Clinical trials: Traumatic Brain Injury (TBI)
Traumatic Brain Injury
CONcussion Treatment After Combat Trauma (CONTACT)
This study compares the effects of Individualized Scheduled Telephone Support (ISTS) and Usual Care (UC) for service members with Mild Traumatic Brain Injury (mTBI). A total of 400 service members will participate in this study.
- Trial name
- CONTACT (NCT01387490)
- Testing
- Individualized Scheduled Telephone Support (ISTS), Usual Care (UC)
- Where
- 4 sites in United States
- Volunteers
- 366 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Craniocerebral Trauma
Microwave Imaging in NeuroTrauma
The study aims to investigate whether microwave-based technology can be used as a bedside decision-making aid to identify patients who may have a bleed in their head.
- Trial name
- MINT (NCT05960279)
- Testing
- MD100
- Where
- 2 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- King's College Hospital NHS Trust
Traumatic Brain Injury
VR-based EF Rehabilitation for Pediatric TBI
Childhood traumatic brain injury (TBI) poses significant impairment in children's executive functions (EFs) for moderate to severe injuries, yet interventions specifically designed for children's EF rehabilitation post-TBI and…
- Trial name
- NCT03611062
- Testing
- VR Executive Functions Training
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Massachusetts, Lowell
Concussion, Brain
Comparing and Interactive Concussion Education Platform to Current Education Standards
Purpose: The purpose of this study is to evaluate the effectiveness of a theory- driven education platform to improve concussion-related norms and perceptions in an effort to improve student-athletes concussion-related…
- Trial name
- NCT04122274
- Testing
- NCAA education sheet, Decision-based interactive concussive education platform
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Brain Disease, Brain Mapping
PET Imaging in Chronic Traumatic Encephalopathy
Background: Chronic traumatic encephalopathy (CTE) is a brain disease caused in part by head injury. The brain changes from CTE can only be seen at autopsy.
- Trial name
- NCT02211820
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Dementia, Mixed, Dementia of Alzheimer Type
REACH Hope Intervention for Dementia and TBI Caregivers
This three-year randomized clinical trial will evaluate a behavioral intervention for caregivers of Veterans with traumatic brain injury (TBI) and Alzheimer's dementia or mixed Dementia (AD/MD) to reduce caregiver depression…
- Conditions
- Dementia, Mixed, Dementia of Alzheimer Type, TBI (Traumatic Brain Injury)
- Trial name
- REACH Hope (NCT04969796)
- Testing
- REACH Hope
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Memphis VA Medical Center
TBI (Traumatic Brain Injury)
Sedation of Ventilated Traumatic Brain Injury Patients With Midazolam Alone Versus Combination With Dexmedetomidine or Magnesium Sulfate; Monitored by Ultrasonograghic Optic Nerve Sheath Diameter
In TBI, there is a strong correlation between increased ICP and bad outcome. So, appropriate monitoring can be the gold standard in management of TBI. ICP can be measured by invasive and noninvasive methds.
- Trial name
- NCT05340803
- Testing
- Ultrasonograghic optic nerve sheath diameter US-ONSD, midazolam, dexmedetomidine
- Volunteers
- 108 people
- Sponsor
- Assiut University
Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic
Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients
This is a prospective observational cohort study of adult patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic, Cerebral Hemorrhage, Ischemic Stroke
- Trial name
- NCT07577713
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD)
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program.
- Conditions
- Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder)
- Trial name
- GEN-HOPE (NCT07493096)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Healing Hope International
Traumatic Brain Injury (TBI), Subarachnoid Hemorrhage (SAH)
Non-invasive Brain Pressure Monitoring After Trauma or Hemorrhage
Introduction: Increased intracranial pressure (ICP) is considered to be the most important intracranial mechanism causing secondary injury in patients admitted after acute traumatic brain injury (TBI) and intracranial haemorrhage…
- Trial name
- NCT02172703
- Testing
- Non-invasive ICP measurement device
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- Javier Fandino, MD
Multiple Sclerosis, Traumatic Brain Injury
Remediation of Emotional Deficits in Multiple Sclerosis and Traumatic Brain Injury
This study will examine the efficacy of a clinical intervention for improving emotional processing in individuals with MS and TBI.(1)The main outcome measure will be changes in emotional processing measures from pre to post…
- Trial name
- NCT04408274
- Testing
- Emotional Processing Training
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury, Coma
Optimized Therapy in Severe Traumatic Brain Injured Patients
Severe traumatic brain injury is associated with life-threatening and incapacitating secondary injury. Contemporary therapeutic interventions are aimed at preventing and treating secondary damage.
