Clinical trials: Traumatic Head Injury
Traumatic Brain Injury
Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury
New learning and memory impairment (NLMI) is a common and devastating manifestation of TBI associated with substantial life burdens. Persons with moderate to severe TBI have shown improvement in NLM for prose material (e.g.
- Trial name
- CRUSH-IT (NCT05716048)
- Testing
- KF-mSMT Plus Aerobic Exercise Training, KF-mSMT Plus Stretching Exercise Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kessler Foundation
Neurologic Disorder, Disorder of Consciousness
Prognostic Factors to Regain Consciousness
The study aims to identify factors that predict the medium and long-term outcome of patients with disorders of consciousness (DOC) undergoing early neurological rehabilitation.
- Conditions
- Neurologic Disorder, Disorder of Consciousness, Traumatic Brain Injury, Stroke
- Trial name
- NCT04445649
- Testing
- Coma-Recovery-Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Mild Traumatic Brain Injury
Graded Exposure Therapy for Fear Avoidance Behaviour After Concussion
Concussions are very common. Although many people recover well from concussion, some will have persistent symptoms and difficulties with daily activities.
- Trial name
- GET-FAB (NCT05365776)
- Testing
- Graded Exposure Therapy, Prescribed aerobic exercise, Enhanced usual care
- Where
- 7 sites in Canada
- Volunteers
- 220 people
- Sponsor
- University of British Columbia
Traumatic Optic Neuropathy
Surgery for Traumatic Optic Neuropathy
The pathophysiology of Traumatic Optic Neuropathy (TON) include a primary and secondary mechanism of injury. At present, no studies validate a particular approach to the management of TON.
- Trial name
- NCT02711982
- Testing
- Optic canal and optic nerve sheath decompression, methylprednisolone
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Shanghai Changzheng Hospital
Traumatic Brain Injury, Concussion, Brain
Understanding Concussion/Mild Traumatic Brain Injury
Using the Blink Reflexometer, athletes are scanned if they are potentially thought to have a concussion during a game or practice.
- Trial name
- NCT03381638
- Testing
- Blink Reflexometer
- Where
- 5 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Blinktbi, Inc.
Traumatic Brain Injury
The Utility of Positive Psychology in Military TBI Rehabilitation
Service members and veterans (SMVs) report more persisting symptoms following traumatic brain injury (TBI) compared to civilian populations (Ommaya, Ommaya, Dannenber, \& Salazar, 1996).
- Trial name
- NCT04257435
- Testing
- Positive Psychological Group Treatment, Traditional Behavioral Health Treatment
- Where
- United States
- Sponsor
- Fort Belvoir Community Hospital
Mild Traumatic Brain Injury
OPTIMA-TBI Pilot Study
This is a double-blind, randomized controlled trial comparing the effect of omega-3 fatty acid versus placebo on blood biomarkers of brain injury, inflammation and neurogenesis.
- Trial name
- OPTIMA (NCT03345550)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Disorder of Consciousness, Traumatic Brain Injury
Changes in Glutamatergic Neurotransmission of Severe TBI Patients
Studies in patients with disorders of consciousness (DOC) after severe brain injury implicate dysfunction of the anterior forebrain mesocircuit dysfunction a key underlying mechanism.
- Trial name
- NCT04244058
- Testing
- Amantadine + L-DOPA, NMDA blocker
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
TBI (Traumatic Brain Injury)
Long Lasting Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Traumatic Brain Injury Patients
To evaluate the cognitive functions of patients who suffered brain injury due to traumatic head injury and were previously treated in a hyperbaric chamber between one and four years after the end of treatment.
- Trial name
- NCT07430150
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Mild Traumatic Brain Injury
Symptom-Targeted Rehabilitation for Concussion
The investigators are comparing two methods for helping improve everyday cognitive functioning in Canadian Armed Forces (CAF) veterans who have sustained a mild traumatic brain injury (mTBI).
- Trial name
- STAR-C2 (NCT05520710)
- Testing
- Cognitive Rehabilitation, Education
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- McMaster University
Traumatic Brain Injuries, Neurobehavioral Manifestations
Self-defining Memories in Patients With a TBI
The study will be conducted over 18 months. The main objective of this study is to explore the relationships between autobiographical memory and specific cognitive measures, as well as emotional and behavioural measures in…
- Conditions
- Traumatic Brain Injuries, Neurobehavioral Manifestations, Cognition Disorders, Memory Deficits
- Trial name
- IDENTITY (NCT02680210)
- Testing
- Questionnaires and cognitive measures
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Traumas, Brain, Alzheimer Disease
The COACH Project: Combined Online Assistance for Caregiver Health
This study evaluates the effect of a physical exercise + caregiver skills training on feelings of burden, mood, and biological markers of inflammation in persons who provide care for Veterans with a TBI or dementia.
- Conditions
- Traumas, Brain, Alzheimer Disease, Dementia, Head Injury
- Trial name
- COACH (NCT03123224)
- Testing
- Combined Aerobic and Resistance Exercise + Caregiver Skills Training, Stretching Balance and Flexibility + Caregiver Skills Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Subdural Hematoma, Chronic
Endovascular vs Conservative Treatment in Patients With Chronic Subdural Hematomas and Mild Symptoms
Embotrial-1 is an Italian multicenter prospective randomized clinical trial with open-label treatment and blinded outcome assessment (PROBE) to assess the superiority of MMA embolization compared to conservative treatment.
- Trial name
- NCT06274580
- Testing
- embolization of the middle meningeal artery
- Volunteers
- 300 people
- Sponsor
- Ospedale Policlinico San Martino
Traumatic Brain Injury, Cognitive Impairment
"Cognitive Rehabilitation With Direct Current Transcranial Stimulation in Post-Traumatic Brain Injury Patients"
The goal of this clinical trial is to investigate the impact of daily self-administered transcranial direct current stimulation (tDCS) therapy on the cognitive function of individuals with moderate to severe cognitive impairment…
- Trial name
- tDCS-TEC (NCT06228872)
- Testing
- Cognitive Computerized Training (CCT) plus Anodic transcranial Direct Current Stimulation (tDCS)
- Where
- Chile
- Volunteers
- 38 people
- Sponsor
- Mutual de Seguridad Hospital Clinico
Brain Injuries, Traumatic
Determining the Incidence of Vestibular Dysfunction in Traumatic Brain Injury Patients
The purpose of this study is to determine the incidence of vestibular dysfunction in traumatic brain injury patients admitted to acute inpatient rehabilitation.
- Trial name
- NCT04592575
- Testing
- Vestibular Evaluation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Shirley Ryan AbilityLab
Traumatic Brain Injury, Ischemic Stroke
Shared Decision Making to Improve Goals-of-Care Decisions for Families of Severe Acute Brain Injury Patients
Severe acute brain injury (SABI), including large artery acute ischemic stroke, intracerebral hemorrhage, and severe traumatic brain injury continue to be the leading cause of death and disability in adults in the U.S.
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT03833375
- Testing
- Decision Aid
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Massachusetts, Worcester
Traumatic Brain Injury
Growth Hormone or Sildenafil as Therapies for Fatigue in Mild- Traumatic-brain-injury (MTBI)
The overall goal is to determine whether perceptual or performance fatigue can be reduced in MTBI patients with and without growth hormone (GH) deficiency by treating them in a crossover fashion based upon GH status.
- Trial name
- NCT02114775
- Testing
- Growth Hormone, Sildenafil
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The University of Texas Medical Branch, Galveston
TBI (Traumatic Brain Injury), Status Epilepticus
Augmented Renal Clearance in Neurocritical Care
Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion…
- Conditions
- TBI (Traumatic Brain Injury), Status Epilepticus, Bacterial Meningitis, Augmented Renal Clearance (ARC)
- Trial name
- Neuro-ARC (NCT07410624)
- Where
- 3 sites in United States, Canada
- Volunteers
- 512 people
- Sponsor
- University of Alberta
Concussion, Brain, Traumatic Brain Injury
Ghrelin (OXE--103) for Acute Concussion Management
Concussions are the leading form of mild traumatic brain injury. Management of concussions and mild traumatic brain injury is a high priority medical focus, social concern, and research topic.
- Trial name
- NCT04558346
- Testing
- Ghrelin (OXE-103)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Michael Rippee
Traumatic Brain Injury
Ocular Ultrasonography as a Tool for Monitoring the Management of Traumatic Brain Injury
Raised intracranial pressure (ICP) is a common and life threatening condition especially in patients with traumatic brain injury.There are many methods for monitoring the increased (ICP) either invasive or non- invasive ,but the…
- Trial name
- NCT03795896
- Testing
- Optic nerve sheath diameter
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University Hospital
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