Clinical trials: Traumatic Head Injury
Tbi, Vasospasm
Cerebral Autoregulation and Vasospasm in Patients With TBI
Traumatic brain injury (TBI) affects 1.5 million patients per year in the United States, resulting in more than 50,000 deaths and more than 230,000 hospitalizations annually.
- Conditions
- Tbi, Vasospasm, Cerebral Ischemia, Cerebral Infarct
- Trial name
- NCT02351518
- Testing
- No intervention
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Traumatic Brain Injury (TBI) Patients
Early Neuromodulation in Traumatic Brain Injury
The two goals of the proposed study are: (1) To determine how brain activity changes with cognitive recovery over time from acute to chronic phases of traumatic brain injury (TBI).
- Trial name
- NCT06871124
- Testing
- transcranial electrical stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Traumatic Brain Injury, Attention Deficit Disorder
Treatment of Traumatic Brain Injury (TBI)-Related Attention Deficits in Children
The purpose of this research study is to evaluate whether Vyvanse, a psychostimulant, can help children ages 6-16 with attention deficits due to traumatic brain injury (TBI).
- Trial name
- TBIC (NCT02712996)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Brain Injuries, Traumatic Brain Injury
Tbit System Precision and Correlation of Different Blood Samples
The Tbit™ System will detect S100B and GFAP concentrations with the blood specimen to produce and compare repeated measures from 3 blood samples from 3 fingersticks from one subject and one 1 venous whole blood sample will be…
- Trial name
- NCT04478812
- Testing
- Single Group Assignment
- Volunteers
- 81 people
- Sponsor
- BioDirection Inc
Traumatic Brain Injury
Analysis and Valuation of the Expertise of Use of the Close Friends of People Victims of Traumatic Brain Injury
Post-traumatic behavioral disorders : analysis and valuation of the expertise of use of the close friends of people victims of traumatic brain injury.
- Trial name
- AVEC-TC (NCT02341092)
- Testing
- Traumatic brain injury
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Angers
Traumatic Brain Injury
Assessment of Traumatic Brain Injury Using Transcranial Magnetic Stimulated Evoked Potentials
Patients evaluated at Penn Presbyterian Medical Center for traumatic brain injury (TBI), who sign the informed consent, will undergo assessment of electrophysiologic potentials evoked by transcranial magnetic stimulation (TMS)…
- Trial name
- (TMS-EEG) (NCT06963775)
- Testing
- Delphi-MD device (QuantalX Neuroscience Ltd., Saba Israel)
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Ramon Diaz-Arrastia
Concussion, Brain
Interest of an Attentional Evaluation by a Computerized Battery in the Management of Concussion in Young Rugby Players
The goal of this study is to test the ability of a computerized neuropsychological battery to identify attentional disorders resulting from a concussion occurring during the practice of rugby.
- Trial name
- NeuropsyCor (NCT05719844)
- Testing
- Neuropsychological tests
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Traumatic Brain Injury
Pilot and Feasibility of MEMI for Chronic Traumatic Brain Injury
This is a pilot and feasibility study for a mobile phone-delivered intervention for memory, called MEMI (memory ecological momentary intervention), that was designed to support adults with chronic traumatic brain injury with…
- Trial name
- NCT06375421
- Testing
- MEMI (Memory Ecological Momentary Intervention) Spaced Retrieval, Blocked Retrieval
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Mild Head Injury, Anticoagulant
Medico-economic Interest of the Protein S100b in Mild Head Trauma Under Anti-thrombotics
Head trauma is a common injury in emergency department. Investigation to search for complication is guided by the clinical examination and the case history, such as taking anti-thrombotics.
- Conditions
- Mild Head Injury, Anticoagulant, Antiplatelet
- Trial name
- ISTCAT (NCT04305821)
- Testing
- Dosage of S100β protein
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Rennes University Hospital
Traumatic Brain Injury, Immuno-Deficiency
Effects of Immunonutrition on Biomarkers in Traumatic Brain Injury
Background: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to…
- Conditions
- Traumatic Brain Injury, Immuno-Deficiency, Nutrient Deficiency
- Trial name
- NCT03166449
- Testing
- Neomune, Fresubin® HP energy
- Where
- Malaysia
- Volunteers
- 36 people
- Sponsor
- University of Malaya
PTSD, mTBI
Vagal Nerve Stimulation in mTBI
Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) are important conditions for the Veterans Administration (VA) that frequently occur together in combat Veterans from the conflicts in Afghanistan and…
- Trial name
- VNS mTBI (NCT04437498)
- Testing
- nVNS
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
Head Trauma
Ketamine and Glutamate After Brain Injury : a Microdialysis Study
The objective of the study is to compare the effects of 48 hours ketamine infusion versus sufentanil infusion on brain glutamate concentrations measured with microdialysis after traumatic brain injury.
- Trial name
- KETABRAIN (NCT02232347)
- Testing
- Ketamine, Sufentanil
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Pierre-Julien CUNGI
Moderate to Severe Traumatic Brain Injury
Ante-hypophyseal Dysfunctions in Children Following Moderate to Severe Traumatic Brain Injuries
Annual incidence of severe traumatic brain injuries (TBI) varies from 180 to 300 out of 100.000. Mortality or severe sequelae risk is increased 8 fold after a TBI.
- Trial name
- Endoc-TC (NCT01250132)
- Testing
- Biological and behavioral explorations
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Hospices Civils de Lyon
Chronic Subdural Hematoma
Low Intracranial Pressure Treatment Strategies for Chronic Subdural Hematoma Patients
The proportion of the elderly population is increasing rapidly. Chronic subdural hematoma has become the most common cause of surgery in neurosurgery for elderly patients. The standard treatment for cSDH is mostly surgery.
- Trial name
- CSDH-LP (NCT04607447)
- Testing
- low intracranial pressure strategy treatment, Atorvastatin plus Dexamethasone
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Huashan Hospital
Traumatic Brain Injury
Effect of Progesterone Therapy on Traumatic Subarachinoid Haemorrhage on Clinical Outcome and Resistive Vasculer Indices of Middle Cerebral Artery Transcranial Doppler
Traumatic subarachinoid hemorrhage is associated with serious complications related to mortality . Delayed neuronal ischemia and rebleeding are most common and serious. Progesterone can delay both .
- Trial name
- NCT04426487
- Testing
- Progesterone
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Minia University
Traumatic Brain Injury, Posttraumatic Stress Disorders
Telepharmacy Robotic Medicine Delivery Unit "TRMDU" Assessment
The objective of this study is to evaluate whether use of TRMDU in addition to medication review leads to improved outcomes and reduced health care costs for patients when compared with medication review alone.
- Conditions
- Traumatic Brain Injury, Posttraumatic Stress Disorders, Trauma, Combat Disorders
- Trial name
- NCT01007006
- Testing
- TMRDU
- Where
- 3 sites in United States
- Sponsor
- University of Illinois Chicago
Brain Concussion, Mild Traumatic Brain Injury
The Role of Mechanical Diagnosis and Therapy in the Management of Concussion
The purpose of this study is to examine the role of a Mechanical Diagnosis and Therapy (MDT) examination in identifying participants diagnosed with concussion who display a directional preference compared to who don't display a…
- Trial name
- NCT05859815
- Testing
- Physical Therapy
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- State University of New York at Buffalo
Brain Injuries, Post-Concussive Symptom
Metacognitive Therapy for Post-concussive Symptoms After Mild Traumatic Brain Injury
The purpose of this open trial is to investigate the feasibility, acceptability, and effect of metacognitive therapy in patients with prolonged post-concussive symptoms after mild traumatic brain injury.
- Conditions
- Brain Injuries, Post-Concussive Symptom, Post-Concussive Syndrome
- Trial name
- NCT02690584
- Testing
- Metacognitive therapy
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- Norwegian University of Science and Technology
Traumatic Brain Injury, TBI (Traumatic Brain Injury)
Cervical Transcutaneous SCS for TBI
The goal of this study is to test the effects of non-invasive electrical stimulation of the spinal cord (called transcutaneous spinal cord stimulation, or tSCS) on arm and hand movement in people with motor impairments after a…
- Trial name
- NCT07147816
- Testing
- Transcutaneous electrical stimulation of the cervical spinal cord (tSCS)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Roberto de Freitas
Traumatic Brain Injury
Executive Function Training Intervention for Chronic Traumatic Brain Injury
Traumatic Brain Injury (TBI) is a prevalent disorder developed by military personnel. While some individuals recover function within months after injury, others continue to suffer from cognitive problems months to years later and…
- Trial name
- NCT03704116
- Testing
- Expedition
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The University of Texas at Dallas
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