Clinical trials: Trauma Prevention
Elbow Fracture, Elbow Injury
PrEvention of Posttraumatic Joint contractuRes With Ketotifen 2
PrEvention of posttraumatic contractuRes with Ketotifen 2 (PERK 2) is a Phase III randomized, controlled, double blinded multicenter trial with 3 parallel groups (Ketotifen 2 mg or 5 mg or lactose placebo twice daily orally for 6…
- Conditions
- Elbow Fracture, Elbow Injury, Elbow Dislocation
- Trial name
- PERK2 (NCT03582176)
- Testing
- Ketotifen Fumarate 2mg, Ketotifen Fumarate 5mg
- Where
- 15 sites in United States, Canada
- Volunteers
- 395 people
- Sponsor
- University of Calgary
Breast Cancer, Myocardial Fibrosis
Losartan in Prevention of Radiation-Induced Heart Failure
This study is being done to see if losartan affects the chances of developing radiation-induced heart failure in patients who are receiving radiation therapy as part of standard of care treatment for breast cancer.
- Conditions
- Breast Cancer, Myocardial Fibrosis, Radiation-Induced Fibrosis
- Trial name
- NCT05607017
- Testing
- Losartan, Radiation Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Obsessive Compulsive Disorder (OCD), Comorbid Post-Traumatic Stress Disorder and OCD
ERP to Improve Functioning in Veterans With OCD
Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no…
- Trial name
- NCT05240924
- Testing
- Exposure and Response Prevention, Stress Management Training
- Where
- 19 sites in United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development
Hamstring Flexibility, Hamstring Muscle Tightness
Effects of Combining PNF With NMES in Young Football Players
Hamstring muscle injuries are common in sports like football and often lead to extended periods of inactivity. This study aims to compare the effects of two different stretching programs on hamstring flexibility, with a secondary…
- Trial name
- PNF+NMES (NCT07075497)
- Testing
- Neuromuscular electrical stimulation (NMES), Contract-Relax PNF (crPNF)
- Where
- Spain
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Infection; Cesarean Section, Surgical Wound Infection
Controlled Clinical Trial of Supplemental Oxygen for the Prevention of Post-Cesarean Infectious Morbidity
Previous studies have demonstrated that patients who undergo surgery while they under general anesthesia have fewer wound infections if they receive higher concentrations of oxygen but this has never been studied in women who are…
- Conditions
- Infection; Cesarean Section, Surgical Wound Infection, Endometritis
- Trial name
- Peri-Op (NCT00603603)
- Testing
- 80% inhaled oxygen via non-rebreather mask, 30% inhaled oxygen via nasal cannula
- Where
- United States
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Perineal Trauma, Obstetric Anal Sphincter Injury
Papaverine for Prevention of Perineal Trauma
Perineal trauma is a common complication of vaginal delivery, particularly among primiparous patients, and may result in short- and long-term maternal morbidity, including pain, dyspareunia, and pelvic floor dysfunction.
- Trial name
- NCT07641543
- Testing
- Papaverine Hydrochloride
- Volunteers
- 412 people
- Sponsor
- Dr Raneen Abu Shqara
Heart Failure Acute, Renal Dysfunction
Contrast-Induced Acute Kidney Injury Prevention in Acute Heart Failure
The K-PROSE study is a randomized clinical investigation evaluating strategies to prevent contrast-induced acute kidney injury (CI-AKI) in patients hospitalized with acute heart failure and moderate renal dysfunction (eGFR 30-75…
- Trial name
- K-PROSE (NCT07550790)
- Testing
- Furosemide, 0.9 % Normal Saline
- Where
- South Korea
- Volunteers
- 190 people
- Sponsor
- Jin Joo Park
Myocardial Injury, Myocardial Infarction
Prevention of Myocardial Injury in Non-cardiac Surgery
Worldwide, more than 200 million patients have major non-cardiac surgery annually and a significant proportion of these patients suffer major cardiovascular complications (e.g.
