Clinical trials: Traumatic Brain Damage
Traumatic Brain Injury
Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans
The primary purpose of this project is to determine the effect of morning bright light therapy (MBLT) on sleep in Veterans with traumatic brain injury (TBI).
- Trial name
- NCT03968874
- Testing
- Light box therapy, Negative Ion Generator
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Portland VA Medical Center
Mild Traumatic Brain Injury
Elucidate the Mechanisms, Development and Effectiveness of Balance Control and Gait Strategy After Mild Traumatic Brain Injury: Develop Innovative Design of Computerized Dual-task Balance Module
The purpose of this study is to innovatively design and develop computerized dual-task balance training modules and home modules, and conduct proactive clinical verification to focus on the effectiveness of balance control and…
- Trial name
- NCT05638659
- Testing
- Computerized dual-task balance and home program, Medical consultation and traditional balance training
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Concussion
Vitamin Therapy in Concussion Management: A Randomized Control Trial
The purpose of this study is to assess the efficacy of vitamin therapy in concussion when compared to placebo with respect to multiple endpoints including symptom severity, cognitive performance on computer based…
- Trial name
- NCT02382679
- Testing
- Experimental: Vitamin Mixture
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Neurodegenerative Diseases
Cerebrovascular Reactivity and Oxygen Metabolism as Markers of Neurodegeneration After Traumatic Brain Injury
This grant award entitled, "Cerebrovascular Reactivity and Oxygen Metabolism as Markers for Neurodegeneration after Traumatic Brain Injury" (hereafter, "Neurovascular Study"), aims to determine if neurovascular contributors to…
- Trial name
- NCT04820881
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Platelet Dysfunction, Traumatic Brain Injury
Correcting Platelet Dysfunction After Traumatic Brain Injury
This study evaluates the impact of platelet transfusion on geriatric patients with platelet dysfunction from Traumatic Brain Injury.
- Trial name
- NCT03182946
- Testing
- Platelet mapping Thromboelastography
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Traumatic Brain Injury, Post Traumatic Stress Disorder
A Study of Brain Aging in Vietnam War Veterans
Traumatic brain injury (TBI) and post traumatic stress disorder (PTSD) are common combat related problems and may be associated with a greater risk of Alzheimer's disease (AD).
- Conditions
- Traumatic Brain Injury, Post Traumatic Stress Disorder, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- DOD-ADNI (NCT01687153)
- Where
- 19 sites in United States
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Brain Injuries, Brain Injuries, Traumatic
Visual Feedback in Lower Limb Rehabilitation
Severe Acquired Brain Injury (sABI) is defined as "an encephalic impairment that occurs after birth and is not related to a congenital or degenerative disease.
- Conditions
- Brain Injuries, Brain Injuries, Traumatic, Brain Injuries, Vascular
- Trial name
- NCT05179330
- Testing
- OMEGO®
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Concussion, Brain, Musculoskeletal Pain
The Impact of Eye and Body Training on the Injury Rate of Concussions in Female Soccer Players
The research project aims to find out how special training influences the frequency and severity of injuries among female footballers in the top Swiss league.
- Trial name
- NCT06473883
- Testing
- Training recommendation
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- BrainCare Medical Group
Traumatic Brain Injury, Cortical Excitability
Cortical Excitability in Post-traumatic Epilepsy
To test whether measures of cortical excitability derived from motor cortex transcranial magnetic stimulation (TMS) in patients with traumatic brain injury reflect heightened excitability relative to healthy controls and whether…
- Conditions
- Traumatic Brain Injury, Cortical Excitability, Epilepsy
- Trial name
- NCT05517954
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mid-Atlantic Epilepsy and Sleep Center, LLC
Traumatic Brain Injury
Early Digital, Analyte and Neurologic Biomarkers of Acute and Chronic Brain Injury and Recovery in CQT Instructors
Repetitive blast exposure has been shown to lead to more severe neurobehavioral impairments versus a single exposure. Blast-induced Traumatic Brain Injury (TBI) can lead to short- and long-term adverse outcomes Even mild brain…
- Trial name
- NCT05917665
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Concussion
Protection Against Potential Brain Injury During Competitive Football
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). An externally-worn medical device that applies mild jugular compression according to the principle of the Queckenstedt Maneuver (the…
- Trial name
- NCT02696200
- Testing
- Q Collar
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion
A Study to Assess the Effectiveness of the Nautilus BrainPulse™ as an Aid in the Diagnosis of Concussion
The objective of the study is to evaluate, in a blinded fashion, the effectiveness of the Nautilus BrainPulse device when used as an aid in the diagnosis of concussion.
- Trial name
- NCT02660164
- Testing
- Nautilus BrainPulse Recording
- Where
- 4 sites in United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Mild Traumatic Brain Injury
The Use of the VOMS Tool With Military Personnel to Track mTBI Recovery and RTD Status
The purpose of the proposed project is to determine if the VOMS is an effective screening tool to identify and track recovery of vestibular and ocular motor impairment and symptoms following mTBI, that corpsman-level medical…
- Trial name
- NCT02634944
- Testing
- Vestibular Ocular Motor Screening Tool (VOMS)
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury, Penetrating Head Injury
Vietnam Head Injury Study - Phase III
The Vietnam Head Injury Study (VHIS)-Phase III is a prospective, long-term follow-up study of head-injured Vietnam veterans. The purpose of this research study is to determine the long-term consequences, if any, of head injury.
- Conditions
- Traumatic Brain Injury, Penetrating Head Injury, Closed Head Trauma
- Trial name
- NCT00132249
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Concussion, Mild
The Combined Effect of Chronic Cannabis Use and Subconcussive Head Impacts on Brain Health
The purpose of this pilot study is to better understand the effects of chronic cannabis (THC) use on the neural responses to subconcussive head impacts, as a form of repetitive soccer headings.
- Trial name
- NCT04641832
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Indiana University
Phantom Limb
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group.
- Trial name
- NCT01462448
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Vestibular Disorder
Vestibular Treatment in Adolescents Following Sport Related Concussion
Each year, nearly 2 million children and adolescents have a sport-related concussion (SRC) in the U.S., but 57% of them do not receive appropriate clinical care following their injury.
- Trial name
- NCT03555370
- Testing
- Vestibular Exercise Intervention, Standard of Care
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy, CVA
Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbaric Medicine and Research Center at the Years 2017-2019.
DELPhI software developed for the analysis of EEG recordings in response to magnetic stimulation in relation to clinical data.
- Conditions
- Healthy, CVA, Hemorrhage, TBI (Traumatic Brain Injury)
- Trial name
- NCT04095377
- Testing
- No intervention, this is a retrospective study.
- Where
- Israel
- Volunteers
- 875 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Concussion Mild, Concussion, Brain
Sport-Related Concussion Recovery in Athletes
The goal of this study is to enhance the accuracy and sensitivity of concussion evaluation by integrating traditional assessment tools with emerging neuroimaging technologies, such as Functional Near-Infrared Spectroscopy…
- Trial name
- NCT06852300
- Testing
- Concussion Assessment Battery
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Central Arkansas
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital