Clinical trials: Traumatic Brain Injury (TBI)
Mild Traumatic Brain Injury
Sub-symptom Threshold Aerobic Exercise After Mild Traumatic Brain Injury
This Randomized Controlled Trial (RCT) will explore the effect of sub-symptom threshold aerobic exercise on persistent post-concussion symptoms and exercise intolerance in patients with mild Traumatic Brain Injury (TBI).
- Trial name
- NCT05086419
- Testing
- Sub-symptom threshold aerobic exercise
- Where
- Norway
- Volunteers
- 105 people
- Sponsor
- Oslo University Hospital
Ischemic Stroke, Hemorrhagic Stroke
Stroke and Traumatic Acute Brain Injury Line Indicator System for Emergent Recognition (STABILISER-I)
In the search for a novel marker of stroke that could be rapidly assessed in blood, the investigators developed a point-of-care (POC) lateral flow device (LFD) that rapidly (< 15 min) detects levels of a biomarker that is…
- Conditions
- Ischemic Stroke, Hemorrhagic Stroke, Traumatic Brain Injury
- Trial name
- STABILISER-I (NCT02514902)
- Testing
- Lateral Flow Device
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Justin Fraser
Traumatic Brain Injury, Caregiver
The REACH Intervention for Caregivers of Veterans and Service Members With TBI
This randomized waitlist control trial will evaluate the effects of a psychoeducational intervention called Resources for Enhancing All Caregivers' Health - Traumatic Brain Injury (REACH TBI) to decrease caregiver strain (primary…
- Trial name
- REACH TBI (NCT06111794)
- Testing
- REACH TBI
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Virginia
Traumatic Brain Injury
Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values
The purpose of this study is to determine whether hypertonic saline is as much effective as mannitol to treat intracranial hypertension after traumatic brain injury and has at least the same effects on PtiO2 and cerebral…
- Trial name
- NCT01028339
- Testing
- Hypertonic saline, Mannitol
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Traumatic Brain Injury
S-100B as Pre-Head CT Scan Screening Test After Mild Traumatic Brain Injury
The purpose of the study is to determine if a specific blood protein, S-100B, can help predict who will have a traumatic abnormality on head CT scan after a concussion.
- Trial name
- NCT00717301
- Where
- 6 sites in United States
- Volunteers
- 1,252 people
- Sponsor
- University of Rochester
Traumatic Brain Injury
Functional Near-Infrared Spectroscopy (fNIRS) Assessing Neural Activity During Virtual Reality Walking Intervention
The purpose of this study is to evaluate the safety and feasibility of using a portable neuroimaging device called functional near-infrared spectroscopy (fNIRS) to successfully analyze fNIRS data in individuals with chronic TBI…
- Trial name
- fNIRS (NCT06276894)
- Testing
- Motek C-Mill™ treadmill, training session with and without VR wearing the fNIRS cap
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Craig Hospital
Severe Traumatic Brain Injury, Intracranial Hypertension
Ketamine for Sedation in Severe Traumatic Brain Injury
This protocol is for an open-label randomized trial evaluating the safety of using ketamine in combination with propofol for sedation versus the standard of care analgosedation in patients admitted to the intensive care unit with…
- Conditions
- Severe Traumatic Brain Injury, Intracranial Hypertension, Intracranial Hemorrhage, Hypertensive
- Trial name
- Ketamine (NCT06429657)
- Testing
- Ketamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Traumatic Brain Injury
Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury
The purpose of this study is to examine the efficacy of sertraline to prevent the onset of mood and anxiety disorders during the first six months after traumatic brain injury.
- Trial name
- NCT00704379
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Baylor College of Medicine
Minor Traumatic Brain Injury, Treatment by Antiplatelet
Interest of S100B Protein for Patient Victim of Minor Traumatic Brain Injury and Treated by Antiplatelet
All the patients admitted in emergency department for minor traumatized cranial, with antiplatelet therapy, can be included, after checked inclusion and non inclusions criterias.
- Trial name
- PETEChIA (NCT03780062)
- Testing
- S100B protein dosing
- Where
- 4 sites in France
- Volunteers
- 720 people
- Sponsor
- Poitiers University Hospital
Concussion Mild
Yoga and Female Concussion
Most research on the impact of mild Traumatic Brain Injury/Concussions have been deficit-based and focused on the impairments induced by the injury. Research shows that trauma doesn't always have negative effects.
