Clinical trials: Trauma Prevention
Physical Fatigue, Return to Sport
The Effect of Physical Fatigue on Lower Limb Functional Performance Tests in a Healthy Population
The main objective of this project is: 1. To assess the influence of physical fatigue on a return-to-play test battery in a healthy population. In a later stage, these experiments could be carried out in a clinical context (e.g.
- Conditions
- Physical Fatigue, Return to Sport, Injury Prevention, Functional Performance
- Trial name
- NCT04029935
- Testing
- Physical Fatigue, Control
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Bronchopulmonary Dysplasia
PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates
There is increasing evidence linking a fetal and early neonatal systemic inflammatory response syndrome to the subsequent development of bronchopulmonary dysplasia (BPD) and white matter injury (WMI) in very preterm infants.
- Trial name
- PREMILOC (NCT00623740)
- Testing
- hydrocortisone
- Where
- France
- Volunteers
- 523 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Venous Thromboembolism (VTE), Trauma Related Injuries
Anti-Xa Guided Dosing of Low Molecular Weight Heparin for Prevention of Venous Thromboembolism Following Traumatic Injury: a Multicentre Pilot Randomized Trial
This multicentre pilot trial will assess the feasibility of a full-scale, randomized trial to determine whether bloodwork guided dosing of blood thinners reduces the risk of clotting in high-risk trauma patients.
- Trial name
- PrOVE iT (NCT06662253)
- Testing
- Anti-Xa Guided Dosing of Low Molecular Weight Heparin, Standard of Care Dosing
- Volunteers
- 150 people
- Sponsor
- Alexandre Tran
BPD - Bronchopulmonary Dysplasia, Pulmonary Hypertension
Controlled Remote Monitoring and Optimization of Oxygen Therapy in Preterm Infants
The project is a national, prospective, multicenter, interventional pilot project focused on controlled remote monitoring and optimization of oxygen therapy for premature infants in the Czech Republic.
- Trial name
- NCT07161908
- Testing
- Pulse oximeter
- Where
- 4 sites in Czechia
- Volunteers
- 70 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Colorectal Cancer, Liver Metastases
SAMe in Prevention of Oxaliplatin-associated Liver Injury
This is an open-label, phase II study that may provide evidence that taking S-adenosylmethionine (SAMe) supplementation prevents oxaliplatin, a type of chemotherapy drug, associated liver toxicity in patients with resectable…
- Conditions
- Colorectal Cancer, Liver Metastases, Liver Metastasis Colon Cancer, Liver Injury
- Trial name
- NCT06258525
- Testing
- Standard of care oxaliplatin-based chemotherapy, S-adenosylmethionine (SAMe) supplement, Surgery
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Cedars-Sinai Medical Center
Contrast-induced Nephropathy
Contrast-Induced Nephropathy After Revision of the Prophylaxis Threshold
After administration of intravascular iodinated contrast media Contrast-Induced Nephropathy (CIN), also known as Contrast-Induced Acute Kidney Injury (CIAKI), may occur.
- Trial name
- CINART (NCT03227835)
- Testing
- intravascular iodinated contrast material administration
- Where
- Netherlands
- Volunteers
- 1,372 people
- Sponsor
- Maastricht University Medical Center
Wounds
A Clinical Study of An Antimicrobial Gauze Dressing
The purpose of this study is to determine if a new antimicrobial gauze dressing is better than the current method of dressing open wounds with plain sterile gauze.
- Trial name
- NCT00203489
- Testing
- KERLIX A.M.D. Gauze
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Tyco Healthcare Group
Injury Prevention
Brief Child Safety Interventions in Emergency Departments (Safety in Seconds)
Safety in seconds is a randomized controlled trial of a computer tailored Injury Prevention program which was conducted in the waiting area of a level 1 pediatric trauma center.
- Trial name
- NCT01432041
- Testing
- tailored health education
- Volunteers
- 901 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Knee Valgus
Integrated Training Program On Jump Performance And Knee Valgus In Youth Football Players
This study aimed to investigate the effects of stretching, strength, and plyometric exercise training programs, applied in addition to regular training, on jumping performance and knee valgus values in football players.
- Trial name
- NCT07009041
- Testing
- Strength training program, Stretching exercises program, Plyometric exercises program
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Critical Illness, Length of Stay
Advantages and Disadvantages of Long Term Sedation in Intensive Care Unit Patients
The purpose of the study is to determine whether sedation of the critical ill patient prolongs the time receiving mechanical ventilation.
