946317
- Testing
- Lingual nerve function assessed after removal of mandibular third molar with lingual split technique
- Where
- Syria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Latakia University
Head Injuries With Non Missile Penetrating Objjects
Non-missile Penetrating Head Trauma,Cases Registry in Sohag University Hospital
A retrospective study was done in Neurosurgery trauma unit, Sohag University. Eighteen patients reported with different mechanisms of trauma. All patients clinically tested involving neurological evaluation.
- Trial name
- trauma (NCT03768778)
- Testing
- Debridement and dural repair
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sohag University
Carpal Tunnel Syndrome, Diabetic Neuropathies
Neuromuscular Ultrasound in Correlation to Neurophysiological Findings
1. Study the neuromuscular ultrasound findings in different types of neuropathies 2. correlation between ultrasound and neurophysiological findings in peripheral nerve diseases 3.
- Conditions
- Carpal Tunnel Syndrome, Diabetic Neuropathies, Guillain-Barre Syndrome
- Trial name
- NCT04092140
- Testing
- ultrasound
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Spinal Cord Injury
Test of Discomfort and Malaise of Two Different Urine Catheters in Healthy Volunteers
The purpose of this study is to evaluate the safety of a new developed catheter in comparison with an catheter on the market. The study is randomised.
- Trial name
- NCT01142115
- Testing
- Intermittent catheter CP063CC, SpeediCath
- Where
- Denmark
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Coloplast A/S
Brain Injuries
Does Cognitive Rehabilitation Demonstrate Benefits in the Group Setting With People Whom Have Experienced Brain Injury?
The purpose of this study is to determine whether there is benefit from providing cognitive rehabilitation in the group setting.
- Trial name
- NCT00166348
- Testing
- Cognitive Group Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Traumatic Brain Injury (TBI) Patients
Chromatic Multifocal Pupillometer for Detection and Follow-up of Acute Head Injury
Traumatic Brain Injury (TBI) is a common injury in combat, terrorist attacks and sports such as football and hockey. Unnecessary delays in the diagnosis and treatment of brain damage in patients who can benefit from evacuation…
- Trial name
- NCT02030366
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Ocular Injury
An Observational, Qualitative Study Assessing Eye Drop Administration
This is a prospective, observational, consecutive, qualitative, multicenter study. Based on the available published evidence that supports patient challenges with eyedrop administration, the purpose of this video-capture study is…
- Trial name
- NCT05307081
- Testing
- Artificial Tears
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ocular Therapeutix, Inc.
Brain Concussion
Mild Traumatic Brain Injury Discrimination
Evaluation of the utility of a multi-modal assessment tool in distinguishing between individuals with and without a history of mild traumatic brain injury.
- Trial name
- MTBID (NCT02453958)
- Testing
- Multi-modal assessment system
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Empirical Technologies Corporation
Asphyxia Neonatorum
Biomarkers And Neurological Outcome in Neonates (BANON)
Validation of biomarkers in a human population for their ability to diagnose the severity of neonatal asphyxia. These biomarkers linked to asphyxia have been identified in animal studies and a preliminary human study.
- Trial name
- NCT03357250
- Where
- 11 sites in Germany
- Volunteers
- 553 people, healthy volunteers welcome
- Sponsor
- Life Science Inkubator
Breast Cancer, Traumatic Brain Injury
Purpose in Life Survey
At present, there is no empirical data that specifies the likely prevalence of purpose in life disruption among various clinical populations.
- Trial name
- PIL (NCT05790278)
- Testing
- Survey
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mary Radomski
Severe Mobility Impairment, Spinal Cord Injuries (SCI)
Effects of Virtual Walking on Chronic Pain and Psychological Distress for Individuals With Severe Mobility Impairment
This randomized controlled trial aims to: (1) examine the effects of virtual walking intervention on chronic pain (primary outcome), and on depression, stress, anxiety, and quality of life (secondary outcomes) compared with the…
- Conditions
- Severe Mobility Impairment, Spinal Cord Injuries (SCI), Poliomyelitis
- Trial name
- NCT07820618
- Testing
- Virtaul walking, Passive observing video
- Where
- Hong Kong
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Osteoarthritis
Sustained Acoustic Medicine for Osteoarthritis Pain
The purpose of this study is to compare Sustained Acoustic Medicine treatment to topical pain relief gel for the symptomatic management of osteoarthritis.
- Trial name
- NCT05254574
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, 2.5% Diclofenac Patches
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Pain, Burns
The Effect of Therapeutic Story on Pain, Fear and Anxiety Levels
Aim: The aim of this study was to evaluate the effect of therapeutic story on pain, anxiety, fear and physiological parameters in children undergoing burn dressing.
- Conditions
- Pain, Burns, Fear, Anxiety
- Trial name
- NCT06583668
- Testing
- Therapeutic Story
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Okan University
Military Family, Brain Injuries, Traumatic
Effects of PSTon Mental Health Outcomes in Caregivers of Post-9/11 Combat Veterans With a Traumatic Brain Injury
The primary aim of this study is to assess the efficacy of PST for positively impacting distressed military family caregiver's depression and burden levels (secondary outcomes), ultimately enhancing their mental health quality of…
- Trial name
- NCT03211884
- Testing
- Problem-Solving Thearpy
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Central Sensitisation, Fibromyalgia
The Nociceptive Flexion Reflex as a Diagnostic Tool of Central Sensitization
This experimental study will investigate whether the decreased NFR threshold and increased NFR temporal summation, which are frequently observed in chronic pain patients, are only symptomatic manifestations that occur in the…
- Conditions
- Central Sensitisation, Fibromyalgia, Neck Pain, Low Back Pain
- Trial name
- NFR-CS (NCT05321550)
- Where
- Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Ghent
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