Clinical trials: Traumatic Brain Damage
Brain Injuries, Traumatic
mTBI Identification and Monitoring Through Retinal Scanning
Rebion has developed a device, the Rebion trauma tool (referred to as the head and intraocular trauma tool, or "HITT"), that detects ocular fixation and alignment using a binocular retinal scan.
- Trial name
- NCT06142435
- Testing
- Head and Intraocular Trauma Tool
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rebiscan, Inc.
Concussion, Brain
Diffusion Tensor Brain MRI in the Detection of Structural Abnormality of the White Substance in Concussion
Concussions in sports are a major public health problem because of their frequency, and are often underdiagnosed because of an unspecific clinical picture or sometimes masked by the concussion itself.
- Trial name
- COMMOTION (NCT06144359)
- Testing
- specific MRI Acquisition (Diffusion Tensor Imaging) at 3T
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Traumatic Brain Injury
Developing and Validating Blood and Imaging BIOmarkers of AXonal Injury Following Traumatic Brain Injury
Observational longitudinal study assessing outcomes following moderate-severe traumatic brain injury (TBI).
- Trial name
- BIO-AX-TBI (NCT03534154)
- Testing
- MRI, Blood Sampling, Microdialysis
- Where
- 5 sites in Italy, Slovenia and 2 more
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Traumatic Brain Injury
Exercise and Rehabilitation After Traumatic Brain Injury
The purpose of this study is to examine the effects of exercise on recovery after traumatic brain injury. Investigators will determine if exercise enhances rehabilitation by increasing substances (proteins) that can facilitate…
- Trial name
- NCT03407924
- Testing
- Aerobic Exercise (AER), Rehabilitation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre for Neuro Skills
Traumatic Brain Injury
Study of Reserves After Traumatic Brain Injury
It is hypothesized that the long-term results of rehabilitation and subsequent aging after Brain Trauma depend on brain's premorbid anatomical (structural) and functional (cognitive, emotional) reserves.
- Trial name
- NCT01628003
- Testing
- Brain MRI, MRI
- Where
- Israel
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Brain Concussion, Brain Injuries
Indirect Intracranial Pressure Measurement in Patients With Suspected or Documented Concussion
The HS-1000 is an innovative non-invasive monitoring device that employs advanced acoustic signal analysis to calculate ICP on a continuous basis.
- Trial name
- NCT02699359
- Testing
- HS-1000 recording
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HeadSense Medical
Concussion, Brain
The TRAIN Study: A Concussion Prevention Strategy in Middle Schools
Purpose: The purpose of this study is to evaluate the effectiveness of a theory-driven intervention (TRAIN concussion education) to improve parental concussion-related attitudes, beliefs, intentions, confidence in knowledge, and…
- Trial name
- NCT04841473
- Testing
- TRAIN Concussion Education, Standard Concussion Education
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Brain Injuries
Youth Soccer Header Study
This study aims to establish and validate age-based head kinematics, force-strain models and brain injury probability maps from sensor worn data during soccer heading tasks.
- Trial name
- NCT04919707
- Testing
- Header Session, MRI Session
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Chronic Traumatic Encephalopathy (CTE), Alzheimer Disease
The DIAGNOSE CTE Research Project-II
Each year, millions of people are exposed to repetitive head impacts (RHI) through contact sports. RHI can result in concussions and asymptomatic non-concussions to confer risk for Alzheimer's disease (AD) and related dementias…
- Conditions
- Chronic Traumatic Encephalopathy (CTE), Alzheimer Disease, Alzheimer Disease and Related Dementias (ADRD), Brain Injuries, Traumatic
- Trial name
- NCT06860828
- Where
- 5 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Boston University
Mild Traumatic Brain Injury
Multimodal Neuroimaging Analysis After Mild Traumatic Brain Injury
Mild Traumatic Brain Injury (mTBI), including concussion, is a real public health problem. Indeed mTBI might induce long-term brain disorders with increased risk of neurodegenerative diseases and the healthcare costs can be…
- Trial name
- CHANGE-TBI (NCT03342612)
- Testing
- Brain Magnetic Resonance Imaging (MRI)
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Low-level Blast Exposure
Blast Overpressure Longitudinal Study
The goal of this observational study is to learn about the impact of low-level blast exposure in U.S. Special Operations Forces personnel.
