Clinical trials: Trauma Prevention
Risk Assessment, Parenting
Randomized Controlled Trial of a Risk Reframing Tool to Change Mothers' Parenting Associated With Children's Risky Play
Children's risky play is associated with a variety of positive developmental, physical and mental health outcomes, including greater physical activity, self-confidence and risk management skills.
- Trial name
- NCT03374683
- Testing
- RR Digital Tool, RR In-Person Workshop, Position Statement on Active Outdoor Play
- Where
- Canada
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
HER2-positive Breast Cancer, HER2+ Breast Cancer
HER2HEART-US: Prevention of Cardiotoxicity in Breast Cancer Patients Receiving HER2-directed Therapy
Ten to 15% of patients with breast cancer are HER2 positive, with treatment focused on targeting the HER2 receptor. Although these treatments are generally well tolerated, they are associated with an increased risk of…
- Trial name
- NCT06844669
- Testing
- Carvedilol, Empagliflozin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Washington University School of Medicine
Heat Illness, Quality of Life
Structural Heat Adaptation and Education in Rural Setting
This study aims to understand whether simple, low-cost interventions, such as improved home cooling, practical advice, and minor home modifications, can help protect people's health and quality of life during periods of extreme…
- Trial name
- SHAPES (NCT06983483)
- Testing
- Community education and awareness, Participatory local structural and environmental heat mitigation solutions
- Where
- Pakistan
- Volunteers
- 7,128 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Osteoporosis Fracture
Osteoporosis and Fall Prevention and Posture Correction Interventions in the Metropolitan Area
The investigators' previous studies in 2014 and 2015 have demonstrated that among community-dwelling older adults with high osteoporotic fracture risks.
- Trial name
- NCT02803190
- Testing
- ICG, MTG
- Where
- Taiwan
- Volunteers
- 108 people
- Sponsor
- National Taiwan University Hospital
Surgical Wound Infection, Postoperative Wound Infection
Study the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Infection in Colorectal Surgery
The main objective is to study the efficacy of topical antibiotic therapy with Amoxicillin / Clavulanic acid in the prevention of surgical wound infection in patients undergoing to colorectal surgery
- Conditions
- Surgical Wound Infection, Postoperative Wound Infection, Postoperative Wound Infection Superficial Incisional, Preventive Therapy
- Trial name
- PROTOP (NCT03574090)
- Testing
- Amoxicillin Clavulanate, Physiological Saline
- Where
- Spain
- Volunteers
- 268 people
- Sponsor
- Universitat Internacional de Catalunya
Post-Traumatic Headache, Mild Traumatic Brain Injury
Efficacy and Tolerability of Erenumab in the Prophylactic Treatment of Persistent Post-Traumatic Headache
An exploratory open-label study of PPTH patients to study the efficacy and tolerability of erenumab in the prophylactic treatment of persistent headache attributed to mild traumatic injury to the head.
- Conditions
- Post-Traumatic Headache, Mild Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- NCT03974360
- Testing
- AMG 334
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Headache Center
Injury;Sports, Biomechanical Lesions
Effectiveness of Basketball Pre-injury Attack Program to Reduce the Susceptibility of Injury in Youth Basketball Players
Basketball is an impact, coordination-opposition sport with continuous contact among players and it is considered a sport of medium-high injury incidence.
- Conditions
- Injury;Sports, Biomechanical Lesions, Musculoskeletal Injury, Sports Physical Therapy
- Trial name
- DPL2 (NCT05256186)
- Testing
- Basketball Pre-injury Attack program
- Where
- Spain
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Infection, Surgical Site Infection
Efficacy and Safety of Ertapenem Sodium (MK-0826) Following Colorectal Surgery in Chinese Adults (MK-0826-056)
The purpose of this study is to evaluate the efficacy and safety of ertapenem sodium compared with ceftriaxone sodium/metronidazole for the prophylaxis of surgical site infection following elective colorectal surgery in Chinese…
- Trial name
- NCT01254344
- Testing
- ertapenem sodium, ceftriaxone sodium, metronidazole
- Volunteers
- 599 people
- Sponsor
- Merck Sharp & Dohme LLC
Acute Kidney Injury
Spironolactone on Acute Kidney Injury in Critically Ill Patients
This study was designed to evaluate the effect of spironolactone administration in the incidence and severity of AKI in patients critically ill with invasive mechanical ventilation (IMV) in the critical care unit.