- Trial name
- PIXIE (NCT02344797)
- Testing
- Remote ischemic preconditioning
- Where
- 3 sites in Denmark
- Volunteers
- 573 people
- Sponsor
- Zealand University Hospital
Acute Kidney Injury
Tailored Hydration Based on Bioimpedance Analysis for Prevention of Contrast Induced Acute Kidney Injury
The aim of this study was to evaluate, in patients with "normal fluid status" assessed by the bio-impedance analysis, whether two different protocol of IV isotonic saline infusion are associated with different volume expansion…
- Trial name
- Hydra2 (NCT04215042)
- Testing
- sodium chloride infusion
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Ospedale Misericordia e Dolce
Accident Prevention, Wounds and Injuries
Health Belief Model-Based Web Education for Preventing Home Accidents in Mothers of Children Aged 0-3
This randomized controlled experimental study evaluates the effect of a Health Belief Model (HBM)-based web education program on preventing home accidents among mothers of children aged 0-3 years registered in a Family Health…
- Conditions
- Accident Prevention, Wounds and Injuries, Accidental Falls
- Trial name
- HBM-HAWE (NCT07356934)
- Testing
- HBM-Based Web Education for Home Accident Prevention
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Sports Injury, Orthopedic Disorder
Training of Falling Techniques on Landing Mechanics
The overall purpose of this study is to quantify the effect and retention of one-week training of falling techniques on landing biomechanics associated with anterior cruciate ligament (ACL) loading compared to soft-landing…
- Conditions
- Sports Injury, Orthopedic Disorder, Knee Injuries, Anterior Cruciate Ligament Injuries
- Trial name
- NCT04768088
- Testing
- Falling Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Spinal Cord Injuries (SCI), Multiple Sclerosis
Fall Prevention Among People With Spinal Cord Injury and Multiple Sclerosis Who Use Wheelchairs and Scooters
The research team is conducting a study to determine if a fall prevention program designed specifically for people who use wheelchairs and scooters can help people better prevent and manage falls compared to the standard of care.
- Trial name
- NCT07167680
- Testing
- Individualized reduction of falls (iROLL), Stopping Elderly Accidents, Deaths & Injuries (STEADI)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Illinois at Urbana-Champaign
TBI (Traumatic Brain Injury), VTE (Venous Thromboembolism)
Timing of VTE Prophylaxis in TBI
This study compares the efficacy and complication rates of early (24 hours) versus late (72 hours) VTE prophylaxis administration to TBI patients.
- Trial name
- NCT03081169
- Testing
- Enoxaparin Sodium 150 MG/ML Prefilled Syringe, Heparin
- Where
- United States
- Sponsor
- Loyola University
Traumatic Brain Injury, Spinal Cord Injuries
Continuous Passive Motion Versus Heterotopic Ossification
The investigators hypothesize that Heterotopic Ossification (HO) formation can be suppressed if the application of a Continuous Passive Motion (CPM) device can be performed for a substantial amount of time.
- Conditions
- Traumatic Brain Injury, Spinal Cord Injuries, Stroke
- Trial name
- CPMversusHO (NCT05906056)
- Testing
- Continuous Passive Motion (CPM), Conventional physiotherapy (PT), Zoledronic Acid Injection
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- University of Ioannina
Neuropathic Pain, Spinal Cord Injuries
Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain
This study is a phase IV clinical trial with the objective of evaluating whether pain relief associated with pregabalin for at-level non-evoked and evoked neuropathic pain is more efficient during the early rather than late…
- Trial name
- NCT01479556
- Testing
- Pregabalin
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- Julian Taylor Green
Post-Traumatic Stress Disorder
Effect of Propranolol on Preventing Posttraumatic Stress Disorder
This study will assess the effectiveness of taking propranolol soon after a traumatizing incident in reducing the incidence and severity of posttraumatic stress disorder in acutely traumatized individuals.
- Trial name
- NCT00158262
- Testing
- Propranolol
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Endometritis, Wound Infection
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
The Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) study is a large pragmatic multi-center randomized clinical trial designed to evaluate the comparative effectiveness and safety of azithromycin-based extended-spectrum…
- Conditions
- Endometritis, Wound Infection, Abscess, Surgical Site Infection
- Trial name
- C/SOAP (NCT01235546)
- Testing
- Azithromycin and standard of care
- Where
- 9 sites in United States
- Volunteers
- 2,013 people
- Sponsor
- Alan Tita
Trauma, Venous Thromboembolism
Feasibility Study of Geko vs. IPCs in Trauma
Trauma patients are at a high risk of developing blood clots in the legs (deep vein thrombosis - DVT), which can travel to the lungs and cause serious health consequences.
- Trial name
- GIFT Pilot (NCT01835990)
- Testing
- geko, IPCs
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Hamilton Health Sciences Corporation
the Fall Rates, the Severity of Injuries
Integrated Interdisciplinary Program for Fall Prevention in Hospitalized Patients
Falls are very common accidents in Hospital. It not only results in injuries, less mobility among patients but increases their length of stay, cost and family burdens.
- Trial name
- NCT01817920
- Testing
- integrated multidisciplinary fall prevention program
- Volunteers
- 3,000 people
- Sponsor
- Changhua Christian Hospital
Delirium in Old Age, Fragility Fracture
Use of Anesthetic Block for the Prevention of in Hospital Delirium in Patients of the Orthogeriatric Clinical Care Center of the HUFSFB and HUSJI From 2019 - 2020
The purpose of this study is to identify the association between analgesic management with blockade of the iliac fascia versus intravenous analgesia with the presence of delirium during hospital stay in patients admitted to the…
- Conditions
- Delirium in Old Age, Fragility Fracture, Hip Fractures
- Trial name
- NCT04654962
- Testing
- Anesthetic nerve block
- Where
- Colombia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fundación Santa Fe de Bogota
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