Clinical trials: Traumatic Head Injury
Traumatic Brain Injury, Cerebral Edema
Trial of Dexamethasone for Traumatic Brain Injured Patients With Brain Contusions and Pericontusional Edema
The DEXCON-TBI trial is a multicenter, pragmatic, randomized, triple-blind, placebo controlled trial to quantify the effects of the administration of dexamethasone on the prognosis of TBI patients with brain contusions and…
- Conditions
- Traumatic Brain Injury, Cerebral Edema, Head Injury Trauma
- Trial name
- DEXCON-TBI (NCT04303065)
- Testing
- Dexamethasone Oral
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Jon Pérez Bárcena
TBI (Traumatic Brain Injury)
Traumatic Brain Injury in Veterans and Near-Infrared Phototherapy
This is a proof-of-concept study designed to demonstrate whether increases in cerebral blood flow, improvements in brain functioning, and reductions in symptomology associated with traumatic brain injury (TBI) can result from…
- Trial name
- NCT02635516
- Testing
- Near-Infrared Phototherapy
- Volunteers
- 13 people
- Sponsor
- Cerehealth Corp.
Concussion
EEG Diagnostic for Repetitive Sub-concussive Head Impacts
The purpose of this study is to develop a diagnostic algorithm to help with the detection, diagnosis, and monitoring of sub-concussive head impacts.
- Trial name
- NCT05562544
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mild Traumatic Brain Injury
TBI Evaluation and Management (TEaM)
The purpose of this study is to evaluate a multi-disciplinary, multi-setting intervention with the goal of improving outcomes for children who have experienced a mild traumatic brain injury (mTBI).
- Trial name
- TEaM (NCT04576715)
- Testing
- TEaM Intervention, Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 101 people
- Sponsor
- Emory University
Post-Concussion Syndrome
Hyperbaric Oxygen for Post Concussive Syndrome
We would like to see if Hyperbaric Oxygen can help improve the symptoms that result from Post Concussive Syndrome.
- Trial name
- HBOT for PCS (NCT03205215)
- Testing
- Hyperbaric Oxygen Therapy, Waitlist Hyperbaric Oxygen Therapy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of British Columbia
Hematoma, Subdural, Chronic
Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma
Rationale: Chronic subdural hematoma (cSDH) is a frequently occurring disease, occurring mainly in the elderly. Surgical evacuation is effective, but also associated with life-threatening risks.
- Trial name
- TORCH (NCT03582293)
- Testing
- Tranexamic Acid 500Mg Tablet
- Where
- Netherlands
- Volunteers
- 554 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Schizophrenia, Traumatic Brain Injury
Neuroplasticity in TBI and Schizophrenia
This proposal will examine measures of neuroplasticity (the brain's ability to alter its function or structure in response to changes in the environment or novel experiences) in Veterans with schizophrenia or traumatic brain…
- Trial name
- NVEST (NCT03995368)
- Testing
- Electroencephalography
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury (TBI) Patients, Cognitive Impairment
Mindfulness-Integrated Neuropsychotherapy for Traumatic Brain Injury: A Mixed-Methods Evaluation of Cognitive and Psychosocial Recovery
The goal of this clinical trial is to test the effectiveness of Integrative Mindfulness Enhanced Neuropsychotherapy (IMENP) in improving neurocognitive functioning and wellbeing among adults aged 18 to 44 years with mild to…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Cognitive Impairment, Depression Disorder, Fatigue Severity Scale
- Trial name
- IMENP (NCT07874685)
- Testing
- Integrative Mindfulness Enhanced Neuropsychotherapy (IMENP)
- Where
- India
- Volunteers
- 68 people
- Sponsor
- University of Madras
Hematoma, Subdural, Chronic
Irrigation of Chronic Subdural Hematomas - is More Better?
There are numerous reported ways to treat chronic subdural hematomas (CSDH) and practice is still differing considerably between departments.
