Clinical trials: Trauma Prevention
Athletes With Previous Lateral Ankle Sprain(s)
The Spraino Pilot Trial
This pilot study will establish the preliminary effect and safety of using Spraino® to prevent lateral ankle sprains amongst athletes competing in indoor sports at sub-elite level, with a one-year follow-up.
- Trial name
- NCT03311490
- Testing
- Spraino
- Where
- 2 sites in Denmark
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Spraino
Tetanus
A Phase 4 Study to Evaluate the Effectiveness and Safety of Siltartoxatug Injection for Tetanus Prophylaxis Following Injury
Study sites were selected from hospitals across diverse regions of China. Approximately 6,000 participants who require passive immunization against tetanus due to various injuries (including those with severe wounds or heavily…
- Trial name
- NCT07347938
- Testing
- Siltartoxatug Injection, HTIG/TAT/F(ab')₂
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Zhuhai Trinomab Pharmaceutical Co., Ltd.
Fractures, Closed, Wounds and Injuries
Antibiotic Prophylaxis in Orthopaedic Traumatology
It has been established that providing antibiotic prophylaxis after closed fracture fixation with implants or prosthetic devices has beneficial effects.
- Trial name
- NCT00610987
- Testing
- cefazolin
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- University of Missouri-Columbia
Substance Use Disorders, Post Traumatic Stress Disorder
A Trauma Informed Adaptation of Mindfulness-Based Relapse Prevention for Women in Substance Use Treatment
More than 90% of women in substance use treatment report history of physical and/or sexual trauma, and up to 60% meet criteria for both substance use disorder (SUD) and Post Traumatic Stress Disorder (PTSD).
- Trial name
- NCT03505749
- Testing
- Trauma Informed Mindfulness-Based Relapse Prevention, Treatment As Usual (TAU)
- Where
- 5 sites in United States
- Volunteers
- 96 people
- Sponsor
- Pacific University
Hypertrophic Scarring, Pain, Postoperative
Topical Heparin for Prevention of Hypertrophic Scarring in Split-Thickness Skin Graft Donor Sites
This study is testing whether applying a special dressing soaked with heparin (a medicine that improves blood flow and reduces scar formation) can help prevent thick, raised scars (called hypertrophic scars) and reduce pain at…
- Conditions
- Hypertrophic Scarring, Pain, Postoperative, Wound Healing
- Trial name
- HepScar (NCT07196358)
- Testing
- Standard dressing, Topical Heparin Dressing
- Where
- Pakistan
- Volunteers
- 400 people
- Sponsor
- Dr. Ruth K.M. Pfau Civil Hospital, Karachi
Occupational Musculoskeletal Disorders, Healthy
Impact in Life Quality of a Educational Program for Prevention of Occupational Musculoskeletal Disorders in Workers
The study consists of evaluating the efficacy of an Educational Program for prevention of occupational musculoskeletal problems in workers.
- Trial name
- NCT00874718
- Testing
- educational program, General education
- Where
- Brazil
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Incisional Hernia of Midline of Abdomen, Surgical Wound
Onlay Mesh in Abdominal Aortic Aneurysm Repair.
The aim of the study was to compare the incidence of IH after abdominal aortic aneurysm (AAA) open repair according to the abdominal wall closure technique used.
- Trial name
- NCT07416422
- Testing
- Abdominal Ultrasound or computed tomography
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Radiodermatitis; Acute
A Study of GR1014 Cutaneous Gel for the Prevention of Skin Reactions Caused by Radiation Therapy for Breast Cancer
This clinical trial is testing a new skin gel called GR1014-CG to evaluate its safety and see if it can help prevent or reduce skin irritation (such as redness, soreness, etc.) caused by radiation therapy (RT) after…
- Trial name
- GuARD (NCT07192588)
- Testing
- GR1014-CG 2.4%, Vehicle Gel, Radiation Therapy
- Where
- 4 sites in France, United Kingdom
- Volunteers
- 273 people
- Sponsor
- Graegis Pharmaceuticals Ltd
Mucositis, Hematopoietic Stem Cell Transplantation
Effects of Mesenchymal Stem Cell Supernatant on Prevention and Treatment of Skin/Mucosal Injury in Hematology Patients
This clinical trial is studying the effects of mesenchymal stem cell (MSC) culture supernatant on the prevention and treatment of mucosal injuries in patients undergoing hematopoietic stem cell transplantation (HSCT).
