Clinical trials: Traumatic Brain Injury (TBI)
Traumatic Brain Injury, Post-Traumatic Stress Disorder
Multimodal Neurodiagnostic Imaging of Traumatic Brain Injury and Post-Traumatic Stress Disorder
The purpose of this study is to determine whether the brains of persons with and without traumatic brain injury differ in a meaningful way when advanced technology images of the brain are taken using three newer technologies that…
- Trial name
- SANIC (NCT01075035)
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Traumatic Brain Injury, Post-concussive Headaches
Strength and Awareness in Action: an Intervention for Post-Acute TBI Headaches (SAA-TBI)
The specific aims of the proposed study are to evaluate: 1) the feasibility of design elements of a Strength and Awareness in Action: an Intervention for Post-Acute TBI Headaches (SAA-TBI) intervention trial (e.g., an exercise…
- Trial name
- SAA-TBI (NCT03277859)
- Testing
- SAA-TBI
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- VA Eastern Colorado Health Care System
Traumatic Brain Injury
The Effect of Single Dose D-Cycloserine on Cognitive Outcome in Moderate Traumatic Brain Injury (TBI) Patients
In this study of patients with moderate traumatic brain injury with frontal brain contusions patients will be randomized to treatment with a single dose of either D-cycloserine or placebo given 48-72 hours after injury.
- Trial name
- DCS (NCT01343862)
- Testing
- D-cycloserine
- Where
- 3 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Complete Hemianopia, Incomplete Hemianopia
Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic Lesions
Visual field areas, which are not absolutely blind, are hypothesized to have some residual capacities that constitute their potential for vision restoration.
- Conditions
- Complete Hemianopia, Incomplete Hemianopia, Scotoma, Quadrantanopia
- Trial name
- NCT01418820
- Testing
- Verum stimulation
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University of Magdeburg
Spinal Cord Injury, Hyperalgesia, Secondary
MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI
The goal of this study is to compare the changes that occur in sensation and chemical properties of the brain following SCI between individuals that experience chronic pain and those that do not, and between those with SCI and…
- Conditions
- Spinal Cord Injury, Hyperalgesia, Secondary, Hyperalgesic Sensations
- Trial name
- MRS (NCT00561782)
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Acquired Brain Injury, Depression
MAPLES Pilot Study for Low Mood in ABI
Low mood and depression are common following acquired brain injury (ABI). There is a lack evidence on effective treatments in ABI. Behavioural Activation (BA) is a potentially valuable option.
- Trial name
- MAPLES (NCT03874650)
- Testing
- Activity Planning Group, Activity Engagement Group, Waitlist Group
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Cambridge
TBI, Insomnia
Cognitive Behavior Therapy for Insomnia (CBT-I) in Persons With Traumatic Brain Injury (TBI)
The current study seeks to evaluate cognitive behavior therapy for insomnia (CBT-I), a non-medication treatment, in recent TBI patients compared to a sleep education control intervention.
- Trial name
- NCT02709980
- Testing
- Sleep Education, Cognitive Behavior Therapy for Insomnia
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Johns Hopkins University
Traumatic Brain Injury
Ocular Ultrasonography as a Tool for Monitoring the Management of Traumatic Brain Injury
Raised intracranial pressure (ICP) is a common and life threatening condition especially in patients with traumatic brain injury.There are many methods for monitoring the increased (ICP) either invasive or non- invasive ,but the…
- Trial name
- NCT03795896
- Testing
- Optic nerve sheath diameter
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University Hospital
Concussion, Brain
The Role of Osteopathic Manipulative Medicine in Recovery From Concussions
This project aims to study whether adding osteopathic manipulative treatment (OMT) to usual care of concussed patients will enhance their recovery.
- Trial name
- NCT04932278
- Testing
- Osteopathic manipulative treatment, Usual care
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Michigan State University
Traumatic Brain Injury, Vision Difficulty
Neuroimaging and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury
Mild TBI subjects will initially be identified by providers in the Hennepin County Medical Center (HCMC) TBI Clinic. The subjects will then undergo objective testing by the developmental optometrist to confirm if they do or do…
- Trial name
- NCT02771106
- Testing
- neuro vision rehabilitation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Hennepin Healthcare Research Institute
Head Trauma
Ketamine and Glutamate After Brain Injury : a Microdialysis Study
The objective of the study is to compare the effects of 48 hours ketamine infusion versus sufentanil infusion on brain glutamate concentrations measured with microdialysis after traumatic brain injury.