- Trial name
- NCT01930617
- Testing
- Burr hole surgery with various drainage techniques
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 1,258 people
- Sponsor
- St. Olavs Hospital
Traumatic Brain Injury
Eye Movement Recordings in the Diagnosis of Traumatic Brain Injury
The study investigates whether the use of eye movement recordings can provide a reliable diagnostic of previously undiagnosed mild traumatic brain injury (blast and impact) in Operations Enduring Freedom or Iraqi Freedom…
- Trial name
- NCT00875589
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spasticity
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total…
- Trial name
- LANTIMA (NCT04752774)
- Testing
- Corabotase, Dysport
- Where
- 81 sites in United States, Austria and 12 more
- Volunteers
- 240 people
- Sponsor
- Ipsen
Traumatic Brain Hemorrhage
Traumatic Acute Subdural Haematoma: Management and Outcome
Traumatic acute subdural haematomas (ASDHs) are common pathological entity in neurosurgical practice . The frequency of (ASDHs) has been proposed as approximately 10-20% of patients admitted with traumatic brain injury(TBI)…
- Trial name
- NCT03971240
- Testing
- evacuation of traumatic acute subdural hematoma
- Volunteers
- 39 people
- Sponsor
- Assiut University
Brain Injuries
Behavioral Trial Studying Programmed Training to Improve Advocacy Skills for Individuals With Traumatic Brain Injury
The Midwest Advocacy Project (MAP) is a community-based multiple-site randomized practical behavioral trial of advocacy skill training for individuals with traumatic brain injury (TBI), their families, and significant others.
- Trial name
- MAP (NCT01002677)
- Testing
- Advocacy training curriculum, Self-directed
- Where
- 3 sites in United States
- Volunteers
- 234 people
- Sponsor
- Mayo Clinic
Traumatic Brain Injury, Brain Injuries
Remote Ischemic Conditioning in Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of death among trauma patients accounting for one-third of all trauma mortalities.
- Conditions
- Traumatic Brain Injury, Brain Injuries, Brain Trauma, Brain Injuries, Traumatic
- Trial name
- MOTION (NCT03899532)
- Testing
- Remote Ischemic Conditioning, No-Remote Ischemic Conditioning
- Where
- United States
- Sponsor
- University of Arizona
Neurodegenerative Diseases
Clinical Effect of Acupuncture in Neurodegenerative Diseases on Traumatic Brain Injury Patients
Traumatic brain injury (TBI) is an altered brain function caused by an external force, which may annually have 69 million incidence cases all over the world.
- Trial name
- NCT05839132
- Testing
- Acupuncture
- Where
- Taiwan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Traumatic Brain Injury
Descriptive and Prospective Study of Sphincter Disorders in the Severe Traumatic Brain Injury Population
Severe traumatic brain injury (TCI), defined by an initial GCS of ≤ 8 and/or admitted to a neurosurgical intensive care unit, are responsible for diffuse brain lesions that can lead to multiple deficits, including impairment of…
- Trial name
- TCG (NCT05163262)
- Testing
- sexuality questionnaire
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury
Noninvasive Intracranial Pressure Waveforms Assessment in Traumatic Brain Injury
In clinical practice, hospital admission of patients with altered level of consciousness ranging from drowsiness to decreasing response states or coma is extremely common.
- Trial name
- NCT06423469
- Testing
- Noninvasive ICP monitoring
- Where
- 4 sites in Brazil
- Volunteers
- 345 people
- Sponsor
- Sergio Brasil, MD
Facial Fractures, Maxillofacial Injuries
Epidemiological and Statistical Study of Facial Traumatic Fractures at Assiut University Trauma Hospital
Facial traumatic fractures represent a significant global and regional health burden that can impair essential functions such as breathing, speaking, and chewing, while carrying substantial functional and psychological…
- Conditions
- Facial Fractures, Maxillofacial Injuries, Mandibular Fractures, Maxillary Fractures
- Trial name
- NCT07827209
- Volunteers
- 50 people
- Sponsor
- Assiut University
Chronic Subdural Hematoma, Surgical Procedures, Operative
A National Study Examining the Most Effective Drainage Method After Burr Hole Evacuation of Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease. The main treatment is neurosurgical evacuation and subsequent hematoma drainage.
- Conditions
- Chronic Subdural Hematoma, Surgical Procedures, Operative, Recurrence, Mortality
- Trial name
- SUPERDURA (NCT06621407)
- Testing
- 24 hours active subperiostal drainage, 24 hours passive subdural drainage
- Where
- 4 sites in Denmark
- Volunteers
- 354 people
- Sponsor
- Aalborg University Hospital
Traumatic Brain Injury (TBI)
Monitoring the Alterations That Occur in the Brain Following Traumatic Brain Injury
This project, will combine the data collected from existing and innovative technologies: fMRI scans, mapping brain connectivity using EEG in combination with eye-tracking technology (the BNA technology developed by ELMINDA)…
- Trial name
- TBI (NCT02878577)
- Testing
- fMRI
- Where
- Israel
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
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