- Trial name
- NCT07170488
- Testing
- Yoga, Yoga for wait list control
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Pittsburgh
Iatrogenic Withdrawal Symptomes
Iatrogenic Withdrawal Symptoms in Severe Traumatic Brain Injury
Iatrogenic withdrawal symptomes has been associated with prolonged mechanical ventilation and the and the derived symptoms such as fever and agitation has been shown to cause significantly prolonged ICU and hospital length of…
- Trial name
- NCT04320927
- Where
- Denmark
- Volunteers
- 215 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Platelet Dysfunction, Traumatic Brain Injury
Correcting Platelet Dysfunction After Traumatic Brain Injury
This study evaluates the impact of platelet transfusion on geriatric patients with platelet dysfunction from Traumatic Brain Injury.
- Trial name
- NCT03182946
- Testing
- Platelet mapping Thromboelastography
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Spinal Cord Injury/Disorder, Stroke
Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis
The purpose of this research study is to evaluate the effectiveness of an exercise training intervention (24-36 sessions) to improve muscle strength and endurance in the lower limbs of individuals with paralysis.
- Conditions
- Spinal Cord Injury/Disorder, Stroke, Multiple Sclerosis, Traumatic Brain Injury
- Trial name
- NCT07768761
- Testing
- Exercise with Electrical Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Louis Stokes VA Medical Center
Traumatic Brain Injury
Myocardial Dysfunction at Early Phase of Traumatic Brain Injury : Evaluation by Two Dimensional and Speckle Tracking Transthoracic Echocardiography
Traumatic brain injury (TBI) is a frequent pathology leading to major morbidity and mortality in young people. Cerebral flood flow maintenance is a major goal directed therapy to improve the prognosis of the patient.
- Trial name
- Echo-TC (NCT02380482)
- Testing
- Transthoracic echocardiography on TBI patients, Transthoracic echocardiography on control patients
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Brain Trauma
Magnetic Resonance (MR) Spectroscopy and Diffusion Tensor Imaging in Determining Brain Injury and Subsequent Clinical Outcome in Patients of Moderate Brain Trauma
The purpose of this study is to use magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) to assess for traumatic brain injury and determine if there is any correlation of these findings to clinical outcome.
- Trial name
- NCT00760903
- Testing
- Conventional MRI of the brain, MR spectroscopy (MRS), MR Diffusion Tensor Imaging (DTI)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Stroke, Traumatic Brain Injury
Gait Adaptation for Stroke Patients With Augmented Reality
The GASPAR trial is a pragmatic, parallel-arms, single-center, non-blinded, superiority randomized control trial in neurorehabilitation.
- Conditions
- Stroke, Traumatic Brain Injury, Spinal Cord Injury
- Trial name
- GASPAR (NCT02808078)
- Testing
- Gait training with augmented reality, Standard training
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Philippe Terrier
Concussion, Brain, Mild Traumatic Brain Injury
REhabilitation of MEMory Symptoms After BRain Concussion
Persistent memory symptoms after concussion are common, and likely perpetuated by unhelpful illness beliefs and coping behaviors.
- Trial name
- REMEMBR (NCT06956417)
- Testing
- Cognitive behavioral therapy, Cognitive rehabilitation
- Where
- 8 sites in Canada
- Volunteers
- 184 people
- Sponsor
- University of British Columbia
Trauma, Brain
The Role of Hypoxia on Subconcussive Head Impacts
The purpose of this study is to examine the combined effects of hypoxia and a short bout of subconcussive head impacts on neurocognitive and ocular-motor function and plasma expression of brain-derived blood biomarkers.
- Trial name
- NCT04624152
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indiana University
ICH - Intracerebral Hemorrhage, IVH- Intraventricular Hemorrhage
Placing External Ventricular Drains Using Assistive Augmented Reality or Image-Based Localization
The goal of this clinical trial is to assess if EVD placement using augmented reality is non inferior to image-guidance systems for assistance in adult patients needing an EVD for spontaneous ICH with IVH or severe TBI.
- Conditions
- ICH - Intracerebral Hemorrhage, IVH- Intraventricular Hemorrhage, TBI Traumatic Brain Injury
- Trial name
- PEARL (NCT07042048)
- Testing
- EVD placement - image-guidance assisted, EVD placement - AR assisted
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cooper Health System
Stroke, Acute, Traumatic Brain Injury
Natural Evolution of Muscle Structure and Stiffness Following Brain Lesion
We propose to carry out a single center, prospective, interventional trial to assess the natural evolution of lower limb muscle structure and muscle stiffness of hemiparetic patients following brain damage.
- Trial name
- Navomuss (NCT06718608)
- Testing
- imaging
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
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