- Trial name
- NCT02130674
- Testing
- Dipeptiven
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Mild Traumatic Brain Injury, Intracranial Lesions
TES HT100 Clinical Validation for Brain Injury Screening in Patients With Mild Head Trauma or Neurological Symptoms
The goal of this clinical study is to evaluate how accurately and safely the TES HT100 device can identify intracranial abnormalities in adult emergency department patients with mild head trauma or neurological symptoms that are…
- Conditions
- Mild Traumatic Brain Injury, Intracranial Lesions, Neurological Symptoms Not Related to Head Trauma
- Trial name
- TESCO (NCT07490418)
- Testing
- Temnographic Brain Screening Examination
- Where
- 3 sites in Italy, Poland
- Volunteers
- 850 people
- Sponsor
- B&B srl
Traumatic Brain Injury, Post-traumatic Stress Disorder
Hyperbaric Oxygen Therapy in Chronic Traumatic Brain Injury or Post-Traumatic Stress Disorder
This is an observational research study whose purposes are to see: 1. if 40 Hyperbaric Oxygen Therapy sessions at 1.5 atmospheres (HBOT 1.5) or more (60, or 80 HBOT's) help, worsen, or have no effect on subjects with chronic…
- Trial name
- NBIRR-1 (NCT01105962)
- Where
- 10 sites in United States
- Volunteers
- 133 people
- Sponsor
- International Hyperbaric Medical Foundation
Mild Traumatic Brain Injury, Brain Concussion
Testing mTBI in Athletes
This study will assess the effectiveness of a portable goggle system in the diagnosis of mild traumatic brain injury (mTBI) in athletes.
- Trial name
- NCT02486003
- Where
- United States
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- University of Miami
Traumatic Brain Injuries
Impact of Dexmedetomidine Versus Propofol on Intracranial Pressure in Adult Traumatic Brain Injury Patients: Randomized Controlled Double-Blind Trial
To investigate whether dexmedetomidine or propofol is more effective in controlling intracranial pressure (ICP) (assessed via optic nerve sheath diameter "ONSD" as a primary outcome) and which is more effective in suppressing…
- Trial name
- NCT07807579
- Testing
- Propofol, Dexmedetomidine
- Volunteers
- 80 people
- Sponsor
- Assiut University
Concussion
Smart Phone Application for Postconcussion Symptom Reduction
The proposed study will address a very important issue for the VA both currently and in the future -- the high percentage of OIF/OEF/OND Veterans who have been medically diagnosed with a mild traumatic brain injury (mild TBI) and…
- Trial name
- NCT02501642
- Testing
- Concussion Coach, Treatment as usual
- Where
- 2 sites in United States
- Volunteers
- 479 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Memory Deficits
Multicenter Evaluation of Memory Remediation After TBI With Donepezil
This is a four-site, randomized, parallel design, double-blind, placebo-controlled, 10-week trial of donepezil 10 mg daily for verbal memory problems among adults with TBI in the subacute or chronic recovery period.
- Trial name
- MEMRI-TBI-D (NCT02255799)
- Testing
- Donepezil
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- Baylor College of Medicine
Physiological Post-Concussion Disorder, Post-Concussion Syndrome
Sub-maximal Exercise Prescription in Adolescents With Physiological Post-concussion Disorder
Although the vast majority of individuals sustaining a sport-related concussion (SRC) will receive medical clearance to return to sport within 7-10 days, approximately 30% of children and adolescents reporting to the emergency…
- Conditions
- Physiological Post-Concussion Disorder, Post-Concussion Syndrome, Traumatic Brain Injury, Rehabilitation
- Trial name
- NCT03367507
- Testing
- Sub-symptom aerobic exercise
- Where
- 2 sites in Canada
- Volunteers
- 136 people
- Sponsor
- Sport Injury Prevention Research Centre
Traumatic Brain Injury
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for TBI
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of traumatic brain injury
- Trial name
- NCT05018832
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- Antigua and Barbuda
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
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