Clinical trials: Trauma-related Nightmares
Post-traumatic Stress Disorder
Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance
The purpose of this study is to compare the effectiveness of two cognitive behavioral group psychotherapy interventions in controlling the subjective sleep disturbance in veterans with Post-traumatic Stress Disorder.
- Trial name
- NCT00108628
- Testing
- Imagery Rehearsal, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- US Department of Veterans Affairs
Post Traumatic Stress Disorder, Anxiety
The Effect of Nasal Continuous Positive Airway Pressure Treatment on PTSD Symptoms.
We hypothesize that prevention of Sleep Disordered Breathing among PTSD patients with nasal CPAP will result improve their anxiety, insomnia and alcohol craving (among those who use alcohol to control their symptoms).
- Conditions
- Post Traumatic Stress Disorder, Anxiety, Nightmares, Unrefreshed Sleep
- Trial name
- PTSD (NCT01512771)
- Testing
- CPAP
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Northport Veterans Affairs Medical Center
Nightmares, Insomnia
Treating Insomnia & Nightmares After Trauma: Impact on Symptoms & Quality of Life
Exposure to trauma, especially when it manifests as Posttraumatic Stress Disorder (PTSD), results in numerous negative consequences for patients, families, and society.
- Conditions
- Nightmares, Insomnia, Posttraumatic Stress Disorder
- Trial name
- NCT01009112
- Testing
- PTSD + IRT/CBT-I, PTSD + Supportive Care Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of California, San Diego
Nightmares Associated With Trauma and Stress
Exposure, Relaxation, & Rescripting Therapy-Child
Untreated trauma-related nightmares and sleep-related disorders are associated with chronic health problems, burdening both the suffering individual and the health-care system.
- Trial name
- ERRT-C (NCT01776229)
- Testing
- Exposure, Relaxation, & Rescripting Therapy-Child
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Tulsa
Posttraumatic Stress Disorder
Treating Nightmares in Posttraumatic Stress Disorder With Dronabinol
This randomized controlled exploratory phase II trial will test the hypothesis that oral dronabinol improves nightmares (primary outcome) and other PTSD symptoms (secondary outcomes) to a greater extent than placebo over a ten…
- Trial name
- NCT04448808
- Testing
- BX-1
- Where
- 4 sites in Germany
- Volunteers
- 170 people
- Sponsor
- Charite University, Berlin, Germany
Post Trauma Nightmares, Traumatic Stress
Exposure, Relaxation, & Rescripting Therapy-Child
The study implements a trauma-related nightmare treatment for children aged 8 to 13 years. Relevant outcome progress and outcome measures on symptoms, nightmare distress and duration, academic indicators, and sleep quality will…
- Trial name
- ERRT-C (NCT02184026)
- Testing
- Exposure, Relaxation, & Rescripting Therapy-Child
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Montana
Nightmare
Nightmare Deconstruction and Reprocessing vs. NightWare Wristband
The overall goal of this Phase IIa randomized controlled pilot trial is to assess the potential efficacy of two emerging treatments for post-trauma nightmares and to test the feasibility of study design and methods.
- Trial name
- NDR/NW (NCT06399874)
- Testing
- Nightmare Deconstruction and Reprocessing, NightWare
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Uniformed Services University of the Health Sciences
Insomnia, Nightmares Associated With Trauma and Stress
Restorative Early Sleep Treatment After the Emergency Department
The goal of this randomized controlled trial is to pilot the virtual delivery of cognitive behavioral therapy for insomnia (CBT-I) and nightmares (CBT-I\&N) via telehealth as an early intervention for treating posttraumatic sleep…
- Conditions
- Insomnia, Nightmares Associated With Trauma and Stress, Nightmares, PTSD - Post Traumatic Stress Disorder
- Trial name
- RESTED (NCT07121270)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Cognitive Behavioral Therapy for Insomnia and Nightmares, Sleep Education
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Henry Ford Health System
PTSD - Post Traumatic Stress Disorder, Trauma-related Nightmares
Validation of an Algorithm for Predicting Awakenings Associated With Trauma-related Nightmares, Based on the Analysis of Physiological Patterns in Military and Former Military Patients Suffering From Post-traumatic Stress Disorder
The goal of this clinical trial is to validate an artificial intelligence algorithm called CAUD-PIN (CAUchemar Detection on INdividualized Parameters) to predict nightmare-related awakenings in military personnel and veterans…
- Trial name
- CAUD-PIN (NCT07851480)
- Testing
- CAUD-PIN (CAUchemar Detection on INdividualized Parameters) - AI-based predictive algorithm forTrauma-related nightmare awakenings
- Where
- 3 sites in France
- Volunteers
- 27 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Stress Disorders, Post-Traumatic, Sleep Initiation and Maintenance Disorders
A Transdiagnostic Sleep Health Intervention for Veterans With PTSD
Sleep disturbance is a major problem in Veterans with posttraumatic stress disorder (PTSD). This study will test a version of a sleep treatment that's been shown to be effective in the general population, with some changes to…
- Trial name
- NCT06549049
- Testing
- TranS-C for PTSD, Sleep Psychoeducation Control
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Combat Disorders
Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken)
This study will provide preliminary estimates of safety and efficacy of the NightWare digital therapeutic system (iPhone + Apple watch + proprietary application) for the treatment of nightmare disorder associated with…
- Conditions
- Stress Disorders, Post-Traumatic, Combat Disorders, Ptsd, Nightmare
- Trial name
- TNT/NW (NCT03795987)
- Testing
- NightWare Therapeutic System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NightWare
Nightmares
A Trial of Treatment for Trauma-Related Nightmares in Active Duty Military Personnel
The purpose of this study is to obtain preliminary data of the efficacy of Exposure, Relaxation, and Rescripting Therapy for nightmares among active duty military personnel.
