Clinical trials: Traumatic Coma, active
Acute Brain Injury Coma, Neurocritical Care
Development and Validation of a Prognostic Model for Neurocritical Patients Using Multimodal Brain Monitoring
This study aims to develop and validate a prognostic model for neurocritical patients using multimodal brain monitoring data. By combining data from various monitoring techniques such as EEG, TCD, and NIRS, this model will help…
- Conditions
- Acute Brain Injury Coma, Neurocritical Care, Cerebral Infarction, Intracranial Hemorrhages
- Trial name
- NCT07115459
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Traumatic Brain Injury, Intracerebral Haemorrhage
The EBC Recovery Study
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up…
- Conditions
- Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
- Trial name
- NCT04712591
- Testing
- Auditory stimuli
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Traumatic Brain Injury, Severe Traumatic Brain Injury
Vagus Nerve Stimulation in Patients in Comatose State
Some patients with severe traumatic brain injury cannot respond at the bedside, yet about 1 in 4 may be aware but unable to show it - a hidden state called cognitive motor dissociation.
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Disorders of Consciousness Due to Severe Brain Injury, Coma, Traumatic
- Trial name
- NCT07719595
- Testing
- Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sima Mofakham
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Promoting Recovery After Brain Injury Using Focused Ultrasound
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- ReBOUND (NCT07277309)
- Testing
- Low-intensity focused ultrasound
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Coma, Disorders of Consciousness
Recovery Trajectory for Coma and Disorders of Consciousness
This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest…
- Conditions
- Coma, Disorders of Consciousness, Cardiac Arrest (CA), Traumatic Brain Injuries
- Trial name
- Coma Cohort (NCT07614074)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Francisco
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Ultrasound Stimulation for Patients in a Disorder of Consciousness
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- tFUS (NCT06939348)
- Testing
- The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Coma, Traumatic
Dopaminergic Disruption Induced by Traumatic Coma: Dopaminergic Pathways Abnormalities and Biomarkers of Recovery Using MRI and 18F-LBT-999 PET
The neural correlates of consciousness have been studied at the macroscopic level. However, the neurochemical basis of these processes remains poorly understood.
- Trial name
- ComaDopa (NCT06930261)
- Testing
- LBT-999
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury
Objective: This prospective interventional study introduces "SeeMe," an automated, high-resolution computer vision platform designed to objectively quantify microscopic, auditory command-evoked movements in patients with…
- Trial name
- NCT07560631
- Testing
- SeeMe Multimodal Auditory Command Protocol
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Traumatic Brain Injury
Sodium Lactate in Severe TBI
This is a safety phase 2 clinical trial of intravenous infusion of sodium lactate in patients with severe TBI. This study is intended for patients in the acute setting in an intensive care unit at centers that have been selected…
- Trial name
- NCT06701760
- Testing
- Sodium Lactate
- Volunteers
- 264 people
- Sponsor
- University of California, Los Angeles
Brain Injury Traumatic Severe (Diagnosis), Coma
Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
Phase 1 of the STIMPACT trial is an open label,dose-escalation,safety study of intravenous (IV) methylphenidate (MPH) therapy in patients with disorders of consciousness (DoC) caused by severe brain injuries.
- Conditions
- Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
- Trial name
- STIMPACT (NCT03814356)
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
Neurocritical Care, Traumatic Brain Injury
Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care
Enhanced recovery after surgery (ERAS) is a strategy of perioperative management aimed to accelerate the rehabilitation of patients through various optimized perioperative managements as well as ongoing adherence to a…
- Conditions
- Neurocritical Care, Traumatic Brain Injury, Cerebrovascular Disease, Moderate or Severe Coma
- Trial name
- NCT06241482
- Testing
- Enhanced recovery after surgery, Conventional therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai 6th People's Hospital