Clinical trials: Traumatic Head Injury
Sport-related Concussion
Concussion Screen Use Recovery Time
A two-year parallel randomized clinical trial study to examine the effect of screen time (ST) restriction, exercise alone, and combined ST-restricted-exercise when compared to stretching only (control group) on sports related…
- Trial name
- NCT05373992
- Testing
- Screen Time Restriction (ST-Restricted), Aerobic Exercise (AE), Screen-time restricted plus aerobic exercise (STR+AE)
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Children's Health
Post-Traumatic Headache
Treximet for Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction
This study will evaluate the effectiveness of Treximet when taken for post traumatic headache by measuring any change in the number of headache days or any change in a subject's ability to think following treatment with study…
- Trial name
- NCT01053507
- Testing
- sumatriptan/naproxen sodium
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Cady, Roger, M.D.
Concussion, Mild, Diagnoses, Syndromes, and Conditions
Diagnosis of Sport-related Concussion Using Urine Metabolites
Millions of sport related concussions (SRC) occur yearly in the United States, and current diagnosis of concussion is based upon largely subjective clinical evaluations.
- Trial name
- NCT03653195
- Testing
- urine metabolomics
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Chronic Subdural Hematoma
Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma -2
Chronic subdural hematoma (CSDH), a common disease after minor head trauma, is characterized by blood collection in the subdural space, which can result in severe neurological impairment.
- Trial name
- TRACE-2 (NCT04898712)
- Testing
- Tranexamic Acid 500 MG
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Unity Health Toronto
Chronic Subdural Hematomas
Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma.
Chronic subdural hematoma (cSDH) is a very common disease, primarily affecting older people, and is associated with significant morbidity and mortality.
- Trial name
- iSDH (NCT07556991)
- Testing
- Amoxicillin + clavulanic acid
- Where
- Germany
- Volunteers
- 164 people
- Sponsor
- University of Rostock
TBI (Traumatic Brain Injury)
Self-Advocacy for Independent Life (SAIL) After TBI
Traumatic brain injury (TBI) has been conceptualized as a chronic health condition, warranting self-advocacy for health management services across the lifespan.
- Trial name
- NCT03385824
- Testing
- Self-Advocacy for Independent Life (SAIL)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Craig Hospital
Facial Injuries, Adipose Tissue
A Study to Evaluate the Results of Facial Soft Tissue Reconstruction in Patients Who Have Suffered Traumatic Injury
Injuries resulting in facial trauma are common, and can have devastating consequences on your quality of life. While the facial bones can often be reconstructed, physicians strive to find better ways to accurately restore injured…
- Trial name
- BTI (NCT01345591)
- Testing
- Fat Grafting
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury, Trauma, Nervous System
Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury
The prevention of secondary brain injury is a primary goal in treating patients with severe traumatic brain injury (TBI). Secondary brain injury results from tissue ischemia induced by increased vascular resistance in the at-risk…
- Conditions
- Traumatic Brain Injury, Trauma, Nervous System, Reperfusion Injury, Ischemia, Brain
- Trial name
- NCT03176823
- Testing
- CellAegis Technologies autoRIC device, Best Practice Management of Traumatic Brain Injury
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Chronic Subdural Hematoma
Neuroendoscopy-assisted Drainage Versus Burr Hole Drainage for Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a frequent condition in neurosurgery, leading to fluid accumulation between the meninges, brain compression, neurological dysfunction, and potentially herniation.
- Trial name
- URANUS (NCT07144423)
- Testing
- Endoscope-assisted hematoma drainage, Burr hole hematoma drainage
- Where
- 24 sites in China
- Volunteers
- 770 people
- Sponsor
- Beijing Tiantan Hospital
Concussion
Care for Post-Concussive Symptoms
The proposed study is a pilot randomized trial of a stepped collaborative care intervention designed to decrease post-concussive symptoms and improve post-injury functioning among sports-injured youth aged 11-17.
- Trial name
- CARE4PCS (NCT02268240)
- Testing
- Stepped Care
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Seattle Children's Hospital
REM Sleep Behavior Disorder, Concussion, Brain
The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls
The goal of this observational study is to investigate concussions and contact sports practices in REM sleep behaviour disorder (RBD).
- Trial name
- COSP-RBD (NCT06270290)
- Testing
- Exposure to contact sports or history of concussions
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Brain Death
Organ Donation and Hydrocortisone Treatment
Brain death patients who are selected for organ donation very often suffer from haemodynamic instability. To treat this, high amounts of vasoactive drugs(norepinephrine) may be needed to raise blood pressure.
- Trial name
- HYDRO (NCT00675272)
- Testing
- hydrocortisone, sodium chloride
- Where
- 2 sites in Finland
- Volunteers
- 38 people
- Sponsor
- Kuopio University Hospital
Traumatic Brain Injury
Evidence Based Diagnostics and Treatment Planning Solution for Traumatic Brain Injuries
Adult patients, age ≥ 18 years, with clinically diagnosed mild, moderate or severe brain trauma will be asked to participate in the study.
- Trial name
- NCT02021877
- Where
- 2 sites in Finland, United Kingdom
- Volunteers
- 396 people
- Sponsor
- Turku University Hospital
Traumatic Brain Injury, Ketogenic Dieting
Ketogenic Diet for Traumatic Brain Injury
Traumatic Brain Injury is a major health concern in United States. There is a un-met need to develop new therapeutic options for faster neuron recovery without causing significant side effects.
- Trial name
- KETI (NCT03982602)
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Missouri-Columbia
Brain Injuries
A New Intervention for Social Communication Skills Following Brain Injury
To investigate the effectiveness of a peer-led social skills training intervention compared to social activity (usual care) to improve social communication skills following severe brain injury.
- Trial name
- NCT02211339
- Testing
- Peer facilitator training, Usual care
- Volunteers
- 12 people
- Sponsor
- University College, London
Traumatic Tetraplegia with Cervical Cord Injury
Brain Computer Interface: Neuroprosthetic Control of a Motorized Exoskeleton
The BCI project falls within the very broad field of brain machine interfaces. Its multiple applications include the compensation of motor deficits.
- Trial name
- BCI (NCT02550522)
- Testing
- Brain-computer interface (BCI) platform including two implanted remotely powered ElectroCorticoGraph (ECoG) recording devices and an exoskeleton
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Grenoble
Traumatic Brain Injury
University of Pittsburgh Brain Health Initiative
This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical…
- Trial name
- BHI (NCT04708613)
- Testing
- Cognitive/Neuropsychological Testing, Vestibular/Ocular-Motor Testing, Sleep Evaluation
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- David Okonkwo, MD, PhD
Computed Tomography, Minor Head Injuries
Cerebral Computed Tomography on Patients With Minor Head Injuries
This observational study aims to calculate the prevalence of conditions or diseases requiring immediate medical attention in CTC scans with an indication of bleeding post trauma performed in the ED at Odense University Hospital.
- Trial name
- NCT06399913
- Where
- Denmark
- Volunteers
- 7,106 people
- Sponsor
- University of Southern Denmark
Traumatic Intracranial Hemorrhage
Restart TICrH AP Pilot Trial
A Prospective Randomized Open-Label Blinded Endpoint (PROBE) Pilot Trial of restarting antiplatelet therapy at 1 week versus 3 weeks after traumatic intracranial hemorrhage with a primary composite endpoint of major bleeding and…
- Trial name
- NCT05000060
- Testing
- Timing/1 week, Timing/3 weeks
- Volunteers
- 100 people
- Sponsor
- University of Texas at Austin
MTBI - Mild Traumatic Brain Injury
Retraining Neural Pathways Improves Cognitive Skills After A Mild Traumatic Brain Injury
The proposed study tests the efficacy (Phase II) of 36 or 54 30-minute training sessions of PATH neurotraining followed by digit memory exercises to improve working memory, processing speed and attention in mTBI patients rapidly…
- Trial name
- NCT03655782
- Testing
- PATH + DigitMemory (DM) neurotraining
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Perception Dynamics Institute
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