- Conditions
- Mucositis, Hematopoietic Stem Cell Transplantation, Chemotherapy-Induced Mucositis, Radiation-Induced Mucositis
- Trial name
- MSC-MucInj (NCT06599346)
- Testing
- Standard Care, MSC Supernatant + Standard Care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The General Hospital of Western Theater Command
Injuries, Dancing
"The Show Must go on" : The Experience of Injuries Among Dancers: Fears, Thoughts, and Beliefs. A Qualitative Study
This qualitative, cross-sectional study aims at describing the experience of Italian dancers with injury. Dancers face a high risk of sustaining one or more injuries during their career (87-94%), which may lead to physical…
- Conditions
- Injuries, Dancing, Injury;Sports, Stress, Psychological
- Trial name
- NCT06349928
- Testing
- Focus group or interview
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Siena
Exercise, Hamstring Injury
Effects of Hamstrings Strengthening in Proffesional Athlets
Athelts that meet the inclusion criteria will be randomized into two groups. The experimental group will receive an 8-week (3 days per week) specificl protocol based on hamstring strengthening (isometric, concentric and excentric…
- Trial name
- NCT04257591
- Testing
- hamstring strengthening
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Zaragoza
NSCLC, Nintedanib
Nintedanib for the Prevention of Radiation Pneumonia in Unresectable NSCLC
This study is aimed at patients with unresectable NSCLC who take nintedanib during sequential radiotherapy to explore the incidence of radiation pneumonitis above grade 2 in the nintedanib combined with radiotherapy mode and…
- Conditions
- NSCLC, Nintedanib, Radiation Pneumonitis
- Trial name
- NCT06570317
- Testing
- Nintedanib
- Where
- 7 sites in China
- Volunteers
- 40 people
- Sponsor
- Second Hospital of Shanxi Medical University
Running Biomechanics, Neuromuscular Control
Structured Neuromuscular Exercise Program
This randomized controlled trial aims to investigate the effects of an 8-week structured neuromuscular exercise program on running performance and lower extremity biomechanics in recreational runners.
- Conditions
- Running Biomechanics, Neuromuscular Control, Running-Related Injury Prevention, Recreational Runners
- Trial name
- nmep-run (NCT07596420)
- Testing
- Structured Neuromuscular Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Elif Tunç
Surgery
Hemopatch Safety and Efficacy Evaluation Versus Standard Practice for Sealing the Dura in Cerebrospinal Fluid Leaks
Posterior fossa surgeries are generally complicated by difficulties in creating a watertight dural closure, which often requires the use of dural substitutes.
- Trial name
- NCT04419597
- Testing
- HEMOPATCH, Standard of care
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Blister of Foot, Sport Injury
Evaluation of the Effectiveness of the Local Application of Lemon in the Prevention of Blisters in Ultra-trail Runners
For more than a decade, worldwide participation in ultra-marathons and ultra-trails (running races longer than the 42.195 km marathon) has been increasing.
- Trial name
- BS-2 (NCT05086640)
- Testing
- Lemon foot to prevent blister
- Where
- France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Institut de Formation et de Recherche en Médecine de Montagne
Reperfusion Injury
Remote Ischaemic PreConditioning (RIPC) in Partial Nephrectomy for the Prevention of Ischemia/Reperfusion Injury
"Remote Ischaemic PreConditioning" (RIPC) is performed prior to partial nephrectomy. Postoperative calprotectin dynamics and Blood Oxygen-Level-Dependent (BOLD) MRI are used to to demonstrate the potential renoprotective effect…
- Trial name
- NCT03068689
- Testing
- RIPC
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Leg Injuries, Winter Sport Resorts
Evaluation of the Prevention of Thromboembolic Disease in Patients With a Lower Limb Trauma, Non Surgical, in Winter Sports Resort
The purpose of this study is to evaluate the impact of thromboembolic diseases and heparin complications in patients with a lower limb trauma supported by physicians of mountain.
- Conditions
- Leg Injuries, Winter Sport Resorts, Outpatients
- Trial name
- M2M-Thrombose (NCT01303523)
- Where
- 28 sites in France
- Volunteers
- 1,627 people
- Sponsor
- Floralis
Radiodermatitis, Quality of Life
Monocenter, Open Label Clinical Investigation on the Treatment of Radiation Induced Dermatitis With Xonrid®
To evaluate the performance of Xonrid® in the prevention and treatment of G2 radiation dermatitis in breast and head \& neck cancer patients.
- Trial name
- NCT03255980
- Testing
- Xonrid® gel, Standard of Care
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Helsinn Healthcare SA
Vascular Diseases, Peripheral Vascular Disease
Topical Gentamicin and Vancomycin for Vascular Surgical Site Infection Prophylaxis
Many patients who undergo vascular surgery to improve the blood flow to their legs are at risk of developing an infection in the surgical site and are then at risk of serious complications such as hospital readmission, failure of…
- Conditions
- Vascular Diseases, Peripheral Vascular Disease, Surgical Site Infection, Bypass Complication
- Trial name
- NCT04238923
- Testing
- Topical vancomycin paste (1g vancomycin powder + 4mL sterile saline) and Collatamp G gentamicin-eluting sponge (Azralez Pharmaceuticals; 2.0mg gentamicin sulphate/cm2 to cover wound)
- Volunteers
- 356 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cisplatin, Ototoxicity
Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Systemic Treatment With Cisplatin.
In this study we will aim to determine if cisplatin ototoxicity can be prevented by intratympanic administration of corticosteroids.
- Conditions
- Cisplatin, Ototoxicity, Intratympanic Steroids
- Trial name
- NCT01285674
- Testing
- Intra-tympanic Cisplatinum
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Ziv Hospital
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