- Trial name
- BLES (NCT07606651)
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Traumatic Brain Injury
Repeatability Assessment of Neurovisual Tasks for the Construction of a New Concussion Monitoring Tool (SPORTICARE)
Traumatic brain injury (TBI) is a condition that occurs when a mechanical blow to the head causes damage to the brain. The diagnosis of this pathology requires the evaluation of several dimensions, including clinical symptoms…
- Trial name
- SPORTiCARE (NCT05992194)
- Testing
- multimodal oculomotor measurements
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Traumatic Brain Injury, Concussion
Enhancing Cognitive and Neurobehavioral Functions After Repetitive Traumatic Brain Injuries (rTBI) in Retired NFL Players and Military Veterans.
The purpose of this study is to compare different combinations of cognitive training in retired professional football players and military veterans with a history of repeated concussions and persistent symptoms of impaired…
- Conditions
- Traumatic Brain Injury, Concussion, Mild Cognitive Disorder
- Trial name
- NCT02699476
- Testing
- Psycho-Social Therapy, Cognitive Behavioral Computer Training, Interactive Trainer-Subject Sessions
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brain & Body Health Foundation
Concussion, Mild, Autonomic Nervous System
Acute Nerve Stimulation For Enhancing Human and Cognitive Performance
The goal of this clinical trial is to test a wearable device's effect on performance in tactical populations with a history of concussion.
- Conditions
- Concussion, Mild, Autonomic Nervous System, Cognitive
- Trial name
- NCT05675956
- Testing
- Experimental group with 100% intensity setting on Apollo Neuro device, Active Comparator group with 10% intensity setting on the Apollo Neuro device
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Brain Injuries, Brain Injuries, Traumatic
A Trial Evaluating Effects of COMT Inhibition in Patients With Acquired Brain Injury
This is a follow-up study for an ongoing open label trial conducted by the Sheppard Pratt-Lieber Research Institute utilizing the catechol-O-methyl-transferase (COMT) inhibitor Tolcapone to evaluate its effects on cognition and…
- Conditions
- Brain Injuries, Brain Injuries, Traumatic, Brain Injury, Chronic
- Trial name
- NCT03273062
- Testing
- Tolcapone 200 MG
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sheppard Pratt Health System
Traumatic Brain Injury
The RETINA Project: Reliable Eye Tracking in Neurocognitive Assessment of Traumatic Brain Injury
The purpose of this study is to develop and validate eye-tracking measures that can be used to evaluate neurocognitive dysfunction among individuals with traumatic brain injury (TBI).
- Trial name
- RETINA (NCT01552577)
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Acquired Brain Injury, Stroke
TMS-EEG for Cortical Excitability
This research study is being done to look at the safety and diagnostic benefit of conducting an TMS(transcranial magnetic stimulation)-EEG measured before and after a brief experimental stimulation session using investigational…
- Conditions
- Acquired Brain Injury, Stroke, Traumatic Brain Injury, Healthy
- Trial name
- NCT05472363
- Testing
- Electroencephalogram, Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mild Traumatic Brain Injury
High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for Sensory Deficits in Complex Traumatic Brain Injury
Aim 1: To use magnetoencephalography (MEG) and magnetic resonance imaging (MRI) in Veterans and civilians with mild traumatic brain injury (mTBI) and sensory postconcussive symptoms (PCS) to demonstrate the mechanism of…
- Trial name
- NAVIGATE-TBI (NCT03799458)
- Testing
- Active High-definition transcranial direct current stimulation (HD-tDCS)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Traumatic Brain Injury
Augmented Reality and Treadmill Training After Traumatic Brain Injury
Up to 40 participants will be enrolled in this study in order to obtain complete data on 30 participants. The investigators will be assessing if Augmented reality in combination with treadmill training is safe and feasible to use…
- Trial name
- NCT04553848
- Testing
- Augmented Reality, Treadmill training, Over ground training/standard of care
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Craig Hospital
Brain Concussion, Post-Concussion Syndrome
Investigating the Physiological, Cognitive, and Psychological Effects of a Cognitive-Based Intervention
The primary purpose of this study is to investigate the effectiveness of a brief mindfulness-based intervention for targeting chronic physiological underarousal and post-concussive symptoms following a mild head injury (MHI), as…
- Trial name
- IPCPE-Mind (NCT02906449)
- Testing
- Meditation Technique
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Brock University