Clinical trials: Traumatic Brain Injury (TBI)
Brain Injuries, Traumatic
CREACTIVE - Collaborative REsearch on ACute Traumatic Brain Injury in intensiVe Care Medicine in Europe
CREACTIVE is a large-scale observational cohort study concerning Traumatic Brain Injury (TBI) care in the ICU setting
- Trial name
- CREACTIVE (NCT02004080)
- Testing
- Intensive Care treatment
- Where
- 20 sites in Italy
- Volunteers
- 8,000 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
TBI, Attention Deficits
Galvanic Vestibular Stimulation and Motor Training in Traumatic Brain Injury Survivors
The overall goal of the proposed project is to perform a preliminary study to assess the potential effects of galvanic vestibular stimulation (GVS) on the outcomes of a cognitive test of attention and the outcomes of…
- Conditions
- TBI, Attention Deficits, Motor Impairments
- Trial name
- NCT01749800
- Testing
- GVS, Armeo Spring
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Spaulding Rehabilitation Hospital
Minor/Mild Traumatic Brain Injury
S100 Protein in Minor/Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is a Public Health problem, because of the numbers of events (more than 200,000 per year in France).
- Trial name
- S100 (NCT00822445)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Concussion, Mild
Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion
The goal of this pilot clinical trial is to assess the feasibility of administering a paced breathing exercise intervention program to children and adolescents in the sub-acute period after concussion, and to document the…
- Trial name
- Breathe (NCT06559865)
- Testing
- Breathing exercises
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Sport-related Concussion
Concussion Screen Use Recovery Time
A two-year parallel randomized clinical trial study to examine the effect of screen time (ST) restriction, exercise alone, and combined ST-restricted-exercise when compared to stretching only (control group) on sports related…
- Trial name
- NCT05373992
- Testing
- Screen Time Restriction (ST-Restricted), Aerobic Exercise (AE), Screen-time restricted plus aerobic exercise (STR+AE)
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Children's Health
Concussion, Mild, Diagnoses, Syndromes, and Conditions
Diagnosis of Sport-related Concussion Using Urine Metabolites
Millions of sport related concussions (SRC) occur yearly in the United States, and current diagnosis of concussion is based upon largely subjective clinical evaluations.
- Trial name
- NCT03653195
- Testing
- urine metabolomics
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Calgary
TBI (Traumatic Brain Injury)
Self-Advocacy for Independent Life (SAIL) After TBI
Traumatic brain injury (TBI) has been conceptualized as a chronic health condition, warranting self-advocacy for health management services across the lifespan.
- Trial name
- NCT03385824
- Testing
- Self-Advocacy for Independent Life (SAIL)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Craig Hospital
Traumatic Brain Injury, Trauma, Nervous System
Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury
The prevention of secondary brain injury is a primary goal in treating patients with severe traumatic brain injury (TBI). Secondary brain injury results from tissue ischemia induced by increased vascular resistance in the at-risk…
- Conditions
- Traumatic Brain Injury, Trauma, Nervous System, Reperfusion Injury, Ischemia, Brain
- Trial name
- NCT03176823
- Testing
- CellAegis Technologies autoRIC device, Best Practice Management of Traumatic Brain Injury
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Concussion
Care for Post-Concussive Symptoms
The proposed study is a pilot randomized trial of a stepped collaborative care intervention designed to decrease post-concussive symptoms and improve post-injury functioning among sports-injured youth aged 11-17.
- Trial name
- CARE4PCS (NCT02268240)
- Testing
- Stepped Care
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Seattle Children's Hospital
REM Sleep Behavior Disorder, Concussion, Brain
The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls
The goal of this observational study is to investigate concussions and contact sports practices in REM sleep behaviour disorder (RBD).
- Trial name
- COSP-RBD (NCT06270290)
- Testing
- Exposure to contact sports or history of concussions
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Brain Death
Organ Donation and Hydrocortisone Treatment
Brain death patients who are selected for organ donation very often suffer from haemodynamic instability. To treat this, high amounts of vasoactive drugs(norepinephrine) may be needed to raise blood pressure.