- Trial name
- NCT02506595
- Testing
- ERRT-M for Nightmares
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Nightmare, Insomnia
INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention
The INSIGHT study is a multi-site clinical research program designed to examine how insomnia and symptoms of sympathetic hyperactivity impair sleep, cognition, and physiological restoration in warfighters, and to evaluate whether…
- Conditions
- Nightmare, Insomnia, PTSD, TBI
- Trial name
- INSIGHT (NCT07288593)
- Testing
- NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns.
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Nightmares, Post-traumatic Stress Disorder
Brief Treatment for Trauma Nightmares in Trauma-exposed Adults With Bipolar Disorder
Exposure, relaxation, and rescripting therapy (ERRT) is a promising psychological intervention developed to target trauma-related nightmares and sleep disturbances.
- Trial name
- BERRT (NCT02242110)
- Testing
- ERRT-Bipolar Disorder
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Tulsa
PTSD - Post Traumatic Stress Disorder
REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
The goal of the REVEAL PTSD study is to test how well the Senseye DT works as a diagnostic test for Post-traumatic Stress Disorder (PTSD) in adults 18 and older who are experiencing one or more symptoms that might be related to…
- Trial name
- NCT07280065
- Testing
- Senseye Diagnostic Tool (DT), Clinician Administered PTSD Scale for DSM-5, Revised Version
- Where
- 6 sites in United States, Australia
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Senseye, Inc.
PTSD, Sleep Disorders
Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD
Background: Posttraumatic stress disorder (PTSD) is a debilitating and disabling mental disorder that afflicts at least 25% of Veterans who have suffered life-threatening war zone trauma.
- Trial name
- PACT (NCT00532493)
- Testing
- prazosin
- Where
- 15 sites in United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Cardiovascular Diseases
NightWare and Cardiovascular Health in Women With PTSD
The purpose of this study is to determine whether NightWare therapeutic intervention improves biomarkers of vascular and renal function in premenopausal women with PTSD-related nightmares, and examine whether these improvements…
- Conditions
- Post Traumatic Stress Disorder, Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness
- Trial name
- NCT07021014
- Testing
- NightWare
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Insomnia, PTSD - Post Traumatic Stress Disorder
Accelerated Treatment for Co-occurring Insomnia, Nightmares, and PTSD
This study is a two-arm individually randomized group treatment clinical trial evaluating behavioral therapies for insomnia, nightmares, and PTSD.
- Conditions
- Insomnia, PTSD - Post Traumatic Stress Disorder, Nightmares
- Trial name
- NCT07069517
- Testing
- Cognitive-Behavioral Therapy for Insomnia (CBTi), Cognitive Behavioral Therapy for Nightmares (CBTn), Written Exposure Therapy (WET)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Palo Alto Veterans Institute for Research
Posttraumatic Stress Disorder
Treating Nightmares in Posttraumatic Stress Disorder With Clonidine and Doxazosin
This randomized controlled trial will test the hypothesis that oral Clonidine or Doxazosin improves nightmares (primary outcome), other PTSD symptoms and psychopathology (secondary outcomes) to a greater extent than placebo over…
- Trial name
- NCT05360953
- Testing
- Clonidine, Doxazosin
- Where
- 5 sites in Germany
- Volunteers
- 53 people
- Sponsor
- Charite University, Berlin, Germany
Posttraumatic Stress Disorder, Cardiovascular Diseases
NightWare and Cardiovascular Health in Adults With PTSD
The purpose of this study is to determine whether NightWare therapeutic intervention improves biomarkers of vascular aging and autonomic function in adults with nightmares related to PTSD.
- Conditions
- Posttraumatic Stress Disorder, Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness
- Trial name
- NCT05365607
- Testing
- NightWare
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver