Clinical trials: Traumatic Bleeding
Chronic Subdural Hematoma
Outcome of Chronic Subdural Hematoma Management With Double Burr Hole Craniotomy Versus Single Burr Hole Craniotomy and Subdural Drain Evacuation
The goal of this clinical trial is to compare the outcome of double burr hole versus single burr hole in patients of chronic subdural hematoma undergoing subdural drain evacuation. The main questions it aims to answers are 1.
- Trial name
- NCT07368101
- Testing
- Single Burr hole Craniotomy, Double Burr hole Craniotomy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Chronic Subdural Hematomas
Embolization of Middle Meningeal Artery in Chronic Subdural Hematoma
Chronic subdural hematoma (cSDH) is a common neurological affliction which affects mostly frail and elderly patients. Surgical evacuation by using burr hole craniostomy (BHC) is the most frequently used treatment but carries a…
- Trial name
- ELIMINATE (NCT04511572)
- Testing
- embolization of the middle meningeal artery
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage
The Anaesthetic Ketamine as Treatment for Patients With Severe Acute Brain Injury
Cortical spreading depolarisations are pathological depolarisation waves that occur frequently after severe acute brain injury and has been associated with poor outcome.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage, Traumatic Brain Injury
- Trial name
- KETA-BID (NCT05095857)
- Testing
- S-ketamine
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Aneurysm, Ruptured, Aneurysmal Subarachnoid Hemorrhage
Brain Imaging After Non-traumatic Intracranial Hemorrhage (SAVEBRAINPWI)
The study is an observational prospective evaluation of an approved and unchanged clinical management, evaluating different diagnosis methods to assess brain perfusion in patients with an aneurysmal or AVM-related intracranial…
- Conditions
- Aneurysm, Ruptured, Aneurysmal Subarachnoid Hemorrhage, Arteriovenous Malformations, Intracranial Aneurysm
- Trial name
- SAVEBRAINPWI (NCT05276934)
- Testing
- Brain computed tomography
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Erasme University Hospital
Chronic Subdural Hematoma
Outcome of Single Burr Hole Under Local Anaesthesia in the Management of Chronic Subdural Hematoma
Aim of the work: Is to evaluate the prognosis of single burr hole under local anesthesia in management of CSDH according to clinical picture, risk factors, and age.
- Trial name
- NCT03447327
- Testing
- single burr hole
- Volunteers
- 67 people
- Sponsor
- Zagazig University
Traumatic Brain Injury, Hemorrhage
Fibrinogen Concentrate in Isolated Traumatic Brain Injury
Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropriate firmness.
- Trial name
- NCT03304899
- Testing
- RiaSTAP Injectable Product
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Leila Dehghani
Chronic Subdural Hematoma, Subdural Hematoma
Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma
The goal of this randomized controlled trial is to evaluate whether the adjuvant application of non-thermal plasma (NTP) during standard surgical drainage of chronic subdural hematoma (cSDH) can reduce the recurrence rate at 6…
- Conditions
- Chronic Subdural Hematoma, Subdural Hematoma, Recurrence, Postoperative Complications
- Trial name
- NCT07656818
- Testing
- Standard Surgery Protocol, Non-Thermal Plasma
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Benjamín Gonzalo Rodríguez Méndez
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Shock, Hemorrhagic, Shock, Traumatic
Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients
MP4OX is a novel oxygen therapeutic agent being developed as an ischemic rescue therapy to enhance perfusion and oxygenation of tissues at risk during hemorrhagic shock. MP4OX is a pegylated hemoglobin-based colloid.
- Conditions
- Shock, Hemorrhagic, Shock, Traumatic, Acidosis, Lactic
- Trial name
- NCT01262196
- Testing
- MP4OX, Saline
- Where
- 40 sites in Australia, Austria and 12 more
- Volunteers
- 348 people
- Sponsor
- Sangart
Chronic Subdural Hematoma
Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study
The goal of this clinical trial is to test in moderately symptomatic chronic subdural hematoma (CSDH) patients if middle meningeal artery embolization (MMAE) can be used as an alternative to conventional open surgery.
- Trial name
- CHESS (NCT06347796)
- Testing
- Conventional Surgery, Middle Meningeal Artery Embolization (MMAE)
- Where
- 31 sites in United States
- Volunteers
- 520 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Head Trauma Injury
Mild Head Trauma in the Emergency Room: Assessment of the Risk of Intracranial Hemorrhage in Patients Receving Platelet Inhibitors.
The clinical signs presented by a patient with a mild head injury are highly variable but remain strongly predictive of brain damage.
- Trial name
- Trauma-Head (NCT05589103)
- Where
- France
- Volunteers
- 1,692 people
- Sponsor
- University Hospital, Strasbourg, France
Cerebral Hematoma, Traumatic, Intracerebral Hemorrhage, Traumatic
Interest of Real Time Measurement of Autonomous Nervous System for the Detection of Brain Death
Context: A major lack of organ donors is a serious public health problem. It determines a prolonged delay before a transplant can be performed and thus a significant number of deaths of patients waiting for transplantation.
- Conditions
- Cerebral Hematoma, Traumatic, Intracerebral Hemorrhage, Traumatic, Traumatic Brain Hemorrhage, Traumatic Brain Injury
- Trial name
- MEANS (NCT00918970)
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage
Monitoring Brain Activity in Human Brain Injury
The outcome of brain injury (physical or stroke) may be related to a brain electrical phenomenon known as Cortical Spreading Depression (CSD). This is a brief cessation of function in a local region of brain tissue.
- Conditions
- Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage, Cerebral Infarction, Cerebral Hemorrhage
- Trial name
- NCT00258505
- Testing
- Procedure: intracranial monitoring up to 9 days after injury
- Where
- 2 sites in Germany, Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Chronic Subdural Hematoma
Tranexamic Acid Therapy For The Treatment of Subdural Hematomas
This Phase II randomized, placebo-controlled, double-blinded trial is the first step in our endeavor to improve the clinical outcomes of patients with chronic subdural hematomas (cSDH).
- Trial name
- NCT06718751
- Testing
- Tranexamic Acid 650 MG
- Volunteers
- 240 people
- Sponsor
- Baylor College of Medicine
Hemorrhagic Shock
Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock
Hemorrhagic shock is a pathologic state in which intravascular volume and oxygen delivery are impaired. During circulatory failure associated with hypovolemia and low cardiac output, redistribution of blood flow caused by…
- Trial name
- NCT03235921
- Testing
- Nitroglycerin patch 5mg
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Chronic Non-Traumatic Intracranial Subdural Haemorrhage
Non Traumatic Chronic Subdural Haematoma in Paediatric Age Groups, Management and Outcome
1-Review the management strategies and outcomes in cases of non traumatic chronic subdural haematoma in paediatric age group. 2- Review the underlying causes and risk factors in cases of non traumatic chronic subdural haematoma…
- Trial name
- NCT06743893
- Testing
- Diagnosis and outcome of non traumatic chronic subdural haematoma in pediatric age groups
- Volunteers
- 30 people
- Sponsor
- Assiut University
Traumatic Intracranial Hemorrhage, Traumatic Brain Injury
No Cases of Delayed Intracranial Hemorrhage (d-ICH) Among Patients With Mild Traumatic Brain Injury (mTBI) on Oral Anticoagulation Therapy
Abstract Purpose Patients with anticoagulation therapy has a higher risk of developing traumatic Intracranial Hemorrhage (tICH).
- Trial name
- NCT05609734
- Testing
- no intervention, only observational retrospective study
- Where
- Sweden
- Volunteers
- 249 people
- Sponsor
- Umeå University
Hemorrhage, Intracranial Hemorrhages
Restarting Anticoagulation After Traumatic Intracranial Hemorrhage
Primary Objective: To identify the optimal interval to restart oral anticoagulation after traumatic intracranial hemorrhage that will minimize thrombotic events and major bleeding by performing a response adaptive randomized…
- Conditions
- Hemorrhage, Intracranial Hemorrhages, Bleeding, Trauma
- Trial name
- Restart tICrH (NCT04229758)
- Testing
- Anticoagulants
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- University of Texas at Austin
Trauma, Acute Hemorrhage
Evaluation of a Transfusion Therapy Using Whole Blood in the Management of Coagulopathy in Patients With Acute Traumatic Hemorrhage
The prognosis of traumatized hemorrhages is correlated with the nature of transfusion therapy: a 50% reduction in mortality for an early and massive supply of plasma, and 20% for an early and massive supply of platelets.
- Conditions
- Trauma, Acute Hemorrhage, Coagulopathy
- Trial name
- T-STORHM (NCT04431999)
- Testing
- Whole blood transfusion, Fractionated blood products transfusion
- Where
- 6 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Chronic Subdural Hematoma, Anticoagulant-induced Bleeding
Management of Anticoagulants and Antithrombotics in Patients With CSDH
Primary objective of the study will be to compare, up to 6 months after surgery, number of relapses (post operative re-bleeding) or intracerebral hemorrhage (others than subdural hematomas) and thromboembolic or cardiovascular…
- Conditions
- Chronic Subdural Hematoma, Anticoagulant-induced Bleeding, Thromboembolic Stroke, Cardiovascular Stroke
- Trial name
- THERCA (NCT05079295)
- Testing
- CSDH evacuation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University Hospital of Ferrara