- Conditions
- Critical Illness, Length of Stay, Respiration, Artificial, Intensive Care Units
- Trial name
- NCT00466492
- Testing
- Sedation or no sedation during mechanical ventilation
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Odense University Hospital
Venous Thromboembolism, Embolism and Thrombosis
Factor IX Inhibition in Thrombosis Prevention (The FIXIT Trial)
The purpose of this study is to determine whether TTP889 prevents venous thromboembolism following surgery to repair hip fracture.
- Conditions
- Venous Thromboembolism, Embolism and Thrombosis, Hip Fractures
- Trial name
- NCT00119457
- Testing
- TTP889
- Where
- 21 sites in Czechia, Denmark and 2 more
- Volunteers
- 300 people
- Sponsor
- vTv Therapeutics
Radiation Dermatitis
LED Photomodulation for Prevention of Post-Radiation Treatment Dermatitis
Radiation dermatitis is a common side-effect of radiation therapy in cancer patients who frequently can experience redness, pain, crusting, and even ulceration of the skin causing suffering and treatment interruption.
- Trial name
- NCT00573365
- Testing
- Gentlewaves Select™ handheld high energy LED array, Radiation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of California, Irvine
Concussion, Brain, Traumatic Injury
Sport Concussion Performance-Based Prevention Program
Sport-related concussions and traumatic lower body injuries (e.g., anterior cruciate ligament (ACL) tears) occur frequently in high-speed and contact/collision sports contributing to significant time loss from…
- Trial name
- NCT04992130
- Testing
- Pre-season supplementary neurologic training program
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Radiation Dermatitis
3M Cavilon Advanced Skin Protectant for the Prophylaxis of Radiation Dermatitis
This study observes a liquid skin protectant that is a polymeric-cyanoacrylate solution designed to protect intact or damaged skin due to radiation.
- Trial name
- NCT03546803
- Testing
- 3M™ Cavilon™ Advanced Skin Protectant
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
PTSD, Acute Stress Disorder
PTSD Prevention Using Oral Hydrocortisone
There is currently no evidence-based intervention for individuals exposed to trauma that is designed to aid recovery and prevent the development of post-traumatic stress disorder (PTSD).
- Conditions
- PTSD, Acute Stress Disorder, Trauma-related Stressor
- Trial name
- NCT04924166
- Testing
- Hydrocortisone
- Where
- 3 sites in United States, Israel
- Volunteers
- 201 people
- Sponsor
- Rachel Yehuda
Wound of Skin
Efficacy of Prophylactic Negative Pressure Wound Therapy (NPWT)
The role of prophylactic negative pressure wound therapy (NPWT) is promising in reducing wound-related complications. However, the prophylactic use of NPWT in reducing wound complications in patients who underwent conventional…
- Trial name
- EFESO (NCT05727995)
- Testing
- PICO7, usual care dressing
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Seroma, Wound Dehiscence
Prevention of Seroma Formation and Wound Complications Using NPWT Devices
The specific aim of this study is to improve post-operative wound care in the morbidly-obese body-contouring patient population following massive weight loss undergoing either panniculectomy or formal abdominoplasty, those…
- Conditions
- Seroma, Wound Dehiscence, Wound Infection
- Trial name
- NCT02147288
- Testing
- Renasys*GO Negative Pressure Wound Therapy System
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Yale University
Delirium
A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Hip Fracture Repair Surgery
The purpose of this study is to evaluate the efficacy and safety of perioperative use of dexmedetomidine in the prevention of postoperative delirium in subjects undergoing surgery for fractured hip with general anesthesia.
- Trial name
- NCT00460473
- Testing
- Dexmedetomidine
- Where
- 30 sites in United States
- Volunteers
- 52 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Acute Kidney Injury, Cardiac Disease
The Prevention of Erythropoietin on Cardiac Surgery-associated Acute Kidney Injury
To testify the prevention of Erythropoietin on cardiac surgery associated-acute kidney injury, and trying to provide evidence for protecting the renal function and improving the prognosis for patients after cardiac surgery.
- Conditions
- Acute Kidney Injury, Cardiac Disease, Surgery
- Trial name
- NCT03007537
- Testing
- Erythropoietin, 0.9% sodium chloride, cardiac surgery
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Liver Transplantation, Surgical Site Infection
Surgical Site Infections After Liver Transplantation Based on Perioperative Antibiotics
This study will be to prospectively determine differences in Surgical Site Infection (SSI) if a prolonged course of post-operative antibiotics are used following liver transplantation.
- Trial name
- NCT02717273
- Testing
- standard, extended, liver transplant
- Volunteers
- 102 people
- Sponsor
- University of Virginia
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