- Trial name
- HYDRO (NCT00675272)
- Testing
- hydrocortisone, sodium chloride
- Where
- 2 sites in Finland
- Volunteers
- 38 people
- Sponsor
- Kuopio University Hospital
Traumatic Brain Injury
Evidence Based Diagnostics and Treatment Planning Solution for Traumatic Brain Injuries
Adult patients, age ≥ 18 years, with clinically diagnosed mild, moderate or severe brain trauma will be asked to participate in the study.
- Trial name
- NCT02021877
- Where
- 2 sites in Finland, United Kingdom
- Volunteers
- 396 people
- Sponsor
- Turku University Hospital
Traumatic Brain Injury, Ketogenic Dieting
Ketogenic Diet for Traumatic Brain Injury
Traumatic Brain Injury is a major health concern in United States. There is a un-met need to develop new therapeutic options for faster neuron recovery without causing significant side effects.
- Trial name
- KETI (NCT03982602)
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Missouri-Columbia
Brain Injuries
A New Intervention for Social Communication Skills Following Brain Injury
To investigate the effectiveness of a peer-led social skills training intervention compared to social activity (usual care) to improve social communication skills following severe brain injury.
- Trial name
- NCT02211339
- Testing
- Peer facilitator training, Usual care
- Volunteers
- 12 people
- Sponsor
- University College, London
Traumatic Brain Injury
University of Pittsburgh Brain Health Initiative
This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical…
- Trial name
- BHI (NCT04708613)
- Testing
- Cognitive/Neuropsychological Testing, Vestibular/Ocular-Motor Testing, Sleep Evaluation
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- David Okonkwo, MD, PhD
Computed Tomography, Minor Head Injuries
Cerebral Computed Tomography on Patients With Minor Head Injuries
This observational study aims to calculate the prevalence of conditions or diseases requiring immediate medical attention in CTC scans with an indication of bleeding post trauma performed in the ED at Odense University Hospital.
- Trial name
- NCT06399913
- Where
- Denmark
- Volunteers
- 7,106 people
- Sponsor
- University of Southern Denmark
MTBI - Mild Traumatic Brain Injury
Retraining Neural Pathways Improves Cognitive Skills After A Mild Traumatic Brain Injury
The proposed study tests the efficacy (Phase II) of 36 or 54 30-minute training sessions of PATH neurotraining followed by digit memory exercises to improve working memory, processing speed and attention in mTBI patients rapidly…
- Trial name
- NCT03655782
- Testing
- PATH + DigitMemory (DM) neurotraining
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Perception Dynamics Institute
Traumatic Brain Injury
Role of Electrocardiogram Abnormalities in Prediction of Mortality in Patients With Isolated Traumatic Brain Injury
Most common causes of ECG changes, from surgical view, are extradural haemorrhage , intracerebral haemorrhage, intraventricular haemorrhage and subarachnoid haemorrhage.
- Trial name
- NCT06701279
- Volunteers
- 54 people
- Sponsor
- Assiut University
Brain Injury Traumatic Mild, Brain Injuries
Screening Emotions in Adolescents at the Hospital for mTBI
The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing…
- Conditions
- Brain Injury Traumatic Mild, Brain Injuries, Brain Injuries, Acute, Head Injury With Intracranial Hemorrhage
- Trial name
- SEARCH-mTBI (NCT06370520)
- Testing
- Validated Questionnaires, Questionnaires, Clinician / Medical Record Variables
- Where
- 6 sites in United States
- Volunteers
- 2,592 people
- Sponsor
- University of California, Davis
Brain Injuries
The Value of Multimodal MR Imaging in Cognitive Assessment of Patients With Moderate Traumatic Brain Injury
The goal of this observational study is to learn about in The value of multimodal MR Imaging in cognitive assessment of patients with moderate traumatic brain injury.
- Trial name
- NCT06099210
- Testing
- Glasgow coma scale
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
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