Clinical trials: Traumatic Bleeding, open to volunteers
Chronic Subdural Hematoma
Neuroendoscopy-assisted Drainage Versus Burr Hole Drainage for Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a frequent condition in neurosurgery, leading to fluid accumulation between the meninges, brain compression, neurological dysfunction, and potentially herniation.
- Trial name
- URANUS (NCT07144423)
- Testing
- Endoscope-assisted hematoma drainage, Burr hole hematoma drainage
- Where
- 24 sites in China
- Volunteers
- 770 people
- Sponsor
- Beijing Tiantan Hospital
Intraventricular Hemorrhage, Subarachnoid Hemorrhage
AFFECT Study for Patients With Intraventricular Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, and Ventriculitis
The goal of this clinical trial is to evaluate efficacy and safety of evacuation of cerebrospinal fluid, blood, and harmful bacteria from the intraventricular, subdural and subarachnoid spaces by Active Controlled Irrigation and…
- Conditions
- Intraventricular Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, Ventriculitis
- Trial name
- AFFECT (NCT05649904)
- Testing
- IRRAflow with Active Fluid Exchange System, External Ventricular Drain
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Ohio State University
Hemothorax; Traumatic
Traumatic Hemothorax Drainage and Daily Lavage
This HTX treatment study evaluates the effects of chest tube size and the benefits of daily irrigations on acute HTX. 20 acutely injured but stable trauma patients requiring a chest tube for HTX will be enrolled.
- Trial name
- HTXDLYLAVGE (NCT06937450)
- Testing
- CLR Irrigator, Serial Lavage and Drainage, 28 Fr Open Chest Tube
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Neurologic Decompensation, Acute, Traumatic Brain Injury
Ventilatory Parameters in Acute Neurological Injury
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP)…
- Conditions
- Neurologic Decompensation, Acute, Traumatic Brain Injury, Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT06192342
- Where
- Argentina
- Volunteers
- 19 people
- Sponsor
- Ramos Mejía Hospital
Hemorrhage, Intracranial Hemorrhages
Restarting Anticoagulation After Traumatic Intracranial Hemorrhage
Primary Objective: To identify the optimal interval to restart oral anticoagulation after traumatic intracranial hemorrhage that will minimize thrombotic events and major bleeding by performing a response adaptive randomized…
- Conditions
- Hemorrhage, Intracranial Hemorrhages, Bleeding, Trauma
- Trial name
- Restart tICrH (NCT04229758)
- Testing
- Anticoagulants
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- University of Texas at Austin
Hemorrhagic Shock, Trauma
REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam
The purpose of this study is to demonstrate safety, effectiveness and benefit-risk profile of ResQFoam for the inhospital treatment of exsanguinating, intraabdominal haemorrhage due to trauma in patients where emergent laparotomy…
- Conditions
- Hemorrhagic Shock, Trauma, Exsanguinating Hemorrhage, Shock; Traumatic
- Trial name
- REVIVE (NCT02880163)
- Testing
- ResQFoam
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Arsenal Medical, Inc.
Traumatic Brain Injury
Baricitinib for Moderate and Severe Traumatic Intracerebral Hemorrhage/Contusions
The purpose of the present study is to study the effect of baricitinib administration on outcome of participants with moderate and severe traumatic intracerebral hemorrhage/contusions.
- Trial name
- NCT06065046
- Testing
- Baricitinib 4 MG, Standard treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tang-Du Hospital
TBI (Traumatic Brain Injury), Status Epilepticus
Augmented Renal Clearance in Neurocritical Care
Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion…
- Conditions
- TBI (Traumatic Brain Injury), Status Epilepticus, Bacterial Meningitis, Augmented Renal Clearance (ARC)
- Trial name
- Neuro-ARC (NCT07410624)
- Where
- 3 sites in United States, Canada
- Volunteers
- 512 people
- Sponsor
- University of Alberta
Chronic Subdural Hematoma
Middle Meningeal Artery Embolisation in Chronic Subdural Hematoma
This international multicenter study evaluates the efficacy and safety of middle meningeal artery embolization (MMAE) using PVA particles or liquid embolic agents as a perioperative treatment to prevent the recurrence of chronic…
- Trial name
- EMMA-CS (NCT07751887)
- Testing
- Middle Meningeal Artery Embolisation
- Where
- 6 sites in Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Hradec Kralove
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Chronic Subdural Hematoma
Efficacy of a Minimally Invasive Therapy Adjuvant to the Standards of Care by Cyanoacrylate Embolization
Chronic subdural hematomas (CSH) are collections of blood in the subdural space. CSH are becoming the most common cranial neurosurgical condition among adults, and a significant public health problem, due to an increasing use of…
- Trial name
- LEADH (NCT05374681)
- Testing
- Medical treatment, Surgical treatment, embolization of the MMA
- Where
- 11 sites in France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Brest
Chronic Subdural Hematoma, cSDH
Prospective Multi-center Single Arm Study for Subjects With Chronic Subdural Hematoma Treated With i-ED COILs, Either Alone or in Combination With Burr-holes or Mini-craniotomy
All participants will be asked to have a minimally invasive procedure for the treatment of chronic subdural hematoma, a blood clot on the brain.
- Conditions
- Chronic Subdural Hematoma, cSDH, Chronic Subdural Hematomas
- Trial name
- iCURE cSDH (NCT07214623)
- Testing
- Neuro endovascular embolic coil
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Kaneka Medical America LLC
Chronic Subdural Hematoma, Registry
Registry of Chronic Subdural Hematoma
The goal of this observational study is to better understand how chronic subdural hematoma (CSDH) progresses and how patients are treated and cared for. The study focuses on three main questions: 1.
- Trial name
- CSDH Registry (NCT06759428)
- Where
- 2 sites in Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Erasmus Medical Center
Chronic Non-Traumatic Intracranial Subdural Haemorrhage
Non Traumatic Chronic Subdural Haematoma in Paediatric Age Groups, Management and Outcome
1-Review the management strategies and outcomes in cases of non traumatic chronic subdural haematoma in paediatric age group. 2- Review the underlying causes and risk factors in cases of non traumatic chronic subdural haematoma…
- Trial name
- NCT06743893
- Testing
- Diagnosis and outcome of non traumatic chronic subdural haematoma in pediatric age groups
- Volunteers
- 30 people
- Sponsor
- Assiut University
Hemothorax; Traumatic, Hemopneumothorax; Traumatic
Suction vs Underwater Seal for HemoPneumoThoraX Trial
Traumatic pneumothorax and hemothorax are common consequences of chest injury, often requiring prompt tube thoracostomy to re-expand the lung and drain accumulated blood or air.
- Trial name
- SUS-HPTX (NCT07551791)
- Testing
- Suction, Water Seal
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University Medical Center
Trauma Coagulopathy, Hemorrhage
The Safety of Simplified Tranexamic Acid Regimen
Trauma causes at least 5.8 million deaths worldwide annually, accounting for 1 in 10 of all global deaths. Uncontrolled bleeding within 24 hours after trauma is the leading cause of death in trauma patients, and about one-third…
- Trial name
- NCT07869537
- Testing
- Tranexamic Acid (TXA)
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Trauma Coagulopathy
Tranexamic Acid in Patients With Traumatic Bleeding Based on Dynamic Monitoring of Thromboelastography
Trauma is an important global public health problem and is the leading cause of death in people under 40 years old. Studies have shown that early prehospital administration of TXA 1 g intravenously followed by a continuous…
- Trial name
- NCT06736860
- Testing
- Tranexamic acid (TXA) injection
- Where
- China
- Volunteers
- 580 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Subdural Hematoma
Scalp Block Versus General Anesthesia in Patients Undergoing Evacuation of Subdural Hematoma Via Burr Hole
this study amis to compare between Scalp block versus general anesthesia in patients undergoing evacuation of subdural hematoma via burr hole.
- Trial name
- NCT07143799
- Testing
- Cisatracurium, scalp block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Sohag University
Subarachnoid; Hemorrhage, Nontraumatic, Headache
Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches
The goal of this observational study is to evaluate intravenous lidocaine efficacy and safety in treating headache following non-traumatic subarachnoid hemorrhage. Through this prospective analysis, the investigators hope to: 1.
- Trial name
- NCT06582810
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center