Clinical trials: Trauma and Stress Related Disorders
Skin Cancer, Heat Tolerance
Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals
The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans.
- Conditions
- Skin Cancer, Heat Tolerance, Heat-related Illness, Hyperthermia
- Trial name
- ICARUS (NCT07510061)
- Testing
- Controlled Heat and Ultraviolet Radiation Exposure Protocol
- Where
- 2 sites in Denmark, Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Hazardous Drinking, Posttraumatic Stress Disorder
PFI Hazardous Drinkers With Subclinical PTSD
The objective of the present study is to assist on a randomized controlled trial (RCT), aimed at developing and testing the efficacy of a novel computer based PFI among hazardous drinkers with at least subclinical posttraumatic…
- Trial name
- NCT04836442
- Testing
- Alcohol-PTSD-PFI (AP-PFI), Active Comparison Condition (C-PFI)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Houston
Post-Traumatic Stress Disorders, Major Depressive Disorder
Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
Co-occurring post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) is the most common response to trauma; it is associated with poor clinical outcomes and substantial human disability.
- Trial name
- NCT04032301
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Post Traumatic Stress Disorder, Tai Chi
Evaluation of a Tai Chi Resilience Training Program on Objective and Subjective Measures of Post Traumatic Stress Disorder Severity
The standard of care for PTSD involves both psychotherapy and pharmacotherapy, but treatment resistance is common. The discovery of effective complementary treatment approaches would have major implications for patients with…
- Conditions
- Post Traumatic Stress Disorder, Tai Chi, Aerobic Exercise
- Trial name
- NCT04288830
- Testing
- Tai Chi Moving Mindfulness Meditation and Resilience Training, Aerobic Exercise
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Fibromyalgia, Posttraumatic Stress Disorder
Fibromyalgia in Men Suffering From PTSD
Assessing FM and psychiatric state among PTSD, MDD and healthy participants
- Conditions
- Fibromyalgia, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT00229294
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
PTSD
Exploring Mechanisms of Massed Cognitive Processing Therapy
The overall goal of this randomized controlled trial with partial crossover is to compare the effectiveness of 1-week virtual massed Cognitive Processing Therapy (CPT) to 5-day virtual relaxation training (RT) with regard to…
- Trial name
- NCT05265039
- Testing
- Cognitive Processing Therapy, Relaxation Training
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
PTSD
Acupuncture and Mindfulness Based Stress Reduction for Wellness
AMWELL is a randomized, waitlist-controlled, pilot study to evaluate the comparative efficacy of Mindfulness Based Stress Reduction (MBSR) and Acupuncture (AT) to Wait-List Control (WL) in adult female survivors of childhood…
- Trial name
- AMWELL (NCT04859686)
- Testing
- Mindfulness-Based Stress Reduction, Acupuncture Treatment
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Alcohol Use Disorder, Trauma, Psychological
Adverse Childhood Experiences in Substance-related Disorders
Aversive childhood experiences (ACE) and their relation to the development of an alcohol use disorder will be measured with fMRI.
- Trial name
- NCT03758053
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Posttraumatic Stress Disorders, Dissociative Identity Disorder
Evaluating the Neurobiological Basis of Traumatic Dissociation in Women With Histories of Abuse and Neglect
This study aims to evaluate the neurobiological basis of traumatic dissociation in a cross-diagnostic sample of women who have histories of childhood abuse and neglect.
- Trial name
- NCT02757339
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Post Traumatic Stress Disorder
Technology-Based Tools to Enhance Quality of Care in Mental Health Treatment
Nearly 9 million U.S. children (1 in 8) meet criteria for at least one mental health disorder at any point in time. Effective treatments exist for these disorders, but children and families who seek services rarely receive them…
- Trial name
- NCT01915160
- Testing
- eTF-CBT, TF-CBT
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Disorder
Fear Potentiation and Fear Inhibition in Posttraumatic Stress Disorder
The current study will investigate the ability of people with and without fear symptoms after trauma to inhibit fear in an experimental situation.
