Clinical trials: Traumatic Coma
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Brain Injuries, Disorders of Consciousness
Erigo®Pro Coma Outcome Study - Study on the Effectiveness of a Robotic Tilt Table Device for Recovery of Consciousness
Patients with acquired brain injury (ABI) often suffer from severe disorders of consciousness (DOC), such as coma, unresponsive wakefulness syndrome (UWS), or minimally conscious state (MCS).
- Trial name
- EriCOS (NCT02639481)
- Testing
- Standard physiotherapy, Erigo®Pro group without FES, Erigo®Pro group with FES
- Where
- 2 sites in Germany
- Volunteers
- 47 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Disorder of Consciousness, Traumatic Brain Injury
Validity and Feasibility of the CRSR-FAST
The CRS-R is a standardized and validated bedside assessment of conscious awareness. It is used routinely for diagnosis and prognosis of patients with disorders of consciousness (DOC) as well as in research settings.
- Trial name
- CRSR-FAST (NCT03549572)
- Testing
- Coma Recovery Scale-Revised
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury
Sodium Lactate in Severe TBI
This is a safety phase 2 clinical trial of intravenous infusion of sodium lactate in patients with severe TBI. This study is intended for patients in the acute setting in an intensive care unit at centers that have been selected…
- Trial name
- NCT06701760
- Testing
- Sodium Lactate
- Volunteers
- 264 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Coma
The Efficacy of Familiar Voice Stimulation During Coma Recovery
The purpose of the study is to determine whether familiar vocal stimulation, provided during coma recovery, improves outcomes for persons who are unconscious after severe TBI.
- Conditions
- Traumatic Brain Injury, Coma, Vegetative State, Minimally Conscious State
- Trial name
- FAST (NCT00557076)
- Testing
- Familiar Auditory Sensory Training
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Coma, Traumatic Brain Injury
Continuous Quantified EEG in NeuroIntensive Care
To evaluate the ability of NICU (NeuroIntensive Care Unit) staff to interpret, before and after a training period, symmetry, sedation level, seizures activities and artefact on continuous cEEG/qEEG (continuous…
- Conditions
- Coma, Traumatic Brain Injury, Subarachnoid Hemorrhage, Ischemic Stroke
- Trial name
- CrazyEEG (NCT02901262)
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Ultrasound Stimulation for Patients in a Disorder of Consciousness
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- tFUS (NCT06939348)
- Testing
- The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Postoperative Intracranial Hematoma, Postoperative Intracranial Haemorrhage
A New Approach in Intensive Care Unit Consciousness Assessment: FIVE Score
1. The primary aim of this study is to investigate the correlation between the length of ICU stay and a newly developed FIVE score in neuro-intensive care patients. 2.
- Conditions
- Postoperative Intracranial Hematoma, Postoperative Intracranial Haemorrhage, Supratentorial Cancer, Infratentorial Neoplasms
- Trial name
- NCT06036732
- Where
- Turkey (Türkiye)
- Volunteers
- 223 people
- Sponsor
- Istanbul University - Cerrahpasa
Brain-injury, Stroke
Mechanical Ventilation in Brain-injured Patients
Protective ventilation (association of a tidal volume < 8 ml/kg with a positive end expiratory pressure) is poorly used in severe brain-injured patients.
- Conditions
- Brain-injury, Stroke, Subarachnoid Haemorrhage, Traumatic Brain Injury
- Trial name
- BI-VILI (NCT01885507)
- Testing
- Pass recommendations on ventilation factors and extubation
- Where
- 22 sites in France
- Volunteers
- 560 people
- Sponsor
- Nantes University Hospital
Traumatic Brain Injury
Music Therapy for Comatose Brain Injured Patients
The goal of this single-arm observational study is to determine whether alpha music therapy, initiated early in the recovery period, can improve cognitive function for severe traumatic brain injury patients when compared to…
- Trial name
- NCT07544602
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Mercy Health Ohio
Impaired Consciousness
FOUR Score in Children With Non-traumatic Impairment of Consciousness
Hypothesis: FOUR score is a better predictor of outcome (in hospital mortality and functional outcome at discharge) than GCS in children 5- 18 years age admitted in pediatric ward/ ICU with non-traumatic impaired consciousness.
- Trial name
- NCT01537913
- Volunteers
- 70 people
- Sponsor
- All India Institute of Medical Sciences
Trauma
The Predictive Performance of Glasgow Coma Scale in Relation to Time
The study aims to assess whether time between injury and first Glasgow Coma Scale measurement will affect its predictive value.
- Trial name
- NCT03450525
- Testing
- No intervention
- Where
- 4 sites in India
- Volunteers
- 16,000 people
- Sponsor
- Karolinska Institutet
Neurocritical Care, Traumatic Brain Injury
Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care
Enhanced recovery after surgery (ERAS) is a strategy of perioperative management aimed to accelerate the rehabilitation of patients through various optimized perioperative managements as well as ongoing adherence to a…
- Conditions
- Neurocritical Care, Traumatic Brain Injury, Cerebrovascular Disease, Moderate or Severe Coma
- Trial name
- NCT06241482
- Testing
- Enhanced recovery after surgery, Conventional therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai 6th People's Hospital
Traumatic Brain Injury
Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State
A randomised control trial of patients who have a severe brain injury to determine if patients who receive a standardised sensory stimulation program emerge earlier from a vegetative state.
- Trial name
- NCT00163878
- Testing
- Sensory Stimulation, Sesnory Modality Assessment and Rehabilitation Technique
- Where
- 2 sites in Australia
- Sponsor
- Bayside Health
Traumatic Brain Injury
Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension
Objective: to assess the effectiveness of pentobarbital and thiopental to control raised intracranial pressure (ICP), refractory to first level measures, in patients with severe traumatic brain injury.
- Trial name
- NCT00622570
- Testing
- Pentobarbital, thiopental
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Universitari Son Dureta
Subarachnoid Hemorrhage, Aneurysmal
Predicting 28-Day Mortality in Subarachnoid Hemorrhage
The investigators investigated the predictive ability of clinical and radiological scores, including the Glasgow coma scale (GCS), Hunt-Hess, World Federation of Neurological Surgeons (WFNS), and modified Fisher scales, as well…
- Trial name
- SAHstdy (NCT06563219)
- Testing
- Glasgow coma scale, Hunt-Hess scale, World Federation of Neurological Surgeons (WFNS) scale
- Where
- Turkey (Türkiye)
- Volunteers
- 451 people
- Sponsor
- Haseki Training and Research Hospital
Brain Injury, Acute
Non-Invasive Monitoring Methods in Patients With Acute Brain Injury
Life-threatening mass effect (LTME) arises when brain swelling displaces or compresses crucial midline structures subsequent to acute brain injuries (ABIs) like traumatic brain injury (TBI), ischemic stroke (IS), and…
- Trial name
- NIMABI (NCT06504238)
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- Boston Medical Center
Traumatic Brain Injury, Coma
Optimized Therapy in Severe Traumatic Brain Injured Patients
Severe traumatic brain injury is associated with life-threatening and incapacitating secondary injury. Contemporary therapeutic interventions are aimed at preventing and treating secondary damage.
- Trial name
- NCT02130674
- Testing
- Dipeptiven
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Brain Injuries, Traumatic
Assignment of the Verbal Component Score and Addition of Pupil Reaction to the Glasgow Coma Scale
In this study, it is aimed to determine the prognostic value of GCS-P and the GCS-P score, which is formed by assigning a verbal score, in patients with traumatic brain injury, where all parameters can be evaluated.
- Trial name
- NCT05767502
- Testing
- GCS-Pupil score
- Where
- Turkey (Türkiye)
- Volunteers
- 199 people
- Sponsor
- Uludag University
Brain Death
Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury
This is the proof of concept study with multi-modality approach (using intra-thecal bioactive peptides, stem cells, laser and transcranial IV laser and Median Nerve stimulation as adjuvants) in cases of brain death due to…
- Trial name
- NCT02742857
- Testing
- BQ-A Peptide Extract, Mesenchymal Stem Cells, Transcranial Laser Therapy
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bioquark Inc.