- Trial name
- NCT03206658
- Testing
- Spironolactone 25 mg
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Aging Problems, Frailty
Impact of Skills Acquired Through Judo Training on Risk Factors for Falling in Elderly Men and Women
Falls and injuries from falls are one of the greatest threats to public health. One of the risk factors for accidental falls is a low self-efficacy regarding the perceived capability to perform activities without the risk of…
- Conditions
- Aging Problems, Frailty, Fall Injury, Accidental Fall
- Trial name
- J4BE (NCT04061785)
- Testing
- Judo4Balance - 12 week judo inspired exercise program
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dalarna University
Safety Issues, BPD - Bronchopulmonary Dysplasia
Autologous Cord Blood Cells for Prevention of BPD in Preterm
To study the effect of Autologous cord blood cells infusion on prevention of bronchopulmonary dysplasia in very preterm neonates
- Conditions
- Safety Issues, BPD - Bronchopulmonary Dysplasia, Neonatal Death
- Trial name
- NCT04311476
- Testing
- Autologous Umbilical Cord Blood Mononuclear Cells infusion Therapy, 0.9% Sodiun Chloride
- Where
- China
- Volunteers
- 62 people
- Sponsor
- yangjie
Cardiac Valve Disease, Coronary Artery Disease
The Val-CARD Trial
The Val-CARD trial aims to answer the question: "Does the drug sodium valproate reduce complications affecting the heart and kidneys in patients having heart operations?" Sodium valproate is a drug commonly used in the treatment…
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Organ Failure, Multiple
- Trial name
- Val-CARD (NCT03825250)
- Testing
- Sodium Valproate
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Leicester
Strains
Acute Hamstring Strains in Danish Elite Soccer - Prevention and Rehabilitation
A common soft tissue injury in sports involving sprinting and jumping is the hamstring strain. Not much evidence-based research has been carried out on prevention of hamstring strains.
- Trial name
- NCT00557050
- Testing
- Training
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Amager Hospital
Sunburn, Ultraviolet Radiation Exposure
Test of Interventions to Prevent Skin Cancer Among Danes on Vacation in High UV Index Sunny Destinations
The aim of the study is to test a series of developed effective interventions targeting Danes going on vacation to sunny destinations to decrease sunburn by increasing use of shade, hats, protective clothing, and sunscreen to…
- Conditions
- Sunburn, Ultraviolet Radiation Exposure, Skin Cancer, Malignant Melanoma
- Trial name
- NCT03607578
- Testing
- Other: Control Group - Minimal Intervention, Experimental: Protection Routine 1, Experimental: Protection Routine 2
- Where
- Denmark
- Volunteers
- 1,548 people, healthy volunteers welcome
- Sponsor
- Brian Køster
HIV Prevention, PrEP
A Multi-Level Trauma-Informed Approach to Increase HIV Pre-exposure Prophylaxis Initiation Among Black Women
U.S. epidemiological data indicates that Black women are a high-risk HIV disparity group, yet initiation of novel prevention strategies like pre-exposure prophylaxis (PrEP) among this group is stagnant.
- Conditions
- HIV Prevention, PrEP, Women, Intimate Partner Violence (IPV)
- Trial name
- MATCH (NCT06703060)
- Testing
- Peer Navigation Group
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Injury of Anterior Cruciate Ligament
Real-time Sensorimotor Feedback for Injury Prevention Assessed in Virtual Reality
Traumatic, debilitating anterior cruciate ligament (ACL) injuries occur at a 2 to 10-fold greater rate in female than male athletes.
- Trial name
- NCT02933008
- Testing
- aNMT Biofeedback, Neuromuscular Training
- Where
- 2 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Emory University
Solid Carcinoma, 5-Fluorouracil Toxicity
Prevention of Chest Pain in Chemo-treated Cancer Patients
This is a prospective, exploratory, randomised clinical trial. Patients with diagnosed cancer that are to be treated with 5-fluorouracil (5-FU) will be randomised into standard oncological treatment or a cardiological assessment…
- Conditions
- Solid Carcinoma, 5-Fluorouracil Toxicity, Cardiotoxicity, Chemotherapeutic Toxicity
- Trial name
- CATCH (NCT03486340)
- Testing
- Cardiologic assessment
- Where
- Denmark
- Volunteers
- 218 people
- Sponsor
- Vejle Hospital
Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa
A Study Comparing KB803 and Matched Placebo in Patients With Dystrophic Epidermolysis Bullosa
KB803-EYE-01 is a Phase 3 double-blind, randomized, placebo-controlled, crossover study to evaluate the safety and efficacy of KB803 versus matched placebo in pediatric and adult subjects with recurrent corneal abrasions due to…
- Conditions
- Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa, Dominant Dystrophic Epidermolysis Bullosa
- Trial name
- IOLITE (NCT07016750)
- Testing
- KB803
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Krystal Biotech, Inc.
Perineal Tear and Episiotomy, Perineal Laceration, Tear, or Rupture During Delivery
Improving the Management and Prevention of Perineal Wound Dehiscence From Episiotomies Using Flaminal
The objectives of this study are to assess the effectiveness of Flaminal Forte in the treatment and prevention of perineal wound breakdown.
- Trial name
- FLAMINGO (NCT07468890)
- Testing
- Flaminal anti-microbial gel
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Burns
Use of Pressure Garments for Burn Scars
1. Will Pressure Garment Therapy better control hypertrophic scarring than no Pressure Garment Therapy. 2. How will Pressure Garment Therapy affect functional capacity or scar contracture development across joints either in…
- Trial name
- Jobst (NCT00675974)
- Testing
- Jobst Pressure Garment, Medical Z pressure garment
- Sponsor
- The University of Texas Medical Branch, Galveston
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