Clinical trials: Traumatic Head Injury
Subdural Hematoma
Augmented Reality for Subdural Drain Placement
This study involves using a augmented reality (AR) system to assist in the placement of a subdural evacuating portal system (SEPS).
- Trial name
- NCT06052124
- Testing
- Augmented Reality Device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage
Monitoring Brain Activity in Human Brain Injury
The outcome of brain injury (physical or stroke) may be related to a brain electrical phenomenon known as Cortical Spreading Depression (CSD). This is a brief cessation of function in a local region of brain tissue.
- Conditions
- Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage, Cerebral Infarction, Cerebral Hemorrhage
- Trial name
- NCT00258505
- Testing
- Procedure: intracranial monitoring up to 9 days after injury
- Where
- 2 sites in Germany, Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
TBI (Traumatic Brain Injury)
Brain Development in Young Children Following Mild Traumatic Brain Injury - Pilot Study
Concussions (also known as mild traumatic brain injury) are common in young children. In some children, they can lead to short- and long-term difficulties.
- Trial name
- KAOUENN (NCT06024122)
- Testing
- IRM exam
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Traumatic Brain Injury
Home-Based Exergame Motor-Cognitive Rehabilitation for Traumatic Brain Injury
The goal of this clinical trial is to evaluate the effectiveness of a home-based cognitive-motor telerehabilitation program in individuals with traumatic brain injury (TBI) following discharge from intensive inpatient…
- Trial name
- HOME-TBI (NCT07733336)
- Testing
- HOME-EXER telerehabilitation protocol, OUT-REHAB rehabilitation protocol
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Concussion, Mild, Traumatic Brain Injury
Improving In-hospital and Post-discharge Patient Education for Mild Traumatic Brain Injury
The purpose of this study is to develop and validate ways to provide better patient education and clinical management for individuals who go to the emergency department (ED) with concussion or mild traumatic brain injury (mTBI).
- Trial name
- EDucate (NCT06595914)
- Testing
- Clinical implementation strategies
- Where
- United States
- Volunteers
- 5,831 people
- Sponsor
- Medical College of Wisconsin
Traumatic Brain Injury
Augmentation of Cognitive Training in Children With TBI With D-Cyloserine
Traumatic Brain Injury (TBI) is the most common cause of death and long-term disability in children. Much of the long-term disability stems from neurocognitive impairments that are not greatly helped by current cognitive training…
- Trial name
- DCS (NCT02312635)
- Testing
- D-Cycloserine, Cogmed Working Memory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Vertigo, Concussion
Stationary Bike Study
Investigators will use a stationary bike protocol to investigate whether patients with post concussion syndrome benefit from adding exertion training to a vestibular rehabilitation program.
- Conditions
- Vertigo, Concussion, Dizziness
- Trial name
- NCT02640599
- Testing
- Vestibular Rehabilitation + Aerobic Exercise, Vestibular Rehabilitation
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- NYU Langone Health
Traumatic Brain Injury
Prismatic Adaptation in Cognitive Rehabilitation
The study aims to evaluate the effects of prismatic adaptation and then of a novel rehabilitation protocol that combines PA and Serious Games on cognitive and behavioural deficits in patients with traumatic brain injury …
- Trial name
- PACoR-TBI (NCT06920784)
- Testing
- PRISMATIC ADAPTATION, Serious games
- Where
- 5 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Brain Injuries, Traumatic, Concussion, Brain
Longitudinal Assessment of Post-concussion Driving in Young Adults
Upwards of 3.8 million concussions occur annually in the United States. Driving is a highly complicated activity that requires visual, motor, and cognitive skills, which are commonly impaired after concussion.
- Conditions
- Brain Injuries, Traumatic, Concussion, Brain, Brain Injury Traumatic Mild
- Trial name
- LAPDYA (NCT05942638)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Georgia
Traumatic Brain Injury
Evaluation of a Novel Integrative and Intensive Virtual Rehabilitation Program for Service Members Post TBI
The purpose of the study is to evaluate the feasibility and effectiveness of a novel virtual reality (VR) therapeutic rehabilitative device (BrightBrainerTM) to treat patients with traumatic brain injury (TBI).
- Trial name
- NCT02899468
- Testing
- BrightBrainer Virtual Reality (BBVR) Rehabilitation System
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Injuries, Spinal Cord, CVA (Cerebrovascular Accident)
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
Comparing the efficacy of Intracthecal Baclofen dose between the Prometra II and Medtronic SynchroMed II for patients with spasticity and with current a current SyncroMed II pump needing replacement.
- Conditions
- Injuries, Spinal Cord, CVA (Cerebrovascular Accident), Traumatic Brain Injury, MS (Multiple Sclerosis)
- Trial name
- NCT04530955
- Testing
- Prometra II Programmable Pump - Flowonix Medical
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Culicchia Neurological Clinic
Chronic Subdural Hematoma, Trendelenburg
Effect of the Postoperative Trendelenburg Position on Chronic Subdural Hematoma Recurrence
Objective: Determine the effect of the postoperative trendelenburg position on the recurrence of chronic subdural hematoma (CSH) in patients undergoing surgery.
- Conditions
- Chronic Subdural Hematoma, Trendelenburg, Recurrence, Mortality
- Trial name
- POTHeR (NCT06911736)
- Testing
- Trendelenburg position
- Where
- 3 sites in Colombia
- Volunteers
- 254 people
- Sponsor
- Universidad de Antioquia
Traumatic Brain Injury
Non-invasive Clinical Imaging of Cerebral Metabolism Following Brain Injury Using 13C Magnetic Resonance Spectroscopy.
Despite the decline in fatal traumatic brain injury (TBI) incidence in recent years, TBI morbidity remains a public health challenge and is the leading cause of disability in the United States.
- Trial name
- NCT02745210
- Testing
- 13C magnetic resonance spectroscopy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Brain Injuries, Traumatic
Multiomic Analysis of Body Fluid in Acute Traumatic Brain Injury
The goal of this experimental observation study is to figure out differently expressed biomarkers in body fluid in traumatic brain injury patients.
- Trial name
- MOSS-FAST (NCT05778123)
- Testing
- Type of disease
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Traumatic Brain Injury
Evaluation of Consciousness Impairment in Severe TBI and Full-cycle Neuroregulation Based on Multimodal Imaging
The goal of this observational study is to learn about in Evaluation of consciousness impairment in severe TBI and full-cycle neuroregulation based on multimodal imaging.
- Trial name
- NCT06469827
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
TBI (Traumatic Brain Injury)
Brain Aging in Veterans (BRAVE) Training: A Cognitive Training Pilot Trial in Older Veterans With Traumatic Brain Injury
The purpose of this study is to conduct a pilot trial investigating cognitive training in older Veterans with a history of traumatic brain injury (TBI) to assess training effects, acceptability of training to participants, and to…
- Trial name
- NCT02561403
- Testing
- EVO multitask video game, EVO words video game
- Where
- 2 sites in United States
- Volunteers
- 89 people
- Sponsor
- San Francisco Veterans Affairs Medical Center
Hyperventilation, Traumatic Brain Injury
Treatment of Spontaneous Hyperventilation With Remifentanil in Traumatic Brain Injury Patients
Spontaneous hyperventilation is common in severe traumatic brain injury patients and correlates closely with poor outcomes. How to treat this pathological condition remain unsolved.
- Trial name
- NCT04974060
- Testing
- Remifentanil Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Neurocritical Care, Traumatic Brain Injury
Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care
Enhanced recovery after surgery (ERAS) is a strategy of perioperative management aimed to accelerate the rehabilitation of patients through various optimized perioperative managements as well as ongoing adherence to a…
- Conditions
- Neurocritical Care, Traumatic Brain Injury, Cerebrovascular Disease, Moderate or Severe Coma
- Trial name
- NCT06241482
- Testing
- Enhanced recovery after surgery, Conventional therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai 6th People's Hospital
Traumatic Brain Injury, TBI
Methylphenidate for Attention Problems After Pediatric TBI
Traumatic Brain Injury (TBI) - methylphenidate treatment
- Conditions
- Traumatic Brain Injury, TBI, ADHD
- Trial name
- NCT01933217
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Post-concussive Symptoms, Traumatic Brain Injury
Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)
This is a Phase II randomized trial designed to describe the magnitude of change between baseline and follow-up outcomes for symptom surveys and a battery of neuropsychological tests administered at time points corresponding…
- Trial name
- HOPPS (NCT01306968)
- Testing
- hyperbaric oxygen
- Where
- 5 sites in United States
- Volunteers
- 79 people
- Sponsor
- U.S. Army Medical Research and Development Command
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