- Trial name
- KETABRAIN (NCT02232347)
- Testing
- Ketamine, Sufentanil
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Pierre-Julien CUNGI
Mild Traumatic Brain Injury, Concussion
Advancement of Vestibular Intervention Via Portable Electrical Stimulator (VIPES)
The goal is to assess the potential benefit of stochastic galvanic vestibular stimulation (sGVS) in improving patient performance with respect to balance, gait, and/or overall vestibular function for individuals with known…
- Trial name
- NCT07466589
- Testing
- Stochastic Galvanic Vestibular Stimulation (sGVS)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Vivonics, Inc.
Cerebral Palsy Children, Children With Traumatic Brain Injury
Cerebrolysin Neural Repair Therapy in Children With Traumatic Brain Injury and Cerebral Palsy
Cerebral palsy (CP) is the most frequent cause of motor handicap among children. The economic burden of CP in USA includes $1.18 billion in direct medical costs, $1.05 billion in direct non-medical costs, and an additional $9.24…
- Conditions
- Cerebral Palsy Children, Children With Traumatic Brain Injury, Mental Handicap, Delayed Speech Development
- Trial name
- NCT02116348
- Testing
- Cerebrolysin (Nerve growth factor)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Brain Injuries, Traumatic
Nutritional and Metabolic Biomarkers in Prediction of Outcomes After Traumatic Brain Injury: a Patient Cohort Study
To identify nutritional and metabolic biomarkers that are related to the prognosis of traumatic brain injury patients, and to develop a prognosis prediction model using biomarkers Study Objectives: 1.
- Trial name
- PATOSTBI (NCT04718935)
- Where
- South Korea
- Volunteers
- 1,200 people
- Sponsor
- Seoul National University Hospital
Magnesium Sulphate, Traumatic Brain Injury
Mgso4 as Neuroprotective in Post Traumatic Brain Injury
The aim of this study is to assess the potential role of magnesium sulphate (MgSo4) as a neuroprotective agent using the Glasgow outcome scale following moderate and severe traumatic brain injury.
- Conditions
- Magnesium Sulphate, Traumatic Brain Injury, Brain, Injury
- Trial name
- NCT04646876
- Testing
- Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Osama Mohamed Abdelwahab
Traumatic Brain Injury
Beyond One Option for the Treatment of Severe Traumatic Brain Injury
Severe traumatic brain injury (sTBI) is a public health issue with great disparity among low- and middle-income countries where the implementation of evidence-based guidelines is challenging because resources are often…
- Trial name
- BOOTStraP (NCT06787040)
- Testing
- Resource-Stratified Protocol
- Where
- 3 sites in Colombia
- Volunteers
- 96 people
- Sponsor
- Meditech Foundation
Brain Injuries, Traumatic
HITT Device Pilot Testing for Traumatic Brain Injury
The purpose of this research study is to collect data from the eyes of traumatic brain injury (TBI) patients. Patients will look at a green target that will measure the fixation of the eye for 30 seconds.
- Trial name
- NCT03249818
- Testing
- HITT device
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Rebiscan, Inc.
Head Injury, Sport Injury
Dynamic Vision Testing and Concussion Management Dream Team 65
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol.
- Conditions
- Head Injury, Sport Injury, Concussion, Brain
- Trial name
- NCT05326555
- Testing
- Dynamic Vision Testing (Bertec Vision Advantage System) and Balance Error Scoring System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Pediatric ALL, Concussion, Mild
Concussion Active Rehabilitation
In this study, the investigator plans a randomized trial of active rehabilitation and standard care for acute concussion management.
- Conditions
- Pediatric ALL, Concussion, Mild, Concussion, Brain, Concussion, Intermediate
- Trial name
- NCT04248218
- Testing
- Active Rehabilitation Group/Case
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Traumatic Brain Injury, Subarachnoid Hemorrhage
Optimal Brain Oxygenation in Neurologic Intensive Care Unit : The NeurO2 Study
The NeurO2 study is a multicenter observational study looking at NIRS monitoring in neurocrocritically ill patients during the acute phase of care following an acute brain injury.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Brain Injuries, Near-Infrared Spectroscopy
- Trial name
- NeurO2 (NCT04935866)
- Testing
- Near-infrared spectroscopy (NIRS)
- Where
- 2 sites in Canada
- Volunteers
- 286 people
- Sponsor
- CHU de Quebec-Universite Laval
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