Clinical trials: Traumatic Brain Damage
Traumatic Brain Injury, Controls
Traumatic Brain Injury Feasibility Study (EPIC-011)
The purpose of this research study is to evaluate whether data made by the ClearView System can be used to detect whether someone has a traumatic brain injury and how severe the injury is.
- Trial name
- TBI (NCT02471625)
- Testing
- ClearView Scanning
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Traumatic Brain Injury
Hemp-Derived Botanical Dietary Supplementation During Recovery From Brain Injury
The objective of the proposed research is to evaluate adult subjects currently taking phytocannabinoid Hemp-derived botanical supplements (HDS) during recovery from traumatic brain injury.
- Trial name
- NCT03826368
- Testing
- Hemp-derived botanical dietary supplement
- Volunteers
- healthy volunteers welcome
- Sponsor
- Real Time Diagnostics Ventures INC
Brain Injury
MIND (Management of Traumatic Brain Injury Diagnosis)
Procure blood specimens from individuals presenting to the emergency department with suspected brain injury.
- Trial name
- MIND (NCT02262286)
- Where
- Germany
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Abbott Diagnostics Division
TBI (Traumatic Brain Injury)
Evaluation of Decision-Making Fatigue After Traumatic Brain Injury
This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic brain injury as well as in healthy controls.
- Trial name
- EDIFY (NCT07103200)
- Testing
- COGED, Restless Bandit
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Brain Injury, Chronic, Brain Injuries, Traumatic
Traumatic Brain Injury and the Gut Microbiome
The purpose of the study is to determine whether administration of a prebiotic, inulin, can improve the symptom complex associated with traumatic brain injury and whether inulin administration can alter the bacteria that live in…
- Trial name
- NCT04949607
- Testing
- Inulin fructooligosaccharide
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Centre for Neuro Skills
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after…
- Conditions
- Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury, Mild Cognitive Impairment
- Trial name
- NCT04124029
- Testing
- No Intervention is used for this study but all subjects will be asked to complete electroencephalogram (EEG) testing and an MRI scan., No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure.
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments
While clinical assessment of locomotor function in this population is carried out using tasks involving walking in a straight line without any obstacles, it does not take into account ecological situations (i.e., situations…
- Trial name
- NAVIGO (NCT07230002)
- Testing
- Locomotion in a virtual reality setting
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pôle Saint Hélier
Concussion, Brain, Musculoskeletal Pain
The Impact of Eye and Body Training on the Injury Rate of Concussions in Female Soccer Players
The research project aims to find out how special training influences the frequency and severity of injuries among female footballers in the top Swiss league.
- Trial name
- NCT06473883
- Testing
- Training recommendation
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- BrainCare Medical Group
Concussion, Mild, Autonomic Nervous System
Acute Nerve Stimulation For Enhancing Human and Cognitive Performance
The goal of this clinical trial is to test a wearable device's effect on performance in tactical populations with a history of concussion.
- Conditions
- Concussion, Mild, Autonomic Nervous System, Cognitive
- Trial name
- NCT05675956
- Testing
- Experimental group with 100% intensity setting on Apollo Neuro device, Active Comparator group with 10% intensity setting on the Apollo Neuro device
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Traumatic Brain Injury, Intracranial Hemorrhages
Efficacy and Feasibility Trial of a Portable Near Infra-Red Hematoma Imager (NIRD-HI)
Traumatic Brain Injury (TBI) is a leading cause of death and disability among military personnel, Veterans, and civilians. One of the most dangerous complications of moderate-to-severe TBI is intracranial hemorrhage (ICH).
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Combat Casualty Care, Point of Care
- Trial name
- NIRD-HI (NCT07338383)
- Testing
- NIRD-HI scan at the time of enrollment, Secondary NIRD-HI scan when a planned repeat CT is performed
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Geneva Foundation
Intracranial Pressure
Wideband Tympanometry for Monitoring Intracranial Pressure in Adult Patients in Intensive Care, Operated on for an Intracranial Lesion After Traumatic Brain Injury, or With Intracranial Hemorrhage
Intracranial pressure is usually measured by invasive methods requiring an intracranial sensor. There is no non-invasive monitoring method recognized as a gold standard.
- Trial name
- TYMPIC (NCT04849221)
- Testing
- Tympanometry measurement in both ears, Collection of clinical and paraclinical data, Intracranial pressure reading (ICP)
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Sport-related Concussion
Sub-acute Exercise Following Sport-Related Concussion
Determine the safety and efficacy of sub-maximal aerobic exercise during the subacute phase of recovery following sport-related concussion.
- Trial name
- NCT03575455
- Testing
- Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Mild Traumatic Brain Injury, Balance; Distorted
Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?
Every year 1.7 million people sustain a traumatic brain injury (TBI) in the United States and of these, 84 % are considered mild TBI (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Balance; Distorted, Gait, Unsteady, Quality of Life
- Trial name
- NCT03479541
- Testing
- Timing of Rehabilitation, Biofeedback
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Treatment of Cognitive Deficits After Traumatic Brain Injury
Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury
Posttraumatic consequences are common causes of disability and long-term morbidity. They include cognitive dysfunction, seizures, headache, dizziness, fatigue, sensory deficits, neurodegeneration and psychiatric disorders (e.g.
- Trial name
- NCT06337994
- Testing
- Memantine Hydrochloride
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Traumatic Brain Injury, Depression
A Trial of Two On-Line Interventions for Child Brain Injury
The primary aims of this project are to examine the feasibility and relative efficacy of two models of on-line intervention for families of children with traumatic brain injury: one, a model emphasizing cognitive appraisals and…
- Conditions
- Traumatic Brain Injury, Depression, Anxiety Disorders
- Trial name
- NCT00178022
- Testing
- Case management and problem solving therapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Concussion, Brain
NFL LONG Prospective Study
The purpose of this 5-year prospective research study is to characterize the association between concussions, sub-concussive exposure, and long-term neurologic health outcomes in former NFL players.
- Trial name
- NCT04263337
- Testing
- [11C] PiB, [18F] PBR111, [18F] Flortaucipir
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Concussion, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
This is an open-label, non-randomized, prospective, multi-site, parallel group (segment), hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between…
- Trial name
- mTBI-phase2 (NCT02556177)
- Testing
- MRI
- Where
- 7 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Traumatic Brain Injury
Oculomotor Assessment of Traumatic Brain Injury (TBI)
The purpose of the proposed study is to compare the sensitivity and specificity of three oculomotor test devices in normal subjects versus subjects with history of TBI.
- Trial name
- NCT03156010
- Testing
- Neuro Kinetics IPAS, Oculogica EyeBox, SyncThink EyeSync Device
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Severe Traumatic Brain Injury
The Systemic Nature of Severe Traumatic Brain Injury
Severe traumatic brain injury (sTBI) is a devastating condition with no targeted therapies available to prevent secondary injury.
- Trial name
- MANTRA (NCT07679126)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Corewell Health West