- Trial name
- NCT00209040
- Testing
- Acoustic Startle Testing
- Where
- United States
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Emory University
Moral Injury
Assessing the Implementation and Feasibility of the SMART-MR
The objective of the proposed pilot study is to assess the feasibility and implementation of the SMART-MR program, an integration of stress management, general resilience, and moral resilience skills, with frontline staff who…
- Trial name
- NCT05122910
- Testing
- Stress Management and Resilience Training - Moral Resilience (SMART-MR) program
- Where
- Canada
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Well Being, Happiness
Laughie Prescription on the Well-being, Happiness, and Posttraumatic Stress Level of Nursing Students Affected by the Earthquake
This study aimed to evaluate the effect of the Laughie Prescription on Well-being, Happiness, and Postraumatic stress levels of nursing students affected by the earthquake in Türkiye.
- Conditions
- Well Being, Happiness, Post Traumatic Stress Disorders
- Trial name
- NCT07157176
- Testing
- Daily 3-Minute Laughter Practice (Laughie Prescription)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
PTSD
Losartan and Memory
This study investigates the effect of a single dose of 50mg losartan vs placebo on BOLD signal during memory encoding.
- Trial name
- NCT05828940
- Testing
- Losartan Potassium
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Psychological Trauma, Mental Health
Collaborative Organizational Approach to Selecting and Tailoring Implementation Strategies
The purpose of this study is to partner with the North Carolina Child Treatment Program (NC CTP) and the SAMHSA-funded National Child Traumatic Stress Network (NCTSN) to develop and pilot the Collaborative Organizational Approach…
- Trial name
- COAST-IS (NCT03799432)
- Testing
- COAST-IS, TF-CBT Learning Collaborative
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Post-traumatic Stress Disorder, Post-Traumatic Stress Disorder, Chronic
PTSD Affect Labeling Study
The overall goal of this study is to use fMRI and psychophysiological measures to investigate a novel strategy involving "Affect Labeling" for improving emotion regulation in PTSD that could lead to a new treatment regimen for…
- Trial name
- NCT05924399
- Testing
- Affect Labeling Training
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Psychosis;Schizophrenic, Personality Disorders
The Impact of the COVID-19 (SARS-CoV-2 Disease) on Psychopathology
The outbreak of the SARS-CoV-2 pandemic may be considered a traumatic phenomenon. In a sample of subjects suffering from different psychiatric disorders, psychopathological status and Post-Traumatic Stress Disorder (PTSD)…
- Conditions
- Psychosis;Schizophrenic, Personality Disorders, Mood Disorders, Anxiety Disorders
- Trial name
- NCT04694482
- Testing
- Psychometric scale administration
- Where
- Italy
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Stress Disorders, Post-Traumatic
CPT-fMRI Study for PTSD
Posttraumatic stress disorder (PTSD) is prevalent mental illness (~9% life-time) that results from exposure to trauma. As it is associated with vastly heterogeneous origins, accurate diagnosis and optimal treatment strategies are…
- Trial name
- NCT03229915
- Testing
- cognitive processing therapy
- Where
- Canada
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Post-Traumatic Stress Disorder
Telephone-based Care for OEF/OIF Veterans With PTSD
Objective: OEF/OIF (Operation Enduring Freedom and Operation Iraqi Freedom) veterans are presenting with high rates of PTSD. Translating Initiatives for Depression into Effective Solutions (TIDES) is a model of phone-based care…
- Trial name
- NCT00680524
- Testing
- Phone-based outreach
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Depression, Post Traumatic Stress Disorder
The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Registry
While effective interventions for depression exist, their success rates are unsatisfactory and their provision is haphazard. The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Depression Hub will improve…
- Conditions
- Depression, Post Traumatic Stress Disorder, Bipolar Disorder, Mood Disorder
- Trial name
- NCT02443636
- Where
- Canada
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority