Clinical trials: Traumatic Injuries
PTSD, Alzheimer Disease
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)
The goal of this First-In-Human (FIH) trial is to learn about safety and PharmacoKinetics (PK) in healthy adult volunteers. The main questions it aims to answer are: What is the safety of single ascending doses of the…
- Conditions
- PTSD, Alzheimer Disease, Brain Diseases, Neuro-Degenerative Disease
- Trial name
- NCT05921929
- Testing
- Fluoroethylnormemantine (FENM)
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- ReST Therapeutics
TBI (Traumatic Brain Injury)
Stimulating After Recovery From Traumatic Brain Injury
This is a preliminary, prospective interventional study to investigate the feasibility of using transcutaneous alternating current stimulation (TACS) after a traumatic brain injury (TBI) to improve cognitive function and…
- Trial name
- SMART (NCT05327829)
- Testing
- External non-invasive stimulation, COGED
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Depression, Panic Disorder
Evaluating the Effects of Stress in Pregnancy
This study will evaluate pregnant women with a past or current diagnosis of depression or anxiety to gain a better understanding of how these disorders can affect an infant's development, both during and after pregnancy.
- Conditions
- Depression, Panic Disorder, Generalized Anxiety Disorder, Post-Traumatic Stress Disorder
- Trial name
- NCT00525226
- Where
- United States
- Volunteers
- 1,431 people, healthy volunteers welcome
- Sponsor
- Emory University
Head Injuries With Non Missile Penetrating Objjects
Non-missile Penetrating Head Trauma,Cases Registry in Sohag University Hospital
A retrospective study was done in Neurosurgery trauma unit, Sohag University. Eighteen patients reported with different mechanisms of trauma. All patients clinically tested involving neurological evaluation.
- Trial name
- trauma (NCT03768778)
- Testing
- Debridement and dural repair
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sohag University
Traumatic Brain Injury (TBI) Patients
Chromatic Multifocal Pupillometer for Detection and Follow-up of Acute Head Injury
Traumatic Brain Injury (TBI) is a common injury in combat, terrorist attacks and sports such as football and hockey. Unnecessary delays in the diagnosis and treatment of brain damage in patients who can benefit from evacuation…
- Trial name
- NCT02030366
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Brain Concussion
Mild Traumatic Brain Injury Discrimination
Evaluation of the utility of a multi-modal assessment tool in distinguishing between individuals with and without a history of mild traumatic brain injury.
- Trial name
- MTBID (NCT02453958)
- Testing
- Multi-modal assessment system
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Empirical Technologies Corporation
Breast Cancer, Traumatic Brain Injury
Purpose in Life Survey
At present, there is no empirical data that specifies the likely prevalence of purpose in life disruption among various clinical populations.
- Trial name
- PIL (NCT05790278)
- Testing
- Survey
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mary Radomski
Osteoarthritis, Knee, Rheumatoid Arthritis of Knee
Evaluation of The Safety And Performance of The Freedom Total Knee® System With The PEEK-OPTIMA Femoral Component
Prospective, multi-centre, non-comparative, post-market surveillance clinical study
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis of Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis
- Trial name
- NCT03224689
- Testing
- PEEK-Optima Femoral Component
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maxx Orthopedics Inc
Military Family, Brain Injuries, Traumatic
Effects of PSTon Mental Health Outcomes in Caregivers of Post-9/11 Combat Veterans With a Traumatic Brain Injury
The primary aim of this study is to assess the efficacy of PST for positively impacting distressed military family caregiver's depression and burden levels (secondary outcomes), ultimately enhancing their mental health quality of…
- Trial name
- NCT03211884
- Testing
- Problem-Solving Thearpy
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Posttraumatic Stress Disorder (PTSD)
Non Invasive Brain Stimulation for PTSD
This study is designed to identify changes in the brain that underlie symptoms of combat-related PTSD using brain imaging (fMRI).
- Trial name
- NCT02442843
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Normal Physiology, fMRI
The Effect of Transcranial Magnetic Stimulation on Learning With Reward in Healthy Humans
Background: Two areas on the surface of the brain, the dorsolateral prefrontal cortex (DLPFC) and motor cortex (MC), play a key role during learning.
- Trial name
- NCT01260740
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Traumatic Brain Injury
Aerobic Exercise After Traumatic Brain Injury
The purpose of this study is to examine the effects of individualized aerobic exercise regimen on recovery after traumatic brain injury (TBI).Investigators will determine if exercise facilitates recovery by facilitating…
- Trial name
- AER-TBI1 (NCT05786729)
- Testing
- Aerobic Exercise (AER), Rehabilitation
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Centre for Neuro Skills
Trauma, PTSD
Posttraumatic Stress Symptoms Among Rescuers at Risk
This cross-sectional, anonymous online survey aims to examine how salient variables influence PTSS, well-being, and suicidal ideation across the following professions of rescue workers: firefighters, ambulance personnel, police…
- Conditions
- Trauma, PTSD, Self Efficacy, Coping Skills
- Trial name
- NCT03842553
- Testing
- No Intervention: anonymous online survey
- Where
- Switzerland
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- University of Bern
Posttraumatic Stress Disorder With Attention Defic
Atomoxetine and Executive Function in PTSD
Attention deficits (AD) frequently co-occur with posttraumatic stress disorder (PTSD). The presence of AD is associated with greater PTSD clinical severity and poorer clinical outcomes.
- Trial name
- NCT06573970
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Trauma, Brain
(POCUS) As an Early Screening Tool for Diagnosing Skull Fractures in Children
This study aims to evaluate the accuracy of POCUS as a screening tool for early diagnosis of skull fractures in children with mild closed head injuries admitted to the emergency department.
- Trial name
- NCT05726201
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Assiut University
Attachment Disorder, Stress Disorder
Wear Assessment of Novel PEEK Telescopic Attachment for Overdenture
To assess the wear of Zirconia-PEEK versus cobalt-chromium-PEEK telescopic attachments for implant retained complete mandibular overdenture.
- Trial name
- NCT06434142
- Testing
- implant overdenture
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hamada Zaki Mahross Atia
Concussion, Brain, Traumatic Injury
Sport Concussion Performance-Based Prevention Program
Sport-related concussions and traumatic lower body injuries (e.g., anterior cruciate ligament (ACL) tears) occur frequently in high-speed and contact/collision sports contributing to significant time loss from…
- Trial name
- NCT04992130
- Testing
- Pre-season supplementary neurologic training program
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Traumatic Brain Injury
Comparison of Brain Network Activation (BNA™) Analysis, Clinical Symptoms and Neuro-cognitive Performance in Concussed Children and Young Adults
The use of Event Related Potentials (ERP) and neurocognitive performance in patients following concussion has been examined previously in small cohorts and relatively long after concussion occurred.
- Trial name
- NCT01532271
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Post-traumatic Stress Disorder
Program for Alleviating and Resolving Trauma and Stress 1
This single-arm pilot study (Phase 1) will test the preliminary efficacy of a virtually delivered, live-online 16-week group model of Internal Family Systems (IFS) for individuals with PTSD, called the PARTS program, on PTSD…
- Trial name
- PARTS1 (NCT04713501)
- Testing
- PARTS Program
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Mild Traumatic Brain Injury
SSVEP Evaluation of Brain Function (PRO)
The investigational device used in this clinical investigation, the Nurochek PRO System (NCPRO), is a portable electroencephalogram (EEG) headset which delivers a visual stimulus and measures a VEP.
- Trial name
- NCT06013566
- Testing
- SSVEP
- Where
- Australia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Headsafe MFG
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